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6801 - 6850 of 10000+ citations for 7 CHLORO 1 METHYL 1H PYRAZOLO 4 3 B PYRIDINE since 2019

• MCL-1 inhibition by selective BH3 mimetics disrupts mitochondrial dynamics in iPSC-derived cardiomyocytes

  Megan L. Rasmussen, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-pDRP-1 S616 (Cell Signaling Technologies #3455S). For Incucyte experiments ...
• FOXO mediates organismal hypoxia tolerance by regulating NF-κB in Drosophila

  Elizabeth C Barretto, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-pAkt-S505 (Cell Signaling #4054, 1:1000 dilution). Secondary antibodies were purchased from SantaCruz Biotechnology (sc-2030 ...
• Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression

  Marissa Co, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit a-FOXP2 (#5337S, Cell Signaling Technology, 1:250), rabbit a-SP9 (#PA564038 ...
• Comprehensive Substrate Specificity Profiling of the Human Nek Kinome Reveals Unexpected Signaling Outputs

  Bert van de Kooij, et al., bioRxiv - Biochemistry 2019

  Quote: ... Rabbit-anti-β-Actin (1:1000, Cell Signaling Technology), Rabbit-anti-phospho-tyrosine P-Y-1000 (1:2000 ...
• mRNA compartmentalisation spatially orients tissue morphogenesis

  Guilherme Costa, et al., bioRxiv - Developmental Biology 2019

  Quote: ... 1:1000 rabbit β-Tubulin 9F3 (Cell Signaling Technology), 1:200 mouse ZO-1 1A12 (ThermoFisher Scientific) ...
• NMD is required for timely cell fate transitions by fine-tuning gene expression and controlling translation

  Elena Galimberti, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1:1000 for anti-Eif4a1 (Cell Signaling, 2490T, rabbit), 1:1000 for anti-Nanog (NovusBio ...
• Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras

  Malkiel A. Cohen, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Rabbit anti-human-PD-L1 (1:300, Cell Signaling), Sheep anti-human-CD47 (1:100 ...
• RAB1B interacts with TRAF3 to promote antiviral innate immunity

  Dia C. Beachboard, et al., bioRxiv - Immunology 2019

  Quote: ... R-anti-p-TBK1 (Cell Signaling Technology, 1:1000), R-anti-TBK1(Cell Signaling Technology ...
• RAB1B interacts with TRAF3 to promote antiviral innate immunity

  Dia C. Beachboard, et al., bioRxiv - Immunology 2019

  Quote: ... R-anti-p-IRF3 (Cell Signaling Technology, 1:1000), M-anti-IRF3 ((47) ...
• Protein Interactome of the Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Th17 Cells

  Mohd Moin Khan, et al., bioRxiv - Systems Biology 2019

  Quote: ... CIP2A antibody 1(Ab1) (Cell Signaling Technology; cat#14805) CIP2A antibody 2 (Ab2 ...
• Zoledronate extends healthspan and survival via the mevalonate pathway in a FOXO-dependent manner

  Zhengqi. Chen, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... anti-tubulin 1:1000 (Cell Signaling Technology, Denver, Massachusetts). HRP conjugated secondary antibodies were used at 1:10,000 and visualised using ECL (GE Healthcare ...
• Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

  David Marks, et al., bioRxiv - Neuroscience 2020

  Quote: ... mouse anti-myc (NEB/Cell Signaling, 2276; 1:1500) o/n at 4 °C ...
• Comparative therapeutic strategies for preventing aortic rupture in a mouse model of vascular Ehlers Danlos syndrome

  Anne Legrand, et al., bioRxiv - Genetics 2021

  Quote: ... pERK (1:1000, #4370, Cell Signaling Technology, Danvers, MA), pPKC (1:1000 ...
• CHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing

  Emanuela Kerschbamer, et al., bioRxiv - Genetics 2020

  Quote: ... anti-Histone H3 (1:1.000) (Cell Signaling Tech, #4499), anti-Histone H3K36me3 (1:1.000 ...
• Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilities

  Karine Pozo, et al., bioRxiv - Cancer Biology 2020

  Quote: ... rabbit anti-FOXA2 (1:1000, Cell Signaling Technology 3143), rabbit anti-SCN3A (1:500 ...
• Anti-androgens induce Rab11a-exosome secretion in prostate cancer by suppressing amino acid-sensitive PAT4-mTORC1 signalling

  Kristie McCormick, et al., bioRxiv - Cancer Biology 2020

  Quote: ... rabbit anti-S6 (Cell Signaling Technology #2217, 1:4000), rabbit anti-p-S6-Ser240/244 S6 (Cell Signalling Technology #5364 ...
• Tissue remodeling and cell signaling underpin changes in tumor microenvironment heterogeneity in glioma oncogenesis

  Marija Dinevska, et al., bioRxiv - Cancer Biology 2021

  Quote: ... which include pERK (Cell Signaling Technology #9102, 1:200), pAKT (Cell Signaling Technology #4060 ...
• The C. albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

  Charles M. Russell, et al., bioRxiv - Biophysics 2021

  Quote: ... and phospho-MKP1 (1:1000, Cell Signaling Technology, 2857S) overnight ...
• Environmentally-induced mdig is a major contributor to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism

  Qian Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: Cells were lysed in 1 × RIPA buffer (Cell Signaling), supplemented with 1mM PMSF and protease inhibitor cocktail (Thermo Fisher Scientific) ...
• Gene expression and chromatin accessibility during progressive EMT and MET linked to dynamic CTCF engagement

  Kelsey S. Johnson, et al., bioRxiv - Cell Biology 2020

  Quote: ... N-cadherin (#13116, monoclonal rabbit, 1:1000, Cell Signaling), P-cadherin (#2189 ...
• Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

  Gianmatteo Vit, et al., bioRxiv - Cell Biology 2021

  Quote: ... PP2A scaffold subunit (#2041, 1:2500, Cell Signaling Technology), PPP2R2A (#5689 ...
• Gene expression and chromatin accessibility during progressive EMT and MET linked to dynamic CTCF engagement

  Kelsey S. Johnson, et al., bioRxiv - Cell Biology 2020

  Quote: ... P-cadherin (#2189, monoclonal rabbit, 1:1000, Cell Signaling), Vimentin (#10366-1-AP ...
• Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages

  Eric Yau, et al., bioRxiv - Immunology 2021

  Quote: ... NFκB p65 (Cell Signaling Technology Cat#8242, 1:1000), STING (Cell Signaling Technology Cat#50494 ...
• Synaptic RTP801 Contributes to Motor Learning Dysfunction in Huntington’s Disease

  Núria Martín-Flores, et al., bioRxiv - Neuroscience 2020

  Quote: ... Akt-phospho Ser473 rabbit polyclonal (1:1000, Cell Signaling), mTOR rabbit polyclonal (1:1000 ...
• Histone Variant macroH2A1 Spatially and Functionally Organizes Human Papillomavirus Replication Foci in the Productive Stage of Infection

  Simran Khurana, et al., bioRxiv - Microbiology 2021

  Quote: ... RPA rat monoclonal (Cell Signaling, 2208, dilution 1:250), γH2AX mouse monoclonal (Millipore ...
• Retrograde transport of mannose-6-phosphate receptor depends on several sorting machineries as analyzed by sulfatable nanobodies

  Dominik P. Buser, Martin Spiess, bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-Rab9 (Cell Signaling Technology #5118; 1:1000), mouse anti-SNX1 (BD Biosciences #611482 ...
• Retrograde transport of mannose-6-phosphate receptor depends on several sorting machineries as analyzed by sulfatable nanobodies

  Dominik P. Buser, Martin Spiess, bioRxiv - Cell Biology 2019

  Quote: ... mouse anti-FLAG (Cell Signaling Technology #8146; 1:1000), mouse anti-GFP (Sigma-Aldrich #11814460001-Roche ...
• Retrograde transport of mannose-6-phosphate receptor depends on several sorting machineries as analyzed by sulfatable nanobodies

  Dominik P. Buser, Martin Spiess, bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-FLAG (Cell Signaling Technology #2368; 1:500), and rabbit anti-GM130 (Cell Signaling Technology #12480 ...
• Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV

  Kumari G. Lokugamage, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-STAT1 D1K9Y (1:1000 14994P Cell Signaling Technologies), anti-IFITM1 (1:1000 PA5-20989 Invitrogen) ...
• MiR-137 and miR-122, two outer subventricular zone-enriched non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation

  Ugo Tomasello, et al., bioRxiv - Evolutionary Biology 2021

  Quote: ... Rabbit anti-CASPASE3 (1:3000; Cell signaling technology, #9662S). All secondary antibodies were 488/555/647 conjugated (1:500 ...
• Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimer’s mouse model

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... Pyruvate Dehydrogenase (1:1000, Cell Signaling Technology, cat. #3205), Glut4 (1:1000 ...
• Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint

  JR Ishibashi, et al., bioRxiv - Biochemistry 2021

  Quote: ... phospho-mTOR (Ser 2448) (Cell Signaling 5536, 1:1000), mTOR (Cell Signaling 2972 ...
• Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

  Vukasin M. Jovanovic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-TDP43 total 1:50 (89789, Cell Signaling) and rabbit anti-phospho-TDP43 1:50 (22309-1-AP ...
• Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

  Kei Yamamoto, et al., bioRxiv - Cell Biology 2021

  Quote: ... ppMLC antibody (1:500 dilution; Cell Signaling Technology #3674), phospho-Ezrin/Radixin/Moesin antibody (1:500 dilution ...
• A primed immune transcriptional program is activated in oligodendroglia in multiple sclerosis

  Mandy Meijer, et al., bioRxiv - Neuroscience 2020

  Quote: ... or GAPDH (rabbit monoclonal, 5174S, Cell Signaling, 1:1000) and as secondary antibody anti-rabbit (A6667 ...
• Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

  Xiuxiu Lu, et al., bioRxiv - Molecular Biology 2021

  Quote: ... anti-cleaved caspase-9 (Cell Signaling, 52873s, 1:500), anti-ubiquitin (P4D1 ...
• Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins

  Julia E. Gerson, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-Histone H3 (Cell Signaling, cat. #4499; 1:2000), anti-β-actin (Sigma ...
• Over-expression Screen of Interferon-Stimulated Genes Identifies RARRES3 as a Restrictor of Toxoplasma gondii Infection

  Nicholas Rinkenberger, et al., bioRxiv - Microbiology 2021

  Quote: ... 1:500 anti-IRF1 primary antibody (Cell Signaling Technology) and 1:1000 anti-rabbit Alexa Fluor 488 secondary antibody (Life Technologies ...
• The neocortical progenitor specification program is established through combined modulation of SHH and FGF signaling

  Odessa R. Yabut, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphor-Erk1/2 (1:100 dilution, Cell Signaling (#4370)) ...
• Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis

  Tam Vu, et al., bioRxiv - Bioengineering 2021

  Quote: ... and 1:200 Rabbit anti-Vimentin (5741BF; Cell Signaling) in the same blocking buffer were subsequently added to the samples and incubated overnight at 4°C ...
• Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel

  Harrison L. Hiraki, et al., bioRxiv - Bioengineering 2021

  Quote: ... rabbit anti-SNAI1 (1:1000, Cell Signaling Technologies #3879S), mouse anti-vimentin (1:500 ...
• Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in model systems of cancer

  Qian Wang, et al., bioRxiv - Bioengineering 2020

  Quote: ... and phospho-Akt (Cell Signaling Technology #9271, 1:1000).
• Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking

  María José Lista, et al., bioRxiv - Microbiology 2021

  Quote: ... 1:1000 anti-FLAG (DYKDDDDK, Rabbit, Cell Signaling, 14793), 1:2000 anti-β-actin (Mouse ...
• Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking

  María José Lista, et al., bioRxiv - Microbiology 2021

  Quote: ... 1:5000 anti-mouse HRP (Cell Signaling Technology, 7076), 1:5000 anti-mouse IRDye 680RD (LI-COR ...
• Regulation of KHNYN antiviral activity by the extended di-KH domain and nucleo-cytoplasmic trafficking

  María José Lista, et al., bioRxiv - Microbiology 2021

  Quote: ... 1:5000 anti-rabbit HRP (Cell Signaling Technology, 7074), 1:5000 anti-mouse HRP (Cell Signaling Technology ...
• Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance

  Brandon J. Berry, et al., bioRxiv - Biochemistry 2020

  Quote: ... 1:10,000 anti‐phospho‐AMPKα Rabbit (Cell Signaling, #2535), 1:2,000 anti‐rabbit IgG (Cell Signaling #7074S) ...
• F-domain valency determines outcome of signaling through the angiopoietin pathway

  Yan Ting Zhao, et al., bioRxiv - Biochemistry 2020

  Quote: ... pFAK-Y379 at 1:5000 dilution(Cell signaling, USA); Tie2 and pTie2-Y992 (Cell Signaling ...
• Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

  Nastaran Daneshgar, et al., bioRxiv - Pathology 2021

  Quote: ... phospho-AMPKα (Thr172) (Cell Signaling Technology, 2531, 1:1000), p44/42 MAPK (Erk1/2 ...
• Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

  Eliezra Glasser, et al., bioRxiv - Biophysics 2021

  Quote: ... or GAPDH (Cell Signaling, Cat. No. 2118S, 1:1000). Secondary antibodies included anti-mouse IgG horseradish peroxidase or anti-rabbit IgG horseradish peroxidase (Cytiva Inc. ...
• Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

  Eliezra Glasser, et al., bioRxiv - Biophysics 2021

  Quote: ... H2B (Cell Signaling, Cat. No. 12364, 1:1000 dilution), or GAPDH (Cell Signaling ...