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451 - 500 of 833 citations for 5 Nitro 1H benzo de isoquinoline 1 3 2H dione since 2020

• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 1 μM epoxomicin (Cayman chemical). Samples were treated with 10 μM GI254023X (Cayman chemical) ...
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 1 mM NAD+ (Cayman Chemical, 16077), Triton X-100 ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... 1 µM E-64 (Cayman Chemical), 1 µM leupeptin (Cayman Chemical) ...
• Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

  Monica M. Santisteban, et al., bioRxiv - Neuroscience 2023

  Quote: ... FTY720 (1 mg/kg; Cayman Chemical)24 was injected i.p ...
• Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

  Ling He, et al., bioRxiv - Neuroscience 2023

  Quote: ... temozolomide (1 mM; #14163, Cayman Chemical) or Vincristine (250 nM ...
• AMPK activation induces RALDH^high tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

  E. C. Brombacher, et al., bioRxiv - Immunology 2023

  Quote: ... 1 µM oligomycin (11342, Cayman Chemical), 3 µM fluoro-carbonyl cyanide phenylhydrazone (FCCP ...
• Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

  Blake A. Caldwell, Yajun Wu, Jing Wang, Liwu Li, bioRxiv - Immunology 2023

  Quote: ... and Wnt agonist 1 (Cayman Chemical) experiments ...
• Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

  Patricia Aguilar-Calvo, et al., bioRxiv - Pathology 2023

  Quote: ... and PrP (Cayman Chemical; 1:1200) immunohistochemistry were performed on an automated tissue immunostainer (Ventana Discovery Ultra ...
• INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s disease

  EL Castranio, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM methoxy-XO4 (Cayman Chemical) in 40% EtOH ...
• Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

  Corey D. Holman, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM rosiglitazone (Cayman Chemical, 11884), 1 nM T3 (Sigma ...
• SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

  Haowen Qiao, et al., bioRxiv - Neuroscience 2024

  Quote: ... COX2 (1:200; Cayman Chemical: 160126); CD31(1:800 ...
• AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

  Connor J. Maltby, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 1 μM dorsomorphin (Cayman Chemical). At day 10-12 ...
• OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

  Styliani Panagiotou, et al., bioRxiv - Cell Biology 2023

  Quote: ... OSW-1 was from Cayman Chemical. Cal-590-AM and Cal520-AM were from AAT Bioquest ...
• QUAS-R: Glutamine (Q) Uptake Assay with Single cell Resolution reveals metabolic heterogeneity with immune populations

  Leonard Pelgrom, et al., bioRxiv - Immunology 2022

  Quote: ... 1 part of aminoguanidine (Cayman Chemicals, #81530 ...
• Fluctuation of lysosomal protein degradation in neural stem cells of postnatal mouse brain

  He Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... 100 nM Trin 1 (Cayman Chemical), and 10 μg/ml cycloheximide (Sigma) ...
• The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

  Ling Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... sGCβ1 (1:2,000, Cayman Chemicals,160897), AR (1:8,000 ...
• LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

  Jin Li, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 μg/mL tunicamycin (Cayman Chemical), or 5 mM N-acetylcysteine (NAC ...
• Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

  Matthew Sonnett, et al., bioRxiv - Immunology 2024

  Quote: ... Necrostatin-1 (30 μM, Cayman chemical), anti-CD95 agonist antibody (1 μg/ml ...
• Apical Size Reduction by Macropinocytosis Alleviates Tissue Crowding

  Enzo Bresteau, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 mM Amiloride (#14409, Cayman Chemical), 2 μM LY294002 (#HY-10108 ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM A83-01 (Cayman Chemical), 0.1 μM LDN193189 (LDN ...
• The molecular chronology of mammary epithelial cell fate switching

  Queralt Vallmajo-Martin, et al., bioRxiv - Cell Biology 2024

  Quote: ... SB202190 (1 μM, Cayman Chemical, 10010399), FGF-7 (5 ng/ml ...
• Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation

  Nathaniel J. Hogrebe, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 µM nocodazole (13857, Cayman Chemical), 0.3 µM S1P (62570 ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 1 μM XAV939 (Cayman Chemical). The organoids were then cultured to day 14 for analysis.
• Expression of the type III secretion system genes in epiphytic Erwinia amylovora cells on apple stigmas benefits endophytic infection at the hypanthium

  Zhouqi Cui, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Suspensions were centrifuge at 3,000 g for 5 min and the cAMP levels in supernatants were measured using the cAMP EIA Kit (Cayman Chemical, Ann Arbor, MI, US) according to the manufacturer’s instructions ...
• Ventral tegmental area glutamate neurons mediate the nonassociative consequences of traumatic stress

  Dillon J. McGovern, et al., bioRxiv - Neuroscience 2021

  Quote: ... Baseline firing in response to current injections was collected for 5 min followed by a 10 min bath application of 10 μM clozapine (Cayman Chemical, Ann Arbor, MI). The average number of action potentials generated during five consecutive sweeps was used to quantify baseline activity and the aver-age of five consecutive sweeps during clozapine application was used to quantify firing during hM4Di receptor activation ...
• Partitioning of ribonucleoprotein complexes from the cellular actin cortex

  Isaac Angert, et al., bioRxiv - Biophysics 2022

  Quote: ... were induced along the PM of cultured HeLa cells by adding 10-15% ethanol (25) or 5 µM cytochalasin D (Cayman Chemical, Ann Arbor, MI) to the cell growth medium and incubating for ∼15 min at 37°C and 5% CO2 ...
• Minimal genetically encoded tags for fluorescent protein labeling in living neurons

  Aleksandra Arsić, et al., bioRxiv - Neuroscience 2021

  Quote: ... neurons were washed for 3 h and incubated for 30 min (37 °C, 5% CO2) with either 25 µM spermine-NONOate (a nitric oxide donor; Cayman Chemical, cat. no. 82150) or 25 µM sulpho-NONOate (control compound ...
• A neural mechanism for discriminating social threat from social safety

  Pegah Kassraian, et al., bioRxiv - Neuroscience 2023

  Quote: ... Mice were then injected 30 minutes prior to behavioral experiments intraperitoneally with 5 mg/kg of the iDREADD agonist clozapine-n-oxide (CNO; Cayman Chemical, #34233-69-7) and returned to their homecage until behavioral testing ...
• Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel

  Anna K Greda, et al., bioRxiv - Neuroscience 2024

  Quote: ... C18:2-d4, C20:4-d11, C20:5-d5, C22:0-d43, C22:6-d5, C24:0-d4; 10 ng each; Cayman Chemical, Ann Arbor MI). HPLC measurements were performed using an Agilent 1290 HPLC system with binary pump ...
• LPA₃: Pharmacodynamic differences between lysophosphatidic acid and oleoyl-methoxy glycerophosphothionate. Biased agonism, two sites

  K. Helivier Solís, et al., bioRxiv - Biochemistry 2024

  Quote: 1-Oleyl lysophosphatidic acid (LPA) and 2S-(1-oleoyl-2-O-methyl-glycerophosphothionate) (OMPT) were from Cayman Chemical Co ...
• Developmental cell fate choice employs two distinct cis regulatory strategies

  M. Joaquina Delás, et al., bioRxiv - Developmental Biology 2022

  Quote: ... The media was supplemented on the different days as follows: Day 0 to Day 2, 10ng/ml bFGF (R&D, Cat. No. 100-18B) and 5 µM LGK (Cayman Chemical Company, Cat. No. 1.800.364.9897); Day 2 to Day 3 for 20 h ...
• Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

  Sarah E Dremel, et al., bioRxiv - Microbiology 2023

  Quote: ... for 12 hours at 37°C/5% CO2 in the presence of vehicle (DMSO) or 2 μM JQ1+ to enhance reactivation (Cayman Chemical CAS: 1268524-70-4). Pools of 6 ganglia were homogenized in 1 ml TriPure isolation reagent (Roche ...
• The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

  Kiara Freitag, et al., bioRxiv - Neuroscience 2021

  Quote: A® 1-42 peptides (Cayman Chemicals) were resuspended in hexafluoroisopropanol to obtain 1 mM solution ...
• Synaptic RTP801 Contributes to Motor Learning Dysfunction in Huntington’s Disease

  Núria Martín-Flores, et al., bioRxiv - Neuroscience 2020

  Quote: ... PHLPP1 rabbit polyclonal (1:500, Cayman Chemical), PSD-95 mouse monoclonal (1:1000 ...
• Unique features of magic spot metabolism in Clostridioides difficile

  Asia Poudel, et al., bioRxiv - Microbiology 2021

  Quote: ... 0.67 µg mL−1 fidaxomicin (Cayman Chemical), 1.0 mM diamide (MP Biomedicals) ...
• SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation

  Julia Ghelman, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1 µM SAG (#11914, Cayman Chemical Company), 200 µM L-ascorbic acid (#A4544 ...
• Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

  Elien Grajchen, et al., bioRxiv - Immunology 2022

  Quote: ... SCD1 inhibitor (CAY10566, 1 µM; Cayman Chemicals), ATGL inhibitor (Atglistatin ...
• Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

  J. Justin Milner, et al., bioRxiv - Immunology 2020

  Quote: ... 1 mg of tamoxifen (Cayman Chemical Company) was emulsified in 100 μl of sunflower seed oil (Sigma-Aldrich ...
• mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis

  Bryce W.Q. Tan, et al., bioRxiv - Cell Biology 2020

  Quote: ... Torin-1 (500nM or 1µM, Cayman Chemicals), wortmannin (200nM ...
• The lysine-rich intracellular loop and cell type-specific co-factors are required for IFITM3 antiviral immunity in hematopoietic stem cells

  G. Unali, et al., bioRxiv - Microbiology 2021

  Quote: ... GSK-LSD1 and Spautin-1 (Cayman Chemicals), were resuspended and stored following the manufacturer’s instructions ...
• MISTR: A conserved MItochondrial STress Response network revealed by signatures of evolutionary conflict

  Mahsa Sorouri, et al., bioRxiv - Genetics 2020

  Quote: ... Actinomycin D [1 μg/mL (Cayman Chemical)] ...
• An active traveling wave of Eda/NF-kB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish

  Maya N. Evanitsky, Stefano Di Talia, bioRxiv - Developmental Biology 2023

  Quote: ... IWR-1-endo (Cayman Chemical Company 13659) broadly inhibits Wnt signaling through Axin stabilization ...
• Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes

  A.T. Nelson, et al., bioRxiv - Neuroscience 2023

  Quote: ... and antimycin (1 μM) (all Cayman Chemical). Immediately after the assay ...
• Single-cell sequencing of individual retinal organoids reveals determinants of cell fate heterogeneity

  Amy Tresenrider, et al., bioRxiv - Genomics 2023

  Quote: ... SU5402 (1 uM, Cayman Chemical Co, 13182), and/or SAG (1 uM ...
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... PAPA-NONOate (1 mM) (Cayman Chemical, 82410), with indicated combinations of CoA (100 µM ...
• Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

  Alissandra L. Hillis, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and 1 μM AZD5363 (Cayman Chemicals, 15406) and/or 5 μM pitavastatin (Selleckchem ...
• Maresin 1 Repletion Improves Muscle Regeneration After Volumetric Muscle Loss

  Jesus A. Castor-Macias, et al., bioRxiv - Physiology 2022

  Quote: Maresin 1 (Cayman Chemicals #1268720-28-0) was aliquoted (500 ng per vial ...
• OSBP is a major determinant of Golgi phosphatidylinositol 4-phosphate homeostasis

  Colleen P. Doyle, et al., bioRxiv - Cell Biology 2024

  Quote: ... 20 nM OSW-1 (Cayman Chemical 30310), rCD1 (SiChem SC-7000 ...
• Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem Cells

  Dolunay Kelle, et al., bioRxiv - Developmental Biology 2024

  Quote: ... respectively: Oligomycin at 1 µM (Cayman Chemical) which inhibits the ATP synthase ...
• Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted

  Miguel Reina-Campos, et al., bioRxiv - Immunology 2024

  Quote: ... 1 mg of tamoxifen (Cayman Chemical Company) emulsified in 100 μl of sunflower seed oil (Sigma-Aldrich ...