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801 - 850 of 4006 citations for 2 Amino 6 chloro 9 3 5 di O p toluoyl beta D 2 deoxyribofurnanosyl purine since 2020

• β-RA targets mitochondrial metabolism and adipogenesis, leading to therapeutic benefits against CoQ deficiency and age-related overweight

  Agustín Hidalgo-Gutiérrez, et al., bioRxiv - Physiology 2021

  Quote: ... anti-P-AMPK (Cell Signaling, #2531), anti-ULK1 (Cell Signaling ...
• Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin

  Christian J. Elliehausen, et al., bioRxiv - Physiology 2021

  Quote: ... P-AKT S473 (Cell Signaling, 4060), AKT (Cell Signaling ...
• Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin

  Christian J. Elliehausen, et al., bioRxiv - Physiology 2021

  Quote: ... and p-AMPK (Cell Signaling, 50081) in DH guinea pig skeletal muscle therefore we probed liver tissue ...
• Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

  Matthew R. Swiatnicki, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-s473 AKT (Cell Signaling D9E), total STAT3 (Cell Signaling 79D7) ...
• Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

  Matthew R. Swiatnicki, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-Y705 STAT3 (Cell Signaling D3A7), total FGFR1 (Cell Signaling D8E4) ...
• A CHCHD10 variant causing ALS elicits an unfolded protein response through the IRE1/XBP1 pathway

  Isabella R. Straub, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-PERK (Thr980) (Cell Signaling, 3191), GCN2 (Cell Signaling ...
• A CHCHD10 variant causing ALS elicits an unfolded protein response through the IRE1/XBP1 pathway

  Isabella R. Straub, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-mTOR (Ser2448) (Cell Signaling, 5536P), S6 (Cell Signaling ...
• PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEB-induced Autophagy-Lysosomal Pathway

  Mihyang Do, et al., bioRxiv - Neuroscience 2021

  Quote: ... p-eIF2α (1:1000, Cell Signaling), eIF2α (1:1000 ...
• The compound of baicalein, wogonin, and oroxylin-A inhibits EMT in A549 cell line via PI3K/AKT-TWIST1- glycolysis pathway

  Hui-Juan Cao, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... p-AKT (Cell Signaling Technology, 4060), β-Actin (Proteintech ...
• SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2020

  Quote: ... p-STAT1 (Cell Signaling Technologies; #9171), STAT1 (Cell Signaling Technologies ...
• Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

  Sirle Saul, et al., bioRxiv - Microbiology 2021

  Quote: ... P-p38 (Thr180/Tyr182) (Cell Signaling), and β-actin (Sigma-Aldrich ...
• The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritis

  Sara Fuentelsaz-Romero, et al., bioRxiv - Immunology 2021

  Quote: ... and p-STAT1 (#7649; Cell Signaling). Protein loading was normalized using an antibody against GAPDH (sc-32233 ...
• Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

  Soeun Kim, et al., bioRxiv - Immunology 2021

  Quote: ... anti-p-p38 (#9211, Cell Signaling), anti-β-actin (#sc-47778 ...
• AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

  Mathieu Paquette, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-4EBP1 (Cell Signaling Technology, 9456), S6 (Cell Signaling Technology ...
• Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib

  Isabel Alvarado-Cruz, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p-TBK1 (5483S; Cell Signaling;1,000), IRF3 (11904S ...
• Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib

  Isabel Alvarado-Cruz, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p-IRF3 (37829S; Cell Signaling;1,000), NFκβp65 (8242S ...
• ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer

  Gianluca Mucciolo, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-EGFR (3777; Cell Signaling Technology), CC3 (9664 ...
• Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells

  Pritisha Rozario, et al., bioRxiv - Immunology 2023

  Quote: ... EIF2A-P (Cell Signaling Technology, #3398), NLRP1 (Biolegend ...
• The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain

  Stefanie Fruhwürth, et al., bioRxiv - Immunology 2023

  Quote: ... p-STING S366 (CS50907, Cell Signaling), t-STING (CS13647 ...
• The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain

  Stefanie Fruhwürth, et al., bioRxiv - Immunology 2023

  Quote: ... p-TBK1 S172 (CS5483, Cell Signaling), t-TBK1 (CS3504 ...
• The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain

  Stefanie Fruhwürth, et al., bioRxiv - Immunology 2023

  Quote: ... p-IRF3 S396 (CS29047, Cell Signaling), t-IRF3 (CS4302 ...
• Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia

  Jay Penney, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit-p-ERK (Cell Signaling Technology), rabbit-ERK (Cell Signaling Technology) ...
• CLSTN3B enhances adipocyte lipid droplet structure and function via endoplasmic reticulum contact

  Chuanhai Zhang, et al., bioRxiv - Cell Biology 2024

  Quote: ... p-HSL(s660) (Cell signaling, 4126), HSL (Cell signaling ...
• Cytoplasmic protein-free mRNA induces stress granules by two G3BP1/2-dependent mechanisms

  Sean J. Ihn, et al., bioRxiv - Cell Biology 2024

  Quote: ... P-eIF2α (Cell Signaling Technology, #9721), G3BP1 (Abcam ...
• Interplay between ß-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex

  Matthew E.R. Maitland, et al., bioRxiv - Molecular Biology 2024

  Quote: ... p-S6 (2215S, Cell Signaling Techonologies); S6 (2317S ...
• Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

  Lisa Veghini, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p-ERK (#9101, Cell Signaling Technology), α-SMA (#ab5694 ...
• Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

  Lisa Veghini, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p-STAT3 (#9145, Cell Signaling Technology), and total STAT3 (#12640 ...
• Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

  Lisa Veghini, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p-ERK (#4376, Cell Signaling Technology), α-SMA (#ab5694 ...
• Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

  Lisa Veghini, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p-AKT (#4060, Cell Signaling Technology), total AKT (#9272 ...
• Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation

  Kai-Cheng Li, et al., bioRxiv - Neuroscience 2024

  Quote: ... p-Tau (Cell Signaling Technology, 12885), GluA1 (SYSY ...
• CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

  Jesse Boumelha, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p-STAT1 (T701) (58D6, Cell Signaling) STAT2 (D9J7L ...
• RADIF(C1orf112)-FIGNL1 Complex Regulates RAD51 Chromatin Association to Promote Viability After Replication Stress

  Jessica D. Tischler, et al., bioRxiv - Biochemistry 2023

  Quote: ... CHK1-P-S317 (Cell Signaling, 2344S), CHK1 (Santa Cruz Biotechnology ...
• Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension

  Brandon Elliott, et al., bioRxiv - Physiology 2024

  Quote: ... p-GSK3ϕ3 (1:1,000; Cell signaling), GSK3ϕ3 (1:1,000 ...
• Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation

  Goonho Park, et al., bioRxiv - Neuroscience 2022

  Quote: ... P-PERK (#3179, Cell Signaling Technology), eIF2α (# 5324 ...
• The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

  Pedro Aguilar-Garrido, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p-4E-BP1(Cell Signaling, #2855), Ncl (Abcam ...
• Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation

  Goonho Park, et al., bioRxiv - Neuroscience 2022

  Quote: ... P-eIF2α (# 5324, Cell Signaling Technology), were pre-tested to detect the targeted proteins ...
• YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling

  Linyuan Peng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p-YAP (Cell Signaling Technology, 4911S), MHC-I (Santa Cruz ...
• LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids

  Wenwen Tang, et al., bioRxiv - Cell Biology 2023

  Quote: ... p-AKT473 (Cell Signaling Technology, 4060), mTOR (Cell Signaling ...
• ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer

  Gianluca Mucciolo, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-ERBB2 (2243; Cell Signaling Technology), EGFR (4267 ...
• Multiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting

  Thiruma V. Arumugam, et al., bioRxiv - Systems Biology 2023

  Quote: ... p-GSK3α/β (9331S, Cell Signaling), GSK3α/β (7291 ...
• Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

  Isabel López-García, et al., bioRxiv - Developmental Biology 2024

  Quote: ... p-Stat3 (Y705, Cell Signaling, #9145s), total Stat3 (Cell Signaling ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-Akt T308 (13038, Cell Signaling), CREB (48H2 ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-mTOR S2448 (D9C2, Cell Signaling), P70S6K (PA5-17883 ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-CREB S133 (87G3, Cell Signaling), FOXO3a (D19A7 ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-GSK3b S9 (D85E12, Cell Signaling), GAPDH (ab8245 ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-PRAS40 T246 (D4D2, Cell Signaling), α-rabbit-AlexaFluor 555 ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-Akt S473 (9271, Cell Signaling), p-Akt T308 (13038 ...
• Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34⁺ hematopoietic progenitor cells and humanized mice

  Nicole L. Diggins, et al., bioRxiv - Microbiology 2024

  Quote: ... p-FOXO3a S253 (D18H8, Cell Signaling), GFP (GF28R ...
• NAD⁺ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages

  Jasper Iske, et al., bioRxiv - Immunology 2024

  Quote: ... P-STAT-1 (#9167S, Cell Signaling), STAT-1 (#9172S ...
• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-AKT s473 (Cell Signaling, #4060), HSP90 (Cell Signaling ...