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201 - 250 of 299 citations since 2019

• Fluidic Circuit Board with Modular Sensor and Valves Enables Stand-Alone, Tubeless Microfluidic Flow Control in Organs-on-Chips

  Aisen Vivas, et al., bioRxiv - Bioengineering 2021

  Quote: ... mesodermal differentiation was initiated by addition of Wnt activator CHIR99021 (1.5 μmol/L, Axon Medchem 1386), Activin-A (20 ng/mL ...
• An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis

  Raphaëlle Lesage, et al., bioRxiv - Systems Biology 2021

  Quote: ... PD0325901 (1μM, Axon Medchem), PD161570 (1μM ...
• A combined transcriptional and dynamic roadmap of single human pancreatic endocrine progenitors reveals proliferative capacity and differentiation continuum

  Belin Selcen Beydag-Tasöz, et al., bioRxiv - Developmental Biology 2021

  Quote: ... CHIR99201 (Axon Medchem) at 3 μM and 0.3 μM for the first two days of Stage 1 instead of MCX-928 ...
• A single cell transcriptional roadmap for human pacemaker cell differentiation

  Alexandra Wiesinger, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 1.5 μmol/L CHIR99021 (Axon Medchem, #1386). Three days after initiation ...
• A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

  Lisa Donker, et al., bioRxiv - Cell Biology 2021

  Quote: The following reagents were used at the indicated concentrations: MK 1775 (Axon Medchem; 1494, 500 nM), Calyculin A (Enzo ...
• Profiling of human neural crest chemoattractant activity as replacement of fetal bovine serum for in vitro chemotaxis assays

  Xenia Dolde, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... From day 2 on cells were treated with 3 µM CHIR 99021 (Axon Medchem, Reston, Virginia, USA). Noggin and SB431542 were withdrawn at day 3 and 4 ...
• Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia

  Thomas Wilhelm, et al., bioRxiv - Cancer Biology 2021

  Quote: PD0325901 was purchased from Axon Medchem and Imatinib ...
• R-loop-induced p21 expression following CDC73, CTR9, and PAF1 loss protects cancer cells against replicative catastrophe following WEE1 inhibition

  Linda van Bijsterveldt, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Inhibitors used in this study are AZD1775 (MK-1775) (Axon Medchem) and Gemcitabine (Sigma Aldrich).
• TAF8 regions important for TFIID lobe B assembly, or for TAF2 interactions, are required for embryonic stem cell survival

  Elisabeth Scheer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and 3 μM CHIR99021 (Axon Medchem, Cat# 1386) together with 1 μM PD0325901 (Axon Medchem ...
• TAF8 regions important for TFIID lobe B assembly, or for TAF2 interactions, are required for embryonic stem cell survival

  Elisabeth Scheer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... together with 1 μM PD0325901 (Axon Medchem, Cat# 1408) were added freshly to the medium ...
• Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

  Fang Wang, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 1500 U/mL LIF and two inhibitors (2i; 3 µM CHIR99021 and 1 µM PD0325901, Axon MedChem)] ...
• Murine Norovirus infection results in anti-inflammatory response downstream of amino acids depletion in macrophages

  Michèle Brocard, et al., bioRxiv - Microbiology 2021

  Quote: ... GCN2 inhibition was performed by adding A-92 (Axon Medchem) at 500nM to the cells medium for the indicated times.
• PARP Inhibition Impedes the Maturation of Nascent DNA Strands During DNA Replication

  Alina Vaitsiankova, et al., bioRxiv - Cell Biology 2021

  Quote: ... 0.5% Triton X-100) supplemented with 10 μM PARPi (KU0058948, Axon Medchem, Axon 2001) and PARGi (PDD0017273 ...
• PARP Inhibition Impedes the Maturation of Nascent DNA Strands During DNA Replication

  Alina Vaitsiankova, et al., bioRxiv - Cell Biology 2021

  Quote: ... 0.5% Triton X-100) supplemented with 10 μM PARPi (KU0058948, Axon Medchem, Axon 2001) and PARGi (PDD0017273 ...
• Tmed2 regulates Smoothened trafficking and Hedgehog signalling

  Giulio Di Minin, et al., bioRxiv - Cell Biology 2020

  Quote: ... PD0325901 (Axon Medchem), Smoothened agonist (SAG,Calbiochem) ...
• Complement factor C4a does not activate protease activated receptor 1 (PAR1) or PAR4 on human platelets

  Xu Han, Maria de la Fuente, Marvin T. Nieman, bioRxiv - Cell Biology 2020

  Quote: ... Vorapaxar was from Axon Medchem (catalog # 1755, batch 2). All other reagents were from Thermo Fisher Scientific (Pittsburgh ...
• 3D Interferometric Lattice Light-Sheet Imaging

  Bin Cao, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 1 uM PD0325901 (Axon Medchem 1408). Before imaging ...
• RhoA- and Ran-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes

  Benoit Dehapiot, et al., bioRxiv - Developmental Biology 2020

  Quote: ... the culture medium was supplemented with the PLK1 inhibitor Bi-2536 (250 nM; Axon Medchem #1129) or the Rock-1 inhibitor Y-27632 (50 μM ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... P38i/JNKi (BIRB0796 0.8µM - Axon Medchem 1358), PKCi (Go6983 2µM - Axon Medchem 2466) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... P38i/JNKi (BIRB0796 2µM - Axon Medchem 1358), PKCi (Go6983 2µM - Axon Medchem 2466) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... PKCi (Go6983 2µM - Axon Medchem 2466), ROCKi Y27632 (1.2µM - Axon Medchem 1683) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... WNTi/TNKi (IWR1-endo 5µM - Axon Medchem 2510 or XAV939 2µM - Axon Medchem 1527); P38i/JNKi (BIRB0796 0.8µM - Axon Medchem 1358) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... WNTi/TNKi (IWR1-endo 5µM - Axon Medchem 2510 or XAV939 2µM - Axon Medchem 1527); P38i/JNKi (BIRB0796 0.8µM - Axon Medchem 1358) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... ROCKi Y27632 (1.2µM - Axon Medchem 1683), SRCi (CGP77675 1.2µM – Axon Medchem 2097) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and PD0325901 (PD, 1μM – Axon Medchem 1408). Murine naïve ESCs and iPSCs were expanded on gelatin-coated plates ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... SHHi (RU-SKI43 3µM, Axon Medchem 2035), G9a inhibitor (BIX01294 0.5µM – Axon Medchem 1692) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... BRAFi (SB590885, 0.5µM, Axon Medchem 2504), ERK5i (BIX02189 5µM ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... SRCi CGP77675 (CGP77675 1µM – Axon Medchem 2097), TNKi (IWR1-endo 4µM - Axon Medchem 2510) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Where indicated 2i was added: small-molecule inhibitors CHIR99021 (CH, 3μM-Axon Medchem) and PD0325901 (PD ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... G9a inhibitor (BIX01294 0.5µM – Axon Medchem 1692), Medium with inhibitors was replaced every 24 hours ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Gamma Secretase / NOTCH pathway inhibitor (DBZ 0.35µM – Axon Medchem 1488), BRAFi (SB590885 ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... ERK5i (BIX02189 5µM, Axon Medchem 1809), SHHi (RU-SKI43 3µM ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... TGFRßi/ALK inhibitor A83-01 (0.3µM, Axon Medchem 1421), Kenopaullone (KP ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... CHIR99021 (0.3-1µM - Axon Medchem 2510); P38i/JNKi (BIRB0796 2µM - Axon Medchem 1358) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and the following small molecule inhibitors: MEKi/ERKi (PD0325901 1 µM - Axon Medchem 1408); WNTi/TNKi (IWR1-endo 5µM - Axon Medchem 2510 or XAV939 2µM - Axon Medchem 1527) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... ROCKi Y27632 (1.2µM - Axon Medchem 1683), 20 ng/ml recombinant human ACTIVIN A (Peprotech 120-14E ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... For tHENSM conditions titrate concentration of ERKI were used (0.33microM PD0325901 - Axon Medchem 1408) together with DBZ (0.15-0.3 µM – TOCRIS 4489) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and the following small molecule inhibitors: MEKi/ERKi (PD0325901 1 µM - Axon Medchem 1408); CHIR99021 (0.3-1µM - Axon Medchem 2510) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... SRCi (CGP77675 1.2µM – Axon Medchem 2097). For HENSM-ACT ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... PKCi (Go6983 2µM - Axon Medchem 2466), ROCKi Y27632 (1.2µM - Axon Medchem 1683) ...
• Context-dependent functional compensation between Ythdf m6A readers

  Lior Lasman, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and small-molecule inhibitors CHIR99021 (CH, 3 μM-Axon Medchem) and PD0325901 (PD ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... DASA-58 (Selleckchem S7928) and TEPP-46 (Axon Medchem 2240).
• Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

  Christopher B. Mulholland, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and 2i (1 μM PD032591 and 3 μM CHIR99021 (Axon Medchem, Netherlands)).
• Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

  Christopher B. Mulholland, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Naïve ESCs were maintained on flasks treated with 0.2% gelatin in defined media containing 2i (1 μM PD032591 and 3 μM CHIR99021 (Axon Medchem, Netherlands)) ...
• Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors

  Manoj K Rathinaswamy, et al., bioRxiv - Biochemistry 2020

  Quote: ... PIK-90 [61] from Axon Medchem (Groningen, The Netherlands, #Axon1362); AS-604850 (PI 3-Kγ Inhibitor II ...
• 4β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor

  Ofer Moldavski, et al., bioRxiv - Biochemistry 2020

  Quote: ... LXR antagonist GSK-2033 (Axon Medchem) was used at 500nM ...
• Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

  Cemre Celen, et al., bioRxiv - Genetics 2020

  Quote: ... Either 20 mg/kg canertinib or 20 mg/kg NR4A1 antagonist C-DIM8-DIM-C-pPhOH (Axon Medchem # Axon 2827) was administered daily through gavage starting a day before PPx until sacrificing mice day 7 post-PPx.
• Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination

  Darpan Saraswat, et al., bioRxiv - Neuroscience 2020

  Quote: ... CHIR-99021 (3µM, Axon MedChem), XAV939 (0.1µM ...
• THE DYNAMIC INTERPLAY BETWEEN HOMEODOMAIN TRANSCRIPTION FACTORS AND CHROMATIN ENVIRONMENT REGULATES PRONEURAL FACTOR OUTCOMES

  Cheen Euong Ang, et al., bioRxiv - Genomics 2020

  Quote: ... Human embryonic stem cells were plated in clumps in the presence of Y27632 (10mg/ml, 1000x, Axon MedChem). The hES colonies were allowed to grow in mTESR for another day before the media was switch to differentiation media (1X N2 ...
• Aβ oligomers induce sex-selective differences in mGluR5 pharmacology and pathophysiological signaling in Alzheimer mice

  Khaled S. Abd-Elrahman, et al., bioRxiv - Neuroscience 2020

  Quote: CTEP (1972) was purchased from Axon Medchem. β-Amyloid [1 42] PTD Human protein (03111) ...