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9001 - 9050 of 10000+ citations for 7 hydroxy 1H 1 2 4 triazolo 1 5 a pyrimidin 5 one since 2019

• Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD⁺ signaling

  Mustafa N. Okur, et al., bioRxiv - Cell Biology 2020

  Quote: ... mitofusin 2 (Cell signaling, #9482), total OXHOS rodent cocktail (Abcam ...
• Peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

  Kanji Okumoto, et al., bioRxiv - Cell Biology 2020

  Quote: ... and Erk1/2 (Cell Signaling), mouse monoclonal antibodies to HA (16B12 ...
• Functional analysis of KIT gene structural mutations causing porcine dominant white phenotype by using genome edited mouse models

  Guangjie Sun, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Erk1/2 (#4695; Cell Signaling), Akt (#9272 ...
• Mitogen-Activated Protein Kinase-Dependent Fiber-Type Regulation in Skeletal Muscle

  Justin G. Boyer, et al., bioRxiv - Developmental Biology 2019

  Quote: ... MEK1/2 (Cell Signaling Technology), anti-MYH7 (1:50) ...
• Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling

  Brian Czaya, et al., bioRxiv - Cell Biology 2021

  Quote: ... ERK1/2 (4695, Cell Signaling), STAT3 (4904 ...
• Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

  Behnam Nabet, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ERK1/2 (Cell Signaling, #4696), phospho-AKT S473 (Cell Signaling ...
• Peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

  Kanji Okumoto, et al., bioRxiv - Cell Biology 2020

  Quote: ... phospho-Erk1/2 (Cell Signaling), cytochrome P450 reductase (Santa Cruz Biotechnology ...
• LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

  Donatella Delle Cave, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MMP-2 (4022S, Cell Signaling), Vimentin (3932 ...
• COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS

  Elizabeth R. Tucker, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ERK1/2 (Cell Signaling #4695), pERK1/2 (Cell Signaling #9101) ...
• Hemodynamic stress activates inflammatory responses and cell death through spectrin-dependent modulation of Store Operated Calcium Entry

  Lance Hsieh, et al., bioRxiv - Cell Biology 2022

  Quote: ... ERK1/2 (4695, Cell Signaling), SPTAN1 (MAB1622 ...
• Apoptosis-induced FGF signalling promotes non-cell autonomous resistance to cell death

  Florian J. Bock, et al., bioRxiv - Cell Biology 2020

  Quote: ... pERK1/2 (4370, Cell Signaling), CASPASE 3 (9662 ...
• Oncogenic signaling alters cell shape and mechanics to facilitate cell division under confinement

  Helen K. Matthews, et al., bioRxiv - Cell Biology 2019

  Quote: ... ERK1/2 (Cell Signaling 9102), phospho-Akt (Ser473 ...
• Apoptosis-induced FGF signalling promotes non-cell autonomous resistance to cell death

  Florian J. Bock, et al., bioRxiv - Cell Biology 2020

  Quote: ... BCL-2 (2762, Cell Signaling), ERK1/2 (4695 ...
• Apoptosis-induced FGF signalling promotes non-cell autonomous resistance to cell death

  Florian J. Bock, et al., bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 (4695, Cell Signaling), FGFR1 (9740 ...
• Double-targeted knockdown of miR-21 and CXCR4 inhibits malignant glioma progression by suppression of the PI3K/AKT and Raf/MEK/ERK pathways

  Feijiao Liu, Bo Yang, bioRxiv - Cancer Biology 2020

  Quote: ... ERK1/2 (Cell Signaling Technology), and phospho-ERK1/2 (Cell Signaling Technology) ...
• The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

  Anna Moskovskich, et al., bioRxiv - Cell Biology 2019

  Quote: ... MEK1/2 (#9126, Cell Signaling), ARF4 (#11673-1-AP ...
• Targeted phosphoproteomics of the Ras signaling network reveal regulatory mechanisms mediated by oncogenic KRAS

  Anatoly Urisman, et al., bioRxiv - Cancer Biology 2019

  Quote: ... pERK1/2 (Cell Signaling, 9101); Rb (Santa Cruz ...
• Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

  Paula García-Huerta, et al., bioRxiv - Neuroscience 2020

  Quote: ... SOX-2 (Cell Signaling; #4900S), βIII-tubulin (Abcam ...
• Cell autonomous requirement of imprinted XCI in extra-embryonic polar trophoblast cells

  Feng Wang, et al., bioRxiv - Developmental Biology 2022

  Quote: ... pErk1/2 (Cell Signaling #9102), Fgfr2 (Abcam 10648) ...
• Site-1 Protease inhibits mitochondrial metabolism by controlling the TGF-β target gene MSS51

  Muhammad G. Mousa, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Smad 2 (5339, Cell Signaling); Phospho-AKT (4060 ...
• COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS

  Elizabeth R. Tucker, et al., bioRxiv - Cancer Biology 2022

  Quote: ... pERK1/2 (Cell Signaling #9101), AKT (Cell Signaling #9272) ...
• Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

  Charlien Vandersmissen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... PEN-2 (#8598, Cell signaling), nicastrin (9C3 ...
• Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche

  Hope E. Burks, et al., bioRxiv - Cancer Biology 2022

  Quote: ... total ERK1/2 (Cell Signaling). The rabbit monoclonal antibody EP1576Y (ab52642 ...
• Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

  Damien M. Rasmussen, et al., bioRxiv - Biophysics 2023

  Quote: ... and ERK1/2 (Cell Signaling). Membranes were washed and incubated for 1 h at RT with corresponding species-reactive secondary antibody and then imaged using an Odyssey CLx near-infrared imager (LI-COR Biosciences).
• YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

  Orlando Chirikian, et al., bioRxiv - Cell Biology 2024

  Quote: ... pMST1/2 (Cell Signaling 49332) and GAPDH (Proteintech-60004-1 ...
• The Role of Alpha-Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria–ER Membranes

  Peter A. Barbuti, et al., bioRxiv - Neuroscience 2024

  Quote: ... ERLIN-2 (Cell Signaling; 2959S), protein kinase C (Sigma-Aldrich ...
• Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer’s disease brain

  Qiyue Ding, et al., bioRxiv - Biochemistry 2020

  Quote: ... for one hour at 25°C and incubated overnight with the rabbit ACE2 antibody (Catalog # 4355; Cell Signaling), the goat anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH ...
• ASCT2 is the primary serine transporter in cancer cells

  Kelly O. Conger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... coated with one of four ERα antibodies (Milipore 06-935, Abcam Ab3575, Cell Signaling #8644, Santa Cruz HC20). Excess antibody was washed before beginning pulldown ...
• Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria

  Kohta Ikegami, et al., bioRxiv - Genetics 2019

  Quote: ... Coated wells were blocked with 5% non-fat milk and 0.1% Tween 20 and then incubated with anti-phospho-Ser22-Lamin A/C antibody (Cell Signaling 13448S, Lot 1, 1:1000 dilution) or the anti-pan-N-terminal-Lamin A/C antibody (Santa Cruz Biotechnology sc-376248 ...
• SK3-overexpression drives sex-dimorphic working and social memory impairment in mice

  Alline C Campos, et al., bioRxiv - Neuroscience 2020

  Quote: ... slices were incubated overnight at 4 °C with the respective primary antibodies (rat-monoclonal anti- BrdU −1:200- Abcam; Rabbit polyclonal antibody anti-DCX,1:500- Cell Signaling; mouse monoclonal anti-NeuN- Millipore) diluted in a 0.1 % BSA and 0.125 % Triton X-100 solution ...
• In vitro and in vivo analysis of microvesicle-mediated metastasis using a bright, red-shifted bioluminescent reporter protein of extracellular vesicles

  Ahmed A. Zarea, et al., bioRxiv - Cancer Biology 2021

  Quote: ... followed by overnight incubation with the primary antibodies (LC3B Cell Signaling 3868S rabbit polyclonal, 1:300; or F4/80 Cell Signaling 70076S rabbit monoclonal, 1:200). Next day ...
• The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn²⁺-binding domain essential for ligand binding and activity

  Simon Sander, et al., bioRxiv - Biochemistry 2022

  Quote: ... The membrane parts were probed for 18 h with anti-hsTRPM2 antibody from rabbit (Novus #nb500-241 at 1:50000 dilution) and anti-Na+/K+-ATPase antibody from rabbit (Cell Signaling #3010 at 1:1000 dilution), respectively ...
• A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the Vestigial expression pattern

  Luis Manuel Muñoz-Nava, et al., bioRxiv - Developmental Biology 2019

  Quote: ... samples were stained with primary antibodies at 4°C overnight at the following dilutions: rabbit anti-Vg (a gift from Sean Carroll and Kristen Guss, 1:200) and rabbit anti-Caspase 3 (Cell Signaling Technology, Cat# 9661, 1:200), mouse anti-beta Galactosidase (Promega ...
• SARS-CoV-2 ORF8 limits expression levels of Spike antigen

  Ik-Jung Kim, et al., bioRxiv - Microbiology 2022

  Quote: ... and then incubated at room temperature with HRP-conjugated secondary antibodies ((goat anti-rabbit HRP conjugated, Cell Signaling, Cat #: 7074, 1:5,000 dilution) (goat anti-mouse HRP conjugated, Cell Signaling, Cat #: 7076, 1:5,000 dilution) prepared in the WB blocking buffer ...
• Toxoplasma type II effector GRA15 has limited influence in vivo

  Emily F. Merritt, et al., bioRxiv - Microbiology 2024

  Quote: ... blocked in 3% goat serum for 1 hour at room temperature and incubated in mouse anti-Sag1(28) [DG52] and anti-NF-κB (Cell Signaling Technology, 8242S, 1:1000 antibodies) overnight at 4°C ...
• BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer

  Shipra Shukla, et al., bioRxiv - Cancer Biology 2024

  Quote: ... #PP-B6502A-00; 1:1000 for Western blotting), anti-HNF1A (Santa Cruj Biotechnology, sc6547X; 1:1000 for Western blotting) anti-HNF1A (Cell Signaling Technology Cat# 89670 (also 89670S), RRID:AB_2728751 ...
• Prenatal cadmium exposure alters proliferation in mouse CD4⁺ T cells via LncRNA Snhg7

  Jamie L. McCall, et al., bioRxiv - Immunology 2021

  Quote: ... GAPDH (D16H11; 51745, lot 4, Cell Signaling Technologies) 1:1000 ...
• eIf2α-regulated translation modulates the early adhesion of mesenchymal-like cells

  Alexia Caillier, et al., bioRxiv - Cell Biology 2022

  Quote: ... α4 (8440; Cell Signaling Technology, Danvers, MA, USA), Hsp70 (C92F3A-5 ...
• PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER-stress reduction

  Yuxin Wang, et al., bioRxiv - Biochemistry 2022

  Quote: ... 4) XBP-1s (#12782, Cell Signaling, Danvers, MA); and 4 ...
• Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

  Aarathy Ravi Sundar Jose Geetha, et al., bioRxiv - Immunology 2023

  Quote: ... and IRF1 (Cell signaling, Catalog # 8478, 4 µl). 50µl of magnetic beads per sample were added for 3 hours at 4°C while rotating ...
• SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

  Christopher J. Neufeldt, et al., bioRxiv - Microbiology 2020

  Quote: ... Rabbit anti-phospho-p65/RELA (Cell Signaling: 3033, WB - 1:1000); Rabbit anti-IkB (Cell Signaling ...
• Nucleus translocation of tRNA synthetase mediates late integrated stress response

  Na Wei, et al., bioRxiv - Molecular Biology 2020

  Quote: ... rabbit monoclonal p-p70 S6K (1:1000, Cell Signaling Technology, #9234), rabbit monoclonal p-4E-BP1 (1:1000 ...
• Nucleus translocation of tRNA synthetase mediates late integrated stress response

  Na Wei, et al., bioRxiv - Molecular Biology 2020

  Quote: ... rabbit monoclonal p-4E-BP1 (1:1000, Cell Signaling Technology, #2855), rabbit monoclonal p70 S6K (1:1000 ...
• Nucleus translocation of tRNA synthetase mediates late integrated stress response

  Na Wei, et al., bioRxiv - Molecular Biology 2020

  Quote: ... rabbit polyclonal cleaved caspase 3 (1:1000, Cell Signaling Technology, #9661), rabbit monoclonal PARP (1:1000 ...
• PIP₂-dependent coupling of voltage sensor and pore domains in K_v7.2

  Shashank Pant, et al., bioRxiv - Biophysics 2021

  Quote: ... Antibodies used include anti-GAPDH (Cell Signaling #2118, 1:1000 dilution), anti-α-tubulin (Cell Signaling #2144 ...
• Human Satellite III long non-coding RNA imparts survival benefits to cancer cells

  Manjima Chatterjee, Sonali Sengupta, bioRxiv - Cancer Biology 2021

  Quote: ... and anti-p53 (Cell signaling Technology®, USA; dilution 1:4000). The secondary antibodies used were ...
• Inhibition of Metastatic Uveal Melanoma Cell Proliferation by the Histone Deacetylase 6 Inhibitor, Ricolinostat, is Linked to Altered Microphthalmia-associated Transcription Factor and Phospho-ERK Expression

  Husvinee Sundaramurthi, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Blots were probed for HDAC6 (1:1000; #7558, Cell Signaling Technology; Danvers ...
• Nucleotide Biosynthesis Links Glutathione Metabolism to Ferroptosis Sensitivity

  Amy Tarangelo, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p21 C’-terminus (Cat# 2947, 12D1, Cell Signaling Technology, 1:1000), p21 N’-terminus (Cat # ab80633 ...
• Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

  Odessa R. Yabut, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and cleaved-Caspase 3 (1:250 dilution; Cat. #: 9661S, Cell Signaling). To detect primary antibodies ...
• Stat3 co-operates with mutant Ezh2^Y641F to regulate gene expression and limit the anti-tumor immune response in melanoma

  Sarah M. Zimmerman, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Lysates were incubated with Stat3 antibody (1:100, Cell Signaling #9139) for 24 hours ...