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8801 - 8850 of 10000+ citations for 7 hydroxy 1H 1 2 4 triazolo 1 5 a pyrimidin 5 one since 2019

• Mimicking the breast metastatic microenvironment: characterization of a novel syngeneic model of HER2⁺ breast cancer

  Aaron G. Baugh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Epcam (1:100 dilution; Cell Signaling Technology, cat. 93790). Cells were then incubated with FITC-conjugated anti-rabbit secondary antibody (1 µg/mL ...
• Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

  Matteo Gentili, et al., bioRxiv - Systems Biology 2024

  Quote: ... and p62 (1:300, Cell Signaling Technology Cat# 88588, RRID:AB_2800125) in 3% BSA (VWR Cat# 97061-422 ...
• Three Modes of Viral Adaption by the Heart

  Cameron D. Griffiths, et al., bioRxiv - Systems Biology 2024

  Quote: ... MK2 p-Thr344 (Cell Signaling Technology, 3007, 1:1000 dilution); p38 (Santa Cruz Biotechnology ...
• Tumor-specific neutrophils originating from meninges promote glioblastoma

  Jiarui Zhao, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or anti-mouse Cd274 (1:200, #64988, Cell Signaling Technology). The sections were incubated with the anti-mouse/rabbit HRP secondary antibody and detected by DAB solution ...
• RSPO/LGR signaling mediates astrocyte-induced proliferation of adult hippocampal neural stem cells

  Daniela Valenzuela-Bezanilla, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-DCX (4604, Cell Signaling Technology Inc., 1:750), goat anti-RSPO1 (AF3474 ...
• Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1

  P. C. Dave P. Dingal, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and phosphorylated Smad2 (1:1000 rabbit IgG, Cell Signaling, RRID:AB_2798798). Fluorescent secondary antibodies used were goat anti-chicken Alexa 488 conjugate (1:2000 ...
• Dopamine-iron homeostasis interaction rescues mitochondrial fitness in Parkinson’s disease

  Chiara Buoso, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-SOD2 (1:1,000, Cell Signaling Technology, 13141, RRID:AB_2636921), rabbit anti-β-actin (1:1,000 ...
• MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo

  Emily C. Kelly-Castro, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit-anti-MARK2 (1:1000, Cell Signaling Tech, Boston, MA), mouse anti-MARK3 (C-TAK ...
• HELZ promotes R loop resolution to facilitate DNA double-strand break repair by homologous recombination

  Ramona Haji-Seyed-Javadi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Lamin A/C (Cell Signaling #2032; 1:1000 for western) RFP (abcam # ab125244 ...
• Human pluripotent stem cell-derived hepatocyte-like cells for hepatitis D virus studies

  Huanting Chi, et al., bioRxiv - Microbiology 2023

  Quote: ... Rabbit anti-FoxA2 (1:400) was purchased from Cell Signaling, mouse anti-AFP (1:1000 ...
• RSPO/LGR signaling mediates astrocyte-induced proliferation of adult hippocampal neural stem cells

  Daniela Valenzuela-Bezanilla, et al., bioRxiv - Neuroscience 2023

  Quote: ... goat anti-Sox2 (2748, Cell Signaling Technology Inc., 1:100), goat anti-DCX (SC-8066 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-p-AKT-S473 (1:2000; 4060S; Cell Signaling Technology), anti-AKT (1:1000 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-p-PDK1-S241 (1:1000; 3061S; Cell Signaling Technology), anti-PDK1 (1:1000 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-p-PAK1-S144 (1:1000; 2606S; Cell Signaling Technology), anti-p-PAK1-T423 (1:1000 ...
• ATR promotes mTORC1 activation via de novo cholesterol synthesis in p16-low cancer cells

  Naveen Kumar Tangudu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-Chk1 (Ser345) (Cell Signaling Technology, Cat# 2348, 1:1000); Mouse anti Chk1 (Cell Signaling Technology ...
• ATR promotes mTORC1 activation via de novo cholesterol synthesis in p16-low cancer cells

  Naveen Kumar Tangudu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Mouse anti Chk1 (Cell Signaling Technology, Cat# 2360, 1:1000); Rabbit anti-Phospho-Chk2 (Thr68 ...
• Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

  Claire D. James, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-S139 Histone yH2AX 1/200 (Cell Signaling Technology, 9718). Immune complexes were visualized using Alexa 488- or Alexa 595-labeled anti-species specific antibody conjugates (Molecular Probes) ...
• Tropism of AAV.CPP.16 in the respiratory tract and its application for a CRISPR-based gene therapy against SARS-CoV-2

  Zhi Yang, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit anti-α-Tubulin (1:200, D20G3, Cell signaling technology), mouse anti-MUC5A (1:400 ...
• Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

  John D. Mason, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-p-Akt-Ser473 (Cell Signaling #4060, 1:500), rabbit anti-Caveolin-1 (Cell Signaling Technology #3238 ...
• Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

  John D. Mason, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-p-EGFR-Tyr1068 (Cell Signaling #3777, 1:500), rabbit anti-p44/42 MAPK (ERK ...
• Aurora Kinase A Inhibition plus Tumor Treating Fields Suppress Glioma Cell Proliferation in a Cilium-Independent Manner

  Jia Tian, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or 1× radioimmunoprecipitation assay (RIPA) buffer (Cell Signaling; Cat# 501015489) containing 1× protease inhibitor cocktail (Sigma ...
• Tropism of AAV.CPP.16 in the respiratory tract and its application for a CRISPR-based gene therapy against SARS-CoV-2

  Zhi Yang, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit anti-α-Tubulin (1:400, 5335, Cell signaling technology), rabbit anti-α-Tubulin (1:200 ...
• CAR T cells recognizing CD276 and Dual-CAR T cells against CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

  Andrea Timpanaro, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-rabbit IgG HRP-linked (1:10’000; Cell Signaling, #7074P2). Flow Cytometry primary antibodies and working dilutions ...
• Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy

  Natalie K. Horvat, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 1% phosphatase and protease inhibitor cocktail (Cell Signaling #5870). Protein concentration was determined using the Pierce™ BCA Protein Assay Kit (ThermoFisher #23227) ...
• A minimum threshold for myelination of pyramidal cells in human and mouse neocortex

  M. Pascual-García, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-pS6S235/236 (1:300, Cell Signaling Technologies, 2211S) in PBS buffer containing 0.4% Triton X-100 and 2% NHS ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... phospho-mTOR (Ser2448) (1:1000, Cell Signaling Technology, Cat# 5536), mTOR (1:1000 ...
• Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney

  Toshiyuki Nishiji, et al., bioRxiv - Cell Biology 2023

  Quote: ... mouse anti-HA tag (Cell Signaling Technology, #2367, 1/1000), rabbit anti-Nrf2 (Cell Signaling ...
• Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

  Sohyon Lee, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-Ki67 (1:300, Cell Signaling Technology, #9129S, clone D3B5), goat anti-rabbit IgG (H+L ...
• Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

  Sohyon Lee, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-Ki67 (1:300, Cell Signaling Technology, #9129S, clone D3B5). For unconjugated primary antibodies ...
• The ability of the LIMD1 and TRIP6 LIM domains to bind to f-actin under strain is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1

  Samriddha Ray, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti α-E-Catenin (1:500, Cell Signaling, 3236). Alexa Fluor 568 conjugated Phalloidin was used to stain for F-actin (1:100 ...
• Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation

  Samaresh Malik, et al., bioRxiv - Microbiology 2023

  Quote: ... with 1 x protease inhibitor cocktail (Cell Signaling Technology Inc.). Protein samples were estimated by Bradford reagent (BIO-RAD) ...
• Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

  Marco Leibinger, et al., bioRxiv - Neuroscience 2023

  Quote: ... and phosphorylated (Tyr705) STAT3 (1:200; Cell Signaling Technology, RRID:AB_2491009). Secondary antibodies included donkey-anti-mouse and anti-rabbit antibodies conjugated to Alexa Fluor 488 or 594 (1:1000 ...
• Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

  Marco Leibinger, et al., bioRxiv - Neuroscience 2023

  Quote: ... total GSK3α/β (1:1000; Cell Signaling Technology, RRID: AB_10547140), T514-phosphorylated CRMP2 (1:1000 ...
• Apoptotic signaling clears engineered Salmonella in an organ-specific manner

  Taylor J. Abele, et al., bioRxiv - Immunology 2023

  Quote: ... caspase-9 (1:750, mouse, Cell Signaling Technology, Cat. 9508), cleaved caspase-7 (1:1000 ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 1:500 dilution of anti xCT (D2M7A, Cell Signaling Technology), 1:1000 dilution of anti-β-actin (49070S ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 1:1000 dilution of anti-GPX4 (52455, Cell Signaling Technology), 1:500 dilution of anti xCT (D2M7A ...
• Multimodal profiling of chordoma immunity reveals distinct immune contextures

  S. van Oost, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and Ki-67 (8D5, 1:200, Cell Signaling Technology, #9449) and DAPI as a nuclear staining ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 1:1000 dilution of anti-PKM2 (4053S, Cell Signaling Technology), 1:1000 dilution of anti-GPX4 (52455 ...
• TANK binding kinase 1 promotes BACH1 degradation through both phosphorylation-dependent and -independent mechanisms without relying on heme and FBXO22

  Liang Liu, et al., bioRxiv - Biochemistry 2024

  Quote: ... rabbit anti-TBK1 (1:1000, D1B4, Cell Signaling, Danvers, MA), mouse anti-SRC (1:1000 ...
• Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward Connexin 43

  Lauren P. Latchford, et al., bioRxiv - Biochemistry 2023

  Quote: ... preincubated with 1 µL total Cx43 antibodies (Cell Signaling Technologies, Cat ...
• Nuclear NFκB Activity Balances Purine Metabolism in Cellular Senescence

  Sho Tabata, et al., bioRxiv - Systems Biology 2023

  Quote: ... IκBα (1:1000; Cell Signaling Technology, Danvers, MA, USA, #4814), IκBα (1:1000 ...
• UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency

  Joseph H. Chapman, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and 1:5000 mouse anti-beta actin (Cell Signaling 3700) was used for beta actin detection ...
• Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

  Matt J. Matrongolo, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-amyloid beta (1:400, Cell Signaling, D54D2, RRID:AB_2797642), rabbit anti-Aqp4 (1:500 ...
• Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

  Sohyon Lee, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-CHI3L1 (1:300, Cell Signaling Technology, #47066S, clone E2L1M), anti-Nestin (1:150 ...
• Acetylation-dependent coupling between G6PD activity and apoptotic signaling

  Fang Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-Cleaved Caspase 3 (Cell Signaling Technology, # 9664; 1:1000), anti-Bcl-2 (Abcam ...
• The budding yeast heterochromatic protein Sir3 modulates genome-wide gene expression through transient direct contacts with euchromatin

  Pritha Bhattacharjee, et al., bioRxiv - Molecular Biology 2023

  Quote: ... or monoclonal anti-T7 (Cell Signaling Technology, DSE1X (lot#1)) (Supplementary Figure S5) ...
• Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

  Caiqi Zhao, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-STAT3 (1:1000, Cat#12640S, Cell Signaling Technology), rabbit anti-Cleaved Caspase-3 (Asp175 ...
• Multiple HP1 binding motifs in SUV420H2 heterochromatic targeting module

  Masaru Nakao, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit polyclonal anti-HP1γ (1:1,000; Cell Signaling Technology; #2619), and rabbit polyclonal anti-GFP (1:2,000 ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... phospho-CREB (Ser133) (1:1000, Cell Signaling Technology, Cat# 9198), CREB1 (1:2000 ...
• Inferring a role for programmed cell death during the origin and evolution of wing polyphenism in ants

  Lisa Hanna, et al., bioRxiv - Evolutionary Biology 2024

  Quote: ... and anti-LC3A/B (1:100, Cell Signaling Technology, #4108). For all immunohistochemistry assays ...