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401 - 450 of 794 citations for 1 6 Chloropyridazin 3 yl piperidine 4 carboxamide since 2020

• Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

  Sarah E Dremel, et al., bioRxiv - Microbiology 2023

  Quote: ... for 12 hours at 37°C/5% CO2 in the presence of vehicle (DMSO) or 2 μM JQ1+ to enhance reactivation (Cayman Chemical CAS: 1268524-70-4). Pools of 6 ganglia were homogenized in 1 ml TriPure isolation reagent (Roche ...
• An adipocyte-specific lncRAP2 – Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

  Juan R. Alvarez-Dominguez, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM rosiglitazone (Cayman Chemical # 71742), 1 nM 3,3,5-triiodo-L-thyronine (T3 ...
• ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration

  Sonia Muliyil, et al., bioRxiv - Neuroscience 2020

  Quote: ... 10 μm TAPI-1 (Cayman Chemicals) or DMSO (Sigma ...
• Structural basis for receptor selectivity and inverse agonism in S1P₅ receptors

  Elizaveta Lyapina, et al., bioRxiv - Biophysics 2022

  Quote: ... 1 μM E-64 (Cayman Chemical), 1 μM leupeptin (Cayman Chemical) ...
• The unfolded protein response triggers the immune deficiency pathway in ticks

  Lindsay C. Sidak-Loftis, et al., bioRxiv - Immunology 2022

  Quote: ... 1 µM KIRA6 (Cayman Chemical, 19151), or 0.1% DMSO ...
• Rapid and efficient in vivo astrocyte-to-neuron conversion with regional identity and connectivity?

  Lei-Lei Wang, et al., bioRxiv - Neuroscience 2020

  Quote: Tamoxifen (10540-29-1; Cayman Chemical) was dissolved in a mixture of ethanol and sesame oil (1:9 by volume ...
• Blocking the Rac1-TRPC5 pathway protects human podocytes

  Yiming Zhou, et al., bioRxiv - Cell Biology 2021

  Quote: ... CP21R7 (1 µM, Cayman Chemical, #20573), and BMP4 (25 ng/mL ...
• Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1)

  Cameron Moshfegh, et al., bioRxiv - Cell Biology 2021

  Quote: ... 1 µM CHIR99021 (Cayman Chemical, 13122) and 1 µM PD 0325901 (Cayman Chemical ...
• NAK associated protein 1 is required to activate Tank binding kinase 1 to regulate mitosis

  Swagatika Paul, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1 μM TAK243 (30108, Cayman Chemical), 50 μM chloroquine diphosphate (C2301100G ...
• ECPAS/Ecm29-Mediated 26S Proteasome Disassembly is an Adaptive Response to Glucose Starvation

  Won Hoon Choi, et al., bioRxiv - Biochemistry 2022

  Quote: ... MLN7243 (1 μM, 30108, Cayman Chemical), Cycloheximide (80 μg/mL ...
• G₄C₂ repeat RNA mediates the disassembly of the nuclear pore complex in C9orf72 ALS/FTD

  Alyssa N Coyne, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 1 μM SAG (Cayman Chemicals). Media was exchanged daily until day 12 ...
• C-Jun N-terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-mediated ALS and FTD

  TG Sahana, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 1 μM SAG (Cayman Chemicals) until Day 12 ...
• STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

  Aaron R. Cox, et al., bioRxiv - Immunology 2020

  Quote: ... 1 μM rosiglitazone (Cayman Chemical Co.), 1 μM dexamethasone (Sigma Chemical Co.) ...
• Functional delineation of tissue-resident CD8⁺ T cell heterogeneity during infection and cancer

  J. Justin Milner, et al., bioRxiv - Immunology 2020

  Quote: ... 1 mg tamoxifen (Cayman Chemical Company) emulsified in 100 μl of sunflower seed oil (Sigma-Aldrich ...
• ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

  Gang Du, et al., bioRxiv - Immunology 2023

  Quote: ... Torin-1 (Cayman Chemical Company, 10997) at 2 μM ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 1 μM epoxomicin (Cayman chemical). Samples were treated with 10 μM GI254023X (Cayman chemical) ...
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 1 mM NAD+ (Cayman Chemical, 16077), Triton X-100 ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... 1 µM E-64 (Cayman Chemical), 1 µM leupeptin (Cayman Chemical) ...
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  Monica M. Santisteban, et al., bioRxiv - Neuroscience 2023

  Quote: ... FTY720 (1 mg/kg; Cayman Chemical)24 was injected i.p ...
• Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

  Ling He, et al., bioRxiv - Neuroscience 2023

  Quote: ... temozolomide (1 mM; #14163, Cayman Chemical) or Vincristine (250 nM ...
• AMPK activation induces RALDH^high tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

  E. C. Brombacher, et al., bioRxiv - Immunology 2023

  Quote: ... 1 µM oligomycin (11342, Cayman Chemical), 3 µM fluoro-carbonyl cyanide phenylhydrazone (FCCP ...
• Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

  Blake A. Caldwell, Yajun Wu, Jing Wang, Liwu Li, bioRxiv - Immunology 2023

  Quote: ... and Wnt agonist 1 (Cayman Chemical) experiments ...
• Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

  Patricia Aguilar-Calvo, et al., bioRxiv - Pathology 2023

  Quote: ... and PrP (Cayman Chemical; 1:1200) immunohistochemistry were performed on an automated tissue immunostainer (Ventana Discovery Ultra ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM methoxy-XO4 (Cayman Chemical) in 40% EtOH ...
• Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

  Corey D. Holman, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM rosiglitazone (Cayman Chemical, 11884), 1 nM T3 (Sigma ...
• SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

  Haowen Qiao, et al., bioRxiv - Neuroscience 2024

  Quote: ... COX2 (1:200; Cayman Chemical: 160126); CD31(1:800 ...
• AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

  Connor J. Maltby, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 1 μM dorsomorphin (Cayman Chemical). At day 10-12 ...
• OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

  Styliani Panagiotou, et al., bioRxiv - Cell Biology 2023

  Quote: ... OSW-1 was from Cayman Chemical. Cal-590-AM and Cal520-AM were from AAT Bioquest ...
• QUAS-R: Glutamine (Q) Uptake Assay with Single cell Resolution reveals metabolic heterogeneity with immune populations

  Leonard Pelgrom, et al., bioRxiv - Immunology 2022

  Quote: ... 1 part of aminoguanidine (Cayman Chemicals, #81530 ...
• Fluctuation of lysosomal protein degradation in neural stem cells of postnatal mouse brain

  He Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... 100 nM Trin 1 (Cayman Chemical), and 10 μg/ml cycloheximide (Sigma) ...
• The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

  Ling Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... sGCβ1 (1:2,000, Cayman Chemicals,160897), AR (1:8,000 ...
• LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

  Jin Li, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 μg/mL tunicamycin (Cayman Chemical), or 5 mM N-acetylcysteine (NAC ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... Necrostatin-1 (30 μM, Cayman chemical), anti-CD95 agonist antibody (1 μg/ml ...
• Apical Size Reduction by Macropinocytosis Alleviates Tissue Crowding

  Enzo Bresteau, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 mM Amiloride (#14409, Cayman Chemical), 2 μM LY294002 (#HY-10108 ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM A83-01 (Cayman Chemical), 0.1 μM LDN193189 (LDN ...
• The molecular chronology of mammary epithelial cell fate switching

  Queralt Vallmajo-Martin, et al., bioRxiv - Cell Biology 2024

  Quote: ... SB202190 (1 μM, Cayman Chemical, 10010399), FGF-7 (5 ng/ml ...
• Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation

  Nathaniel J. Hogrebe, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 µM nocodazole (13857, Cayman Chemical), 0.3 µM S1P (62570 ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 1 μM XAV939 (Cayman Chemical). The organoids were then cultured to day 14 for analysis.
• LPA₃: Pharmacodynamic differences between lysophosphatidic acid and oleoyl-methoxy glycerophosphothionate. Biased agonism, two sites

  K. Helivier Solís, et al., bioRxiv - Biochemistry 2024

  Quote: 1-Oleyl lysophosphatidic acid (LPA) and 2S-(1-oleoyl-2-O-methyl-glycerophosphothionate) (OMPT) were from Cayman Chemical Co ...
• The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

  Kiara Freitag, et al., bioRxiv - Neuroscience 2021

  Quote: A® 1-42 peptides (Cayman Chemicals) were resuspended in hexafluoroisopropanol to obtain 1 mM solution ...
• Synaptic RTP801 Contributes to Motor Learning Dysfunction in Huntington’s Disease

  Núria Martín-Flores, et al., bioRxiv - Neuroscience 2020

  Quote: ... PHLPP1 rabbit polyclonal (1:500, Cayman Chemical), PSD-95 mouse monoclonal (1:1000 ...
• Unique features of magic spot metabolism in Clostridioides difficile

  Asia Poudel, et al., bioRxiv - Microbiology 2021

  Quote: ... 0.67 µg mL−1 fidaxomicin (Cayman Chemical), 1.0 mM diamide (MP Biomedicals) ...
• The role of the cannabinoid system in fear memory and extinction in male and female mice

  Ikumi Mizuno, et al., bioRxiv - Neuroscience 2021

  Quote: ... SR141716 (1, 5 mg/kg) (Cayman Chemicals) was dissolved in saline with 5% DMSO and 0.1% Tween 20 ...
• SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation

  Julia Ghelman, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1 µM SAG (#11914, Cayman Chemical Company), 200 µM L-ascorbic acid (#A4544 ...
• Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

  Elien Grajchen, et al., bioRxiv - Immunology 2022

  Quote: ... SCD1 inhibitor (CAY10566, 1 µM; Cayman Chemicals), ATGL inhibitor (Atglistatin ...
• Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

  J. Justin Milner, et al., bioRxiv - Immunology 2020

  Quote: ... 1 mg of tamoxifen (Cayman Chemical Company) was emulsified in 100 μl of sunflower seed oil (Sigma-Aldrich ...
• mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis

  Bryce W.Q. Tan, et al., bioRxiv - Cell Biology 2020

  Quote: ... Torin-1 (500nM or 1µM, Cayman Chemicals), wortmannin (200nM ...
• The lysine-rich intracellular loop and cell type-specific co-factors are required for IFITM3 antiviral immunity in hematopoietic stem cells

  G. Unali, et al., bioRxiv - Microbiology 2021

  Quote: ... GSK-LSD1 and Spautin-1 (Cayman Chemicals), were resuspended and stored following the manufacturer’s instructions ...
• MISTR: A conserved MItochondrial STress Response network revealed by signatures of evolutionary conflict

  Mahsa Sorouri, et al., bioRxiv - Genetics 2020

  Quote: ... Actinomycin D [1 μg/mL (Cayman Chemical)] ...
• An active traveling wave of Eda/NF-kB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish

  Maya N. Evanitsky, Stefano Di Talia, bioRxiv - Developmental Biology 2023

  Quote: ... IWR-1-endo (Cayman Chemical Company 13659) broadly inhibits Wnt signaling through Axin stabilization ...