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151 - 200 of 290 citations since 2020

• Mitigation of Injury from Myocardial Infarction by TH1834, an Inhibitor of the Acetyltransferase Tip60

  Xinrui Wang, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... TH1834 was purchased from Axon Medchem (The Netherlands; cat. #2339). Daily injections were performed for 14 consecutive days ...
• Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

  Tomokazu Tamura, et al., bioRxiv - Microbiology 2022

  Quote: ... CHIR99021 (Axon Medchem, Cat# 1386), and SB431542 (FUJIFILM Wako ...
• Chimeric 3D-gastruloids – a versatile tool for studies of mammalian peri-gastrulation development

  Alexandra E. Wehmeyer, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and PD0325901 (Axon Medchem, 1 μM) on 0.1% gelatine-coated dishes ...
• Chimeric 3D-gastruloids – a versatile tool for studies of mammalian peri-gastrulation development

  Alexandra E. Wehmeyer, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and 2i: CHIR99021 (Axon Medchem, 3 μM) and PD0325901 (Axon Medchem ...
• Complex Intracellular Mechanisms of TBK1 Kinase Activation Revealed by a Specific Small Molecule Inhibitor

  Junqiang Ye, Noah Dephoure, Tom Maniatis, bioRxiv - Molecular Biology 2022

  Quote: ... GSK8612 was purchased from Axon Medchem; MRT67307 ...
• m6A-ELISA, a simple method for quantifying N6-methyladenosine from mRNA populations

  Imke Ensinck, et al., bioRxiv - Biochemistry 2022

  Quote: ... with additional use of small molecule inhibitors: 1μM PD0325901 (04-0006, Stemgent) and 3μM CHIR99021 (1386 Axon Medchem). Cells were passaged using Stempro-Accutase (A1110501 ...
• The FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin

  Colin Stok, et al., bioRxiv - Cancer Biology 2022

  Quote: ... or 5μM CDK inhibitor RO-3306 (Axon Medchem) for 4 h ...
• MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

  Ada Lerma Clavero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... navtemadlin (2639, Axon Medchem), and staurosporine (Sigma Aldrich ...
• Comprehensive chromatin proteomics resolves functional phases of pluripotency

  Enes Ugur, et al., bioRxiv - Biochemistry 2022

  Quote: ... 2i (1 μM PD032591 and 3 μM CHIR99021 (Axon Medchem, Netherlands)) ...
• p16^High senescence restricts totipotent potential during somatic cell reprogramming

  Bogdan B. Grigorash, et al., bioRxiv - Cell Biology 2022

  Quote: ... 0.5 μM A83-01 (Axon Medchem #1421). N2B27 basal media consist of Knockout DMEM (Gibco # 10829018 ...
• A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation

  Teresa E. Knudsen, et al., bioRxiv - Cell Biology 2022

  Quote: ... 3 μM Gsk3i (Chir99021: Axon Medchem) and 1μM MEKi (PD0325901 ...
• Viral proteins and virus-like particles of the LTR5_Hs endogenous retrovirus in human primordial germ cell-like cells

  Mutsumi Kobayashi, et al., bioRxiv - Developmental Biology 2022

  Quote: ... medium containing 10μM Y27632 ROCK inhibitor (Axon Medchem, 1683) at 1.0 × 107 cells/mL ...
• Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence

  Venkatesh Mallikarjun, et al., bioRxiv - Cell Biology 2022

  Quote: ... and HSF1A (Axon MedChem) were used at 1 µM and 50 µM ...
• TRAIL-induces Src mediated MEK/ERK, SMAD3 and β-catenin signalling in apoptosis resistant NSCLC cells

  Margot de Looff, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Selumetinib (AZD6244, Axon Medchem) and SIS3 (Cayman chemical ...
• Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL

  Nadine Weinelt, et al., bioRxiv - Cell Biology 2022

  Quote: ... HOIPIN-8 from Axon Medchem LLC (Reston ...
• Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

  Anne Margriet Heijink, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 16 μM veliparib (Axon Medchem), 7 nM talazoparib (Axon Medchem) ...
• Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

  Anne Margriet Heijink, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 20 μM BO2 (Axon Medchem). VE-821 (ATRi ...
• Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

  Anne Margriet Heijink, et al., bioRxiv - Cancer Biology 2021

  Quote: ... simultaneously with BrdU treatment at the following concentrations: 0.5 μM olaparib (Axon Medchem), 16 μM veliparib (Axon Medchem) ...
• Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

  Anne Margriet Heijink, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 7 nM talazoparib (Axon Medchem), 50 nM mitomycin C (Sigma) ...
• Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

  Anne Margriet Heijink, et al., bioRxiv - Cancer Biology 2021

  Quote: ... VE-821 (ATRi; Axon Medchem) was added simultaneously with colcemid for 3 h at a concentration of 1.0 μM ...
• Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

  Anne Margriet Heijink, et al., bioRxiv - Cancer Biology 2021

  Quote: ... or talazoparib (all from Axon Medchem) for 3 days ...
• Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibition

  Elisabeth Peer, et al., bioRxiv - Cancer Biology 2021

  Quote: ... SR-3029 (Axon Medchem, Groningen, Netherlands) and CK1D008 (4SC AG ...
• Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

  C Cintas, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pan-PI3K and isoform-selective PI3K inhibitors from Axon Medchem; Gemcitabine was a kind gift of hospital (IUCT-O ...
• Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies

  Patrick M. Lelliott, et al., bioRxiv - Immunology 2021

  Quote: ... 20 μM of the NE inhibitor GW 311616A (Axon Medchem, Netherlands), or 10 μg/ml azide-free blocking antibodies for integrin β1 (CD29 ...
• Extraembryonic endoderm cells induce neuroepithelial tissue in gastruloids

  Noémie M. L. P. Bérenger-Currias, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 150 µL of prewarmed N2B27 supplemented with 3 µM of GSK3 inhibitor (CHIR99021, Axon Medchem) was added to each well ...
• Extraembryonic endoderm cells induce neuroepithelial tissue in gastruloids

  Noémie M. L. P. Bérenger-Currias, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 150 µL of prewarmed N2B27 supplemented with 3 µM of GSK3 inhibitor (CHIR99021, Axon Medchem) was added to each well ...
• LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice

  Chaitanya K. Gavini, et al., bioRxiv - Neuroscience 2021

  Quote: Aged mice were treated with vehicle or LXR agonist (GW3965; 25mg/kg BW) (Axon Medchem, Virginia, USA) by i.p ...
• SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells

  Veronique Fischer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 3 μM CHIR99021 (Axon Medchem, Cat# 1386) and 1 μM PD0325901 (Axon Medchem ...
• SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells

  Veronique Fischer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and 1 μM PD0325901 (Axon Medchem, Cat# 1408) were added freshly to the medium ...
• ATR facilitates the degradation of Api5 through the ubiquitin-proteasome pathway via FBXW2 to regulate apoptosis upon DNA damage

  Virender Kumar Sharma, et al., bioRxiv - Molecular Biology 2021

  Quote: ... USA and the selective ATR kinase ATR inhibitor (VE 821) was purchased from Axon Medchem, USA ...
• A dynamic equilibrium between TTP and CPEB4 controls mRNA stability and inflammation resolution

  Clara Suñer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... For the inhibition of p38α, we used 1 μM PH-797804 (Selleckchem, S2726) or 10 μM SB203580 (Axon MedChem).
• In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection

  Amy Dumigan, et al., bioRxiv - Microbiology 2021

  Quote: ... cells were treated with DMSO or STAT6 inhibitor AS1715499 (50 nM/mL, 919486-40-1; AXON Medchem) 2 h prior to infection and maintained throughout ...
• aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis

  Olivia Molinar-Inglis, et al., bioRxiv - Cell Biology 2021

  Quote: ... for 30 min, or with 1 µM MK-2206 (Selleck, #S1078) or 10 µM Vorapaxar (Axon Medchem, #1755) for 1 h.
• Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells

  Hegias Mira-Bontenbal, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 5000 U mL-1 LIF) supplemented with 2i (1 μM PD0325901 – Selleckchem, 3 μM CHIR99021 – Axon Medchem) on irradiated male mouse embryonic fibroblasts.
• Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co-Culture

  Aisen Vivas, et al., bioRxiv - Bioengineering 2021

  Quote: ... mesodermal differentiation was initiated by addition of Wnt activator CHIR99021 (1.5 μmol/L, Axon Medchem 1386), Activin-A (20 ng/mL ...
• SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation

  Julia Ghelman, et al., bioRxiv - Neuroscience 2021

  Quote: ... 3 µM CHIR99021 (#1386, Axon MedChem) and 150 µM L-ascorbic acid (#A4544 ...
• The lipid kinase PI3Kα is required for the cohesion and survival of cancer cells disseminated in serous cavities

  B Thibault, et al., bioRxiv - Cancer Biology 2021

  Quote: ... A66 (Axon Medchem) PI3Kα inhibitor (in vitro IC50 in nM ...
• STRAIGHT-IN: A platform for high-throughput targeting of large DNA payloads into human pluripotent stem cells

  Catarina Grandela, et al., bioRxiv - Cell Biology 2021

  Quote: ... the cells were refreshed with mBEL medium containing 5 µM CHIR99021 (Axon Medchem). On differentiation d2 ...
• LAP1 supports nuclear plasticity during constrained migration

  Yaiza Jung-Garcia, et al., bioRxiv - Cell Biology 2021

  Quote: ROCKi GSK269962A (Axon MedChem) was used at 1 μM and Staurosporin (Cell Guidance Systems ...
• An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis

  Raphaëlle Lesage, et al., bioRxiv - Systems Biology 2021

  Quote: ... PD161570 (1μM, Axon Medchem), ITSA1 (50μM ...
• An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis

  Raphaëlle Lesage, et al., bioRxiv - Systems Biology 2021

  Quote: ... LDN-193189 (0.5μM, Axon Medchem), LY294002 (20μM ...
• An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis

  Raphaëlle Lesage, et al., bioRxiv - Systems Biology 2021

  Quote: ... Cells were treated with one or a combination of the following compounds: Forskolin (1μM, Axon Medchem), Recombinant Human/Mouse/Rat Activin A Protein (100ng/ml ...
• An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis

  Raphaëlle Lesage, et al., bioRxiv - Systems Biology 2021

  Quote: ... LY294002 (20μM, Axon Medchem) and IWP2 (2μM ...
• Long-term decreased cannabinoid type-1 receptor activity restores specific neurological phenotypes in the Ts65Dn mouse model of Down syndrome

  Anna Vázquez-Oliver, et al., bioRxiv - Neuroscience 2021

  Quote: Rimonabant was purchased from Axon Medchem. Rimonabant was first prepared as a 40 mM stock solution in ethanol ...
• Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation

  MA Jiajia, et al., bioRxiv - Cell Biology 2021

  Quote: ... 1.2μM (Axon-1528, Axon Medchem); Dimethyl fumarate ...
• CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependencies

  Gregory A. Breuer, et al., bioRxiv - Cancer Biology 2021

  Quote: ... AG-014699 (Axon Medchem; #1529), BGB-290 (BeiGene).
• CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependencies

  Gregory A. Breuer, et al., bioRxiv - Cancer Biology 2021

  Quote: ... KU-0058948 (Axon Medchem; #2001), NMS-P118 (Selleckchem ...
• Targeted enzyme assisted chemotherapy (TEAC) – a novel microRNA-guided and selenium-based regimen to specifically eradicate hepatocellular carcinoma

  Arun Kumar Selvam, et al., bioRxiv - Cancer Biology 2021

  Quote: ... BFF-122 was purchased from Axon Medchem (Groningen, Netherlands), NADPH was purchased from Acros Organics (Geel ...
• Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells

  Junko Yoshida, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 3 µM of GSK3 inhibitor CHIR99021 (Cat. Axon1386, Axon Medchem). We routinely added LIF to the serum-free medium (2i/LIF) ...
• Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells

  Junko Yoshida, et al., bioRxiv - Developmental Biology 2021

  Quote: ... The serum-free 2i medium was composed of N2B27 supplemented with 1 µM of MEK inhibitor PD0325901 (Cat. Axon1408, Axon Medchem) and 3 µM of GSK3 inhibitor CHIR99021 (Cat ...