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1 - 50 of 223 citations for 5 Alpha dihydroprogesterone since 2020

• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 0.2 mM alpha-ketoisocaproate (Cayman Chemical, 21052-5), and 5 µM rotenone (VWR ...
• Distinct bioenergetic features of human invariant natural killer T (iNKT) cells enable retained functions in nutrient-deprived states

  Priya Khurana, et al., bioRxiv - Immunology 2021

  Quote: ... containing 500ng/mL alpha-galactosylceramide (Cayman Chemicals; KRN7000) and 50U/mL recombinant IL-2 (PeproTech) ...
• Periodic ER-plasma membrane junctions support long-range Ca²⁺ signal integration in dendrites

  Lorena Benedetti, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 250 nM Kainic Acid (alpha Kainic Acid, Cayman Chemicals, 78050) to increase neuronal activity ...
• Integrative computational approach identifies new targets in CD4+ T cell-mediated immune disorders

  Bhanwar Lal Puniya, et al., bioRxiv - Systems Biology 2020

  Quote: We purchased alpha-difluoromethylornithine (DFMO) and eicosapentaenoic Acid (EPA) from Cayman Chemical. DFMO was resuspended in water at 50mM while EPA was already resuspended in ethanol at 826 mM ...
• Polyunsaturated fatty acid arachidonic acid increases the virulence of gut pathogen, Yersinia enterocolitica

  Denise Chac, et al., bioRxiv - Microbiology 2021

  Quote: ... alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) (Cayman Chemicals, Ann Arbor, MI). PUFAs were diluted in 200 proof ethanol (VWR ...
• Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice

  Keith Z. Hazleton, et al., bioRxiv - Microbiology 2022

  Quote: ... alpha-muricholic acid (a_MCA) and beta-muricholic acid (b_MCA) were obtained from Cayman Chemical (Ann Arbor, Michigan). Chenodeoxycholic acid-d4 (CDCA ...
• Distinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation

  Gisela Cairo, et al., bioRxiv - Cell Biology 2023

  Quote: ... 5-Iodotubercidin (5-Itu; Cayman Chemicals; 0.5μM) was used to inhibit haspin kinase with ethanol (Fisher ...
• Meiosis-specific decoupling of the pericentromere from the kinetochore

  Bo Pan, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5-iodotubercidin (5-Itu) (Cayman Chemical, cat# 10010375), at 0.5 µM ...
• The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures

  Hiroyuki Mori, et al., bioRxiv - Physiology 2020

  Quote: ... 5 μg/ml insulin and 5 μM rosiglitazone (Cayman Chemical) in DMEM:F12 containing 10% FBS ...
• Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

  Zander Harpel, et al., bioRxiv - Cell Biology 2023

  Quote: ... 5-fluorouracil (Cayman Chemical), floxuridine (Cayman Chemical) ...
• Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

  Zander Harpel, et al., bioRxiv - Cell Biology 2023

  Quote: ... 5-methyluridine (Cayman Chemical), 5-fluorouracil (Cayman Chemical) ...
• Tissue- and sex-specific DNA damage tracks aging in rodents and humans

  Axel Guilbaud, et al., bioRxiv - Biochemistry 2022

  Quote: ... 5’-Ethynyl-2’-deoxycytidine and 5’-chloro-2’- deoxycytidine were obtained from Cayman Chemical Company (Ann Arbor ...
• Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

  Allison K. Meyers, et al., bioRxiv - Immunology 2021

  Quote: ... UK5099 (5 μM, Cayman Chemical), CPI-613 (200 μM ...
• Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix Metalloproteinases

  Catherine Delbrouck, et al., bioRxiv - Cancer Biology 2023

  Quote: ... C75 (Cayman Chemicals: 10005270-5) and TVB-2640 (Selleckchem ...
• A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles

  Anan Chen, et al., bioRxiv - Biochemistry 2024

  Quote: ... 5’-ethynyl-uridine (Cayman Chemical), actinomycin D (Cayman Chemical) ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM U0126 (Cayman Chemical) and 1 μM XAV939 (Cayman Chemical) ...
• Extensive N4 Cytosine Methylation is Essential for Marchantia Sperm Function

  James Walker, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 5-Me-2’-deoxycytidine (Cayman chemicals), 2’-Deoxy-N4-methylcytidine (CarboSynth) ...
• Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia

  Alec W. Stranahan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... or 5 μM LY293111 (Cayman Chemical, cat no ...
• Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

  Kazuki Hattori, et al., bioRxiv - Bioengineering 2022

  Quote: ... 5 μM monensin (#16488, Cayman Chemical) was coencapsulated in droplets without pretreatment ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 5 μM ionomycin (Cayman chemical). HUVECs were exposed to 500 μM H2O2 (Sigma-Aldrich ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ICG-001 (Cayman Chemical #16257-5), Nutlin-3a (Cayman Chemical #10004372).
• Mechano-inhibition of Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis

  Mehmet H. Kural, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 5 μM Dyngo-4a (Cayman Chemical), or 2 µM Pitstop-2 (Abcam) ...
• Robust Methods For Quantifying Neuronal Morphology And Molecular Signaling Reveal That Psychedelics Do Not Induce Neuroplasticity

  Umed Boltaev, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5-MeO-DMT from Cayman Chemical, DMSO from Acros Organics ...
• Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue

  Jens O. Watzlawik, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 μM valinomycin (Cayman Chemicals, 10009152), or 2 μM valinomycin ...
• Hidden route of protein damage through confined oxygen gas

  Seoyoon Kim, et al., bioRxiv - Biochemistry 2024

  Quote: ... 5 μM HPF (Cayman Chemical, 10159) was dissolved in each buffer solution ...
• Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

  Luisa Saecker, Hanns Häberlein, Sebastian Franken, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... capadenoson (Cayman Chemicals, 544417-40-5), isopenaline hydrochloride (Iso ...
• Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity

  Michael J. McFadden, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Thioflavin T (Cayman Chemical, 5 µM) was added 2 hours prior to endpoint ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... LCL-161 (5 μM, Cayman chemical), Thapsigargian (1 μM ...
• Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation

  Magdalena A. Sutcliffe, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM Tranylcypromine (Cayman Chemicals 10010494), 50 nM DZNep (Apexbio A8182) ...
• The role of the cannabinoid system in fear memory and extinction in male and female mice

  Ikumi Mizuno, et al., bioRxiv - Neuroscience 2021

  Quote: ... SR141716 (1, 5 mg/kg) (Cayman Chemicals) was dissolved in saline with 5% DMSO and 0.1% Tween 20 ...
• Structure and Mechanism of Hedgehog Acyl Transferase

  Claire E. Coupland, et al., bioRxiv - Biophysics 2021

  Quote: ... and 5 mM valproic acid (Cayman Chemical). For biotinylated proteins ...
• Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

  Kazuki Hattori, et al., bioRxiv - Bioengineering 2022

  Quote: 5 μM manumycin A (#10010497, Cayman Chemical) was used as a pretreatment for 1 hour (37 °C in culture medium) ...
• On the Origin of Ultraslow Spontaneous Na⁺ Fluctuations in Neurons of the Neonatal Forebrain

  Carlos Perez, et al., bioRxiv - Neuroscience 2020

  Quote: ... (2R)-amino-5-phosphonopentanoate) from Cayman Chemical
• Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

  Melanie Wallace, et al., bioRxiv - Cell Biology 2023

  Quote: ... IWR-1 (5 µM, #13659, Cayman Chemical) in B27-INS was added at D3 and changed to fresh B27-INS at D5 ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 50% 5 μM methoxy-XO4 (Cayman Chemical) in 50% EtOH for 2 minutes ...
• Ca²⁺-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress

  Wei Chen, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 μM Ionomycin (No. 10004974, Cayman Chemical); 250 μM CPZ (No ...
• The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS^hiGITR^hi Blimp-1⁺ effector regulatory T cells in breast tumors

  Marie Boutet, et al., bioRxiv - Immunology 2024

  Quote: ... 5 μM Y-27632 (Cayman Chemical, #10005583) and 5% Matrigel (Corning ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 μM CB-839 (22038, Cayman Chemical), 300 μM BSO (14484 ...
• Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

  Margaret S. Collins, et al., bioRxiv - Cell Biology 2023

  Quote: ... NEI (CAS#1448314-31-5, Cayman Chemical), SIV (CAS# 201677-61-4 ...
• Characterising replisome disassembly in human cells

  Rebecca M. Jones, et al., bioRxiv - Cell Biology 2022

  Quote: ... 5 µM Wee1i (MK-1775, Cayman Chemicals, 21266 ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM BMS-5 (Cayman Chemical, #21072) or 2 μM ML-7 (Cayman Chemical ...
• Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

  Katjana Schwab, et al., bioRxiv - Genomics 2022

  Quote: ... 5-FU (25 μg/ml, Cayman Chemicals), or Doxorubicin (0.2 µg/ml ...
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 5 µM SU5402 (Cayman Chemical, #13182). Starting at d28 ...
• PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

  David J. Sherman, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 µM Triacsin C (Cayman Chemical, #10007448) dissolved in dimethyl sulfoxide (DMSO ...
• Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

  Deborah Y. Moss, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Metformin (Cayman Chemicals, #13118, 3-5 mM), IACS-10759 (Selleckchem ...
• The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

  David Z. Kochan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 5-FOA was bought from Cayman Chemical (17318). Ampure XP beads were from Beckman Coulter (A63881) ...
• De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

  Thomas Laval, et al., bioRxiv - Immunology 2021

  Quote: ... LTB4-d4 and 5-HETE-d8 (Cayman Chemicals), and centrifuged at 5000rpm for 15min at 4°C ...
• The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures

  Hiroyuki Mori, et al., bioRxiv - Physiology 2020

  Quote: ... 5-(tetradecyloxy)-2-furoic acid (TOFA) (Cayman Chemical)
• Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward Discovery of Biased D1 Agonists

  Haoxi Li, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... coelenterazine h (Cayman Chemicals, 5 μM final concentration), was added per well ...
• Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2

  Julia S.P. Mawer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 5-FOA was bought from Cayman Chemicals (17318). Protein-G coupled Dynabeads™ (10004D ...