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2201 - 2250 of 10000+ citations for 7 hydroxy 1H 1 2 4 triazolo 1 5 a pyrimidin 5 one since 2019

• Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

  Keerthana Gnanapradeepan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Akt 1:1000 (Cell Signaling, 9272), Deptor 1:1000 (Novus Bio ...
• Sporadic activation of an oxidative stress-dependent NRF2–p53 signaling network in breast epithelial spheroids and premalignancies

  Elizabeth J. Pereira, et al., bioRxiv - Cancer Biology 2019

  Quote: ... CDK4 (Cell Signaling #12790, 1:1000), CDK2 (Santa Cruz Biotechnology #sc-6248 ...
• ECSIT prevents Alzheimer’s disease pathology by regulating neuronal mitochondrial ROS and mitophagy

  Alice Lepelley, et al., bioRxiv - Neuroscience 2020

  Quote: ... Parkin (1:1,000, Cell Signaling, Prk8), PINK1 (1:1,000 ...
• Reduced Shmt2 expression impairs mitochondrial folate accumulation and respiration, and leads to uracil accumulation in mouse mitochondrial DNA

  Joanna L. Fiddler, et al., bioRxiv - Biochemistry 2021

  Quote: ... and GAPDH (Cell Signaling, 1:2000) were used ...
• Multiscale profiling of enzyme activity in cancer

  Ava P. Soleimany, et al., bioRxiv - Bioengineering 2021

  Quote: ... PDGFRβ (3169, Cell Signaling, 1: 100), and desmin (ab227651 ...
• The role of muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury

  Francesca Boscolo Sesillo, et al., bioRxiv - Cell Biology 2021

  Quote: ... α-SMA (Cell Signaling, 19245S, 1:100), collagen I (Invitrogen ...
• Single cell 3’UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism

  Manuel Göpferich, et al., bioRxiv - Neuroscience 2020

  Quote: ... GAPDH (Cell Signaling, Rabbit, 1:1000), Histone H3 (Cell Signaling ...
• SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice

  Alan T. Tang, et al., bioRxiv - Microbiology 2021

  Quote: ... β-Actin (1:1000; Cell Signaling; 4970).
• mTORC1 and JUN are activated after deletion of Prohibitin 1 in Schwann cells and may link mitochondrial dysfunction to demyelination

  Gustavo Della-Flora Nunes, et al., bioRxiv - Neuroscience 2020

  Quote: ... eIF2α 1:500 (Cell signaling #5324), p-eIF2α 1:500 (Cell signaling #3398) ...
• Vorinostat corrects cognitive and non-cognitive symptoms in a mouse model of fragile X syndrome

  Qi Ding, Xueting Wu, Xuan Li, Hongbing Wang, bioRxiv - Neuroscience 2020

  Quote: ... and H4 (Cell Signaling, 1:1000). The relative amount of loading was determined by β-actin ...
• Inhibition of mTOR during a postnatal critical sensitive window rescues deficits in GABAergic PV cell connectivity and social behavior caused by loss of TSC1

  Mayukh Choudhury, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-pAMPK (1:800, Cell Signaling), and anti-GAPDH (1:5000 ...
• Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

  Emmanouela Kallergi, et al., bioRxiv - Neuroscience 2020

  Quote: ... ULK1 (1:1000, Cell Signaling, #8054), p62 (1:2000 ...
• Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

  Emmanouela Kallergi, et al., bioRxiv - Neuroscience 2020

  Quote: ... FIP200 (1:1000, Cell Signaling, #12436), Atg101 (1:1000 ...
• Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

  Emmanouela Kallergi, et al., bioRxiv - Neuroscience 2020

  Quote: ... Atg101 (1:1000, Cell Signaling, #13492), ULK1 (1:1000 ...
• Docosahexaenoic Acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain

  JE Le Belle, et al., bioRxiv - Neuroscience 2020

  Quote: ... EGFR (Cell Signaling Technology, 1:100), ID1 (Biocheck ...
• MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

  Dario Zimmerli, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pSTAT1 (1:1000, Cell Signaling, # 8826) and beta-Actin (1:10.000 ...
• Endogenous neural stem cells modulate microglia and protect from demyelination

  Béatrice Brousse, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-EGFR (1/50; Cell Signaling), rat anti-CD68 (1/200 AbCam).
• Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

  Abigail H. Cleveland, et al., bioRxiv - Neuroscience 2021

  Quote: ... SOX2 1:200 (Cell Signaling, #4900S), SOX9 1:200 (R&D Systems ...
• Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

  Abigail H. Cleveland, et al., bioRxiv - Neuroscience 2021

  Quote: ... NESTIN 1:500 (Cell Signaling, #4760), IBA1 1:2000 (Wako Chemicals ...
• Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content related to inflammation and recovery processes

  Annika Bub, et al., bioRxiv - Neuroscience 2021

  Quote: ... CD81 (1:1,000; #10037; Cell Signaling), Flotilin-1 (1:1,000 ...
• THE DYNAMIC INTERPLAY BETWEEN HOMEODOMAIN TRANSCRIPTION FACTORS AND CHROMATIN ENVIRONMENT REGULATES PRONEURAL FACTOR OUTCOMES

  Cheen Euong Ang, et al., bioRxiv - Genomics 2020

  Quote: ... rabbit-HSP90 (1:2500, Cell Signaling), rabbit-FLAG (1:500 ...
• Wilms Tumorigenesis in Human Kidney Organoids

  Verena Waehle, et al., bioRxiv - Cancer Biology 2021

  Quote: ... SIX1 (Cell Signaling #12891; 1:200), SIX2 (Proteintech #11562-1-AP ...
• The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

  Muzhou Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... MITF (Cell Signaling, 12590s, 1:1000), AXL (Cell Signaling ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CTSB (1:1000; Cell Signaling, 31718), CTSD (1:1000 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... AKT1 (1:1000; Cell Signaling, 9272), phospho(Ser473)-AKT1 (1:2000 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CTSD (1:1000; Cell Signaling, 2284), VCP (1:400 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... RPS6 (1:1000; Cell Signaling, 2317), phosphor(Ser240/244)-RPS6 (1:1000 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ATG7 (1:500; Cell Signaling, 8558), RB1CC1 (1:1000 ...
• Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

  Elvin Wagenblast, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-STAG2 (Cell Signaling, 1:50) and anti-GAPDH (Cell Signaling ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... PERK (Cell signaling #3192; 1/1000), phospho-PERK (Cell signaling #3179 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... eIF2α (Cell Signaling #2103, 1/1000), phospho-eIF2α (Cell Signaling #3398 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... Calnexin (Cell signaling #2679; 1/1000), α-Tubulin (Santa Cruz #sc-32293 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... ATF4 (Cell Signaling #11815, 1/1000), CHOP (Cell Signaling #5554 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... CHOP (Cell Signaling #5554, 1/1000), Bcl-xL (Cell Signaling #2764 ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... β-Tubulin (Cell Signaling 2128, 1:2000), Huwe1 (Abcam ab70161 ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... AMPKα (Cell Signaling 2532, 1:1000), phospho-AMPKα (Cell Signaling 2531 ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... S6K (Cell Signaling 2708, 1:1000), phospho-S6K (Cell Signaling 97596 ...
• Transcriptional Control of Brain Tumour Stem Cells by a Carbohydrate Binding Protein

  Ahmad Sharanek, et al., bioRxiv - Cancer Biology 2021

  Quote: ... STAT3 (1:1000, Cell Signaling, #9139), phospho-STAT3 (Tyr705 ...
• Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation

  MA Jiajia, et al., bioRxiv - Cell Biology 2021

  Quote: ... 1:100 (#4370, Cell Signaling Technology), Rabbit anti-p44/42 MAPK (Erk1/2) ...
• Counteracting Genome Instability by p53-dependent Mintosis

  Jianqing Liang, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-γH2AX (1:200; Cell Signaling; #9718 for IF ...
• Cell-to-cell heterogeneities during extrinsic apoptosis arise from cell cycle progression and transmitotic apoptosis resistance

  Nadine Pollak, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-Mcl-1 (Cell Signaling), mouse anti-PARP (BD Biosciences) ...
• ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance

  Peng Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: ... CAS3 (Cell Signaling Technology; 1:1,000), Actin (1:1,000) ...
• Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2

  Pooja Hoovina Venkatesh, et al., bioRxiv - Cell Biology 2021

  Quote: ... Beclin-1 (Cell Signaling Technology #3738), IRE-1α (Novus Biologicals #NB100-2323) ...
• Wilms Tumorigenesis in Human Kidney Organoids

  Verena Waehle, et al., bioRxiv - Cancer Biology 2021

  Quote: ... LIN28B (Cell Signaling #4196, 1:250); NPHS1 (R&D Systems #AF4269 ...
• Wilms Tumorigenesis in Human Kidney Organoids

  Verena Waehle, et al., bioRxiv - Cancer Biology 2021

  Quote: ... LIN28A (Cell Signaling #3978, 1:600); LIN28B (Cell Signaling #4196 ...
• Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

  Irene Riera-Tur, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-beclin-1 (3495, Cell Signaling), anti-HPRT (ab10479 ...
• Sex-Specific Role of Myostatin Signaling in Neonatal Muscle Growth, Denervation Atrophy, and Neuromuscular Contractures

  Marianne E Emmert, et al., bioRxiv - Developmental Biology 2022

  Quote: ... GAPDH (1:5000; Cell Signaling #2118) served as a control for sample loading ...
• History of previous midlife estradiol treatment permanently alters interactions of brain insulin-like growth factor-1 signaling and hippocampal estrogen synthesis to enhance cognitive aging in a rat model of menopause

  Nina E. Baumgartner, et al., bioRxiv - Neuroscience 2022

  Quote: ... total Akt (1:1000, Cell Signaling), total ERα (1:1000 ...
• In vivo reprogramming leads to premature death due to hepatic and intestinal failure

  Alberto Parras, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Asp175 (1:200, Cell Signaling, 9661).
• Genetic control of neuronal activity enhances axonal growth only on permissive substrates

  Francina Mesquida-Veny, et al., bioRxiv - Neuroscience 2022

  Quote: ... c-Fos (1:200, Cell Signaling), ChR2 (1:500 ...