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• Evolutionarily Conserved Transcription Factors Drive the Oxidative Stress Response in Drosophila

  Sarah M. Ryan, et al., bioRxiv - Evolutionary Biology 2020

  Quote: ... and rabbit anti-alpha tubulin (1:5000) and either goat anti-mouse HRP 1:20,000 (Jackson Labs) or goat anti-rabbit HRP 1:40,000 (Jackson Labs) ...
• Adipose tissue developmental growth constraints uncouple fat distribution from glucose metabolism in two mouse models of obesity

  Zachary L. Sebo, et al., bioRxiv - Developmental Biology 2020

  Quote: ... ARdY mice (Lyon and Hawkes, 1970) were obtained from Jackson Laboratories (Stock # 001809) and maintained on the C57BL/6J-Aw-j/J background ...
• A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity

  Hannah Sanford-Crane, et al., bioRxiv - Cancer Biology 2020

  Quote: ... C57BL/6J (000664, for models with FC12451) or B6129SF1/J (101043, for models with 688M2) mice from Jackson Laboratory were used for orthotopic transplant experiments at 8-10 weeks of age ...
• Characterizing intra-tumor and inter-tumor variability of immune cell infiltrates in murine syngeneic tumors

  Sepideh Mojtahedzadeh, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Female BALB/c mice were purchased from Jackson laboratories (Sacramento, CA). Cell-line authentication and mycoplasma testing was periodically carried out for all cell lines ...
• High dimensional immunotyping of the obese tumor microenvironment reveals model specific adaptation

  Cara E Wogsland, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Male and female C57BL/6J (stock number: 000664) mice were purchased from Jackson laboratories. Mice were kept in IVC-II cages (SealsafeÒ IVC Blue Line 1284L ...
• POMK regulates dystroglycan function via LARGE-mediated elongation of matriglycan

  Ameya S. Walimbe, et al., bioRxiv - Biochemistry 2020

  Quote: B6SJLF1/J mice were purchased from Jackson Labs (100012; Bar Harbor, ME). Male mice older than 8 weeks were used to breed with 3-5-week-old super-ovulated females to produce zygotes for electroporation ...
• Microglia-targeted dendrimer-2PMPA therapy robustly inhibits GCPII and improves cognition in a mouse model of multiple sclerosis

  Kristen Hollinger, et al., bioRxiv - Neuroscience 2020

  Quote: Female 7-week-old C57BL/6J mice were purchased from Jackson Laboratory (Bar Harbor, ME) and housed in the Miller Research Building Johns Hopkins animal facility ...
• Expression of Tim-3 drives naïve Treg to an effector-like state with enhanced suppressive activity

  Hridesh Banerjee, et al., bioRxiv - Immunology 2020

  Quote: ... C57BL/6 mice for breeding were obtained from Jackson Labs. For inducible Cre-mediated deletion with the Cre-ERT2 model ...
• Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

  Dana Cruz, et al., bioRxiv - Cell Biology 2020

  Quote: ... was acquired from Jackson Laboratories. Mice hemizygous for the J20 transgene are designated as “AD” or Tg+ ...
• VGLUT modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration

  Silas A. Buck, et al., bioRxiv - Neuroscience 2020

  Quote: We used male mice (8-12 weeks old) expressing Cre recombinase under the control of the DA transporter (DATcre) (Slc6a3IRESCre, Jackson stock 006660, The Jackson Laboratory, Bar Harbor, ME) which were bred on a C57BL/6J genetic background and backcrossed to C57BL/6J for 12 generations ...
• Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

  Liheng Wang, et al., bioRxiv - Cell Biology 2020

  Quote: ... and subcutaneously injected into NSG mice (The Jackson laboratory, stock no. 005557). 2-3 months later ...
• Superresolution microscopy reveals photoreceptor-specific subciliary location and function of Cep290

  Valencia L. Potter, et al., bioRxiv - Cell Biology 2020

  Quote: ... Cep290rd16 and Cep290tm1.1Jgg mice backcrossed to C57BL/6 were acquired from Jackson Laboratory (CEP290rd16-Stock No ...
• Spatial organization of the transcriptome in individual neurons

  Guiping Wang, et al., bioRxiv - Cell Biology 2020

  Quote: ... hippocampus from embryonic day 18 (E18) mouse (timed pregnant C57BL/6J, the Jackson Laboratory, 000664 |Black 6) were isolated and digested with 0.25% trypsin–EDTA (1× ...
• Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

  Jesse R. Holt, et al., bioRxiv - Cell Biology 2020

  Quote: ... Skin specific Piezo1-cKO mice were generated by breeding Piezo1fl/fl mice (Cahalan et al. 2015) (Jax stock 029213) with K14-Cre (The Jackson Laboratory, stock 004782). Skin specific Piezo1-GoF mice were generated by breeding Piezo1cx/cx mice (Ma et al ...
• Differential Requirements for the CENP-O Complex Reveal Parallel PLK1 Kinetochore Recruitment Pathways

  Alexandra L. Nguyen, et al., bioRxiv - Cell Biology 2020

  Quote: ... and Cy5-conjugated secondary antibodies were obtained from Jackson Laboratories and used at 1:300 ...
• CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

  Simona Giunta, et al., bioRxiv - Cell Biology 2020

  Quote: ... and donkey anti-rat 594 (1:50, 712-585-150, Jackson laboratory) for 20min ...
• De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function

  Ruohan Wu, et al., bioRxiv - Cell Biology 2020

  Quote: ... and CD45.1+ mice were obtained from Jackson laboratory (Bar Harbor, ME). CD4-Cre ...
• The ESCRT protein CHMP5 restrains skeletal progenitor cell senescence by preserving endo-lysosomal-mitochondrial network

  Xianpeng Ge, et al., bioRxiv - Cell Biology 2020

  Quote: ... The Rosa26mTmG mouse was purchased from Jackson Laboratories. To generate experimental animals ...
• Capturing limbal epithelial stem cell population dynamics, signature, and their niche

  Anna Altshuler, et al., bioRxiv - Cell Biology 2020

  Quote: ... Krt15-GFP (#005244) and UBC-CreERT2 (#008085) were from Jackson Laboratories (Bar Harbor, ME). To induce Cre recombinase activity ...
• Self-renewal of double negative 3 (DN3) early thymocytes allows for thymus autonomy but compromises the β-selection checkpoint

  Rafael A. Paiva, et al., bioRxiv - Immunology 2020

  Quote: ... Cells were blocked with mouse IgG (Jackson laboratories) before staining ...
• SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

  Evelien Eenjes, et al., bioRxiv - Cell Biology 2020

  Quote: ... Sox2-CreERT (Jackson Labs, stock number 017593) and SOX21-KO (gift of Stavros Malas ...
• Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission

  Katherine W. Eyring, et al., bioRxiv - Cell Biology 2020

  Quote: ... hemizygote Amigo2-Cre mice (Jackson Labs; Stock No. 030215) and homozygous OXTR-ires-Cre (provided by Dr ...
• Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission

  Katherine W. Eyring, et al., bioRxiv - Cell Biology 2020

  Quote: ... with Ai9 mice (Jackson Labs; Stock No. 007909).
• Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission

  Katherine W. Eyring, et al., bioRxiv - Cell Biology 2020

  Quote: ... Homozygous Oxytocin-ires-Cre (Jackson Labs; Stock No. 024234), hemizygote Amigo2-Cre mice (Jackson Labs ...
• Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission

  Katherine W. Eyring, et al., bioRxiv - Cell Biology 2020

  Quote: ... Targeted interneuron recordings were made from the offspring of crosses between either PV-Cre (Jackson Labs; Stock No. 008069) or SST- ires-Cre mice (Jackson Labs ...
• Oxytocin signals via Gi and Gq to drive persistent CA2 pyramidal cell firing and strengthen CA3-CA1 neurotransmission

  Katherine W. Eyring, et al., bioRxiv - Cell Biology 2020

  Quote: ... or SST- ires-Cre mice (Jackson Labs; Stock No. 013044) with Ai9 mice (Jackson Labs ...
• Intravital imaging of islet Ca²⁺ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

  Elina Akalestou, et al., bioRxiv - Cell Biology 2020

  Quote: ... this Department) to mice that express GCaMP6f downstream of a LoxP-flanked STOP cassette (The Jackson Laboratory, stock no. 028865). Islets donated from either sex were used for transplantation.
• Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion

  Xiuping Fu, et al., bioRxiv - Cell Biology 2020

  Quote: Pronuclear injection of one-cell C57BL/6J embryos (Jackson Laboratories) was performed by the JHU Transgenic Core using standard microinjection techniques [21] with a mix of Cas9 protein (30ng/ul ...
• Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion

  Xiuping Fu, et al., bioRxiv - Cell Biology 2020

  Quote: ... we bred mice with one of these floxed alleles with mice from one of the following Cre lines obtained from Jackson Labs: Adipoq-Cre (#028020) ...
• Image-based elastography of heterochromatin and euchromatin domains in the deforming cell nucleus

  Soham Ghosh, et al., bioRxiv - Cell Biology 2020

  Quote: We obtained B6.Cg-Tg (HIST1H2BB/EGFP) 1Pa/J mice from Jackson Laboratory (#006069). Nuclei of the cells from homozygous mice bred from this colony display a strong fluorescence at 488 nm caused by the green fluorescence tag attached to its histone H2B ...
• Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding at cis-regulatory elements and TAD boundaries

  Shinichi Kadota, et al., bioRxiv - Cell Biology 2020

  Quote: ... ES cells were cultured on γ-irradiated mouse embryonic fibroblasts (MEFs) that were isolated from Tg(DR4)1Jae/J mice (The Jackson Laboratory). To transduce ES cells ...
• An adipocyte-specific lncRAP2 – Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

  Juan R. Alvarez-Dominguez, et al., bioRxiv - Cell Biology 2020

  Quote: C57BL/6J mice were bred in house or purchased from Jackson Laboratories (stock # 000664). All mice were housed under a 12 hour light / dark cycle at constant temperature (20°C) ...
• Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids

  Bing Zhao, et al., bioRxiv - Cell Biology 2020

  Quote: ... Cy3-conjugated donkey anti-rabbit IgG (Jackson Lab,711-165-152), Alexa Fluor 488-conjugated donkey anti-mouse IgG (Jackson Lab ...
• Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids

  Bing Zhao, et al., bioRxiv - Cell Biology 2020

  Quote: ... Alexa Fluor 488-conjugated donkey anti-mouse IgG (Jackson Lab, 715-545-151).
• Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

  Kai Wang, et al., bioRxiv - Cell Biology 2020

  Quote: ... Teratoma formation assay was performed by injecting 1 million h-iPSCs mixed in 100 μL Matrigel into the dorsal flank of nude mice (Jackson Lab). Four weeks after the injection ...
• PIE-FLIM measurements of two different FRET-based biosensor activities in the same living cells

  C.A. Reissaus, et al., bioRxiv - Cell Biology 2020

  Quote: ... Male C57BL/6J mice 8 weeks of age (Jackson Labs, Bar Harbor, ME) were utilized ...
• Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of immune-mediated kidney disease

  James Dylewski, et al., bioRxiv - Cell Biology 2020

  Quote: podFcRn KO mice were obtained by crossing C57BL/6J FcRn floxed mice (38) (a kind gift from Dr. Sally Ward, UT Southwestern) with C57BL/6J podocin-Cre mice (Jackson Labs, Bar Harbor, Maine) as previously described (36) ...
• Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo

  A. Marieke Oudelaar, et al., bioRxiv - Genomics 2020

  Quote: ... Cells were immunostained at 4 °C in the presence of rabbit IgG (200 μg/ml, Jackson Laboratories 015-000-003) to block Fc receptors ...
• A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

  Zijun Wang, et al., bioRxiv - Immunology 2020

  Quote: ... Cg-Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ mice (FcRn -/- hFcRn) (The Jackson Laboratory, #004919) aged 7-8 weeks were intravenously injected (Retro-orbital vein ...
• Emergence of Non-Canonical Parvalbumin-Containing Interneurons in Hippocampus of a Murine Model of Type I Lissencephaly

  Tyler G. Ekins, et al., bioRxiv - Neuroscience 2020

  Quote: ... B6.129P2-Pvalbtm1(cre)Arbr/J) and tdTomato mice (Jackson Labs stock no. 007909, B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J) ...
• Stem Cell Transplantation Rescued A Primary Open-Angle Glaucoma Mouse Model

  Siqi Xiong, et al., bioRxiv - Developmental Biology 2020

  Quote: Four-month old wildtype (WT) C57BL/6J mice were purchased from Jackson Laboratory as the normal control ...
• Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

  Wenqing Zhou, et al., bioRxiv - Cell Biology 2020

  Quote: All mice used in this study were purchased from Jackson Laboratories. Conditional Mfn2 knockout mice (B6.129(Cg)-Mfn2tm3Dcc/J ...
• Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

  Zhong Chen, et al., bioRxiv - Genomics 2020

  Quote: ... The 16-week-old female C57 BL/6J mice (Jackson Lab, Bar Harbor, ME) were used in this study as part of the NASA RR-1 project consortium ...
• Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity

  Lauren Y. Shields, et al., bioRxiv - Neuroscience 2020

  Quote: ... CamKCre mice (71) were obtained from Jackson Laboratory. Mice were group-housed in a colony maintained with a standard 12 h light/dark cycle and given food and water ad libitum ...
• Soluble corn fiber reduces ovalbumin-induced sinonasal inflammation via the gut microbiota-airway axis

  Sierra A. Jaramillo, et al., bioRxiv - Microbiology 2020

  Quote: ... Female Balb/c mice (Jackson Laboratory) at 7 weeks old were randomly separated into 2 diet groups ...
• Injectable Nanoelectrodes Enable Wireless Deep Brain Stimulation of Native Tissue in Freely Moving Mice

  Kristen L. Kozielski, et al., bioRxiv - Bioengineering 2020

  Quote: Experiments were performed on 68 male naïve mice (C57Bl/6J; Jackson Laboratory). Mice were socially housed under controlled conditions (21±2°C and 40-60% humidity ...
• JAGGED1 Stimulates Cranial Neural Crest Cell Osteoblast Commitment Pathways and Bone Regeneration Independent of Canonical NOTCH Signaling

  Archana Kamalakar, et al., bioRxiv - Genomics 2020

  Quote: ... 6-8-week-old male and female C57BL/6 mice (The Jackson Laboratory, 000664) were used ...
• Acquisition of Innate Odor Preference Depends on Spontaneous and Experiential Activities During Critical Period

  Qiang Qiu, et al., bioRxiv - Neuroscience 2020

  Quote: ... (Jackson laboratory, stock number 009136 ...
• A peptide-signal amplification strategy for the detection and validation of neoepitope presentation on cancer biopsies

  Sri H. Ramarathinam, et al., bioRxiv - Immunology 2020

  Quote: ... NSG mice were obtained from Jackson Laboratory and both male and female mice were used ...
• ZBTB38 is dispensable for hematopoiesis and antibody responses

  Rachel Wong, Deepta Bhattacharya, bioRxiv - Immunology 2020

  Quote: ... or VavCre (Jackson Laboratory, stock no. 008610) and maintained as ZBTB38 f/f or ZBTB38 x CMV- or Vav-Cre where littermates were used as controls ...