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401 - 450 of 712 citations for L Phenylalanine N 1 oxo 4 1 pyrenyl butyl since 2020

• Activation induces shift in nutrient utilization that differentially impacts cell functions in human neutrophils

  Emily C. Britt, et al., bioRxiv - Biochemistry 2023

  Quote: ... 2-chloro-4,5-difluoro-N-[[[2-methoxy-5-[[(methylamino)carbonyl]amino]phenyl]amino] carbonyl]-benzamide (Cayman Chemical, no. 17578) were used ...
• Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

  Dasmanthie De Silva, et al., bioRxiv - Molecular Biology 2021

  Quote: ... cells were incubated with AKT inhibitor AZD5363 at 1 μM (Cayman Chemical), mTOR inhibitor Torin1 250 nM (Cayman Chemical ...
• Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

  Yao-Chang Tsan, et al., bioRxiv - Cell Biology 2021

  Quote: ... and we additionally included retinol inhibitor (BMS 453, Cayman Chemical, 1 µM) for days 3-6 to minimize atrial lineage differentiation.35 hPSC-CMs were maintained in CDM3 until purification by metabolic selection in CDM3-lactate using glucose-deprived ...
• 2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

  Amanda Morgan, et al., bioRxiv - Neuroscience 2022

  Quote: The MAGL inhibitor JZL184 (10 mg/kg-1, Cayman Chemical, MI, USA), CB1R inverse agonist Rimonabant (3 mg kg-1 APIChem ...
• Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

  Amanda R. Dicks, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 1 µM ML329 (cat. num. 22481; Cayman Chemical, Ann Arbor, MI) at 5 x 105 cells/mL ...
• Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

  Lucas J. D’Souza, et al., bioRxiv - Immunology 2021

  Quote: ... 1×106 5TGM1 cells were cultured with 20μg/mL 2NBDG (Cayman Chemical) in complete media for 1 hour at 37°C followed by antibody staining ...
• AURKB/Ipl1 restarts replication forks to recover from replication stress

  Erin Moran, et al., bioRxiv - Cell Biology 2021

  Quote: ... The ATP analogue 1-naphthyl-pyrazolo[3,4-d]pyrimidine (NAPP, Cayman Chemicals) was added to YPD at 75 μM ...
• Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons

  Breanna Q. Shen, et al., bioRxiv - Neuroscience 2022

  Quote: ... The DP1 antibody (101640, dilution 1:200) was obtained from Cayman Chemicals and the SOX10 antibody (ab216020 ...
• PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities

  Nina Đukić, et al., bioRxiv - Cell Biology 2023

  Quote: ... Olaparib (Cayman Chemical; 1 μM for U2OS; 2 μM for 293T cells), 1 μM PARGi PDD00017273 (Sigma ...
• LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

  N Cobo-Vuilleumier, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Prostaglandin E2 (PGE2, 1 μM, Cayman Chemical, Ann Arbor, MI, USA) to obtain mature DCs (mDCs) ...
• RudLOV—a new optically synchronized cargo transport method reveals unexpected effect of dynasore

  Tatsuya Tago, et al., bioRxiv - Cell Biology 2023

  Quote: ... After 1 h of incubation with 100 μM of dynasore (Cayman Chemical), the cells were fixed in 0.1 M cacodylate buffer (pH 7.4 ...
• Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

  Nicole M. Marsh, et al., bioRxiv - Cell Biology 2024

  Quote: ... before and after injection of 1 μM CCCP (Cayman Chemical Company, 25458) in KCl buffer ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1 µL 30 mM aldehyde reactive probe (Cayman Chemicals, ARP/aminooxy biotin) is added first ...
• Nascent transcript O-MAP reveals the molecular architecture of a single-locus subnuclear compartment built by RBM20 and the TTN RNA

  Evan E. Kania, et al., bioRxiv - Genomics 2024

  Quote: ... Cells were then treated with 1 μM CHIR-99021 (Cayman Chemical; 13122). On day 0 ...
• Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems

  Rupsa Datta, et al., bioRxiv - Immunology 2024

  Quote: ... the zebrafish larvae were preincubated with 1 mM 6-AN (Cayman Chemicals) for 1 hour before adding PMA.
• Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

  Yun Qiu, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and STY-BODIPY were from Cayman Chemical Company (Ann Arbour ...
• Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio

  Katherine R. Ferrick, et al., bioRxiv - Cell Biology 2024

  Quote: ... 100 nM Torin2 (Cayman Chemical Cat#14185, CAS#1223001-51-1, mTORi), 100 nM PD0325901 (Selleck Chemicals Cat#S1036 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-7-hexadecenoic acid (cis-7-C16:1, Cayman Chemical, Cat# 10007290), cis-8-octadecenoic acid (cis-8-C18:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 14(Z)-eicosenoic acid (cis-14-C20:1, Cayman Chemical, Cat# 10009375), cis-vaccenic acid (cis-11-C18:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10(Z)-pentadecenoic acid (cis-10-C15:1, Cayman Chemical, Cat# 22362), 10(E)-pentadecenoic acid (trans-10-C15:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and trans-vaccenic acid (trans-11-C18:1, Cayman Chemical, Cat# 15301).
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10(E)-pentadecenoic acid (trans-10-C15:1, Cayman Chemical, Cat# 22467), cis-11-eicosenoic acid/11(Z ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-6-hexadecenoic acid (cis-6-C16:1, Cayman Chemical, Cat# 9001845), cis-7-hexadecenoic acid (cis-7-C16:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-10-heptadecenoic acid (cis-10-C17:1, Cayman Chemical, Cat# 19748), trans-10-heptadecenoic acid (trans-10-C17:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-8-octadecenoic acid (cis-8-C18:1, Cayman Chemical, Cat# 27447), cis-10-heptadecenoic acid (cis-10-C17:1 ...
• ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

  Aaron I. Weiner, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 0.025mg/g (E/Z)-4-hydroxytamoxifen (17308, Cayman Chemical) of a 100mg/mL stock in DMSO was sonicated into 30uL PBS at 4°C using an S220 Focused-Ultrasonicator (Covaris ...
• Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

  Fangfang Song, et al., bioRxiv - Physiology 2023

  Quote: ... Metformin hydrochloride (4 mg/mL, Cayman Chemical, No. 13118) and Dox (1mg/mL ...
• Near-anoxia induces immobilisation and sustains viability of sperm in ant queens: Novel insights into mechanisms of prolonged sperm storage

  Ayako Gotoh, Mika Takeshima, Ken-ichi Mizutani, bioRxiv - Zoology 2022

  Quote: ... and carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP) (Cayman chemical) in PBS as inhibitors of the mitochondrial respiratory pathway ...
• Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

  Jennifer M. Hafycz, et al., bioRxiv - Neuroscience 2023

  Quote: Sodium 4-phenylbutyrate (PBA) (Cayman Chemical, Ann Arbor, MI) was administered as previously described (Hafycz et al. ...
• Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functions

  Mari Takalo, et al., bioRxiv - Neuroscience 2024

  Quote: ... carbonyl cyanide-4 (trifluoromethoxy) phenylhydrazone (FCCP) (#15218, Cayman Chemical) and a mixture of rotenone (#13995 ...
• Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase

  Hayden T. Pacl, et al., bioRxiv - Microbiology 2021

  Quote: ... was treated with 300 nM of purified recombinant SARS-Cov2 NSP13 with an N-terminal His-tag (Cayman Chemicals #30589) in the presence of 50 mM Tris pH-7.4 ...
• The impact of light and thioredoxins on the plant thiol-disulfide proteome

  Liang-Yu Hou, et al., bioRxiv - Plant Biology 2023

  Quote: ... Approximate 80 μg of total protein was used for biotin labeling in the presence of 0.4 mM thiol-reactive N-[6-(Biotinamido) hexyl]-3’-(2’-pyridyldithio) propionamide (biotin-HPDP; Cayman Chemical). The sample was then incubated for 60 min at 25°C with mild shaking in the dark followed by acetone precipitation and cleanup ...
• The Non-Mevalonate Pathway Requires a Delicate Balance of Intermediates to Maximize Terpene Production

  Indu Raghavan, Zhen Q. Wang, bioRxiv - Bioengineering 2023

  Quote: ... and 0.97 – 1000 mg/L dimethylallyl pyrophosphate (DMAPP) (Cayman Chemical Company, Ann Arbor, MI, USA) commercial standards prepared in 10 mM ammonium acetate were adjusted to pH=9 using ammonium hydroxide ...
• Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β

  Rebecca M Fleeman, et al., bioRxiv - Neuroscience 2022

  Quote: ... Lactate levels in cell culture media were measured by L-Lactate Assay Kit (Cayman Chemical) following the manufacturer’s protocol ...
• The Hox gene Antennapedia regulates wing development through 20-hydroxyecdysone in insect

  Chunyan Fang, et al., bioRxiv - Developmental Biology 2021

  Quote: ... The solid matter remaining was redissoved in 1 mL EIA buffer (Cayman Chemical) for 20E measurement and 1 mL sample diluents (BIOHJ ...
• Directing multicellular organization by varying the aspect ratio of soft hydrogel microwells

  Gayatri J. Pahapale, et al., bioRxiv - Bioengineering 2021

  Quote: ... Primary antibodies included rabbit anti-VE-cadherin antibody (160840, Cayman Chemicals,1:150) and rabbit anti-Phospho-Paxillin (69363 ...
• Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs

  Sven Fengler, et al., bioRxiv - Cell Biology 2021

  Quote: ... Ac-YVAD-CMK (caspase-1 inhibitor II; Cayman chemicals No.10014; 541 MW), Z-DEVD-FMK (SelleckChem S7312 ...
• A MICROFLUIDIC DEVICE FOR LONG-TERM MAINTENANCE OF ORGANOTYPIC LIVER CULTURES

  José M. de Hoyos Vega, et al., bioRxiv - Bioengineering 2022

  Quote: ... HGF (SU11274) and TGFβ-1 (A83-01) inhibitors were purchased from Cayman Chemical and StemCell technologies ...
• Material-mediated histogenesis using mechano-chemically microstructured cell niches

  Peter L. H. Newman, et al., bioRxiv - Bioengineering 2022

  Quote: ... where hADSCs were treated with mitomycin (10 µg mL−1) (Cayman Chemical, 11435) for 2 h ...
• 2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

  Amanda Morgan, et al., bioRxiv - Neuroscience 2022

  Quote: ... and CB2R inverse agonist AM630 (3 mg kg-1, Cayman Chemical, MI, USA) were prepared in DMSO and injected i.p.at 1 μl g-1 bodyweight ...
• Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation

  Matthew Walker, Michel Godin, Andrew Pelling, bioRxiv - Cell Biology 2020

  Quote: ... TGF-β1 receptors were blocked with 10µM GW788388 (GW) (16255-1, Cayman Chemicals) during dedifferentiation ...
• Identification of G Protein α_i Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

  Naincy R. Chandan, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... Cells were treated with vehicle or 1 M forskolin (Fsk) (11018, Cayman Chemicals), and luminescence was measured using a Varioskan™ LUX multimode microplate reader for 30 min.
• Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure in Toxoplasma gondii

  William J. O’Shaughnessy, et al., bioRxiv - Cell Biology 2020

  Quote: ... and then incubated with HBSS containing 1 μM calcium ionophore A23187 (Cayman Chemical) for 10 min at 37°C before fixation and imaging ...
• High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

  Kayleigh Slater, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and probed with primary antibodies (CysLT1 : Abcam [ab151484], 1:1000, CysLT2 : Cayman Chemical [CAY120560] 1:1000 ...
• An Alzheimer’s disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons

  Holly N. Cukier, et al., bioRxiv - Genetics 2023

  Quote: ... the culture media was supplemented with 1 µM Cytochalasin D (Cayman Chemical, #11330), 10 nM Jasplakinolide (Cayman Chemical ...
• Constitutive Endolysosomal Perforation in Neurons allows Induction of α-Synuclein Aggregation by Internalized Pre-Formed Fibrils

  Anwesha Sanyal, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 1 mM MgCl2) and containing 1μM each of Nigericin (Cayman Chemicals 11437) and Monensin (Cayman Chemicals 16488) ...
• Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle

  Corie M. Owen, Laurinda A. Jaffe, bioRxiv - Developmental Biology 2023

  Quote: ... the mice were injected intraperitoneally with 1 nmol kisspeptin-54 (Cayman Chemical, #24477) to stimulate an endogenous LH surge [36] ...
• TRiPPing the sensors: The osmosensing pathway of Polycystin 2

  K.M. Márquez-Nogueras, et al., bioRxiv - Physiology 2023

  Quote: ... Some slides were co-incubated with 647-phalloidin (1:1000, 20555, Cayman Chemicals) during the secondary incubation step ...
• Determinants of the Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids

  Petra Geiser, et al., bioRxiv - Microbiology 2024

  Quote: ... murine enteroids were pre-treated with mOGM/1 mM valproic acid (Cayman chemicals)/3 µM CHIR99021 (Cayman chemicals ...
• LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

  Jin Li, et al., bioRxiv - Cell Biology 2024

  Quote: ... Drug treatments used for human islet cultures included 1 μM CDDO (Cayman Chemical), 1 μg/mL tunicamycin (Cayman Chemical) ...