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901 - 950 of 4006 citations for 2 Amino 6 chloro 9 3 5 di O p toluoyl beta D 2 deoxyribofurnanosyl purine since 2020

• Secreted soluble factors from tumor-activated mesenchymal stromal cells confer platinum chemoresistance to ovarian cancer cells

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) as per the manufacturers’ instructions ...
• EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

  Sukanya Chakraborty, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2-Thr202/Tyr204 (#9101) from Cell Signaling Technology; and anti-beta-actin (#A5441 ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Cell Signaling 4376S, 1:1000) and Vinculin (Abcam ab129002 ...
• Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function

  Rajan K C, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 4695S, 1:1,000), p-p44/42 MAPK (pERK1/2 ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... mouse anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-phospho myosin light chain 2 (Cell signaling ...
• Spatiotemporal Proteomics Deciphers Functional Selectivity of EGFR ligands

  Akihiro Eguchi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... mouse anti-phospho-Erk1/2 (T202/T204) (#9106; Cell Signaling Technology), rabbit anti-Clint1 (ab251892 ...
• HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

  Hongbo Ling, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2 (Thr202/Tyr204) (Cell Signaling Technology, #9101, RRID:AB_331646), anti-ERK1/2 (Cell Signaling Technology ...
• Ascites in malignant ovarian cancer confer ovarian cancer cells chemoresistance to platinum. Combination treatment with crizotinib and 2-hydroxyestradiol restores platinum sensitivity

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) according to the manufacturers’ instructions ...
• Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

  Anagha Inguva Sheth, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Primary antibodies used include BCL-2 (Cell Signaling Technologies, no.15071), SERCA3 (Biorad ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist

  Chih-Chieh Chang, et al., bioRxiv - Biochemistry 2023

  Quote: ... rabbit anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, USA), anti-phospho-p44/42 MAPK (p-ERK1/2 ...
• FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

  Richard D. Lutze, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-pERK1/2 (Thr202/Tyr204, 9101S, Cell Signaling Technologies, 1:1000) and anti-GAPDH (ab181602 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-MAPKAPK-2 (Thr222) (1:1000, Cell Signaling 3316), rabbit anti-p38 MAPK (1:1000 ...
• Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

  Qin Ni, et al., bioRxiv - Biophysics 2024

  Quote: ... anti-p44/42 MAPK (ERK1/2; Cell Signaling; 4695; 1:1000). GAPDH was used as a loading control (Cell Signaling ...
• PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions

  Anella Saviano, et al., bioRxiv - Immunology 2024

  Quote: ... rabbit monoclonal COX-2 (1:1000; D5H5; both from Cell Signaling) and mouse monoclonal anti-beta-actin (0.01 µg mL−1 ...
• Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial maturity

  E O’Loughlin, et al., bioRxiv - Cancer Biology 2024

  Quote: ... phospho-SHP-2 (1:1000 for immunoblot; Cell Signaling Technology #3751), phospho-MEK (1:1000 for immunoblot ...
• Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression

  Nathaniel Shannon, et al., bioRxiv - Cell Biology 2024

  Quote: ... phospho-MEK1/2 (S217/S221) (1:1000, Cell Signaling Technology #9121), total MEK1/2 (1:1000 ...
• Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

  Kaitlin P. McCreery, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK phospho-Erk1/2 (Cell Signaling 4376, 1:2000), p44/42 MAPK Erk1/2 (Cell Signaling 4695 ...
• PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α and lipid metabolism reprogramming

  Lucía Celada, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit anti-p44/42 MAPK (Erk1/2) (#9102 Cell Signaling Technology) at 1:1,000 dilution ...
• Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex

  Bibek R. Karki, et al., bioRxiv - Biochemistry 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling #4376), p44/42 MAPK (Erk1/2 ...
• Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

  Mary C. Rominger, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAPK 1:1000 (Erk1/2) (Cell Signaling Technology, 9107), Phospho-p44/42 MAPK (Erk1/2 ...
• The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells

  Shadi Zahedi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAP kinase (Erk1/2) (#9102) (Cell Signaling, Danvers, MA); LC3 (#NB100–2220 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology), Phospho-p44/42 MAPK (Erk1/2 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology), and Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2 ...
• ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin’s lymphoma and testicular cancer cells

  Daniel Constantin, Christian Widmann, bioRxiv - Cancer Biology 2020

  Quote: ... and the one against beta actin from Cell signaling (CLS4970; lot 14). Our anti FLAG antibody was purchased from Sigma (F1804-1MG ...
• ZDHHC5 targets Protocadherin 7 to the cell surface by a palmitoylation-dependent mechanism to promote successful cytokinesis

  Nazlı Ezgi Özkan Küçük, et al., bioRxiv - Cell Biology 2022

  Quote: ... The following antibodies and reagents were used: Beta-Tubulin (Cell Signaling, CS2128S), Alpha Tubulin (Cell Signaling ...
• Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

  Shreoshi Sengupta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Integrin beta-1 (Cell Signaling Technology #9699 Rabbit mAb, WB 1:1000), Integrin alphaV (Cell Signaling Technology #4711 Rabbit Ab ...
• Neurotrophin signaling is modulated by specific transmembrane domain interactions

  María L. Franco, et al., bioRxiv - Biochemistry 2021

  Quote: ... soluble human beta nerve growth factor (hβ-NGF; Cell Signaling Technology; 5221SC) was diluted to a final concentration of 100 ng/µl with the hypo-osmotic media before adding to the cells.
• The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation

  Sherif Rashad, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-beta actin antibody (1:5000 dilution, Cell signaling technologies, Cat# 4970S); HRP-linked anti-mouse antibody (1:2000 ...
• Classic oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer

  Ayushi S. Patel, et al., bioRxiv - Cancer Biology 2020

  Quote: Cells were stained with Senescence beta-galactosidase Staining Kit (Cell signaling #9860) according to manufacturer’s recommendations.
• Biomechanical and biochemical assessment of YB-1 expression in melanoma cells

  Anna Cykowska, et al., bioRxiv - Cancer Biology 2021

  Quote: ... beta-tubulin (rabbit, 1:100 #2129 9F3, Cell Signaling, Danvers, MA, USA), fibrillin I (mouse ...
• Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential

  Mikaela M. Mallin, et al., bioRxiv - Cancer Biology 2022

  Quote: ... diluted 1:200 OR Beta-Actin (8H10D10) Mouse mAb (Cell Signaling Technologies diluted 1:5,000 in a solution of 1% Bovine Serum Albumin (BSA ...
• Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells

  Camille Ternet, et al., bioRxiv - Systems Biology 2022

  Quote: ... The following antibodies were used for Western blotting: beta-Actin (Cell Signaling, #4970 ...
• RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence

  Sarah E. Hickson, Jennifer L. Hyde, bioRxiv - Microbiology 2024

  Quote: ... The following antibodies were used: beta-Actin Mouse mAb (Cell signaling, 8H10D10), beta-Actin Rabbit mAb (Cell signaling ...
• Extracellular vesicles adhere to cells predominantly through the interaction of CD151-associated integrin heterodimers and GM1 with laminin

  Tatsuki Isogai, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit polyclonal anti-integrin beta 4 (1:500, Cell Signaling, Cat# 4707S), rabbit polyclonal anti-integrin beta 5 (1:500 ...
• Improved split prime editors enable efficient in vivo genome editing

  Rongwei Wei, et al., bioRxiv - Genomics 2024

  Quote: ... The primary antibodies anti-beta-actin (Cell Signaling Technology, dilution: 1:1,000) or anti-Cas9 (Cell Signaling Technology ...
• Biomarkers of Cardiovascular Toxicity of Benzene Inhalation in Mice

  Marina V. Malovichko, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... and cleaved caspase-9 antibody (Cell Signaling Technology, Danvers, MA). The microparticles (<1μm ...
• Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

  Niraj Nag, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-cleaved caspase 9 antibody (Cell Signaling Technology Cat# 7237), anti-p65 antibody (Cell Signaling Technology Cat# 4764 ...
• Apoptotic signaling clears engineered Salmonella in an organ-specific manner

  Taylor J. Abele, et al., bioRxiv - Immunology 2023

  Quote: ... caspase-9 (1:750, mouse, Cell Signaling Technology, Cat. 9508), cleaved caspase-7 (1:1000 ...
• Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor

  Patricia D.B. Tiburcio, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cleaved Caspase-9 (Cell Signaling Technology 7237, RRID:AB_10895832; 1:1,000), Cyclin D2 (Cell Signaling Technology 3741 ...
• Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution compared to standard antibodies

  Nathalie Khoury, et al., bioRxiv - Neuroscience 2024

  Quote: ... The pellet was resuspended and incubated with the enzyme P mix at 37°C for 10min along with the transcriptional and translational inhibitors Actinomycin D (Cell Signaling Technology, cat. #15021, 5uM final concentration) and Anisomycin (Cell Signaling Technology ...
• The cellular basis of protease activated receptor type 2 (PAR2) evoked mechanical and affective pain

  Shayne N Hassler, et al., bioRxiv - Neuroscience 2020

  Quote: ... at 1:500 and rabbit-anti-P-p44/42 MAPK T202/Y204 (p-ERK; 9101; Cell Signaling Technology) at 1:250 in blocking buffer ...
• Automated Enrichment of Phosphotyrosine Peptides for High-Throughput Proteomics

  Alexis Chang, et al., bioRxiv - Systems Biology 2023

  Quote: ... p-Tyr-100 and p-Tyr-1000 antibodies were purchased as magnetic bead conjugates from Cell Signaling Technology® and mixed in a 1:1 ratio by volume ...
• CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics

  Kumarkrishna Raychaudhuri, et al., bioRxiv - Immunology 2024

  Quote: ... anti-p-TCRζ-Y142 (BD Pharmingen, Cat no. 558402, anti-p-ZAP70-Y319 (Cell Signaling, Cat. No. 2717S), anti-p-PLCγ-1-Y783 (Cell Signaling ...
• ECM degradation in the stump region induced by Fgf during functional joint regeneration in frogs

  Haruka Matsubara, Takeshi Inoue, Kiyokazu Agata, bioRxiv - Developmental Biology 2023

  Quote: ... diluted 1:100), Rat anti-GFP monoclonal antibody (nacalai tesque, GF090R, diluted 1:1000) and rabbit anti-pSmad1/5/9 antibody (Cell Signaling Technology, #13820, diluted 1:100). After the primary antibody incubation ...
• Rpl24^Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

  John R. P. Knight, et al., bioRxiv - Cancer Biology 2021

  Quote: ... P-eEF2 T56 (Cell Signaling Technology (CST) #2331) ...
• SGK1 Signaling Promotes Glucose Metabolism and Survival in Extracellular Matrix Detached Cells

  Joshua A. Mason, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-GSK3β (Cell Signaling Technologies, pS9, #9322), and mtCOXII (Invitrogen ...
• SGK1 Signaling Promotes Glucose Metabolism and Survival in Extracellular Matrix Detached Cells

  Joshua A. Mason, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-NDRG1 (Cell Signaling Technologies, pT346, #5482), GLUT1 (Cell Signaling Technologies ...