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1 - 50 of 355 citations for Ethyl 5 4 fluorophenyl 5 oxovalerate since 2020

• Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells

  Corina M. Stewart, et al., bioRxiv - Microbiology 2022

  Quote: ... 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA, Cayman Chemical), and Akt Inhibitor VIII (Cayman Chemical ...
• Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2

  Chrystian Junqueira Alves, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or 90 min with 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) (50µM; Cayman Chemical)59 ...
• Distinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation

  Gisela Cairo, et al., bioRxiv - Cell Biology 2023

  Quote: ... 5-Iodotubercidin (5-Itu; Cayman Chemicals; 0.5μM) was used to inhibit haspin kinase with ethanol (Fisher ...
• Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease

  Sanchari Datta, et al., bioRxiv - Cell Biology 2020

  Quote: ... – 5 μg/ml in DMSO for 6hr (4) Etomoxir (Cayman chemical, 11969) – 10 μM in DMSO (5 ...
• Meiosis-specific decoupling of the pericentromere from the kinetochore

  Bo Pan, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5-iodotubercidin (5-Itu) (Cayman Chemical, cat# 10010375), at 0.5 µM ...
• The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures

  Hiroyuki Mori, et al., bioRxiv - Physiology 2020

  Quote: ... 5 μg/ml insulin and 5 μM rosiglitazone (Cayman Chemical) in DMEM:F12 containing 10% FBS ...
• Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

  Zander Harpel, et al., bioRxiv - Cell Biology 2023

  Quote: ... 5-fluorouracil (Cayman Chemical), floxuridine (Cayman Chemical) ...
• Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

  Zander Harpel, et al., bioRxiv - Cell Biology 2023

  Quote: ... 5-methyluridine (Cayman Chemical), 5-fluorouracil (Cayman Chemical) ...
• Tissue- and sex-specific DNA damage tracks aging in rodents and humans

  Axel Guilbaud, et al., bioRxiv - Biochemistry 2022

  Quote: ... 5’-Ethynyl-2’-deoxycytidine and 5’-chloro-2’- deoxycytidine were obtained from Cayman Chemical Company (Ann Arbor ...
• Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

  Allison K. Meyers, et al., bioRxiv - Immunology 2021

  Quote: ... UK5099 (5 μM, Cayman Chemical), CPI-613 (200 μM ...
• Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix Metalloproteinases

  Catherine Delbrouck, et al., bioRxiv - Cancer Biology 2023

  Quote: ... C75 (Cayman Chemicals: 10005270-5) and TVB-2640 (Selleckchem ...
• A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles

  Anan Chen, et al., bioRxiv - Biochemistry 2024

  Quote: ... 5’-ethynyl-uridine (Cayman Chemical), actinomycin D (Cayman Chemical) ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM U0126 (Cayman Chemical) and 1 μM XAV939 (Cayman Chemical) ...
• Extensive N4 Cytosine Methylation is Essential for Marchantia Sperm Function

  James Walker, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 5-Me-2’-deoxycytidine (Cayman chemicals), 2’-Deoxy-N4-methylcytidine (CarboSynth) ...
• Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia

  Alec W. Stranahan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... or 5 μM LY293111 (Cayman Chemical, cat no ...
• Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

  Kazuki Hattori, et al., bioRxiv - Bioengineering 2022

  Quote: ... 5 μM monensin (#16488, Cayman Chemical) was coencapsulated in droplets without pretreatment ...
• Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue

  Jens O. Watzlawik, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 μM valinomycin (Cayman Chemicals, 10009152), or 2 μM valinomycin ...
• Robust Methods For Quantifying Neuronal Morphology And Molecular Signaling Reveal That Psychedelics Do Not Induce Neuroplasticity

  Umed Boltaev, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5-MeO-DMT from Cayman Chemical, DMSO from Acros Organics ...
• Mechano-inhibition of Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis

  Mehmet H. Kural, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 5 μM Dyngo-4a (Cayman Chemical), or 2 µM Pitstop-2 (Abcam) ...
• Hidden route of protein damage through confined oxygen gas

  Seoyoon Kim, et al., bioRxiv - Biochemistry 2024

  Quote: ... 5 μM HPF (Cayman Chemical, 10159) was dissolved in each buffer solution ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 5 μM ionomycin (Cayman chemical). HUVECs were exposed to 500 μM H2O2 (Sigma-Aldrich ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ICG-001 (Cayman Chemical #16257-5), Nutlin-3a (Cayman Chemical #10004372).
• Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

  Luisa Saecker, Hanns Häberlein, Sebastian Franken, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... capadenoson (Cayman Chemicals, 544417-40-5), isopenaline hydrochloride (Iso ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... LCL-161 (5 μM, Cayman chemical), Thapsigargian (1 μM ...
• Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity

  Michael J. McFadden, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Thioflavin T (Cayman Chemical, 5 µM) was added 2 hours prior to endpoint ...
• Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation

  Magdalena A. Sutcliffe, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM Tranylcypromine (Cayman Chemicals 10010494), 50 nM DZNep (Apexbio A8182) ...
• Sleep pressure accumulates in a voltage-gated lipid peroxidation memory

  H. Olof Rorsman, et al., bioRxiv - Neuroscience 2024

  Quote: ... Standards were prepared by applying 5 µl-droplets of a 10-fold dilution series of 4-ONE (Cayman Chemical) in methyl acetate ...
• IGF-1 facilitates extinction of conditioned fear

  José A. Noriega-Prieto, et al., bioRxiv - Neuroscience 2020

  Quote: ... or the IGF-1R antagonist 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-]pyrimidin-4-amine (NVP-AEW 541, 40 μM; Cayman Chemicals) plus IGF-1 were infused into the IL ...
• Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

  Keerthana Gnanapradeepan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... for 5 hours or treated with 10 µM of buthionine sulfoximine for 24 hours (BSO, Cayman Chemicals, 83730-53-4) and fixed with 4% paraformaldehyde (Electron Microscopy Sciences ...
• The role of the cannabinoid system in fear memory and extinction in male and female mice

  Ikumi Mizuno, et al., bioRxiv - Neuroscience 2021

  Quote: ... SR141716 (1, 5 mg/kg) (Cayman Chemicals) was dissolved in saline with 5% DMSO and 0.1% Tween 20 ...
• Structure and Mechanism of Hedgehog Acyl Transferase

  Claire E. Coupland, et al., bioRxiv - Biophysics 2021

  Quote: ... and 5 mM valproic acid (Cayman Chemical). For biotinylated proteins ...
• Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

  Kazuki Hattori, et al., bioRxiv - Bioengineering 2022

  Quote: 5 μM manumycin A (#10010497, Cayman Chemical) was used as a pretreatment for 1 hour (37 °C in culture medium) ...
• On the Origin of Ultraslow Spontaneous Na⁺ Fluctuations in Neurons of the Neonatal Forebrain

  Carlos Perez, et al., bioRxiv - Neuroscience 2020

  Quote: ... (2R)-amino-5-phosphonopentanoate) from Cayman Chemical
• Characterising replisome disassembly in human cells

  Rebecca M. Jones, et al., bioRxiv - Cell Biology 2022

  Quote: ... 5 µM Wee1i (MK-1775, Cayman Chemicals, 21266 ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM BMS-5 (Cayman Chemical, #21072) or 2 μM ML-7 (Cayman Chemical ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 50% 5 μM methoxy-XO4 (Cayman Chemical) in 50% EtOH for 2 minutes ...
• Ca²⁺-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress

  Wei Chen, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 μM Ionomycin (No. 10004974, Cayman Chemical); 250 μM CPZ (No ...
• The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS^hiGITR^hi Blimp-1⁺ effector regulatory T cells in breast tumors

  Marie Boutet, et al., bioRxiv - Immunology 2024

  Quote: ... 5 μM Y-27632 (Cayman Chemical, #10005583) and 5% Matrigel (Corning ...
• Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

  Melanie Wallace, et al., bioRxiv - Cell Biology 2023

  Quote: ... IWR-1 (5 µM, #13659, Cayman Chemical) in B27-INS was added at D3 and changed to fresh B27-INS at D5 ...
• Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

  Katjana Schwab, et al., bioRxiv - Genomics 2022

  Quote: ... 5-FU (25 μg/ml, Cayman Chemicals), or Doxorubicin (0.2 µg/ml ...
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 5 µM SU5402 (Cayman Chemical, #13182). Starting at d28 ...
• Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

  Margaret S. Collins, et al., bioRxiv - Cell Biology 2023

  Quote: ... NEI (CAS#1448314-31-5, Cayman Chemical), SIV (CAS# 201677-61-4 ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 μM CB-839 (22038, Cayman Chemical), 300 μM BSO (14484 ...
• PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

  David J. Sherman, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 µM Triacsin C (Cayman Chemical, #10007448) dissolved in dimethyl sulfoxide (DMSO ...
• Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

  Deborah Y. Moss, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Metformin (Cayman Chemicals, #13118, 3-5 mM), IACS-10759 (Selleckchem ...
• Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

  Gaspare La Rocca, et al., bioRxiv - Molecular Biology 2021

  Quote: Mice kept in doxycycline-containing chow were treated for 5 days with 4% w/v DSS (FW 40.000) (Cayman Chemical #23250) dissolved in drinking water ...
• PALP: An imaging method for detecting and quantifying polyunsaturated phospholipids via peroxidation

  Yilong Zou, et al., bioRxiv - Cell Biology 2020

  Quote: ... arachidonic acid (AA, C20:4), docosapentaenoic acid (DPA, C22:5), and docosahexaenoic acid (DHA, C22:6) were purchased from Cayman Chemicals and conjugated with fatty-acid free BSA (Sigma-Aldrich ...
• Inhibition of Acyl-CoA Synthetase Long Chain Isozymes Decreases Multiple Myeloma Cell Proliferation and Causes Mitochondrial Dysfunction

  Connor S. Murphy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and resuspended in tetramethylrhodamine ethyl ester (TMRE) buffer (Cayman Chemicals) containing 100 nM TMRE (Cayman Chemicals ...
• The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

  David Z. Kochan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 5-FOA was bought from Cayman Chemical (17318). Ampure XP beads were from Beckman Coulter (A63881) ...
• De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

  Thomas Laval, et al., bioRxiv - Immunology 2021

  Quote: ... LTB4-d4 and 5-HETE-d8 (Cayman Chemicals), and centrifuged at 5000rpm for 15min at 4°C ...