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151 - 200 of 599 citations for 1 1' Diethyl 4 4' bipyridinium dibromide since 2020

• A combined computational-biochemical approach offers an accelerated path to membrane protein solubilization

  Mariah R. Pierce, et al., bioRxiv - Biochemistry 2023

  Quote: ... The membrane was incubated in 1:1000 1° MBOAT4 Polyclonal antibody (Cayman Chemical #18614) and 10 mL of EveryBlot Blocking Buffer (BioRad;#12010020) ...
• Ozanimod Attenuates Human Cerebrovascular Endothelial Derived MMP-9 Activity and Preserves Barrier Properties Following In Vitro Acute Ischemic Injury

  Trevor S. Wendt, Rayna J. Gonzales, bioRxiv - Physiology 2023

  Quote: ... a selective sphingosine-1-phosphate receptor 1 (S1PR1) ligand (Cayman Chemical; Catalogue number: 19922), was prepared fresh under sterile conditions on the same day of administration for planned experiments as previously described ...
• Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

  Allison K. Meyers, et al., bioRxiv - Immunology 2021

  Quote: ... AOAA (1 mM, Cayman Chemical), fumonisin B1 (15 μM ...
• Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

  Tammy Szu-Yu Ho, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1 µM SAG (Cayman Chemical), 100 nM LDN-163189 (Sigma-Aldrich ...
• Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning

  Nuno G.B. Neto, et al., bioRxiv - Bioengineering 2022

  Quote: ... Oligomycin (1 mM, Cayman Chemicals), carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP ...
• Structural basis for receptor selectivity and inverse agonism in S1P₅ receptors

  Elizaveta Lyapina, et al., bioRxiv - Biophysics 2022

  Quote: ... 1 μM leupeptin (Cayman Chemical), 150 nM aprotinin (A.G ...
• Neuronal activity promotes nuclear proteasome-mediated degradation of PDCD4 to regulate activity-dependent transcription

  Wendy A. Herbst, et al., bioRxiv - Neuroscience 2021

  Quote: ... LY2584702 (1 μM, Cayman Chemical) or Ro-31-8425 (5 μM ...
• Inhibiting coronavirus replication in cultured cells by chemical ER stress

  Mohammed Samer Shaban, et al., bioRxiv - Immunology 2020

  Quote: Thapsigargin (Cayman Chemicals; Cay10522-1) was dissolved in DMSO as a 10 mM stock solution ...
• Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosis

  Ruthellen H. Anderson, et al., bioRxiv - Cell Biology 2021

  Quote: ... Atorvastatin (1 μM, Cayman Chemical), or Simvastatin (Cayman Chemical) ...
• Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

  Chi G. Weindel, et al., bioRxiv - Immunology 2021

  Quote: ... 1 mM GNE9605 (Cayman Chemicals), 1μM disulfram (Sigma) ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... 1 µM leupeptin (Cayman Chemical), 150 nM aprotinin (AG Scientific) ...
• Effect of the LSD1 Inhibitor RN-1 on γ-globin and Global Gene Expression during Erythroid Differentiation in Baboons (Papio anubis)

  Vinzon Ibanez, et al., bioRxiv - Molecular Biology 2023

  Quote: ... RN-1 (Cayman Chemical Company) was administered to baboons (0.25mg/kg/d for three consecutive days and from baboons treated with RN-1 (0.25mg/kg/d ...
• OrBITS: Label-free and time-lapse monitoring of patient derived organoids for advanced drug screening

  Christophe Deben, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 1 µM SB202190 (Cayman Chemicals) and 5 µM Y-27632 (only used after passaging and thawing) ...
• MXRA8 promotes adipose tissue whitening to drive obesity

  Wentong Jia, et al., bioRxiv - Physiology 2024

  Quote: ... 1 μM rosiglitazone (Cayman Chemical), 1 nM 3,3′,5-Triiodo-L-thyronine (Sigma) ...
• NF-κB Signaling is Required for X-Chromosome Inactivation Maintenance Following T cell Activation

  Katherine S. Forsyth, et al., bioRxiv - Immunology 2024

  Quote: ... or TPCA-1 (Cayman Chemical).
• NF-κB Signaling is Required for X-Chromosome Inactivation Maintenance Following T cell Activation

  Katherine S. Forsyth, et al., bioRxiv - Immunology 2024

  Quote: ... or TPCA-1 (Cayman Chemical).
• Mitochondrial Function is Preserved Under Cysteine Starvation via Glutathione Catabolism in NSCLC

  Nathan P. Ward, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ferrostatin-1 (Cayman Chemical, 17729), Z-VAD-FMK (Fisher Scientific ...
• Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis

  Lydia Zhang, et al., bioRxiv - Biochemistry 2023

  Quote: ... Ferrostatin-1 (Cayman chemicals, 17729) was added to the wells (2μM final ...
• Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s Disease

  Rikesh M. Rajani, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 µM SAG (Cayman Chemical), 10 ng/ml PDGF (Peprotech) ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... Thapsigargian (1 μM, Cayman chemical), Halofuginone (500 nM ...
• Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

  Anna S. Nam, et al., bioRxiv - Cancer Biology 2022

  Quote: ... age and gender-matched 10-16 week old Tal1-creERT2 control mice and Dnmt3a R878H Tal1-creERT2 mice were treated with tamoxifen (4 mg/kg/day; Cayman Chemical, Ann Arbor, Michigan) for 2 doses ...
• Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel

  Anna K Greda, et al., bioRxiv - Neuroscience 2024

  Quote: ... C18:2-d4, C20:4-d11, C20:5-d5, C22:0-d43, C22:6-d5, C24:0-d4; 10 ng each; Cayman Chemical, Ann Arbor MI). HPLC measurements were performed using an Agilent 1290 HPLC system with binary pump ...
• Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s disease

  Bruno A. Benitez, et al., bioRxiv - Neuroscience 2024

  Quote: ... and GALC enzyme assays using the respective 4-Methylumbelliferyl (4MU)-conjugated fluorometric substrates [PPT1 – 4MU-6-thio-palmitate-β-D-glucopyranoside (Cayman Chemical Co, #19524), GALC – 6HMU-β-D-galactoside (Carbosynth ...
• DHCR7 as a novel regulator of ferroptosis in hepatocytes

  Naoya Yamada, et al., bioRxiv - Molecular Biology 2022

  Quote: Ferrostatin-1 (Fer-1, #17729) and AY9944 were purchased from Cayman Chemical (Ann Arbor, MI). Deferoxamine (DFO ...
• Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

  Sarah E Dremel, et al., bioRxiv - Microbiology 2023

  Quote: ... for 12 hours at 37°C/5% CO2 in the presence of vehicle (DMSO) or 2 μM JQ1+ to enhance reactivation (Cayman Chemical CAS: 1268524-70-4). Pools of 6 ganglia were homogenized in 1 ml TriPure isolation reagent (Roche ...
• An adipocyte-specific lncRAP2 – Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

  Juan R. Alvarez-Dominguez, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM rosiglitazone (Cayman Chemical # 71742), 1 nM 3,3,5-triiodo-L-thyronine (T3 ...
• ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration

  Sonia Muliyil, et al., bioRxiv - Neuroscience 2020

  Quote: ... 10 μm TAPI-1 (Cayman Chemicals) or DMSO (Sigma ...
• Structural basis for receptor selectivity and inverse agonism in S1P₅ receptors

  Elizaveta Lyapina, et al., bioRxiv - Biophysics 2022

  Quote: ... 1 μM E-64 (Cayman Chemical), 1 μM leupeptin (Cayman Chemical) ...
• The unfolded protein response triggers the immune deficiency pathway in ticks

  Lindsay C. Sidak-Loftis, et al., bioRxiv - Immunology 2022

  Quote: ... 1 µM KIRA6 (Cayman Chemical, 19151), or 0.1% DMSO ...
• Rapid and efficient in vivo astrocyte-to-neuron conversion with regional identity and connectivity?

  Lei-Lei Wang, et al., bioRxiv - Neuroscience 2020

  Quote: Tamoxifen (10540-29-1; Cayman Chemical) was dissolved in a mixture of ethanol and sesame oil (1:9 by volume ...
• Blocking the Rac1-TRPC5 pathway protects human podocytes

  Yiming Zhou, et al., bioRxiv - Cell Biology 2021

  Quote: ... CP21R7 (1 µM, Cayman Chemical, #20573), and BMP4 (25 ng/mL ...
• Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1)

  Cameron Moshfegh, et al., bioRxiv - Cell Biology 2021

  Quote: ... 1 µM CHIR99021 (Cayman Chemical, 13122) and 1 µM PD 0325901 (Cayman Chemical ...
• NAK associated protein 1 is required to activate Tank binding kinase 1 to regulate mitosis

  Swagatika Paul, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1 μM TAK243 (30108, Cayman Chemical), 50 μM chloroquine diphosphate (C2301100G ...
• ECPAS/Ecm29-Mediated 26S Proteasome Disassembly is an Adaptive Response to Glucose Starvation

  Won Hoon Choi, et al., bioRxiv - Biochemistry 2022

  Quote: ... MLN7243 (1 μM, 30108, Cayman Chemical), Cycloheximide (80 μg/mL ...
• G₄C₂ repeat RNA mediates the disassembly of the nuclear pore complex in C9orf72 ALS/FTD

  Alyssa N Coyne, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 1 μM SAG (Cayman Chemicals). Media was exchanged daily until day 12 ...
• C-Jun N-terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-mediated ALS and FTD

  TG Sahana, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 1 μM SAG (Cayman Chemicals) until Day 12 ...
• STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

  Aaron R. Cox, et al., bioRxiv - Immunology 2020

  Quote: ... 1 μM rosiglitazone (Cayman Chemical Co.), 1 μM dexamethasone (Sigma Chemical Co.) ...
• Functional delineation of tissue-resident CD8⁺ T cell heterogeneity during infection and cancer

  J. Justin Milner, et al., bioRxiv - Immunology 2020

  Quote: ... 1 mg tamoxifen (Cayman Chemical Company) emulsified in 100 μl of sunflower seed oil (Sigma-Aldrich ...
• ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

  Gang Du, et al., bioRxiv - Immunology 2023

  Quote: ... Torin-1 (Cayman Chemical Company, 10997) at 2 μM ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 1 μM epoxomicin (Cayman chemical). Samples were treated with 10 μM GI254023X (Cayman chemical) ...
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 1 mM NAD+ (Cayman Chemical, 16077), Triton X-100 ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... 1 µM E-64 (Cayman Chemical), 1 µM leupeptin (Cayman Chemical) ...
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  Monica M. Santisteban, et al., bioRxiv - Neuroscience 2023

  Quote: ... FTY720 (1 mg/kg; Cayman Chemical)24 was injected i.p ...
• Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

  Ling He, et al., bioRxiv - Neuroscience 2023

  Quote: ... temozolomide (1 mM; #14163, Cayman Chemical) or Vincristine (250 nM ...
• AMPK activation induces RALDH^high tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

  E. C. Brombacher, et al., bioRxiv - Immunology 2023

  Quote: ... 1 µM oligomycin (11342, Cayman Chemical), 3 µM fluoro-carbonyl cyanide phenylhydrazone (FCCP ...
• Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

  Blake A. Caldwell, Yajun Wu, Jing Wang, Liwu Li, bioRxiv - Immunology 2023

  Quote: ... and Wnt agonist 1 (Cayman Chemical) experiments ...
• Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

  Patricia Aguilar-Calvo, et al., bioRxiv - Pathology 2023

  Quote: ... and PrP (Cayman Chemical; 1:1200) immunohistochemistry were performed on an automated tissue immunostainer (Ventana Discovery Ultra ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM methoxy-XO4 (Cayman Chemical) in 40% EtOH ...
• Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

  Corey D. Holman, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM rosiglitazone (Cayman Chemical, 11884), 1 nM T3 (Sigma ...
• SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

  Haowen Qiao, et al., bioRxiv - Neuroscience 2024

  Quote: ... COX2 (1:200; Cayman Chemical: 160126); CD31(1:800 ...