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51 - 100 of 439 citations for 2 Triisopropylsilyl Oxazole 5 Carbaldehyde since 2020

• Hidden route of protein damage through confined oxygen gas

  Seoyoon Kim, et al., bioRxiv - Biochemistry 2024

  Quote: ... 5 μM HPF (Cayman Chemical, 10159) was dissolved in each buffer solution ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 5 μM ionomycin (Cayman chemical). HUVECs were exposed to 500 μM H2O2 (Sigma-Aldrich ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ICG-001 (Cayman Chemical #16257-5), Nutlin-3a (Cayman Chemical #10004372).
• Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

  Luisa Saecker, Hanns Häberlein, Sebastian Franken, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... capadenoson (Cayman Chemicals, 544417-40-5), isopenaline hydrochloride (Iso ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... LCL-161 (5 μM, Cayman chemical), Thapsigargian (1 μM ...
• Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity

  Michael J. McFadden, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Thioflavin T (Cayman Chemical, 5 µM) was added 2 hours prior to endpoint ...
• Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation

  Magdalena A. Sutcliffe, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM Tranylcypromine (Cayman Chemicals 10010494), 50 nM DZNep (Apexbio A8182) ...
• Cannabinoids Activate the Insulin Pathway to Modulate Mobilization of Cholesterol in C. elegans

  Bruno Hernandez-Cravero, et al., bioRxiv - Neuroscience 2022

  Quote: 2-AG and 2-AGE were purchased from Cayman Chemical (Ann Arbor, Michigan, USA) and stock solutions are in acetonitrile at 1 mg/ml and are stored at -80 ºC ...
• Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

  Yoshimi Nakagawa, et al., bioRxiv - Physiology 2020

  Quote: ... SREBP-2 (10007663; Cayman Chemical), α-Tubulin (05-829 ...
• Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs

  Matthew J. Keuss, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 μM XAV939 (Cayman Chemical), 10 μM SB431542 (Cayman Chemical ...
• Cholesterol accumulation-induced impairment of AKT signaling in LPS-stimulated macrophages play a dispensable role in suppressing HIF-1α-dependent glycolysis

  Kenneth K.Y. Ting, Myron I. Cybulsky, bioRxiv - Immunology 2024

  Quote: ... 2-NBDG (Cayman Chemicals #11046) (100 μg/mL ...
• Gz Enhanced Signal Transduction assaY (G_ZESTY) for GPCR deorphanization

  Luca Franchini, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... 2-arachidonoyl glycerol (Cayman Chemicals), N-Formyl-Met-Leu-Phe (R&D systems) ...
• The role of the cannabinoid system in fear memory and extinction in male and female mice

  Ikumi Mizuno, et al., bioRxiv - Neuroscience 2021

  Quote: ... SR141716 (1, 5 mg/kg) (Cayman Chemicals) was dissolved in saline with 5% DMSO and 0.1% Tween 20 ...
• Structure and Mechanism of Hedgehog Acyl Transferase

  Claire E. Coupland, et al., bioRxiv - Biophysics 2021

  Quote: ... and 5 mM valproic acid (Cayman Chemical). For biotinylated proteins ...
• Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

  Kazuki Hattori, et al., bioRxiv - Bioengineering 2022

  Quote: 5 μM manumycin A (#10010497, Cayman Chemical) was used as a pretreatment for 1 hour (37 °C in culture medium) ...
• On the Origin of Ultraslow Spontaneous Na⁺ Fluctuations in Neurons of the Neonatal Forebrain

  Carlos Perez, et al., bioRxiv - Neuroscience 2020

  Quote: ... (2R)-amino-5-phosphonopentanoate) from Cayman Chemical
• Characterising replisome disassembly in human cells

  Rebecca M. Jones, et al., bioRxiv - Cell Biology 2022

  Quote: ... 5 µM Wee1i (MK-1775, Cayman Chemicals, 21266 ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM BMS-5 (Cayman Chemical, #21072) or 2 μM ML-7 (Cayman Chemical ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 50% 5 μM methoxy-XO4 (Cayman Chemical) in 50% EtOH for 2 minutes ...
• Ca²⁺-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress

  Wei Chen, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 μM Ionomycin (No. 10004974, Cayman Chemical); 250 μM CPZ (No ...
• The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS^hiGITR^hi Blimp-1⁺ effector regulatory T cells in breast tumors

  Marie Boutet, et al., bioRxiv - Immunology 2024

  Quote: ... 5 μM Y-27632 (Cayman Chemical, #10005583) and 5% Matrigel (Corning ...
• Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

  Melanie Wallace, et al., bioRxiv - Cell Biology 2023

  Quote: ... IWR-1 (5 µM, #13659, Cayman Chemical) in B27-INS was added at D3 and changed to fresh B27-INS at D5 ...
• Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

  Katjana Schwab, et al., bioRxiv - Genomics 2022

  Quote: ... 5-FU (25 μg/ml, Cayman Chemicals), or Doxorubicin (0.2 µg/ml ...
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 5 µM SU5402 (Cayman Chemical, #13182). Starting at d28 ...
• Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

  Margaret S. Collins, et al., bioRxiv - Cell Biology 2023

  Quote: ... NEI (CAS#1448314-31-5, Cayman Chemical), SIV (CAS# 201677-61-4 ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 μM CB-839 (22038, Cayman Chemical), 300 μM BSO (14484 ...
• PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

  David J. Sherman, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 µM Triacsin C (Cayman Chemical, #10007448) dissolved in dimethyl sulfoxide (DMSO ...
• Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

  Deborah Y. Moss, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Metformin (Cayman Chemicals, #13118, 3-5 mM), IACS-10759 (Selleckchem ...
• Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

  Yi-Hsuan Wu, et al., bioRxiv - Microbiology 2020

  Quote: TEPP-46 (ML-265) and 2-deoxy-D-Glucose (2-DG) were ordered from Cayman Chemical. DASA-58 was purchased from SelleckChem ...
• LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

  Ahmed M. Fahmy, et al., bioRxiv - Immunology 2023

  Quote: ... 2’’3’’-cGAMP ELISA was done using the 2’’3’’-cGAMP ELISA Kit (Cayman Chemical Co.) according to the manufacturer’s instructions.
• Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

  Andrew M. Tidball, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2 µM XAV939 (Cayman Chemical, 13596), and 10 µM SB431542 (Cayman Chemical ...
• Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

  Kota Nagasaka, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 mM Trolox (Cayman Chemical; 10011659)) and 5 mM ATP (Jena Biosciences ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis

  Bongsoo Park, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM) (Cayman Chemical), and hLIF (10 ng/ml ...
• A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

  Taylor N. Takla, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2 µM XAV939 (Cayman Chemical, 13596), and 10 µM SB431542 (Cayman Chemical ...
• Sex-Specific Cardiovascular Adaptations to Simulated Microgravity in Sprague-Dawley Rats

  Ebrahim Elsangeedy, et al., bioRxiv - Physiology 2024

  Quote: ... rabbit anti-cyclooxygenase-2 (COX-2, 1:200 dilution; Cayman Chemicals, Ann Arbor, MI, USA; Cat#: 160126), mouse anti-endothelial nitric oxide synthase (eNOS ...
• The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

  David Z. Kochan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 5-FOA was bought from Cayman Chemical (17318). Ampure XP beads were from Beckman Coulter (A63881) ...
• De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

  Thomas Laval, et al., bioRxiv - Immunology 2021

  Quote: ... LTB4-d4 and 5-HETE-d8 (Cayman Chemicals), and centrifuged at 5000rpm for 15min at 4°C ...
• Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward Discovery of Biased D1 Agonists

  Haoxi Li, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... coelenterazine h (Cayman Chemicals, 5 μM final concentration), was added per well ...
• Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2

  Julia S.P. Mawer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 5-FOA was bought from Cayman Chemicals (17318). Protein-G coupled Dynabeads™ (10004D ...
• Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

  Tomasz H. Benedyk, et al., bioRxiv - Microbiology 2022

  Quote: ... supplemented with 5 μM clickable sphingosine (Cayman Chemical) for 5 min (pulse) ...
• Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

  Alissandra L. Hillis, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or 5 µg/mL GGPP (Cayman Chemicals, 63330). At the endpoint ...
• An expanded 2-pyridinecarboxaldehyde (2PCA)-based chemoproteomics toolbox for probing protease specificity

  Haley N. Bridge, Clara L. Frazier, Amy M. Weeks, bioRxiv - Biochemistry 2023

  Quote: ... Biotin azide (5) was purchased from Cayman Chemical. Azide-SS-biotin (6 ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 1 or 5 µM 7-HDHA (Cayman Chemical), 1 or 10 nM Leukotriene B4 (Cayman Chemical ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 1 or 5 µM 17-HDHA (Cayman Chemical), 3 ...
• Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

  Niklas J. Lang, et al., bioRxiv - Cell Biology 2023

  Quote: ... and lysophosphatidic acid (LPA) (5 µM, Cayman chemical) as described before20 ...
• SARS-CoV-2 Envelope-mediated Golgi pH dysregulation interferes with ERAAP retention in cells

  Valerie Vargas-Zapata, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 10 uM nigericin (Cayman Chemical, 11437-5). Cells co-transfected with pHluorin and viral proteins were resuspended in Na-Ringer buffer ...
• Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability

  Adam J. Sugarman, et al., bioRxiv - Cancer Biology 2023

  Quote: ... folic acid and 5-methyl-THF (Cayman Chemical).