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1101 - 1150 of 10000+ citations for 7 Chloro 1 3 dihydro 1 methyl 5 phenyl 2H benzo 1 4 diazepin 2 one 4 oxide since 2019

• ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle

  Antentor Hinton Jr., et al., bioRxiv - Biophysics 2023

  Quote: ... glyceraldehyde 3-phosphate dehydrogenase (GAPDH; 1:5,000; Cell Signaling Technology: Danvers, MA, USA; #2118), MFN1 (1:1,000 ...
• An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant

  Rebecca A. Lee, et al., bioRxiv - Cell Biology 2024

  Quote: ... The primary antibodies were rabbit anti-cleaved caspase-3 (Cell Signaling; 9661; 1:100), chicken anti-GFP (Aves Labs ...
• Small Extracellular Vesicles Secreted by Region-specific Astrocytes Ameliorate the Mitochondrial Function in a Cellular Model of Parkinson’s Disease

  Loredana Leggio, et al., bioRxiv - Neuroscience 2021

  Quote: ... Coverslips were fixed with 4% PFA and stained with rabbit polyclonal anti-cleaved caspase-3 (Cell Signaling, 9664) primary antibody and with mouse monoclonal anti-map2 primary antibody (Merck Millipore ...
• Neuron-intrinsic NF-κB Signaling Mediates Reovirus Virulence

  Andrea J. Pruijssers, et al., bioRxiv - Microbiology 2020

  Quote: ... for evaluation of histopathologic changes by H&E staining or for immunohistochemical detection of reovirus antigen (1:45,000 dilution) or the cleaved (active) form of caspase-3 (Cell Signaling, 9664; 1:300 dilution). Images were captured at a magnification of ×20 and a resolution of 0.5 μm/pixel using a high-throughput Leica SCN400 slide scanner automated digital imaging system.
• The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway

  Hao Chen, et al., bioRxiv - Neuroscience 2023

  Quote: Cryosections of P0 mouse brains were immunolabeled with cleaved-caspase 3 (c-cas 3) antibody (Cell Signaling #9961, 1:4000) for apoptosis analysis ...
• Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

  Honglin Jiang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Phospho-Erk1/2 (Thr202/Tyr204) (Cell Signaling Technology, 4370, Dilution: 1:1000); Erk1/2 (Cell Signaling Technology ...
• Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells

  Dhruv Raina, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Primary antibodies used were anti-pERK1/2 1:200 (4370S, Cell Signaling), anti-E-Cad 1:200 (M108 ...
• Endothelial cell polarity and extracellular matrix production rely on functional ATP6AP2 during developmental and pathological angiogenesis

  NR Patel, A Blanks, Y Li, MC Prieto, SM Meadows, bioRxiv - Molecular Biology 2021

  Quote: ... anti-phospho-p44/42 MAPK (pErk1/2) (Cell signaling, 9101, 1:1000), anti-Collagen type III (Abcam ...
• The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

  Brian Hurwitz, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1/100 Phospho-Myosin Light Chain 2 (Ser19) (Cell Signaling Technologies, 3675); 1/250 p62/SQSTM (Cell Signaling Technologies ...
• Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

  Timothy N. Hoang, et al., bioRxiv - Immunology 2020

  Quote: ... pSTAT3 (Cell Signaling; Cat. No. 9145L at 1:200 for 2 hours), Iba-1 (BioCare ...
• A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary

  Wen Lu, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit phospho-MLC (pMLC 2/Ser19, 1:100, Cell Signaling, Cat# 3671); mouse monoclonal anti-DHC antibody (2C11-2 ...
• Negative durotaxis: cell movement toward softer environments

  Aleksi Isomursu, et al., bioRxiv - Biophysics 2020

  Quote: ... rbt anti-ERK1/2 (Cell Signaling Technology, 9102, 1:1000 for WB), rbt anti-p-ERK1/2 (T202/Y204 ...
• Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

  Parishmita Sarma, et al., bioRxiv - Biochemistry 2022

  Quote: ... and anti-tERK1/2 (1:5000; Cell Signaling Technology, Cat. no. 9102). CXCR7pp2 was synthesized at the Tufts University Core Facility.
• Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotype

  Jordi Creus-Muncunill, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) Antibody (1:1000, #9102, Cell Signaling), anti-C1q [4.8] (1:500 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p44/42 MAPK (ERK1/2) (Cell Signaling Technology, Cat. #: 9102, 1:1000), phospho-PR (S294 ...
• Transferrin-dependent crosstalk between the intestinal tract and commensal microbes contributes for immune tolerance

  Xiaopeng Tang, et al., bioRxiv - Immunology 2020

  Quote: ... anti-total-IκBα (1:2□000 dilution, 4814T, Cell Signaling Technology, USA), anti-phospho-NF-κB p65 (1:1□000 dilution ...
• Biased agonists of the chemokine receptor CXCR3 differentially drive formation of G_αi:β-arrestin complexes

  Kevin Zheng, et al., bioRxiv - Biochemistry 2020

  Quote: ... phosphorylated extracellular regulated kinase 1/2 (ERK) (Cell Signaling Technology, Danvers, MA) and total ERK (Millipore ...
• Jak2^V617F Reversible Activation Shows an Essential Requirement for Jak2^V617F in Myeloproliferative Neoplasms

  Andrew Dunbar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and phospho-44/42 MAPK (Erk1/2) (Cell Signaling 4376, 1:100). Pictures were taken at 100X ...
• ATP allosterically stabilizes Integrin-linked kinase for efficient force generation

  Isabel M. Martin, et al., bioRxiv - Biophysics 2021

  Quote: ... phospho-Myosin Light Chain 2 (Thr18/Ser19) (Cell Signaling; 3674; 1:200), Paxillin (BD Transduction Laboratories ...
• Oxidative Stress and Neuroinflammation in a Rat Model of Co-Morbid Obesity and Psychogenic Stress

  Jose M. Santiago Santana, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-rabbit SOD-2 (1:2000; catalog #13141S; Cell Signaling, Danvers, MA); anti-rabbit GFAP (1:5000 ...
• Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

  Odessa R. Yabut, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-phospho-Erk1/2 (1:250 dilution; Cat. #: 4370, Cell Signaling); γH2AX (1:100 dilution ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-phospho-ERK1/2 (T202/Y204) (Cell Signaling 4370, 1:2000), rabbit anti-ERK1/2 (Cell Signaling 4695 ...
• TOP-2 is differentially required for the proper maintenance of cohesin on meiotic chromosomes in C. elegans spermatogenesis and oogenesis

  Christine Rourke, Aimee Jaramillo-Lambert, bioRxiv - Genetics 2021

  Quote: ... rabbit anti-AIR-2 [(1:500) Figure 2B] (Cell Signaling Technology, 2914S), Histone H3 phospho-T3 (1:750 ...
• Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

  Brittany L. Dunkerly-Eyring, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 1:1000). Total protein stain used was Revert Total Protein Stain (Licor) ...
• Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit

  Muhammad Shoaib, et al., bioRxiv - Neuroscience 2021

  Quote: ... and Total AMPK β1/2 (1:1000; Cell Signaling Technology, Beverly, MA). Detection used anti-rabbit horseradish peroxidase–conjugated secondary antibody (1:2000 ...
• Retinoid acid receptor β mechanically regulates the activity of pancreatic cancer cells

  Carlos Matellan, et al., bioRxiv - Bioengineering 2022

  Quote: ... or anti-MLC-2 antibodies (Cell Signaling Technology, 3672S, Rabbit, 1:100) and anti-PAN cytokeratin (Abcam ...
• An atlas of epithelial cell states and plasticity in lung adenocarcinoma

  Guangchun Han, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAPK (ERK1/2, rabbit, Cell Signaling Technology, 9102, 1:2000), or S6 (E.573.4 ...
• Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression

  Giusy Pizzirusso, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1:1000 anti-Synaptotagmin-2 polyclonal rabbit antibody (#60889, Cell Signaling Technology), 1:1000 anti-GABA-A Receptor beta 3 polyclonal rabbit antibody (#NB300-199 ...
• Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function

  Rajan K C, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p-p44/42 MAPK (pERK1/2) (Cell Signaling Technology, 9101S, 1:1,000) and β-actin (Cell Signaling Technology ...
• Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish

  Nanami Morooka, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (1:500, Cell signaling), and mouse anti-RFP (1:500 ...
• Endosome dysfunction leads to gain-of-function TLR7 and human lupus

  Harshita Mishra, et al., bioRxiv - Immunology 2023

  Quote: ... anti-Phospho-p44/42 (ERK1/2) (1:1000, 197G2, 4377T, Cell Signaling), anti-p44/42 (ERK1/2 ...
• Diet-induced obesity results in endothelial cell desensitization to VEGF-A and permanent islet vascular dysfunction

  Yan Xiong, et al., bioRxiv - Physiology 2023

  Quote: ... Erk1/2 antibody (rabbit, 1:2000; all from Cell Signaling Technology, USA), and α-tubulin antibody (mouse,1:1000 ...
• Subfamily C7 Raf-like kinases MRK1, RAF26, and RAF39 regulate immune homeostasis and stomatal opening in Arabidopsis thaliana

  Márcia Gonçalves Dias, et al., bioRxiv - Plant Biology 2023

  Quote: ... 1:2,000 rabbit anti-p44/42 MAPK (Erk1/2) (Cell Signaling 9102S); 1:10,000 goat anti-rabbit-IgG (Sigma A0545) ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:1000; 9101; Cell Signaling Technology, Inc.); ERK1/2 (1:1000 ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:1000, Cell Signaling Technology, Cat# 9106), ERK1/2 (1:1000 ...
• Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

  Zhuxuan Li, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (#4370, Cell Signaling Technology, 1:1000), ERK (#9102S ...
• Drug-Induced p53 Activation Promotes Acinar Cell Identity and Prevents Pancreatic Cancer Initiation

  Jennifer J Twardowski, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit monoclonal anti-p-ERK1/2 (Cell Signaling Technology 4370S, 1:100), rabbit polyclonal anti-p53 (Invitrogen PA5-88098 ...
• Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells

  Inês Caldeira Brás, et al., bioRxiv - Neuroscience 2021

  Quote: ... Flotilin-1 (1:1000, #18634, Cell Signaling), GFP (1:1000 ...
• Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophy

  Victoriane Peugnet, et al., bioRxiv - Cell Biology 2021

  Quote: ... beclin-1 (3738, Cell signaling, 1/1000); catalase (CO979 ...
• LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome

  Laura Bozal-Basterra, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-PCM-1 (Cell Signaling, 1:100) and anti-Centrobin (Genetex ...
• Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway

  Julia Noack, et al., bioRxiv - Cell Biology 2020

  Quote: ... OPA-1 1:1000 (Cell Signaling Technology), MRPP3 1:1000 (Proteintech) ...
• Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN Haploinsufficiency

  Jon Ondaro, et al., bioRxiv - Neuroscience 2024

  Quote: ... LC3Bxp (1:1 000, #3868, Cell Signaling), SQSTM1/P62 (1:1 000 ...
• Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme

  Chatrawee Duangjan, et al., bioRxiv - Cell Biology 2023

  Quote: ... IRS-1 (Cell Signaling Technology, 1:500), pIRS-1 (Millipore Sigma ...
• Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

  Jinhai Deng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Caspase 1(1:1000, Cell Signaling Technology), TXNIP (1:1000 ...
• Epitranscriptomics m⁶A analyses reveal distinct m⁶A marks under tumor necrosis factor α (TNF-α)-induced apoptotic conditions in HeLa cells

  Azime Akçaöz-Alasar, et al., bioRxiv - Cell Biology 2023

  Quote: ... Following nuclear staining with 4′,6-diamidino-2-phenylindole (DAPI; 4083S, Cell Signaling Technology, MA, USA), larvae were mounted in 80% glycerol between two coverslips and imaged using fluorescence confocal microscopy ...
• Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation

  Edward S. Wickstead, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit monoclonal, 1:1000), haem oxygenase-1 (HO-1; rabbit polyclonal, 1:1000) or IκBα (mouse monoclonal, 1:1000; Cell Signaling Technology, Leiden, The Netherlands) in Tris-buffer saline solution containing 0.1% Tween-20 and 5% (w/v ...
• Quantitative Measurement of Secretory Protein Mistargeting by Proximity Labeling and Parallel Reaction Monitoring

  Ziqi Lyu, Joseph C. Genereux, bioRxiv - Cell Biology 2023

  Quote: ... anti-GAPDH (1:1000, 42 mg mL−1, Cell Signaling Technology or 1:1000, 600 μg mL−1, Proteintech) followed by secondary goat anti-rabbit antibody (IRDye 800 CW ...
• Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules that Affect Aging Pathways and Extend C. elegans’ Lifespan

  Peichuan Zhang, et al., bioRxiv - Genetics 2019

  Quote: ... fixed with 4% paraformaldehyde for 30 minutes and then blocked with 5% normal goat serum (Cell Signaling) and 0.3% Triton X-100 for 1 hour ...
• The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

  Shu Yang, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-Phospho-Smad1/5 (Ser463/465) (Cell Signaling Technology, 9516; 1/100); mouse anti-HA.11 (Covance ...
• TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

  Prasanna Vasudevan Iyengar, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and phospho-SMAD1/5/8 (1:50, #9511, Cell Signaling, Leiden, The Netherlands). Sections were incubated with secondary antibody Alexa Fluor 488 donkey anti-rabbit (1:250 ...