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6751 - 6800 of 10000+ citations for 7 CHLORO 1 METHYL 1H PYRAZOLO 4 3 B PYRIDINE since 2019

• Structural basis for Parkinson’s Disease-linked LRRK2’s binding to microtubules

  David M. Snead, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-GAPDH (Cell Signaling Technology, 1:3000 dilution), and rabbit anti-phospho-T73-RAB10 (Abcam ...
• Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1-associated progerias

  Rhiannon M. Sears, Kyle J. Roux, bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-Emerin (1:1000; 2659S; Cell Signaling Technology), and rabbit anti-Ankle2 (1:1000 ...
• Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

  Carlos F. H. Serra, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-Acetyl-α-Tubulin (Cell Signaling #5335, 1:300), anti-beta IV Tubulin (Abcam #ab11315 ...
• Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

  Wenli Yang, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-UBC9 (1:50; Cell Signaling Technology, Cat. # 4786), anti-SUMO1 (1:100 ...
• A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila

  Alice C. Yuen, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit anti-phospho-ERK (1:100, Cell Signaling 9101S); guinea pig anti-Tj (1:3000 ...
• Dpp and Hedgehog promote the Glial response to neuronal damage in the developing Drosophila Visual system

  Sergio B. Velarde, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-cleaved Dcp1 1:200 (Cell Signaling Technology), mouse anti-Patch 1:500 (Gift from Isabel Guerrero) ...
• FIP200 organizes the autophagy machinery at p62-ubiquitin condensates beyond activation of the ULK1 kinase

  Eleonora Turco, Irmgard Fischer, Sascha Martens, bioRxiv - Cell Biology 2020

  Quote: ... rabbit anti-p62 ph-S403 (1:1000, Cell Signaling); rabbit anti-ATG14 ph-S29 (1:1000 ...
• FIP200 organizes the autophagy machinery at p62-ubiquitin condensates beyond activation of the ULK1 kinase

  Eleonora Turco, Irmgard Fischer, Sascha Martens, bioRxiv - Cell Biology 2020

  Quote: ... rabbit anti-p62 ph-S349 (1:1000, Cell Signaling); rabbit anti-p62 ph-S403 (1:1000 ...
• FIP200 organizes the autophagy machinery at p62-ubiquitin condensates beyond activation of the ULK1 kinase

  Eleonora Turco, Irmgard Fischer, Sascha Martens, bioRxiv - Cell Biology 2020

  Quote: ... rabbit anti-ATG14 ph-S29 (1:1000, Cell Signaling); rabbit anti-ATG9A (1:1000 ...
• FIP200 organizes the autophagy machinery at p62-ubiquitin condensates beyond activation of the ULK1 kinase

  Eleonora Turco, Irmgard Fischer, Sascha Martens, bioRxiv - Cell Biology 2020

  Quote: Antibody dilutions: rabbit anti-FIP200 (1:1000, Cell Signaling); mouse anti-p62 (1:3000 ...
• Xist spatially amplifies SHARP recruitment to balance chromosome-wide silencing and specificity to the X chromosome

  Joanna W. Jachowicz, et al., bioRxiv - Molecular Biology 2021

  Quote: ... anti-Ezh2 (mouse, Cell signaling AC22 3147S, 1:500); anti-SHARP (rabbit ...
• Interferon-gamma Induces Melanogenesis Via Post-Translational Modification of Tyrosinase

  Xuan Mo, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and Gapdh-HRP (D16H11, 1:1000, Cell Signaling Technology). The secondary antibodies used for detection were HRP-conjugated goat anti-mouse and goat anti-rabbit IgG (1:5000 ...
• tiRNA-Val promotes angiogenesis via Sirt1–Hif-1α axis in mice with diabetic retinopathy

  Yan Xu, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and Hif-1α (1:1,000,Cell Signaling Technology, USA). Anti-rabbit and anti-mouse peroxidase-conjugated secondary antibodies (1:2,000,Cell Signaling Technology ...
• A conformational switch controlling the toxicity of the prion protein

  Karl Frontzek, et al., bioRxiv - Molecular Biology 2021

  Quote: ... phospho-eIF2α (1:1’000, clone #D9G8, Cell Signaling Technologies), eIF2α (1:1’000 ...
• The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

  Heather M. Kudyba, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-Phospho-eIF2α 119A11 (Cell Signaling, 1:1,000), rat anti-HA (Roche 3F10 ...
• Sir2 non-autonomously controls differentiation of germline cells in the ovary of Drosophila melanogaster

  Champakali Ayyub, Ullas Kolthur-Seetharam, bioRxiv - Developmental Biology 2019

  Quote: ... rabbit anti-pERK from Cell Signaling Technology (1:100), rabbit anti-pMad (1 ...
• IP6K1 upregulates the formation of processing bodies by promoting proteome remodeling on the mRNA cap

  Akruti Shah, Rashna Bhandari, bioRxiv - Cell Biology 2020

  Quote: ... anti-eIF4G1 (Cell Signaling Technology, 8701S; IB 1:2000); anti-eIF4E (Novus Biologicals ...
• Estrogen-related receptor beta activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma

  DM Tiek, et al., bioRxiv - Cancer Biology 2019

  Quote: ... and total histone H3 (1:1000, Cell Signaling, #9715S). Beta-Tubulin (1:5000 ...
• Copy number aberrations drive kinase re-wiring leading to genetic vulnerabilities in cancer

  Danish Memon, et al., bioRxiv - Genomics 2019

  Quote: ... p-YAP (S127)(4911S/ Cell Signaling Technology, 1:1000) and GAPDH (MAB374/EMD Millipore ...
• Profiling APOL1 Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell Transcriptomics

  Esther Liu, et al., bioRxiv - Genomics 2019

  Quote: ... anti-β-actin (#4970; Cell Signaling Technologies; 1:1000). Immunoblot signals were developed under chemiluminescence (Thermo Fisher ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... p-FAK Tyr397 (1:1000, ref.3283, Cell Signaling), FAK (1:1000 ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... p-Akt Ser473 (1:1000, ref.4060, Cell Signaling), Akt (1:1000 ...
• FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

  Ryan J Kast, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Rabbit anti-DARPP-32 (1:500; Cell Signaling #2306).
• Girdin is a component of the lateral polarity protein network restricting cell dissemination

  Cornélia Biehler, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-E-cadherin (1:100, Cell Signaling Technology). Cysts were washed three times for 15 min in 0.5% Triton X-100/PBS before and after incubation with secondary antibodies ...
• 2'3'-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

  Jacqueline A Carozza, et al., bioRxiv - Biochemistry 2019

  Quote: ... and rabbit anti-STING (D2P2F Cell Signaling, 1:1,000), IRDye 800CW goat anti-rabbit (LI-COR ...
• 2'3'-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

  Jacqueline A Carozza, et al., bioRxiv - Biochemistry 2019

  Quote: ... rabbit anti-mouse cGAS (D2O8O Cell Signaling, 1:1,000), mouse anti-tubulin (DM1A Cell Signaling ...
• p63 sets the threshold for induction of apoptosis using a kinetically encoded ‘doorbell-like’ mechanism

  Jakob Gebel, et al., bioRxiv - Biochemistry 2019

  Quote: ... 1:200 and anti-cleaved PARP (D6X6X, Cell Signaling) and 1 µg/ml DAPI ...
• The unjamming transition is distinct from the epithelial-to-mesenchymal transition

  Jennifer A. Mitchel, et al., bioRxiv - Biophysics 2019

  Quote: ... as follows: E-cadherin (1:200, Cell Signaling Technology), ZO-1 (1:100 ...
• Deterioration of dry skin in arthritis model mice via stress-induced changes in immune cells in the thymus and spleen

  Kenji Goto, et al., bioRxiv - Physiology 2019

  Quote: ... GATA3 (1:1000; Cell Signaling Technology, Danvers, MA, USA), and β-actin (1:5000 ...
• HMGB1 orchestrates uterine macrophage trafficking to safeguard embryo implantation

  Shizu Aikawa, et al., bioRxiv - Developmental Biology 2019

  Quote: ... anti-HMGB1 antibody (1:2000, 6893S, Cell Signaling Technology) and anti-CD68 antibody (1:1000 ...
• LUXendins reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

  Julia Ast, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-insulin 1:500 (Cell Signaling Technology, #3014), mouse monoclonal anti-glucagon 1:2000 (Sigma-Aldrich ...
• Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal

  Thao Pham, et al., bioRxiv - Cancer Biology 2019

  Quote: ... GAPDH (14C10) 1:2500 (Cell Signaling Technology, Danvers, MA), Cleaved Caspase 3 (Asp175 ...
• Organotypic slice culture model demonstrates interneuronal spreading of alpha-synuclein aggregates

  Sara Elfarrash, et al., bioRxiv - Neuroscience 2019

  Quote: ... NF-L (mouse mAb #2835, Cell signaling. 1:500) NeuN (mouse mAb clone A60 ...
• IL-10 Promotes Endothelial Progenitor Cell Driven Wound Neovascularization and Enhances Healing via STAT3

  Swathi Balaji, et al., bioRxiv - Physiology 2019

  Quote: ... STAT3 (1:500, Cell Signaling Technology 9139, Danvers, MA), Phospho-STAT3 (Tyr705 ...
• The transcriptional co-repressor CtBP is a negative regulator of growth that antagonizes the Yorkie and JNK/AP-1 pathways

  Taryn M. Sumabat, et al., bioRxiv - Developmental Biology 2019

  Quote: ... 1:500 rabbit anti-HA (C29F4, Cell Signaling Technology); 1:400 guinea pig anti-Yki ...
• Staging Alzheimer's disease in the brain and retina of B6.APP/PS1 mice by transcriptional profiling

  Gareth Howell, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit polyclonal anti-pSTAT3 (1:100, Cell Signaling Technologies), mouse monoclonal anti-β-Amyloid ...
• Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

  George Sharbeen, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and HSP90 (Cell Signaling Technology, Cat. 4875, 1:1000).
• Expression and distribution of Trophoblast Glycoprotein in the mouse retina

  Colin M Wakeham, Gaoying Ren, Catherine W Morgans, bioRxiv - Neuroscience 2019

  Quote: Mouse anti-β-actin (1:2500; Cell Signaling Technology; Danvers ...
• Regenerative capacity in Drosophila imaginal discs is controlled by damage-responsive, maturity-silenced enhancers

  Robin E. Harris, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Nuclear staining was by DAPI (1:1000, Cell Signaling). Samples were imaged on a Leica TCS SP5 Scanning Confocal ...
• Neuroinflammation and EIF2 signaling persist in an HiPSC tri-culture model of HIV infection despite antiretroviral treatment

  Sean K. Ryan, et al., bioRxiv - Pathology 2019

  Quote: ... mouse anti-GFAP (Cell Signaling Cat#3670S, 1:1,000), and mouse anti-Actin (1:10,000 dilution ...
• Vascular smooth muscle-derived TRPV1-expressing progenitors are a new source of cold-induced thermogenic adipocytes

  Farnaz Shamsi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and Anti-Perilipin-1 (D1D8 #9349, Cell Signaling Technology) overnight at 4°C ...
• Coordination between stochastic and deterministic specification in the Drosophila visual system

  Maximilien Courgeon, Claude Desplan, bioRxiv - Neuroscience 2019

  Quote: ... Rabbit anti-HA (1:200) (Cell Signaling Technology, #3724), Rat anti-Flag (1:200 ...
• A mutation in Hnrnph1 that decreases methamphetamine-induced reinforcement, reward, and dopamine release and increases synaptosomal hnRNP H and mitochondrial proteins

  Qiu T. Ruan, et al., bioRxiv - Neuroscience 2019

  Quote: ... and PSD95 (1:10,000, rabbit monoclonal; Cell Signaling D27E11).
• A versatile ES cell-based melanoma mouse modeling platform

  Ilah Bok, et al., bioRxiv - Cancer Biology 2019

  Quote: ... pAkt T308 (1:500, Cell Signaling Technology, Cat. # 13038T), pAkt S473 (1:2,000 ...
• A versatile ES cell-based melanoma mouse modeling platform

  Ilah Bok, et al., bioRxiv - Cancer Biology 2019

  Quote: ... pAkt S473 (1:2,000, Cell Signaling Technology, Cat. # 4060S), AKT (1:5,000 ...
• Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM

  A Bohm, et al., bioRxiv - Cancer Biology 2019

  Quote: ... and anti-β-actin (1:5000; Cell Signaling 3700). Secondary antibodies were goat anti-mouse and anti-rabbit IgG-HRP (1:2000 ...
• Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues

  Ivana Gasic, et al., bioRxiv - Cell Biology 2019

  Quote: ... 1:10’000 Histone H3 (Cell Signaling Technologies, USA, #4499), and 1:500 phospho-Akt S437 (Cell Signaling Technologies ...
• Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

  Jakob Morgenstern, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Gapdh (1:2500 dilution; 5174S; rabbit; Cell Signaling Technology) Beta-actin (1:2500 dilution ...
• Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

  Jakob Morgenstern, et al., bioRxiv - Molecular Biology 2020

  Quote: ... γH2aX (1:1000 dilution; 9718S; rabbit; Cell Signaling Technology), Histone H3 (1:2500 dilution ...
• The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer

  Zane A Gibbs, et al., bioRxiv - Cancer Biology 2020

  Quote: ... V5 (13202; 1:1000; Cell Signaling Technology, Danvers, MA), SMAD3 (ab28379 ...