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201 - 250 of 513 citations for 3 hydroxy 20 oxopregn 5 en 21 yl acetate since 2020

• On the Origin of Ultraslow Spontaneous Na⁺ Fluctuations in Neurons of the Neonatal Forebrain

  Carlos Perez, et al., bioRxiv - Neuroscience 2020

  Quote: ... (2R)-amino-5-phosphonopentanoate) from Cayman Chemical
• Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

  Melanie Wallace, et al., bioRxiv - Cell Biology 2023

  Quote: ... IWR-1 (5 µM, #13659, Cayman Chemical) in B27-INS was added at D3 and changed to fresh B27-INS at D5 ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 50% 5 μM methoxy-XO4 (Cayman Chemical) in 50% EtOH for 2 minutes ...
• Ca²⁺-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress

  Wei Chen, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 μM Ionomycin (No. 10004974, Cayman Chemical); 250 μM CPZ (No ...
• The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS^hiGITR^hi Blimp-1⁺ effector regulatory T cells in breast tumors

  Marie Boutet, et al., bioRxiv - Immunology 2024

  Quote: ... 5 μM Y-27632 (Cayman Chemical, #10005583) and 5% Matrigel (Corning ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 μM CB-839 (22038, Cayman Chemical), 300 μM BSO (14484 ...
• Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

  Margaret S. Collins, et al., bioRxiv - Cell Biology 2023

  Quote: ... NEI (CAS#1448314-31-5, Cayman Chemical), SIV (CAS# 201677-61-4 ...
• Characterising replisome disassembly in human cells

  Rebecca M. Jones, et al., bioRxiv - Cell Biology 2022

  Quote: ... 5 µM Wee1i (MK-1775, Cayman Chemicals, 21266 ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM BMS-5 (Cayman Chemical, #21072) or 2 μM ML-7 (Cayman Chemical ...
• Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

  Katjana Schwab, et al., bioRxiv - Genomics 2022

  Quote: ... 5-FU (25 μg/ml, Cayman Chemicals), or Doxorubicin (0.2 µg/ml ...
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 5 µM SU5402 (Cayman Chemical, #13182). Starting at d28 ...
• PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

  David J. Sherman, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 µM Triacsin C (Cayman Chemical, #10007448) dissolved in dimethyl sulfoxide (DMSO ...
• Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

  Piotr Kolata, Rouslan G. Efremov, bioRxiv - Biochemistry 2021

  Quote: ... complex I was incubated with 20 µM Piericidin A (Cayman Chemical) for 5 min in the assay buffer at 30°C prior to Q1 addition.
• Lipid droplets are a metabolic vulnerability in melanoma

  Dianne Lumaquin, et al., bioRxiv - Cancer Biology 2022

  Quote: ... cells were treated with 20 µM T-863 (Cayman Chemicals, 25807). Cells were fixed with 4% formaldehyde for 15 minutes ...
• OzFAD: Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome

  Jan Philipp Menzel, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 0.1 mL of a 20 mM solution of AMP+ (Cayman Chemical) in acetonitrile/dimethylformamide 4:1 (v/v ...
• Vti1a/b support distinct aspects of TGN and cis-/medial Golgi organization

  Danique M van Bommel, et al., bioRxiv - Cell Biology 2022

  Quote: ... DIV7 neurons were treated with 20 μM C6-Ceramide (Cayman Chemical), 8 μM L-Erythro-Sphingosine (Cayman Chemical ...
• Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer

  Raphaël Mattiuz, et al., bioRxiv - Immunology 2024

  Quote: ... mice were administered 20 µg of FTY720 (Cayman Chemical, Cat # 10006292) daily over the indicated time periods ...
• Imaging translational control by Argonaute with single-molecule resolution in live cells

  Charlotte A. Cialek, et al., bioRxiv - Molecular Biology 2021

  Quote: ... cells were treated with 3 μg/mL of Harringtonine (Cayman Chemical) to inhibit translation initiation (Huang ...
• Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

  Soham Chakraborty, et al., bioRxiv - Biophysics 2022

  Quote: ... Drugs were commercially purchased: cyanidin 3-O-glucoside (1151935, Cayman chemicals); letrozole (L6545 ...
• An Investigation of the Mechanism for a Novel Influenza Inhibitor Designed to Target the Import of PB1

  Alexander Dorius, David D. Busath, bioRxiv - Microbiology 2021

  Quote: ... treated with 3 µM VNXR (Cayman Chemical Company, Ann Arbor, MI) or 30 µM GM30 (a gift from Dr ...
• Robust bidirectional communication between electronics and an engineered multi-functional microbial community

  Jessica L. Terrell, et al., bioRxiv - Synthetic Biology 2020

  Quote: ... N-3-oxo-dodecanoyl-L-Homoserine lactone (AHL) from Cayman Chemicals. Various biological fixatives included formaldehyde (ThermoFisher Scientific ...
• Coupling of translation quality control and mRNA targeting to stress granules

  Stephanie L. Moon, et al., bioRxiv - Molecular Biology 2020

  Quote: ... and 15 minutes later harringtonine (3 µg/mL, Cayman Chemical Company) was added ...
• A single-dose intramuscular immunization of pigs with lipid-nanoparticle DNA vaccines based on the hemagglutinin antigen confers complete protection against challenge infection with the homologous influenza virus strain

  The Nhu Nguyen, et al., bioRxiv - Microbiology 2023

  Quote: ... 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) (Cayman Chemical, Ann Arbor, MI), Cholesterol (Sigma Aldrich) ...
• Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3

  Maxinne Watchon, et al., bioRxiv - Neuroscience 2023

  Quote: ... cells were treated with SB (3 mM, Cayman Chemicals [Cat #13121]) or vehicle control (autoclaved water ...
• Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

  Zehua Sun, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and 3 equivalents of CL2A-SN-38 (Cayman Chemical CAT#33941) were added and incubated overnight at 4°C ...
• CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

  Savvas Nikolaou, et al., bioRxiv - Cancer Biology 2022

  Quote: ... For LPAR1/3 inhibitor treatment with KI16425 antagonist (Cayman chemicals, #10012659), cells were incubated for 1h in serum free medium in 1:1000 dilution prior preparation and assembly of the “Insall” chambers ...
• The genetic basis of replicated bullseye pattern reduction across the Trionum Complex

  May T. S. Yeo, et al., bioRxiv - Plant Biology 2024

  Quote: ... and anthocyanin cyanidin 3-O-glucoside (chloride) (Cayman Chemicals item 16406) as reference compounds.
• Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma

  Émilie Lavallée, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 3) FCCP 0.5 µM (#15218, Cayman Chemical, Ann Arbor, MI, USA), 4 ...
• The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

  Femke M. Feringa, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 3 µg/mL puromycin was added (Cayman Chemical, 13884-25). On day 3 ...
• The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

  David Z. Kochan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 5-FOA was bought from Cayman Chemical (17318). Ampure XP beads were from Beckman Coulter (A63881) ...
• De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

  Thomas Laval, et al., bioRxiv - Immunology 2021

  Quote: ... LTB4-d4 and 5-HETE-d8 (Cayman Chemicals), and centrifuged at 5000rpm for 15min at 4°C ...
• The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures

  Hiroyuki Mori, et al., bioRxiv - Physiology 2020

  Quote: ... 5-(tetradecyloxy)-2-furoic acid (TOFA) (Cayman Chemical)
• Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward Discovery of Biased D1 Agonists

  Haoxi Li, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... coelenterazine h (Cayman Chemicals, 5 μM final concentration), was added per well ...
• Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2

  Julia S.P. Mawer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 5-FOA was bought from Cayman Chemicals (17318). Protein-G coupled Dynabeads™ (10004D ...
• An expanded 2-pyridinecarboxaldehyde (2PCA)-based chemoproteomics toolbox for probing protease specificity

  Haley N. Bridge, Clara L. Frazier, Amy M. Weeks, bioRxiv - Biochemistry 2023

  Quote: ... Biotin azide (5) was purchased from Cayman Chemical. Azide-SS-biotin (6 ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 1 or 5 µM 7-HDHA (Cayman Chemical), 1 or 10 nM Leukotriene B4 (Cayman Chemical ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 1 or 5 µM 17-HDHA (Cayman Chemical), 3 ...
• Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

  Alissandra L. Hillis, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or 5 µg/mL GGPP (Cayman Chemicals, 63330). At the endpoint ...
• Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

  Tomasz H. Benedyk, et al., bioRxiv - Microbiology 2022

  Quote: ... supplemented with 5 μM clickable sphingosine (Cayman Chemical) for 5 min (pulse) ...
• Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

  Niklas J. Lang, et al., bioRxiv - Cell Biology 2023

  Quote: ... and lysophosphatidic acid (LPA) (5 µM, Cayman chemical) as described before20 ...
• SARS-CoV-2 Envelope-mediated Golgi pH dysregulation interferes with ERAAP retention in cells

  Valerie Vargas-Zapata, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 10 uM nigericin (Cayman Chemical, 11437-5). Cells co-transfected with pHluorin and viral proteins were resuspended in Na-Ringer buffer ...
• The Cancer Testes Antigen, HORMAD1, is a Tumor-Specific Replication Fork Protection Factor

  Luis Reza Herrera, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5-ethynyl-2’-deoxyuridine (EdU) (Cayman chemicals (#20518)) was used at final concentration of 20 μM for 10 minutes ...
• Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability

  Adam J. Sugarman, et al., bioRxiv - Cancer Biology 2023

  Quote: ... folic acid and 5-methyl-THF (Cayman Chemical).
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 0.2 mM alpha-ketoisocaproate (Cayman Chemical, 21052-5), and 5 µM rotenone (VWR ...
• Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation

  Lorenz Waltl, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: Human recombinant 5-LOX (Cayman Chemical, 10 U) was pretreated with vehicle (DMSO ...
• Mesoscale regulation of MTOCs by the E3 ligase TRIM37

  Zhong Y. Yeow, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and 5 μg/mL cytochalasin B (Cayman Chemical) for 1 h 15 min to depolymerize microtubule and actin networks ...
• A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis

  Genta Ishikawa, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 5 μM lysophosphatidic acid (Cayman Chemical, 62215). PCLS were then treated in the absence or presence of 10 µM terazosin (U.S ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... supplemented with 5 μM CHIR99021 (CHIR, Cayman Chemical), 50 ng ml−1 of Activin A (PeproTech) ...
• The neurodevelopmental disorder-linked PHF14 complex that forms biomolecular condensates detects DNA damage and promotes repair

  Eva-Lotta Käsper, et al., bioRxiv - Molecular Biology 2021

  Quote: ... then for another 20 min in 250 μM CldU (Cayman Chemical 18155). Depending on the assay ...
• Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

  Caterina Bartolacci, et al., bioRxiv - Cancer Biology 2021

  Quote: ... we incubated them with 20 µM arachidonic acid alkyne (Cayman Chemical, 10538) in RPMI with 2% ultra-fatty acid free BSA (SIGMA ALDRICH ...