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801 - 850 of 1505 citations for 1 6 Chloropyridazin 3 yl piperidine 4 carboxamide since 2020

• Epileptiform GluN2B–driven excitation in hippocampus as a therapeutic target against temporal lobe epilepsy

  Adam Gorlewicz, et al., bioRxiv - Neuroscience 2021

  Quote: ... The following primary antibodies and their dilutions were used: rabbit anti GluN2B (Frontier Institute, 1:100) and rabbit anti synaptoporin (Synaptic Systems, 1:400). The following secondary antibodies and their dilutions were used ...
• PKA-mediated phosphorylation of Neuroligin-2 regulates its cell surface expression and synaptic stabilisation

  Els F. Halff, et al., bioRxiv - Neuroscience 2020

  Quote: ... Neurons were then stained for 1h at RT with primary antibody diluted in block solution (1:100 Rabbit-anti-NL2 (Alomone Labs, ANR-036) or 1:500 Guinea Pig-anti-γ2 (Synaptic Systems, 224-004)) ...
• Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

  Kristine Oevel, et al., bioRxiv - Neuroscience 2023

  Quote: ... spontaneously active synaptic boutons were labeled by incubating cells with CypHer5E-conjugated antibodies against the luminal domain of vGAT (1:500 from a 1 mg/ml stock; Synaptic Systems; Cat#131,103CpH) for 2 h in their respective conditioned culture media at 37 °C and 5 % CO2 prior to imaging.
• A Spinal Circuit That Transmits Innocuous Cool Sensations

  Lorraine R Horwitz, et al., bioRxiv - Neuroscience 2022

  Quote: ... The washed tissue were then moved into new 1.5 ml centrifuge tubes for primary antibody staining (usually diluted 1:100 – 1:500) with: chicken anti-Homer (160006, Synaptic Systems, Goettngen, Germany), guinea pig anti-Bassoon (#141004 ...
• Mapping memories: pulse-chase labeling reveals AMPA receptor dynamics during memory formation

  Doyeon Kim, et al., bioRxiv - Neuroscience 2023

  Quote: ... the slices were incubated with a rat anti-cFos primary antibody (1:1000 dilution in 1% BSA in PBST, Synaptic Systems, 226 017) for 24 hours at room temperature on a shaker ...
• Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke

  Egor Dzyubenko, et al., bioRxiv - Neuroscience 2023

  Quote: ... and rabbit anti-IBA1 (1:500; Cat# 019-19741, Wako, Neuss, Germany) or guinea pig anti-IBA1 (1:300, Cat# 234308, Synaptic Systems, Göttingen, Germany) antibodies ...
• Hippocampal CA2 neurons disproportionately express AAV-delivered genetic cargo

  Georgia M. Alexander, et al., bioRxiv - Neuroscience 2024

  Quote: ... Primary antibodies included PCP4 (Invitrogen, PA5-52209, 1:500, raised in rabbit, and Synaptic Systems, 480 004, 1:500, raised in Guinea pig), GFP (Invitrogen ...
• ABBA, a novel tool for whole-brain mapping, reveals brain-wide differences in immediate early genes induction following learning

  Nicolas Chiaruttini, et al., bioRxiv - Neuroscience 2024

  Quote: ... The second contained a mixture of a rabbit anti NPAS4 antibody (1:1000, Activity Signaling, #AS-AB18A-100) and guinea pig anti-cFos antibody (1:1000, Synaptic System #226 008). Both were dissolved in PBS 1% and Tryton 0.1% ...
• Anterior cingulate cortex hypofunction causes anti-social aggression in mice

  S. van Heukelum, et al., bioRxiv - Neuroscience 2020

  Quote: ... sections were incubated overnight at room temperature in Iba1anti-rabbit (1:1500, Wako, product code: 019-19741) and GFAP anti-guinea pig (1:1500, Synaptic Systems, product code: 173004) as well as a marker for neurons (NeuN anti-chicken ...
• Parallel streams of raphe VGLUT3-positive inputs target the dorsal and ventral hippocampus in each hemisphere

  Justine Fortin-Houde, et al., bioRxiv - Neuroscience 2022

  Quote: ... guinea pig anti-Tph2 (1:1000, Frontier Institute cat. No. TPH2-GP-Af900) or guinea pig anti-VGLUT3 (1:1000, Synaptic Systems cat. No. 135204). Sections were then washed in PGT (3 × 15 min ...
• Phosphorylation alters FMRP granules and determines their transport or protein synthesis abilities

  Shivani C. Kharod, et al., bioRxiv - Neuroscience 2023

  Quote: ... and stained according to the immunohistochemistry protocol above (primary antibodies: anti-ZnT3, rabbit polyclonal, 1:500, Synaptic Systems; anti-puromycin 1:1000, EMD Millipore) and imaged on the Zeiss LSM 880 with Airyscan using a LD LCI Plan-Apochromat 25x/0.8 mm Korr DIC M27 and 1.8x zoom ...
• Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

  Bradley M. Roberts, et al., bioRxiv - Neuroscience 2020

  Quote: ... and guinea-pig anti-parvalbumin (1:1,000, Synaptic Systems, 195004). Sections were then incubated in species-appropriate fluorescent secondary antibodies with minimal cross-reactivity overnight in PBS-Tx at room temperature (Donkey anti-Rabbit AlexaFluor 488 ...
• TRAF6 controls spinogenesis instructing synapse density and neuronal activity through binding neuroplastin

  Sampath Kumar Vemula, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-MAP2 guinea pig (Synaptic Systems, #188 004; 1:1,000) primary antibodies for overnight at 4°C ...
• Stabilization of spine Synaptopodin by mGluR1 is required for mGluR-LTD

  Luisa Speranza, et al., bioRxiv - Neuroscience 2021

  Quote: ... guinea pig anti-Synaptopodin (1/500; Synaptic Systems, RRID: AB_10549419) chicken anti-MAP2 (1/500 ...
• Permeabilization-free en bloc immunohistochemistry for correlative microscopy

  Kara A Fulton, Kevin L Briggman, bioRxiv - Neuroscience 2020

  Quote: ... sections were incubated in rabbit anti-Homer 1 (Synaptic Systems) for 72 hrs ...
• Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease

  Jie Yeap, et al., bioRxiv - Neuroscience 2021

  Quote: ... MAP2 (guinea pig anti-MAP2; Synaptic Systems 188004; 1:1000), Kv3.4A (sheep anti-Kv3.4A ...
• Presynaptically silent synapses are modulated by the density of surrounding astrocytes

  Kohei Oyabu, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1:1,000 (guinea pig polyclonal, antiserum, Synaptic Systems, Göttingen, Germany), anti-vesicular glutamate transporter 1 (anti-VGLUT1) ...
• Low-density lipoprotein receptor-related protein 1 (LRP1) is a negative regulator of oligodendrocyte progenitor cell differentiation in the adult mouse brain

  Loic Auderset, et al., bioRxiv - Neuroscience 2020

  Quote: ... guinea pig anti-IBA1 (1:250, Synaptic Systems 234004; RRID:AB_2493179), and mouse anti-NaBC1 (BCAS1 ...
• Chronic optogenetic stimulation of hippocampal engrams variably modulates social behaviors in mice

  Emily Doucette, et al., bioRxiv - Neuroscience 2020

  Quote: ... and rabbit anti-doublecortin (1:500, Synaptic Systems, # 326 003). Slices were incubated in the primary solution at 4°C for 24 h on an orbital shaker ...
• Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

  Justin H. Trotter, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-Nlgn1 mouse (Synaptic Systems Cat# 129111; 1:1000 IB), anti-Nlgn2 rabbit (Synaptic Systems Cat# 129203 ...
• Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

  Justin H. Trotter, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-Nlgn3 mouse (Synaptic Systems Cat# 129311; 1:2000 IB), anti-GluD1 rabbit (Frontier Institute Cat# GluD1C-Rb-Af1390 ...
• Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

  Justin H. Trotter, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-Nlgn2 rabbit (Synaptic Systems Cat# 129203; 1:1000 IB), anti-Nlgn3 mouse (Synaptic Systems Cat# 129311 ...
• Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

  Justin H. Trotter, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-Nrxn1 rabbit (Synaptic Systems Cat# 175103; 1:1000 IB), anti-pan-Nrxn rabbit (Frontier Institute Cat# AF870 ...
• Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

  Justin H. Trotter, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-GluN1 mouse (Synaptic Systems Cat# 114011; 1:1000 IB), anti-GluN2B mouse (Neuromab Cat# 75-101 ...
• Human Deep Cortical Neurons Promote Regeneration and Recovery After Cervical Spinal Cord Injury

  Vanessa M. Doulames, et al., bioRxiv - Neuroscience 2021

  Quote: ... Homer (160003, 1:200 dilution; Synaptic Systems GmbH, Goettingen, Germany), Iba1 (01919741 ...
• A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

  Kunimichi Suzuki, et al., bioRxiv - Neuroscience 2020

  Quote: ... and anti-Bassoon (Rabbit, 1:500, Synaptic Systems, 141-003). Anti-NP1 and NPR were newly raised by guinea pig immunized with the peptide (NP1 ...
• Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain

  Patrick Weish, et al., bioRxiv - Neuroscience 2021

  Quote: ... guinea pig anti-synaptophysin 1 antibody (Synaptic Systems, Göttingen, Germany); and for the human tissue ...
• Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain

  Patrick Weish, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-synapsin 1 (SYN1) antibody (Synaptic Systems, Göttingen, Germany); rabbit anti-ubiquitin antibody (Abcam ab7780 ...
• Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca²⁺-dependent priming

  Bassam Tawfik, et al., bioRxiv - Neuroscience 2020

  Quote: ... and mouse monoclonal α-Syt1 (1:500; Synaptic Systems SY105011) for 2 h at RT ...
• Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca²⁺-dependent priming

  Bassam Tawfik, et al., bioRxiv - Neuroscience 2020

  Quote: ... or mouse monoclonal α-Syt1 (1:500; Synaptic Systems SY105011), overnight at 4°C ...
• Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neurons

  Alison Fellgett, et al., bioRxiv - Neuroscience 2020

  Quote: ... we used Guinea pig anti-GFP (Synaptic Systems, 1:1000) as described recently [9] ...
• NKCC1 modulates microglial phenotype, cerebral inflammatory responses and brain injury in a cell-autonomous manner

  Krisztina Tóth, et al., bioRxiv - Neuroscience 2021

  Quote: ... and guinea pig anti-AQP4 (1:500, #429004, Synaptic Systems), donkey anti-chicken A594 (1:500 ...
• A sensory cell diversifies its output by varying Ca²⁺ influx-release coupling among presynaptic active zones for wide range intensity coding

  Özge Demet Özçete, Tobias Moser, bioRxiv - Neuroscience 2020

  Quote: ... and guinea pig anti-parvalbumin (1:200, Synaptic Systems, 195004) –to detect SGNs ...
• Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission

  Camila de Britto Pará de Aragão, et al., bioRxiv - Neuroscience 2020

  Quote: ... mouse anti-mouse Gephyrin (1:1000, Synaptic Systems, catalog #147021), Neuroligin-1 (1:300 ...
• Ablation of STAT3 in Purkinje Cells Reorganizes Cerebellar Synaptic Plasticity in Long-Term Fear Memory Network

  Jeong-Kyu Han, et al., bioRxiv - Neuroscience 2020

  Quote: ... GluA2 (1:1,000, 182 103, Synaptic Systems, Go[ttingen, Germany), phospho-STAT3 ...
• The Sez6 family inhibits complement at the level of the C3 convertase

  Wen Q. Qiu, et al., bioRxiv - Neuroscience 2020

  Quote: ... and polyclonal chicken anti-Homer1 (Synaptic Systems, 160006, 1:500)) were diluted in blocking buffer and incubated with brain sections for 1-3 days at room temperature with agitation ...
• Altered visual function in a larval zebrafish knockout of neurodevelopmental risk gene pdzk1

  Jiaheng Xie, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-GluN1 (1:400; Synaptic systems; cat. number 114 011) or anti-serotonin (1:500 ...
• The impact of phosphorylated Pten at threonine 366 on cortical connectivity and behaviour

  Julia Ledderose, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-MAP2 guinea pig (1:500, Synaptic System, 188 004), anti-GFP chicken (1:5000 ...
• Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

  Tal M. Dankovich, et al., bioRxiv - Neuroscience 2020

  Quote: ... and mouse anti-Tenascin-R (1:200, Synaptic Systems, 400004) for 24h ...
• Human brain organoid networks

  Tal Sharf, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-synaptobrevin (1:500; Synaptic Systems, Goettingen, Germany; 104-211). Samples were viewed through a 20x oil immersion lens (N.A ...
• A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling

  Chi-Hong Wu, et al., bioRxiv - Neuroscience 2021

  Quote: ... guinea pig or rabbit anti-VGluT1 (1:1000, Synaptic Systems). To stain surface GluA2 ...
• MICAL2 acts through Arp3B isoform-specific Arp2/3 complexes to destabilize branched actin networks

  Chiara Galloni, et al., bioRxiv - Cell Biology 2020

  Quote: ... ARPC5 monoclonal (Synaptic Systems, 305011, clone 323H3, 1:1000 dilution), Arp2 monoclonal (Abcam ...
• Latrophilin GPCR Signaling Mediates Synapse Formation

  Richard Sando, Thomas C. Südhof, bioRxiv - Cell Biology 2021

  Quote: ... anti-PSD95 mouse (Synaptic Systems Cat# 124011; 1:2,000 ICC), anti-vGLUT1 guinea pig (Millipore Cat# AB5905 ...
• Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype

  T.M. O’Shea, et al., bioRxiv - Neuroscience 2022

  Quote: ... guinea pig anti-NeuN (1:1000, Synaptic Systems, 266 004); goat anti-Cd13 (1:200 ...
• Granulocyte Colony Stimulating Factor causes cerebellar deficits and anxiety in a mouse model of CSF-1 receptor-related leukoencephalopathy

  Fabrizio Biundo, et al., bioRxiv - Neuroscience 2022

  Quote: ... VGLUT2 (1:500) (polyclonal guinea pig antiserum, Synaptic Systems RRID:AB_887884). Following incubation with primary antibodies ...
• Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1

  Erica Butti, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti VGAT (Synaptic System, product no: 131002, (1:500)) ...
• Abnormal AMPAR-mediated synaptic plasticity, cognitive and autistic-like behaviors in a missense Fmr1 mutant mouse model of Fragile X syndrome

  Marta Prieto, et al., bioRxiv - Neuroscience 2020

  Quote: ... or a rabbit anti-β3 Tubulin 1/25000 (Synaptic Systems) as indicated ...
• Complement C3-dependent glutamatergic synapse elimination in the developing hippocampus is region- and synapse-specific

  Eric W. Salter, et al., bioRxiv - Neuroscience 2020

  Quote: ... Guinea pig anti-VGLUT2 (1:500, Synaptic Systems, 135 404); Rabbit anti-Homer1 (1:500 ...
• Inhibition of mTOR during a postnatal critical sensitive window rescues deficits in GABAergic PV cell connectivity and social behavior caused by loss of TSC1

  Mayukh Choudhury, et al., bioRxiv - Neuroscience 2020

  Quote: ... guinea pig anti-PV (1:1000,Synaptic Systems, Cat# 195004), mouse anti-gephyrin (1:500 ...
• Cell-type specific transcriptional adaptations of nucleus accumbens interneurons to amphetamine

  David A. Gallegos, et al., bioRxiv - Neuroscience 2021

  Quote: ... Guinea Pig α-Parvalbumin (1:1000; Synaptic Systems, 195 004RRID:AB_2156476), Rabbit α-c-Fos (1:750 ...