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1201 - 1250 of 4006 citations for 2 Amino 6 chloro 9 3 5 di O p toluoyl beta D 2 deoxyribofurnanosyl purine since 2020

• Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

  Vanessa Byles, et al., bioRxiv - Cell Biology 2021

  Quote: ... phospho (P)-S6K1 T389 (Cell Signaling Technologies (CST), 9234 used in cells) ...
• Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

  Hae J. Park, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-4E-BP1 T37/47 (#2855; Cell Signaling), p-4E-BP1 S65 (#9456 ...
• Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s Disease

  Margarida Beatriz, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-p-DRP (1:1000, #3455S, Cell Signaling), anti-DRP1 (1:1000 ...
• Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of IP6K1 and repression of myo-inositol-3-P synthase

  Pablo Lazcano, et al., bioRxiv - Molecular Biology 2022

  Quote: ... p-AMPK (Cell Signaling #2531S, 1:1000 dilution), AMPK (Cell Signaling #2793S ...
• ECPAS/Ecm29-Mediated 26S Proteasome Disassembly is an Adaptive Response to Glucose Starvation

  Won Hoon Choi, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-p-mTOR (5536S, Cell Signaling, 1/1,000), anti-p-AKT (4060S ...
• ECPAS/Ecm29-Mediated 26S Proteasome Disassembly is an Adaptive Response to Glucose Starvation

  Won Hoon Choi, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-p-AKT (4060S, Cell Signaling, 1/1,000), anti-IRE1/ERN1 (3294s ...
• Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic ductal adenocarcinoma

  Wei Zhang, et al., bioRxiv - Cancer Biology 2022

  Quote: ... P-HER3 (1:100; Cell Signaling Technology, 2842), Ki67 (mouse ...
• A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

  Olga Lancho, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p-AMPK (1:1000, 2535S, Cell Signaling), anti-4E-BP1 (1:1000 ...
• ELAV proteins bind and stabilize C/EBP mRNA in the induction of long-term memory in Aplysia

  Anastasios A. Mirisis, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-p-p38 MAPK (Cell Signaling Technology, #4511), anti-β-Tubulin (Cell Signaling Technology ...
• Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy

  Lena H. Nguyen, et al., bioRxiv - Neuroscience 2021

  Quote: ... p-4E-BP1 Thr37/46 (Cell Signaling Technology #2855 ...
• TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-κB signaling

  Constanza E. Espada, et al., bioRxiv - Microbiology 2020

  Quote: ... p-IκBα and TRAF6 (Cell Signaling, #9246S, #8028), p-p38 and p38 MAPK (Cell Signaling ...
• Influenza-induced oxidative stress sensitizes lung cells to bacterial toxin-mediated necroptosis

  Norberto Gonzalez-Juarbe, et al., bioRxiv - Microbiology 2020

  Quote: ... p-MLKL (1:1000, #37333S, Cell Signaling Technologies) and cytoskeletal actin (1:10000 ...
• Small molecule cognitive enhancer reverses age-related memory decline in mice

  Karen Krukowski, et al., bioRxiv - Neuroscience 2020

  Quote: ... and p-eIF2 (Cell Signaling, Cat No 3597) and β-actin (Sigma-Aldrich ...
• Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration

  Andrew M. Hamilton, Laura N. Borodinsky, bioRxiv - Neuroscience 2020

  Quote: ... and 1:1500 P-CREB (Cell Signaling 9198) for 4-5 days at 4°C ...
• The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer

  Theodora A. Constantin, et al., bioRxiv - Molecular Biology 2022

  Quote: ... P-S807/811 Rb (Cell Signaling Technology, 8516), Rb (Abcam ...
• Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

  Debolina Ganguly, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p-p65 (1:1000, Cell Signaling, 3033S), anti-actin (1:2500 ...
• Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts

  Pei Ying Ng, et al., bioRxiv - Cell Biology 2022

  Quote: ... p-AKT (Cell Signaling Technology, 1/1000 dilution), t-AKT (Cell Signaling Technology ...
• Estrogen controls mTOR signaling and mitochondrial function via WNT4 in lobular carcinoma cells

  Madeleine T. Shackleford, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p-mTOR-S2448 (Cell Signaling, D9C2, cat#5536); MCL-1 (Cell Signaling ...
• EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma

  Xianping Shi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-P-mTOR (S2448) (Cell Signaling Technology, 2971S), anti-P-p38 MAPK (T180/Y182 ...
• Localized phosphorylation of RNA Polymerase II by G1 cyclin-Cdk promotes cell cycle entry

  Mardo Kõivomägi, et al., bioRxiv - Cell Biology 2021

  Quote: ... P-cdc2 (T161) Rabbit antibody (Cell Signaling Technology) or anti-FLAG ...
• Discoidin domain receptor 2 drives melanoma drug resistance through AXL-dependent phenotype switching

  Margaux Sala, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit monoclonal anti-P-AKt (2965S, Cell Signaling), rabbit monoclonal anti-Akt (9272S ...
• Discoidin domain receptor 2 drives melanoma drug resistance through AXL-dependent phenotype switching

  Margaux Sala, et al., bioRxiv - Cancer Biology 2021

  Quote: ... mouse monoclonal anti-P-Erk (9106S, Cell Signaling); rabbit monoclonal anti-Erk (9102S ...
• Discoidin domain receptor 2 drives melanoma drug resistance through AXL-dependent phenotype switching

  Margaux Sala, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit monoclonal anti-P-DDR1 (14531, Cell Signaling), rabbit monoclonal anti-P-DDR2 (MAB25382 ...
• EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma

  Xianping Shi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-P-Akt (S473) (Cell Signaling Technology, 4060S), anti-p70 S6 Kinase (Cell Signaling Technology ...
• Invasive dedifferentiated melanoma cells inhibit JAK1-STAT3-driven actomyosin contractility of human fibroblastic reticular cells of the lymph node

  Christopher Rovera, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and P-MLC2 (S19) (#3671, Cell Signaling Technology) primary antibodies diluted 1:100 in PBS 0.1% Triton ...
• Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues

  Brian Thompson, et al., bioRxiv - Developmental Biology 2021

  Quote: ... P-NF-κB P65 (Cell Signaling Technologies, 3033T), IKK-β (Cell Signaling Technologies ...
• The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

  Leila Revollo, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti p-Akt (S473) (Cell Signaling Technology, #4060), anti Akt (Cell Signaling Technology ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... p-Akt S473 (#4060L, 1:1000, Cell Signaling), Akt (#9272S ...
• Role of microRNA-145 in DNA damage signalling and senescence in vascular smooth muscle cells of Type 2 diabetic patients

  Karen E Hemmings, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-p53 (ser15) (#9284) (all Cell Signaling Technologies), with α-tubulin (ab8226 ...
• Hexapeptide induces M2 macrophage polarization via the JAK1/STAT6 pathway to promote angiogenesis in bone repair

  Xinyun Han, et al., bioRxiv - Biochemistry 2021

  Quote: ... p-STAT6 (1:1000) (Cell Signaling Technology, USA), β-tubulin (1:5000 ...
• PTHrP Induces STAT5 Activation, Secretory Differentiation and Mammary Tumor Progression

  Diego Y. Grinman, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-p(Tyr694)Stat5 (Cell Signaling, Cat# #9359), anti-Stat5 (Cell Signaling ...
• The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

  Margaret E. Torrence, et al., bioRxiv - Cell Biology 2021

  Quote: ... phospho (P)-S6K1 T389 (Cell Signaling Technologies (CST), 9234) ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-CREB (Cell Signaling Technology, #9198, 1:1000), CREB (Cell Signaling Technology ...
• FKBPL and FKBP8 regulate DLK degradation and neuronal responses to axon injury

  Bohm Lee, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-p-SEK1/MKK4 (Cell Signaling, CST-9151), anti-GST (Santa Cruz ...
• Characterization of early Alzheimer’s-like pathological alterations in non-human primates with aging: a pilot study

  Hannah Jester, et al., bioRxiv - Molecular Biology 2021

  Quote: ... p-ACC1 (1:1000; Ser79) (Cell Signaling, Cat#), ACC1 (1:1000 ...
• Characterization of early Alzheimer’s-like pathological alterations in non-human primates with aging: a pilot study

  Hannah Jester, et al., bioRxiv - Molecular Biology 2021

  Quote: ... p-LKB1 (1:1000; Ser428) (Cell Signaling, Cat#), LKB1 (1:1000 ...
• Elucidating spatially-resolved changes in host signaling during Plasmodium liver-stage infection

  Elizabeth K.K. Glennon, et al., bioRxiv - Microbiology 2021

  Quote: ... p-IK-Ba 1:200 (Cell Signaling 2850), p-Akt 1:100 (Cell Signaling 9271) ...
• Cylindromatosis Drives Synapse Pruning and Weakening by Promoting Macroautophagy through Akt-mTOR Signaling

  Alexis S. Zajicek, et al., bioRxiv - Neuroscience 2021

  Quote: ... p-AKT [T308] (1:1000; Cell Signaling, 9275), CYLD (1:1000 ...
• Cylindromatosis Drives Synapse Pruning and Weakening by Promoting Macroautophagy through Akt-mTOR Signaling

  Alexis S. Zajicek, et al., bioRxiv - Neuroscience 2021

  Quote: ... p-mTOR [S2448] (1:1000; Cell Signaling, 5536), p62 (1:1000 ...
• IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor

  Tommaso Virgilio, et al., bioRxiv - Immunology 2021

  Quote: ... anti-p(Y705)Stat3 (9131, Cell Signaling Technology). Mouse monoclonal anti-GAPDH (clone FF26A/F9 ...
• Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

  Allison K. Meyers, et al., bioRxiv - Immunology 2021

  Quote: ... p-ACC (Cell Signaling, no. 3661s; 1:750), TUFM (Novus Biologicals ...
• SCARF1-induced efferocytosis plays an immunomodulatory role in humans, and autoantibodies targeting SCARF1 are produced in patients with systemic lupus erythematosus

  April M. Jorge, et al., bioRxiv - Immunology 2021

  Quote: ... p-STAT1-Alexa488 (Tyr701, Cell Signaling clone 58D6), Erk1/ 2 p-44/42-Alexa488 (Cell Signaling clone 137F5) ...
• Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to-mesenchymal transition

  Marko Marjanović, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-eIF2α (1:1000, Cell Signaling Technologies, 3597), CREB-2 (1:100 ...
• Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

  Benjamin Ng, et al., bioRxiv - Immunology 2022

  Quote: ... p-ERK (Cell Signaling Technology, 4370, 1:100), Ki67 (Abcam ...
• The Gene Knockout of Angiotensin II Type 1a Receptor Improves High-fat Diet-Induced Obesity in rat via Promoting Adipose Lipolysis

  Aiyun Li, et al., bioRxiv - Physiology 2022

  Quote: ... P-GSK-3β (ser9) (5558S, Cell Signaling Technology), GSK-3β (9315S ...
• In vivo KRAS G12D/V degradation mediated by CANDDY using a modified proteasome inhibitor

  Satoshi Imanishi, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... p-Akt (1:2000, #4060; Cell Signaling Technology), and Akt (1:2000 ...
• Transcriptomic analyses reveal prenatal stress promotes late-onset neural stem cell proliferation in adult male offspring

  Z. Wang, et al., bioRxiv - Neuroscience 2023

  Quote: ... p-MAPK3/1 (Cell Signaling 4370, 1:200), and MAPK3/1 (Cell Signaling 4695 ...
• Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia

  Jay Penney, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit-p-p38 (T180/182, Cell Signaling Technology), rabbit-p38 (Cell Signaling Technology) ...
• Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia

  Jay Penney, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit-pan-p-PKC (T514, Cell Signaling Technology), rabbit-p-ERK (Cell Signaling Technology) ...
• The metabolite α-ketobutyrate increases health and life spans by activating AMPK

  Chieh Chen, et al., bioRxiv - Physiology 2022

  Quote: ... Antibodies used: P-AMPK T172 (Cell Signaling, 2535S), GAPDH (Thermo Fisher Scientific ...