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201 - 250 of 936 citations for 7 bromo 1 methyl 1 3 dihydro 2H benzo d imidazol 2 one since 2020

• Mechanically induced cytoskeletal remodeling in trabecular meshwork cells requires TRPV4 - Rho signaling interactions

  Monika Lakk, David Križaj, bioRxiv - Cell Biology 2020

  Quote: ... The ROCK1/2 inhibitor Trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride (Y-27632) was obtained from Cayman Chemical (Ann Arbor, MI, USA) and the calcium indicator Fura-2 AM from Life Technologies (Carlsbad ...
• α-Melanocyte-Stimulating Hormone Regulates Pathological Cardiac Remodeling by Activating Melanocortin 5 Receptor in Cardiomyocytes

  Anni Suominen, et al., bioRxiv - Physiology 2023

  Quote: ... LD211 was used as a selective agonist for MC1-R (compound 28 in the original publication),23 [D-Trp8]-γ-MSH as a selective MC3-R agonist,24 THIQ as a selective MC4-R agonist (Cayman Chemical, USA, # 312637-48-2)25 and PG-901 as a selective MC5-R agonist.26 PG-20N was used as a selective MC5-R antagonist.27 LD211 ...
• The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

  Madel V. Tutor, et al., bioRxiv - Microbiology 2023

  Quote: ... one culture was treated with 250 nM rapamycin (Cayman Chemical, 13346) and another with 100% DMSO (equal volume to rapamycin) ...
• A method to determine the double bond position in unsaturated fatty acids by solvent plasmatization using liquid chromatography-mass spectrometry

  Shigeo Takashima, et al., bioRxiv - Biochemistry 2020

  Quote: ... 15-octadecatrienoic acid (C18:3 ω-3, α-linolenic acid; Cayman Chemical, #90210), all cis-6 ...
• DHCR7 as a novel regulator of ferroptosis in hepatocytes

  Naoya Yamada, et al., bioRxiv - Molecular Biology 2022

  Quote: Ferrostatin-1 (Fer-1, #17729) and AY9944 were purchased from Cayman Chemical (Ann Arbor, MI). Deferoxamine (DFO ...
• Altered specificity of 15-LOX-1 in the biosynthesis of 7S,14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5

  Steven C. Perry, et al., bioRxiv - Biochemistry 2020

  Quote: ... Mar1 and 7-epi-Mar standards purchased from Cayman Chemicals (Ann Arbor, MI).
• Rapid and sensitive detection of native glycoRNAs

  Helena Hemberger, et al., bioRxiv - Molecular Biology 2023

  Quote: ... The samples are briefly allowed to cool to room temperature (2-3 min), then working quickly, 1μL 30 mM aldehyde reactive probe (ARP, aminooxy) biotin (22582, Cayman Chemicals, stock made in water) is added first ...
• Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs

  Sachiko Haga-Yamanaka, et al., bioRxiv - Neuroscience 2023

  Quote: HDAC activity of class I HDACs (HDAC1, 2, 3 and 8) was measured with the fluorometric HDAC Activity Assay kit: HDAC1 (10011563, Cayman Chemical, Ann Arbor, MI), HDAC2 ...
• γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

  Natasja L. de Vries, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 3 µM SB202190 (Cayman Chemicals) and 10 nM prostaglandin E2 (Cayman Chemicals) ...
• APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

  Yuhua Tian, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 3 μM CHIR99021 (Cayman Chemical), 300 nM LDN193189 (Cayman Chemical ...
• Pluripotent stem cell SOX9 and INS reporters facilitate differentiation into insulin-producing cells

  Rabea Dettmer, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 nM staurosporine (Cayman Chemical), 5 µM Y-27632 ...
• Self-organized anteroposterior regionalization of early midbrain and hindbrain using micropatterned human embryonic stem cells

  Tianfa Xie, et al., bioRxiv - Bioengineering 2022

  Quote: ... IWP2 (3 μM, Cayman Chemical), GANT61 (10 μM ...
• Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health

  Maria Rafailia Theodorou, et al., bioRxiv - Immunology 2024

  Quote: ... BPTES (3 μM; Cayman Chemical), Εtomoxir (4 μM ...
• Determinants of the Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids

  Petra Geiser, et al., bioRxiv - Microbiology 2024

  Quote: ... murine enteroids were pre-treated with mOGM/1 mM valproic acid (Cayman chemicals)/3 µM CHIR99021 (Cayman chemicals) (CV medium ...
• HIV-1 Vpr induces ciTRAN to prevent transcriptional silencing of the provirus

  Vipin Bhardwaj, et al., bioRxiv - Microbiology 2022

  Quote: ... and 0.2 mM D-Luciferin (Cayman chemical, USA)) in 50 μl of cell lysate in 96-well white plates (SPL life sciences ...
• Taste receptor T1R3 in nasal cilia detects Staphylococcus aureus D-amino acids to enhance apical glucose uptake

  Ryan M. Carey, et al., bioRxiv - Physiology 2022

  Quote: ... and D-amino acids were from Cayman Chemical. Fluorometric D-amino acid kit (ab239721 ...
• Invadopodia enable cooperative invasion and metastasis of breast cancer cells

  L. Perrin, et al., bioRxiv - Cancer Biology 2022

  Quote: ... One plate was incubated with a combination of 6-thioguanine (Cayman Chemicals) and puromycin ...
• An adipocyte-specific lncRAP2 – Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

  Juan R. Alvarez-Dominguez, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM rosiglitazone (Cayman Chemical # 71742), 1 nM 3,3,5-triiodo-L-thyronine (T3 ...
• ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration

  Sonia Muliyil, et al., bioRxiv - Neuroscience 2020

  Quote: ... 10 μm TAPI-1 (Cayman Chemicals) or DMSO (Sigma ...
• Structural basis for receptor selectivity and inverse agonism in S1P₅ receptors

  Elizaveta Lyapina, et al., bioRxiv - Biophysics 2022

  Quote: ... 1 μM E-64 (Cayman Chemical), 1 μM leupeptin (Cayman Chemical) ...
• The unfolded protein response triggers the immune deficiency pathway in ticks

  Lindsay C. Sidak-Loftis, et al., bioRxiv - Immunology 2022

  Quote: ... 1 µM KIRA6 (Cayman Chemical, 19151), or 0.1% DMSO ...
• Rapid and efficient in vivo astrocyte-to-neuron conversion with regional identity and connectivity?

  Lei-Lei Wang, et al., bioRxiv - Neuroscience 2020

  Quote: Tamoxifen (10540-29-1; Cayman Chemical) was dissolved in a mixture of ethanol and sesame oil (1:9 by volume ...
• Blocking the Rac1-TRPC5 pathway protects human podocytes

  Yiming Zhou, et al., bioRxiv - Cell Biology 2021

  Quote: ... CP21R7 (1 µM, Cayman Chemical, #20573), and BMP4 (25 ng/mL ...
• Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1)

  Cameron Moshfegh, et al., bioRxiv - Cell Biology 2021

  Quote: ... 1 µM CHIR99021 (Cayman Chemical, 13122) and 1 µM PD 0325901 (Cayman Chemical ...
• NAK associated protein 1 is required to activate Tank binding kinase 1 to regulate mitosis

  Swagatika Paul, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1 μM TAK243 (30108, Cayman Chemical), 50 μM chloroquine diphosphate (C2301100G ...
• ECPAS/Ecm29-Mediated 26S Proteasome Disassembly is an Adaptive Response to Glucose Starvation

  Won Hoon Choi, et al., bioRxiv - Biochemistry 2022

  Quote: ... MLN7243 (1 μM, 30108, Cayman Chemical), Cycloheximide (80 μg/mL ...
• G₄C₂ repeat RNA mediates the disassembly of the nuclear pore complex in C9orf72 ALS/FTD

  Alyssa N Coyne, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 1 μM SAG (Cayman Chemicals). Media was exchanged daily until day 12 ...
• C-Jun N-terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-mediated ALS and FTD

  TG Sahana, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 1 μM SAG (Cayman Chemicals) until Day 12 ...
• STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

  Aaron R. Cox, et al., bioRxiv - Immunology 2020

  Quote: ... 1 μM rosiglitazone (Cayman Chemical Co.), 1 μM dexamethasone (Sigma Chemical Co.) ...
• Functional delineation of tissue-resident CD8⁺ T cell heterogeneity during infection and cancer

  J. Justin Milner, et al., bioRxiv - Immunology 2020

  Quote: ... 1 mg tamoxifen (Cayman Chemical Company) emulsified in 100 μl of sunflower seed oil (Sigma-Aldrich ...
• QUAS-R: Glutamine (Q) Uptake Assay with Single cell Resolution reveals metabolic heterogeneity with immune populations

  Leonard Pelgrom, et al., bioRxiv - Immunology 2022

  Quote: ... 1 part of aminoguanidine (Cayman Chemicals, #81530 ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM methoxy-XO4 (Cayman Chemical) in 40% EtOH ...
• OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

  Styliani Panagiotou, et al., bioRxiv - Cell Biology 2023

  Quote: ... OSW-1 was from Cayman Chemical. Cal-590-AM and Cal520-AM were from AAT Bioquest ...
• SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

  Haowen Qiao, et al., bioRxiv - Neuroscience 2024

  Quote: ... COX2 (1:200; Cayman Chemical: 160126); CD31(1:800 ...
• Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

  Corey D. Holman, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM rosiglitazone (Cayman Chemical, 11884), 1 nM T3 (Sigma ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 1 μM epoxomicin (Cayman chemical). Samples were treated with 10 μM GI254023X (Cayman chemical) ...
• ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

  Gang Du, et al., bioRxiv - Immunology 2023

  Quote: ... Torin-1 (Cayman Chemical Company, 10997) at 2 μM ...
• Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

  Ling He, et al., bioRxiv - Neuroscience 2023

  Quote: ... temozolomide (1 mM; #14163, Cayman Chemical) or Vincristine (250 nM ...
• AMPK activation induces RALDH^high tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

  E. C. Brombacher, et al., bioRxiv - Immunology 2023

  Quote: ... 1 µM oligomycin (11342, Cayman Chemical), 3 µM fluoro-carbonyl cyanide phenylhydrazone (FCCP ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... 1 µM E-64 (Cayman Chemical), 1 µM leupeptin (Cayman Chemical) ...
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  Monica M. Santisteban, et al., bioRxiv - Neuroscience 2023

  Quote: ... FTY720 (1 mg/kg; Cayman Chemical)24 was injected i.p ...
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 1 mM NAD+ (Cayman Chemical, 16077), Triton X-100 ...
• Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

  Patricia Aguilar-Calvo, et al., bioRxiv - Pathology 2023

  Quote: ... and PrP (Cayman Chemical; 1:1200) immunohistochemistry were performed on an automated tissue immunostainer (Ventana Discovery Ultra ...
• Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

  Blake A. Caldwell, Yajun Wu, Jing Wang, Liwu Li, bioRxiv - Immunology 2023

  Quote: ... and Wnt agonist 1 (Cayman Chemical) experiments ...
• Fluctuation of lysosomal protein degradation in neural stem cells of postnatal mouse brain

  He Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... 100 nM Trin 1 (Cayman Chemical), and 10 μg/ml cycloheximide (Sigma) ...
• The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

  Ling Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... sGCβ1 (1:2,000, Cayman Chemicals,160897), AR (1:8,000 ...
• AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

  Connor J. Maltby, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 1 μM dorsomorphin (Cayman Chemical). At day 10-12 ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... Necrostatin-1 (30 μM, Cayman chemical), anti-CD95 agonist antibody (1 μg/ml ...
• LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

  Jin Li, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 μg/mL tunicamycin (Cayman Chemical), or 5 mM N-acetylcysteine (NAC ...
• Apical Size Reduction by Macropinocytosis Alleviates Tissue Crowding

  Enzo Bresteau, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 mM Amiloride (#14409, Cayman Chemical), 2 μM LY294002 (#HY-10108 ...