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1 - 50 of 1519 citations for 1 2 Dihydro 1 2 tetrahydro 2H pyran 2 yl oxy ethyl 5H tetrazole 5 thione d4 since 2020

• FAM57B is a modulator of ceramide synthesis that regulates sphingolipid homeostasis and synaptic composition in the developing brain

  Danielle L. Tomasello, et al., bioRxiv - Neuroscience 2021

  Quote: ... Vesicular Glutamate 1 and 2 (VGlut1/2, Synaptic Systems) or Postsynaptic Density 95 (PSD95 ...
• Impaired neurogenesis and synaptogenesis in iPSC-derived Parkinson’s patient cortical neurons with D620N VPS35 mutation

  Ute Scheller, et al., bioRxiv - Neuroscience 2024

  Quote: ... Synapsin 1/2 (rabbit, 1:500, Synaptic Systems). Cells were washed with 0.1% Triton X-100/2.5% NGS/PBS and incubated with secondary antibodies for 45 min ...
• Human adherent cortical organoids in a multiwell format

  Mark van der Kroeg, et al., bioRxiv - Neuroscience 2024

  Quote: ... Synapsin 1/2 (Synaptic Systems 106003, 1:200); and PSD95 (Thermo Fisher Scientific MA1-046 ...
• Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

  Charles Ducrot, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-RIM-1/2 (1:1000, Synaptic Systems). These were subsequently detected using Alexa Fluor-488-conjugated ...
• ER Stress Impedes Regulated Secretion by Governing Key Exocytotic and Granulogenic Molecular Switches

  Mohima Mukherjee, et al., bioRxiv - Cell Biology 2023

  Quote: ... VAMP 2 (Synaptic Systems, 104202, 1:2000), STX6 (Synaptic Systems ...
• ARGX-119, a therapeutic agonist antibody targeting MuSK

  Roeland Vanhauwaert, et al., bioRxiv - Neuroscience 2024

  Quote: ... or Synapsin 1/2 (Synaptic Systems, 106002) to label motor axons and nerve terminals ...
• Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic eEF2K

  Stefania Beretta, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-synapsin1/2 (1:1000 Synaptic Systems), mouse anti-GABAAR α5 (1:250 NeuroMab) ...
• Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway

  Angelisa Frasca, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Synapsin1/2 (1:500; #106006, Synaptic System), anti-Shank2 (1:300 ...
• Synapses and Ca²⁺ activity in oligodendrocyte precursor cells can predict where myelin sheaths form

  Jiaxing Li, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Synapsin 1/2 (Synaptic Systems 106002) 1:1000 ...
• Characterization of Dnajc12 knockout mice, a model of hypodopaminergia

  Isaac Bul Deng, et al., bioRxiv - Neuroscience 2024

  Quote: ... Synaptobrevin 2 (VAMP2) (Synaptic systems, 104202, 1:1000); tyrosine hydroxylase (pser40 ...
• A dedicated hypothalamic oxytocin circuit controls aversive social learning

  Takuya Osakada, et al., bioRxiv - Neuroscience 2022

  Quote: ... guinea pig anti-c-Fos (1:2000, Synaptic Systems, 226-005, Lot #2-10, 2-13), rabbit anti-Vasopressin (1:5000 ...
• Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

  Shan Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... Guinea pig anti-Synapsin 1/2 (1:1000, Synaptic Systems 106004); Mouse anti-Homer1 (1:500 ...
• A human in vitro neuronal model for studying homeostatic plasticity at the network level

  Xiuming Yuan, et al., bioRxiv - Neuroscience 2023

  Quote: ... Guinea pig anti-Synapsin 1/2 (1:1000, Synaptic Systems 106004); Mouse anti-Ankyrin G (1:200 ...
• Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

  Richard Drexler, et al., bioRxiv - Neuroscience 2023

  Quote: ... guinea pig anti-synapsin1/2 (1:500; Synaptic Systems), chicken anti-neurofilament (M+H ...
• CaBP1 and 2 enable sustained Ca_V1.3 calcium currents and synaptic transmission in inner hair cells

  David Oestreicher, et al., bioRxiv - Neuroscience 2024

  Quote: ... guinea pig anti-Synapsin1/2 (1:200, Synaptic Systems), rabbit anti-RibeyeA (1:200 ...
• A novel pH-sensitive reporter reveals the cocaine-regulated trafficking of dopamine transporters in neuronal processes

  Jacqueline Saenz, et al., bioRxiv - Neuroscience 2022

  Quote: ... Guinea pig anti-synapsin 1/2 (Synaptic System, 106 004, 1:500), mouse anti-TH (Sigma ...
• Capsaicin-induced endocytosis of endogenous presynaptic Ca_V2.2 in DRG-spinal cord co-cultures inhibits presynaptic function

  Krishma H Ramgoolam, Annette C Dolphin, bioRxiv - Neuroscience 2022

  Quote: ... neurons were incubated with rabbit-anti-RIM 1/2 (1:200; Synaptic Systems) antibody overnight at 4°C ...
• Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract

  Kristyna Karova, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit vGlut1/2 (1:500, Synaptic Systems, Göttingen, Germany, #135503). Images of cross sections 1 cm below lesion to visualize vGlut1/2 together with GFP were acquired with Andor Dragonfly 503 spinning disc confocal microscope (Oxford Instruments ...
• Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors

  Amy Cheung, et al., bioRxiv - Neuroscience 2022

  Quote: ... RIM1/2 (Rabbit, Synaptic Systems, 140203, RRID: AB_887775, 1:1000), synaptophysin (guinea pig ...
• Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

  Nare Karagulyan, et al., bioRxiv - Neuroscience 2024

  Quote: ... guinea pig anti-Synapsin1/2 (1:500, 106004, Synaptic Systems), guinea pig anti-Vglut3 (1:500 ...
• Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors

  Amy Cheung, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-RIM1/2 (rabbit, 1:1000, Synaptic Systems, Rb 140203, AB_887775), or anti-RFP (Rabbit ...
• Alpha 9 integrin expression enables reconstruction of the spinal cord sensory pathway

  Katerina Stepankova, et al., bioRxiv - Neuroscience 2023

  Quote: ... and anti-VGLUT1/2 (Synaptic Systems, #1235503, 1:800, 3 days). Goat anti-host antibodies of the respective primary antibodies conjugated with Alexa Fluor 405 ...
• Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion

  Sébastien Houy, et al., bioRxiv - Neuroscience 2022

  Quote: ... and rabbit polyclonal α-bMunc13-2 (1:1000; Synaptic Systems SY126203), followed by HRP-conjugated α-rabbit (1:2000 ...
• Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression

  Solomiia Savchuk, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Primary antibodies guinea pig anti-synapsin1/2 (1:500; Synaptic Systems), rabbit anti-Homer1 (1:500 ...
• Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse model

  Danira Toral-Rios, et al., bioRxiv - Neuroscience 2023

  Quote: Immunofluorescence for synaptic markers Synapsin 1/2 (guinea pig polyclonal, 1:500; Synaptic Systems, 106004) and PSD95 (rabbit polyclonal ...
• Location analysis of presynaptically active and silent synapses in single-cultured hippocampal neurons

  Otoya Kitaoka, et al., bioRxiv - Neuroscience 2023

  Quote: ... Primary antibodies were subsequently applied for 3 h at the following dilutions: anti-microtubule-associated protein 2 (MAP 2) at 1:1,000 (guinea pig polyclonal, antiserum, Synaptic Systems, Göttingen, Germany) and anti-vesicular glutamate transporter 1 (anti-vGLUT1 ...
• Visualizing Synaptic Dopamine Efflux with a 2D Nanofilm

  Chandima Bulumulla, et al., bioRxiv - Neuroscience 2022

  Quote: ... guinea pig anti-synaptobrevin-2 (1:1000; SySy 104 318, Synaptic Systems). TH-GFP signal (after activity imaging ...
• Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength

  A.M. Ramsey, et al., bioRxiv - Neuroscience 2021

  Quote: ... Primary antibodies were: rabbit anti-RIM1/2 (Synaptic System #140203, 1:500), mouse anti-PSD-95 (NeuroMab clone K28/43 ...
• Extremely potent Human Monoclonal Antibodies for the Prophylaxis and Therapy of Tetanus

  Marco Pirazzini, et al., bioRxiv - Pathology 2021

  Quote: ... saturated with PBS 2% BSA for 1 hour at RT and stained with primary antibodies specific for whole VAMP-2 (Synaptic System 104 211). After extensive washing with PBS 0.5% BSA ...
• Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales

  Jochen Meyer, et al., bioRxiv - Cancer Biology 2023

  Quote: ... guinea-pig anti-VGAT (1:500; Synaptic Systems, cn: 131004, ln: 2-41), guinea-pig anti-VGLUT1 (1:2,000 ...
• Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

  Zhefu Que, et al., bioRxiv - Neuroscience 2023

  Quote: ... and guinea pig anti-synapsin1/2 (Synaptic Systems, Catalog No. 106044, 1:1000) were used ...
• Infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala

  Dipan C. Patel, et al., bioRxiv - Neuroscience 2023

  Quote: ... guinea pig polyclonal anti-NeuN antibody (1-2 µg/ml; 266004, Synaptic Systems), rabbit polyclonal anti-NeuN antibody (1 µg/ml ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... Primary antibodies guinea pig anti-synapsin1/2 (1:500; Synaptic Systems, 106-004), rabbit anti-RFP (1:500 ...
• A selective projection from the subthalamic nucleus to parvalbumin-expressing interneurons of the striatum

  Krishnakanth Kondabolu, et al., bioRxiv - Neuroscience 2020

  Quote: ... and rabbit anti-vesicular glutamate transporter 2 (VGluT2; 1:1000; 135403, Synaptic Systems, RRID:AB_887883). After exposure to primary antibodies ...
• Activation of the CA2-vCA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

  Elise C. Cope, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-vesicular glutamate transporter 2 (VGLUT2, 1:500, Synaptic Systems, Cat# 135 403), rabbit anti-vesicular glutamate transporter 1 (VGLUT1 ...
• TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection

  Kristin Metzdorf, et al., bioRxiv - Immunology 2022

  Quote: ... 3 μm thick FFPE sections were stained for SARS-CoV-2 with mouse-anti-nucleocapsid CoV-1/2 (Synaptic Systems, HS-452 11, clone 53E2, subtype: IgG2a) and for macrophages with rat-anti-mouse-MAC2 (Biozol Diagnostica/CEDARLANE,CL8942AP ...
• BETA- AND GAMMA-SYNUCLEINS MODULATE SYNAPTIC VESICLE-BINDING OF ALPHA-SYNUCLEIN

  Kathryn E. Carnazza, et al., bioRxiv - Neuroscience 2020

  Quote: ... synaptobrevin-2 (69.1, Synaptic Systems), αSyn (clone 42 ...
• Activity-dependent endoplasmic reticulum Ca²⁺ uptake depends on Kv2.1-mediated endoplasmic reticulum/plasma membrane junctions to promote synaptic transmission

  Lauren C. Panzera, et al., bioRxiv - Neuroscience 2021

  Quote: ... Synapsin 1/2 rabbit polyclonal antibody (002 106) was obtained from Synaptic Systems (Goettingten, Germany) and used at 1/2000 as described above except that here the secondary antibody was Alexa Fluor 647-conjugated goat anti-rabbit IgG (A21244) ...
• The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes

  Jeremy Krohn, et al., bioRxiv - Neuroscience 2022

  Quote: ... chicken anti microtubule associated protein 2 (MAP2; 1:1000; Synaptic Systems Cat# 188 006, RRID:AB_2619881). After washing in PBS ...
• Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment

  Tyler Ogunmowo, et al., bioRxiv - Neuroscience 2023

  Quote: ... Endogenous Synaptobrevin 2 protein was stained by an anti-Synaptobrevin 2 mouse monoclonal (Synaptic Systems) antibody ...
• Early life stress influences epilepsy outcomes in mice

  Emanuel M Coleman, et al., bioRxiv - Neuroscience 2024

  Quote: ... sections were blocked for 2 hrs in 5% normal goat serum at room temperature and incubated in primary anti-cFos (1:1000; Synaptic Systems, cat. # 226 008) for 2 days at 4°C ...
• Fast resupply of synaptic vesicles requires Synaptotagmin-3

  Dennis J. Weingarten, et al., bioRxiv - Neuroscience 2021

  Quote: ... then in primary antibody for 2 h at RT (rabbit anti-Syt3, 1:3000, Synaptic Systems 105133 ...
• Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment

  Tyler Ogunmowo, et al., bioRxiv - Neuroscience 2023

  Quote: ... Endogenous Synapsin protein was stained by an anti-Synapsin 1/2 guinea pig polyclonal (Synaptic Systems) antibody ...
• Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons

  Olena Kim, et al., bioRxiv - Neuroscience 2023

  Quote: ... or anti-Munc13-2 (Synaptic Systems, Cat # 126 203 ...
• TRAF6 controls spinogenesis instructing synapse density and neuronal activity through binding neuroplastin

  Sampath Kumar Vemula, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2 mM CaCl2) and immediately incubated with an Oyster 550-labeled anti-synaptotagmin-1 rabbit antibody (Synaptic Systems, #105 103C3; 1:500) for 20 min at 37°C ...
• Genetic and pharmacological reduction of CDK14 mitigates α-synuclein pathology in human neurons and in rodent models of Parkinson’s disease

  Jean-Louis A. Parmasad, et al., bioRxiv - Neuroscience 2023

  Quote: ... tissue sections and primary neurons were incubated in primary antibody (Synapsin, 1:2 000, Thermo Fisher Scientific, Waltham, MA, USA, A-6442, PSD95, 1:500, Synaptic Systems, Göttingen ...
• CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

  Sarah Woelfle, et al., bioRxiv - Neuroscience 2022

  Quote: ... Synaptic staining was performed with a synaptophysin (1:300, Synaptic Systems, Göttingen, Germany, G2 in Table 2) and a GLUA1 antibody (1:200 ...
• The neural basis of defensive behaviour evolution in Peromyscus mice

  Felix Baier, et al., bioRxiv - Neuroscience 2023

  Quote: ... and incubated sections for 2 days with rabbit anti-c-Fos antibody (1:4000, Synaptic Systems, 226003). We used donkey anti-rabbit Alexa 647 antibody (1:1000 ...
• The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons

  Florian Wernert, et al., bioRxiv - Cell Biology 2023

  Quote: ... Chicken anti-map2 (against residues 2-314 of human map2, 1:1000 for IF) was from Synaptic Systems (#188006). Chicken anti pan-neurofascin (against residues 25-1031 of rat neurofascin ...
• Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation

  Akanksha Jain, et al., bioRxiv - Neuroscience 2024

  Quote: The following primary mouse antibodies were used in this study: synaptobrevin 2 (WB, 1:2000; Synaptic Systems, 104211, RRID:AB_2619757); synaptotagmin 1 ATTO647N (ICC ...