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201 - 250 of 832 citations for 3 Cyclohex 1 enyl acrylic acid methyl ester since 2020

• A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A

  Robert S. Porter, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and 3 μM SB431542 (Cayman Chemicals). NPCs were differentiated into cortical neurons using previously described protocols with some modifications ...
• Ribosome cooperativity promotes fast and efficient translation

  Maximilian F. Madern, et al., bioRxiv - Molecular Biology 2024

  Quote: ... harringtonine (3 µg/mL; Cayman Chemical) was added to cells at the start of imaging (Figures 2K-2L).
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 3 µM CHIR99021 (Cayman Chemical, #13122), and 5 µM SU5402 (Cayman Chemical ...
• Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants

  Orla Deevy, et al., bioRxiv - Genetics 2024

  Quote: ... 3 μM CHIR99021 (Cayman Chemical Company) and 1 μM PD0325901 (Cayman Chemical Company) ...
• Synergistic innate immune activation and anti-tumor immunity through combined STING and TLR4 stimulation

  Emily F. Higgs, Thomas F. Gajewski, bioRxiv - Immunology 2024

  Quote: ... DMXAA (Cayman Chemical #117570-53-3) and LPS (Cell Signaling #14011 ...
• Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neurons

  Evelyn Pardo, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 µM CHIR99021 (Cayman Chemicals #13122), 5 µM Forskolin (BioGems #6652995 ...
• Dampened α7 nAChR activity contributes to audiogenic seizures and hyperactivity in a mouse model of Fragile X Syndrome

  Sarah Goebel, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 µM PNU-120596 (Cayman Chemical), 0.5 µM TTX ...
• MS/MS fragmentation pattern analysis confirms the production of the new esterified bile acids by the human gut microbiota

  Carlos J. Garcia, et al., bioRxiv - Biochemistry 2023

  Quote: ... 3α-Hydroxy-5β-cholan-24-oic Acid (lithocholic) and 3β-Hydroxy-5β-cholan-24-oic Acid (isolithocholic) were purchased from Cayman Chemical (Ann Arbor, MI, USA).
• Sequential gentle hydration increases encapsulation in model protocells

  Emma M. Gehlbach, et al., bioRxiv - Biochemistry 2023

  Quote: Thin films were prepared by dissolving 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC) and cholesterol (Cayman Chemical) in chloroform to create 50 mg/mL solutions that were partitioned into amber glass vials ...
• Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

  Bryan J. Song, et al., bioRxiv - Neuroscience 2024

  Quote: The drugs used in our study include: D1R antagonist (SKF 83566 hydrobromide, Cayman Chemical #29480; 3 mg kg−1), D2R antagonist (eticlopride hydrochloride ...
• Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells

  Joel C. Thompson, et al., bioRxiv - Physiology 2024

  Quote: HNEC and RPMI 2650 cells were loaded for 15 minutes at RT in the dark with Tetramethylrhodamine ethyl ester (TMRE) and Hoechst dye prepared as described in the Multi-Parameter Apoptosis Assay Kit (Cayman Chemical; Ann Arbor, MI, USA). Cells were imaged with TRITC filters as described above with the Olympus IX-83 microscope system HNEC and RPMI 2650 were treated ...
• Elevated CO₂ alters soybean physiology and defense responses, and has disparate effects on susceptibility to diverse microbial pathogens

  Melissa Bredow, et al., bioRxiv - Plant Biology 2024

  Quote: Approximately 100 mg of each sample was ground and spiked with an internal standard containing 10 µg nonadecanoic acid (1 mg/mL in ethanol) and JA-d5 (Cayman Chemical, Ann Arbor, MI) (JA-d5 ...
• Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

  Yifan Wu, et al., bioRxiv - Cell Biology 2024

  Quote: ... cells cultured on tissue culture treated (TC) plates or gels for one day were treated with valproic acid (Cayman Chemical, 2.5 mg ml-1) for 24 h ...
• Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals

  Hannah R. Monday, et al., bioRxiv - Neuroscience 2021

  Quote: ... okadaic acid and NBQX from Cayman Chemical (Ann Arbor, MI, USA). Reagents were either acutely bath applied or preincubated with slices/cultures ...
• SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

  Octavio A. Romero, et al., bioRxiv - Cancer Biology 2020

  Quote: ... suberoyl anilide hydroxamic acid (Cayman Chemical Company, Ann Arbour, MI, USA); GSK-J4 (Shelleckchem) ...
• Chemoproteomic profiling reveals cellular targets of nitro-fatty acids

  Mingyu Fang, et al., bioRxiv - Biochemistry 2021

  Quote: ... oleic acid and 9-NO2-OA were purchased from Cayman Chemicals. For detailed alk-9-NO2-OA synthesis and characterization ...
• Comparative transcriptomics of the Drosophila olfactory subsystems identifies a support cell-expressed Osiris protein required for pheromone sensing

  Marta Scalzotto, et al., bioRxiv - Neuroscience 2022

  Quote: ... Odor stimuli: trans-palmitoleic acid (Cayman Chemical, CAS 10030-73-6) and 11-cis vaccenyl acetate (Cayman Chemical ...
• A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CM

  Carl Schulz, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... all-trans retinoic acid-d5 (Cayman Chemical, Ann Arbor, MI, USA), were made up in DMSO ...
• IGF-1 facilitates extinction of conditioned fear

  José A. Noriega-Prieto, et al., bioRxiv - Neuroscience 2020

  Quote: ... or the IGF-1R antagonist 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-]pyrimidin-4-amine (NVP-AEW 541, 40 μM; Cayman Chemicals) plus IGF-1 were infused into the IL ...
• Phospholipase A₂ inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

  Yulong Wei, et al., bioRxiv - Bioengineering 2021

  Quote: 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine (thioetheramide-PC) was purchased from Cayman Chemical (Ann Arbor, Michigan). Hydrogenated soy phosphatidylcholine (HSPC) ...
• Lysophospholipid headgroup size, and acyl chain length and saturation differentially affect vacuole acidification, Ca²⁺ transport, and fusion

  Chi Zhang, et al., bioRxiv - Biochemistry 2024

  Quote: ... and 1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (18:0 LPC) were purchased from Cayman Chemical (Ann Arbor, MI) and dissolved in ethanol ...
• The rifampicin-inactivating mono-ADP-ribosyl transferase of Mycobacterium smegmatis significantly influences reactive oxygen species levels in the actively growing cells

  Sharmada Swaminath, et al., bioRxiv - Microbiology 2020

  Quote: ... 3’-(p-hydroxyphenyl) fluorescein (HPF, Cayman chemical) (42) ...
• Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons

  Emiliano Hergenreder, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 3 μM of CHIR99021 (Cayman Chemical) for 24 hours ...
• Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons

  Sally Martin, et al., bioRxiv - Genomics 2020

  Quote: ... 3 µM CHIR 99021 (Cayman Chemical Company) and 0.5 µM PMA (Sigma ...
• Prevention of tau accumulation through inhibition of hnRNP R-dependent axonal Mapt mRNA localization

  Abdolhossein Zare, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 µM CHIR99021 (13122, Cayman Chemical Company) and 0.5 µM purmorphamine (PMA ...
• Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

  Zhijia Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 3-MB-PP1 was from Cayman Chemical. KU-60019 was from Selleck Chemicals ...
• Spatial biology of Ising-like synthetic genetic networks

  Kevin Simpson, et al., bioRxiv - Synthetic Biology 2023

  Quote: ... 3-oxohexanoyl-homoserine lactone (C6HSL, Cayman Chemicals) and 3-oxododecanoyl-homoserine lactone (C12HSL ...
• Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation

  Sara Cascione, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 3 μM CHIR99021 (Cayman Chemical Company, CT99201) were added ...
• eIF2B localisation and its regulation during the integrated stress response is cell type specific

  Filipe M. Hanson, et al., bioRxiv - Cell Biology 2023

  Quote: ... 3 μg/mL tunicamycin (Tm) (Cayman Chemical) for 2h ...
• CD32 allows capturing blood cells emergence in slow motion during human embryonic development

  Rebecca Scarfò, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 3 μM CHIR99021 (Cayman Chemical Company, CT99201) were added ...
• Modulation of WNT, Activin/Nodal and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation During Human iPSC Differentiation

  Yongqin Li, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 3 μM LY294002 (#70920, Cayman Chemicals) was added from day 3 to day 6 of differentiation unless otherwise indicated.
• PROTEOMICS OF HYPOTHERMIC ADAPTATION REVEALS THAT RBM3 ENHANCES MITOCHONDRIAL METABOLISM AND MUSCLE STEM-CELL DIFFERENTIATION

  Paulami Dey, et al., bioRxiv - Biochemistry 2023

  Quote: ... 3 uM FCCP (Cayman chemical 800364-9897), 1.5 uM of antimycin (Cayman chemicals 1397-94-0 ...
• The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores

  Matteo Burigotto, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10 µM 3-MB-PP1 (Cayman Chemical). Thymidine was dissolved in water whereas all other drugs were dissolved in DMSO ...
• Pseudomonas aeruginosa metabolite 3-oxo-C12HSL induces apoptosis through T2R14 and the mitochondrial calcium uniporter

  Zoey A. Miller, et al., bioRxiv - Physiology 2024

  Quote: ... 3-oxo-C12HSL sourced from Cayman Chemical was also used in experiments to validate effects from different suppliers ...
• Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network

  Rebecca M. Sebastian, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 2.5 μM nutlin-3 (Cayman Chemical Company), or 1 μg/mL dox and 2.5 μM nutlin-3 ...
• Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

  Deborah Y. Moss, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Metformin (Cayman Chemicals, #13118, 3-5 mM), IACS-10759 (Selleckchem ...
• Integrative computational approach identifies new targets in CD4+ T cell-mediated immune disorders

  Bhanwar Lal Puniya, et al., bioRxiv - Systems Biology 2020

  Quote: We purchased alpha-difluoromethylornithine (DFMO) and eicosapentaenoic Acid (EPA) from Cayman Chemical. DFMO was resuspended in water at 50mM while EPA was already resuspended in ethanol at 826 mM ...
• Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

  Caterina Bartolacci, et al., bioRxiv - Cancer Biology 2021

  Quote: ... we incubated them with 20 µM arachidonic acid alkyne (Cayman Chemical, 10538) in RPMI with 2% ultra-fatty acid free BSA (SIGMA ALDRICH ...
• Gaseous Signaling Compounds (Hydrogen Sulfide and Nitric Oxide) and Their Relative Roles in Affecting Anaerobic HeLa 229 Cell Viability

  Balbina J. Plotkin, Ira M. Sigar, Amber Kaminski, bioRxiv - Cell Biology 2021

  Quote: ... P-(4-Methoxyphenyl)-P-4-morpholinyl-phosphinodithioic acid (GYY4137; 400μM; Cayman Chemical), pyridoxal phosphate (PLP ...
• Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging

  Xiaoai Zhao, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Single-point internal standard calibration with deuterated oleic acid (Cayman Chemical, 9000432) was used to estimate absolute concentrations for all free fatty acids.
• Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

  Ryan R. Kawalerski, et al., bioRxiv - Cancer Biology 2022

  Quote: K17-disassembly following hyperphosphorylation was assessed using okadaic acid (OA, Cayman Chemical) and sodium orthovanadate (OV ...
• The ORP9-ORP11 dimer promotes sphingomyelin synthesis

  Birol Cabukusta, et al., bioRxiv - Cell Biology 2024

  Quote: Cells were incubated with 20µM ethanolic palmitic acid alkyne (Cayman Chemical #13266) in serum-free medium for 6 hours ...
• A microvascularized in vitro liver model for disease modeling and drug discovery

  Flavio Bonanini, et al., bioRxiv - Bioengineering 2024

  Quote: ... and BSA-Oleate Monosaturated Fatty Acid Complex (oleate, Cayman Chemical Company #29557) which are both provided at a stock concentration of 5 mM ...
• Trapping DNA-radicals with DMPO reduced hypochlorous acid-induced 8-oxo-7,8-dihydro-2’-deoxyguanosine and mutagenesis in lung epithelial cells

  D.C. Ramirez, S.E. Gomez Mejiba, bioRxiv - Biochemistry 2024

  Quote: ... MPO inhibitors (KCN, 4-aminobenzoic acid hydrazide (ABAH, Cayman Chemicals, cat# 4845) or salicyl hydroxamic acid (SHA ...
• Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

  Nadine Tuechler, et al., bioRxiv - Systems Biology 2024

  Quote: ... and 500 μM L-ascorbic acid 2-phosphate (Cayman Chemical Company 16457). TGF-β treated samples received the same medium with an additional 10 ng/ml of recombinant human TGF-β1 (R&D systems 240-B-010) ...
• Advance Glycation End-products accelerate amyloid deposits in adipocyte’s lipid droplets

  Roza Izgilov, et al., bioRxiv - Cell Biology 2023

  Quote: using a fluorescent glucose analog, 2-NBDG (2-Deoxy-2-[(7-nitro-2, 1, 3-benzoxadiazol-4-yl) amino]-D-glucose) (11046, Cayman chemical). Cultured 3T3-L1 cells “starved” in a glucose-free medium at 37°C for 1 hr ...
• CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

  Tom van Schaik, et al., bioRxiv - Molecular Biology 2021

  Quote: ... GSK-3β inhibitor CHIR99021 (3 μM; Cayman Chemical) and 1-thioglycerol (1.5 × 10−4 M ...
• Arginine 65 methylation of Neurogenin 3 by PRMT1 is a prerequisite for development of hESCs into pancreatic endocrine cells

  Gahyang Cho, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 3 μM CHIR99021 (Cayman Chemical, Ann Arbor, MI), and 2 mM LiCl (Sigma ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 0.3 or 3 µM 15-HETE (Cayman Chemical), 0.1 ...
• Genetic mapping identifies Homer1 as a developmental modifier of attention

  Zachary Gershon, et al., bioRxiv - Neuroscience 2024

  Quote: ... and DAPI (Cayman Chemical, Cat#28718-90-3). For immunohistochemistry staining ...