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501 - 550 of 936 citations for 7 bromo 1 methyl 1 3 dihydro 2H benzo d imidazol 2 one since 2020

• Distinct roles of general anesthesia activated CeA neurons in acute versus late phase of neuropathic pain

  Junli Zhao, et al., bioRxiv - Neuroscience 2024

  Quote: ... CNO (3 mg/kg, i.p, Item No. 25780, Cayman Chemical) was injected 30 min before doing behavioral experiments and data were collected between 1-6 hours post-injection.
• Sensing endogenous RNA in living human cells using a CRISPR-activated protease

  Katja Blumenstock, et al., bioRxiv - Bioengineering 2024

  Quote: ... cells were selected with 3 μg/ml Puromycin (Cayman Chemicals). Cells were split 1:3 when reaching confluency ...
• Sex-specific differences in rotarod performance and type 1 cannabinoid receptor levels in a rat model of traumatic brain injury treated with Δ⁹-tetrahydrocannabinol

  Tallan Black, et al., bioRxiv - Neuroscience 2022

  Quote: ... for 1 h before being incubated overnight at 4°C with primary antibodies directed against the N-terminal extracellular region of the CB1R (1:500, rabbit polyclonal antibody, Cayman Chemical Company, Cat# 101500, Lot# 0580081-1) and βactin (1:10,000 ...
• N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication

  Kim M. Stegmann, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Cells were treated with β-D-N4-Hydroxycytidine (NHC/EIDD-1931, Cayman Chemical 9002958), IMU-838 (Immunic Therapeutics) ...
• Functional domain studies uncover novel roles for the ZTL Kelch repeat domain in clock function

  Ann M. Feke, Joshua M. Gendron, bioRxiv - Plant Biology 2020

  Quote: ... then treated with 5 mM D-luciferin (Cayman Chemical Company, cat# 115144-35-9) dissolved in 0.01% TritonX-100 ...
• Single molecule imaging of the central dogma reveals myosin-2A gene expression is regulated by contextual translational buffering

  O’Neil Wiggan, Timothy J. Stasevich, bioRxiv - Cell Biology 2024

  Quote: ... Cells for MKL nuclear-cytoplasmic assessment were treated with 2μM cytochalasin D (Cayman Chemical), 1μM Jasplakinolide (Cayman Chemical ...
• PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

  Brandon T Paradoski, et al., bioRxiv - Immunology 2024

  Quote: ... with fresh stimulation cocktail and fully labelled D-(+)-Glucose-13C6 (Cayman Chemical Company #26707) at a final concentration of 11.1mM ...
• Nanoparticle Cellular Internalization is Not Required for RNA Delivery to Mature Plant Leaves

  Huan Zhang, et al., bioRxiv - Bioengineering 2021

  Quote: ... Wortmannin (19545-26-7, 1mg) was purchased from FisherScientific, and ikarugamycin (36531-78-9, 500 μg) was purchased from Cayman Chemicals. SYBR Gold was purchased from Thermo Fisher ...
• Sleep pressure accumulates in a voltage-gated lipid peroxidation memory

  H. Olof Rorsman, et al., bioRxiv - Neuroscience 2024

  Quote: ... Standards were prepared by applying 5 µl-droplets of a 10-fold dilution series of 4-ONE (Cayman Chemical) in methyl acetate ...
• Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

  Dasmanthie De Silva, et al., bioRxiv - Molecular Biology 2021

  Quote: ... cells were incubated with AKT inhibitor AZD5363 at 1 μM (Cayman Chemical), mTOR inhibitor Torin1 250 nM (Cayman Chemical ...
• Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

  Yao-Chang Tsan, et al., bioRxiv - Cell Biology 2021

  Quote: ... and we additionally included retinol inhibitor (BMS 453, Cayman Chemical, 1 µM) for days 3-6 to minimize atrial lineage differentiation.35 hPSC-CMs were maintained in CDM3 until purification by metabolic selection in CDM3-lactate using glucose-deprived ...
• 2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

  Amanda Morgan, et al., bioRxiv - Neuroscience 2022

  Quote: The MAGL inhibitor JZL184 (10 mg/kg-1, Cayman Chemical, MI, USA), CB1R inverse agonist Rimonabant (3 mg kg-1 APIChem ...
• Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

  Amanda R. Dicks, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 1 µM ML329 (cat. num. 22481; Cayman Chemical, Ann Arbor, MI) at 5 x 105 cells/mL ...
• Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

  Lucas J. D’Souza, et al., bioRxiv - Immunology 2021

  Quote: ... 1×106 5TGM1 cells were cultured with 20μg/mL 2NBDG (Cayman Chemical) in complete media for 1 hour at 37°C followed by antibody staining ...
• Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons

  Breanna Q. Shen, et al., bioRxiv - Neuroscience 2022

  Quote: ... The DP1 antibody (101640, dilution 1:200) was obtained from Cayman Chemicals and the SOX10 antibody (ab216020 ...
• LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

  N Cobo-Vuilleumier, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Prostaglandin E2 (PGE2, 1 μM, Cayman Chemical, Ann Arbor, MI, USA) to obtain mature DCs (mDCs) ...
• RudLOV—a new optically synchronized cargo transport method reveals unexpected effect of dynasore

  Tatsuya Tago, et al., bioRxiv - Cell Biology 2023

  Quote: ... After 1 h of incubation with 100 μM of dynasore (Cayman Chemical), the cells were fixed in 0.1 M cacodylate buffer (pH 7.4 ...
• Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

  Nicole M. Marsh, et al., bioRxiv - Cell Biology 2024

  Quote: ... before and after injection of 1 μM CCCP (Cayman Chemical Company, 25458) in KCl buffer ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1 µL 30 mM aldehyde reactive probe (Cayman Chemicals, ARP/aminooxy biotin) is added first ...
• A two-dose regimen of Qβ virus-like particle-based vaccines elicit protective antibodies against heroin and fentanyl

  Isabella G. Romano, et al., bioRxiv - Immunology 2024

  Quote: ... Morphine and 4ANPP (4-Aminophenyl-1-phenethylpiperidine) were purchased from Cayman Chemical Company Inc ...
• Nascent transcript O-MAP reveals the molecular architecture of a single-locus subnuclear compartment built by RBM20 and the TTN RNA

  Evan E. Kania, et al., bioRxiv - Genomics 2024

  Quote: ... Cells were then treated with 1 μM CHIR-99021 (Cayman Chemical; 13122). On day 0 ...
• Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems

  Rupsa Datta, et al., bioRxiv - Immunology 2024

  Quote: ... the zebrafish larvae were preincubated with 1 mM 6-AN (Cayman Chemicals) for 1 hour before adding PMA.
• Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

  Yun Qiu, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and STY-BODIPY were from Cayman Chemical Company (Ann Arbour ...
• CD300e as a Driver of Immunosuppressive Tumor Microenvironment in Colorectal Cancer

  Annica Barizza, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 1 mM N-acetyl-L-cysteine (Cayman Chemical, Ann Arbor, Michigan, USA), 50 ng/mL EGF (Corning) ...
• Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio

  Katherine R. Ferrick, et al., bioRxiv - Cell Biology 2024

  Quote: ... 100 nM Torin2 (Cayman Chemical Cat#14185, CAS#1223001-51-1, mTORi), 100 nM PD0325901 (Selleck Chemicals Cat#S1036 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 14(Z)-eicosenoic acid (cis-14-C20:1, Cayman Chemical, Cat# 10009375), cis-vaccenic acid (cis-11-C18:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10(Z)-pentadecenoic acid (cis-10-C15:1, Cayman Chemical, Cat# 22362), 10(E)-pentadecenoic acid (trans-10-C15:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and trans-vaccenic acid (trans-11-C18:1, Cayman Chemical, Cat# 15301).
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10(E)-pentadecenoic acid (trans-10-C15:1, Cayman Chemical, Cat# 22467), cis-11-eicosenoic acid/11(Z ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-6-hexadecenoic acid (cis-6-C16:1, Cayman Chemical, Cat# 9001845), cis-7-hexadecenoic acid (cis-7-C16:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-10-heptadecenoic acid (cis-10-C17:1, Cayman Chemical, Cat# 19748), trans-10-heptadecenoic acid (trans-10-C17:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-8-octadecenoic acid (cis-8-C18:1, Cayman Chemical, Cat# 27447), cis-10-heptadecenoic acid (cis-10-C17:1 ...
• Extensive N4 Cytosine Methylation is Essential for Marchantia Sperm Function

  James Walker, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 5-Me-2’-deoxycytidine (Cayman chemicals), 2’-Deoxy-N4-methylcytidine (CarboSynth) ...
• Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

  Andrew M. Tidball, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2 µM XAV939 (Cayman Chemical, 13596), and 10 µM SB431542 (Cayman Chemical ...
• Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

  Kota Nagasaka, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 mM Trolox (Cayman Chemical; 10011659)) and 5 mM ATP (Jena Biosciences ...
• Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis

  Bongsoo Park, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM) (Cayman Chemical), and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

  Taylor N. Takla, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2 µM XAV939 (Cayman Chemical, 13596), and 10 µM SB431542 (Cayman Chemical ...
• Imaging translational control by Argonaute with single-molecule resolution in live cells

  Charlotte A. Cialek, et al., bioRxiv - Molecular Biology 2021

  Quote: ... cells were treated with 3 μg/mL of Harringtonine (Cayman Chemical) to inhibit translation initiation (Huang ...
• Paraoxonase and acylated homoserine lactones in urine from patients with urinary tract infections-- relationship to microbial diversity by 16S rRNA gene sequencing

  John Lafleur, et al., bioRxiv - Microbiology 2021

  Quote: 3-oxo-C12-HSL stock solution 20 mg/ml (Cayman Chemicals) was diluted to 4 micrograms/milliliter in water ...
• Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

  Soham Chakraborty, et al., bioRxiv - Biophysics 2022

  Quote: ... Drugs were commercially purchased: cyanidin 3-O-glucoside (1151935, Cayman chemicals); letrozole (L6545 ...
• An Investigation of the Mechanism for a Novel Influenza Inhibitor Designed to Target the Import of PB1

  Alexander Dorius, David D. Busath, bioRxiv - Microbiology 2021

  Quote: ... treated with 3 µM VNXR (Cayman Chemical Company, Ann Arbor, MI) or 30 µM GM30 (a gift from Dr ...
• Robust bidirectional communication between electronics and an engineered multi-functional microbial community

  Jessica L. Terrell, et al., bioRxiv - Synthetic Biology 2020

  Quote: ... N-3-oxo-dodecanoyl-L-Homoserine lactone (AHL) from Cayman Chemicals. Various biological fixatives included formaldehyde (ThermoFisher Scientific ...
• A method to determine the double bond position in unsaturated fatty acids by solvent plasmatization using liquid chromatography-mass spectrometry

  Shigeo Takashima, et al., bioRxiv - Biochemistry 2020

  Quote: ... 17-eicosapentaenoic acid (20:5 ω-3, EPA; Cayman Chemical, #90110.1), all cis-5 ...
• Coupling of translation quality control and mRNA targeting to stress granules

  Stephanie L. Moon, et al., bioRxiv - Molecular Biology 2020

  Quote: ... and 15 minutes later harringtonine (3 µg/mL, Cayman Chemical Company) was added ...
• A single-dose intramuscular immunization of pigs with lipid-nanoparticle DNA vaccines based on the hemagglutinin antigen confers complete protection against challenge infection with the homologous influenza virus strain

  The Nhu Nguyen, et al., bioRxiv - Microbiology 2023

  Quote: ... 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) (Cayman Chemical, Ann Arbor, MI), Cholesterol (Sigma Aldrich) ...
• Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3

  Maxinne Watchon, et al., bioRxiv - Neuroscience 2023

  Quote: ... cells were treated with SB (3 mM, Cayman Chemicals [Cat #13121]) or vehicle control (autoclaved water ...
• Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

  Zehua Sun, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and 3 equivalents of CL2A-SN-38 (Cayman Chemical CAT#33941) were added and incubated overnight at 4°C ...