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401 - 450 of 7045 citations for 6 Chlorotetrazolo 1 5 b pyridazine since 2019

• Mapping the T cell repertoire to a complex gut bacterial community

  Kazuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... CD4 (RM4-5, BioLegend), CD3e (145-2C11 ...
• Disruption of Z-RNA–binding of ADAR1 induces Aicardi-Goutières syndrome–like encephalopathy in mice

  Taisuke Nakahama, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 (RM4-5; BioLegend), CD8 (53-6.7 ...
• Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection

  Dan Corral, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (RM4-5, Biolegend), CD8a (53-6.7 ...
• 12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

  Abhishek Kulkarni, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (RM4-5, Biolegend), CD80 (16-10A1 ...
• Phosphoproteomic analysis of the AKT signalling axis in cutaneous squamous carcinoma progression reveals novel therapeutic targets

  R Button, C Harwood, RFL O’Shaughnessy, bioRxiv - Cancer Biology 2022

  Quote: ... Keratin 5 (BioLegend Poly19055) (1:1,000 WB) ...
• IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling

  Holly Bachus, et al., bioRxiv - Immunology 2022

  Quote: ... IL-5 (TRFK5; BioLegend), IL-4 (11B11 ...
• Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules

  Pierre-Michaël Coly, et al., bioRxiv - Cell Biology 2023

  Quote: ... α5 integrin (Biolegend, 921704), α6 integrin (Biolegend ...
• CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

  Amélien Sanlaville, et al., bioRxiv - Cancer Biology 2023

  Quote: ... CD4 (RM4-5; Biolegend), NKp46 (29A1.4 ...
• Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

  Jiang Li, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, Biolegend), CD206 (C068C2 ...
• Interferon-γ Elicits Pathological Hallmarks of ALS in Human Motor Neurons

  Changho Chun, et al., bioRxiv - Neuroscience 2023

  Quote: ... CD44 (C44Mab-5, BioLegend), and CD8 (SK1 ...
• Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

  Madeleine F. Jennewein, et al., bioRxiv - Immunology 2023

  Quote: ... IL-5 (BioLegend #504306), and IL-17a (BD Biosciences #560820) ...
• Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic Engineering

  Carsten T. Charlesworth, et al., bioRxiv - Synthetic Biology 2024

  Quote: ... CD4 (RM4-5; Biolegend), CD8 (54-6.7 ...
• A ketogenic diet reduces age-induced chronic neuroinflammation in mice

  Mitsunori Nomura, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, BioLegend), CD8 (53-6.7 ...
• Soquelitinib, A Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase (ITK), is Active in Several Murine Models of T Cell-Mediated Inflammatory Disease

  Lih-Yun Hsu, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, Biolegend), CD44 (IM7 ...
• Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons

  Vania Passos, et al., bioRxiv - Microbiology 2022

  Quote: ... To measure the cytokines/chemokines present in the SN we chose the LEGENDplex™ bead-based immunoassay and quantified the following cytokines/chemokines from the panels COVID-19 Cytokine Storm 1 (CCL2, CCL5, CXCL10, IFN-γ, IL-10, IL-6; Biolegend cat. No. 741088) and Human Neurodegeneration Biomarkers 1 (NFL ...
• The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

  Christiane Pleuger, et al., bioRxiv - Immunology 2022

  Quote: ... table 1) were diluted in blocking solution (F4/80 [Bio-Rad]: 10 µg/ml, Ly6G [abcam]: 1 µg/ml, MHC-II [BioLegend]: 5 µg/ml), CD163 [Invitrogen] ...
• Molecular programs of fibrotic change in aging human lung

  Jasmine Lee, et al., bioRxiv - Genomics 2021

  Quote: ... 5% normal goat serum in PBS for 1 hour and incubated at 4°C overnight with primary antibody (Biolegend, cat. 613402, dilution 1:500), then at room temperature for 3 hours with secondary antibody (Santa Cruz Biotechnology ...
• Autoimmunity increases susceptibility to and mortality from sepsis

  Isaac J. Jensen, et al., bioRxiv - Immunology 2021

  Quote: IL-6 and IL-10 ELISAs (ELISA MAX Deluxe Set, Biolegend) were performed according to the manufacturer’s instructions.
• Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells

  Kamala P. Sundararaj, et al., bioRxiv - Cell Biology 2020

  Quote: ... ELISAs were used to measure IL-6 (Biolegend, San Diego, CA), GM-CSF (R&D systems ...
• Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

  Nicholas J Maurice, et al., bioRxiv - Immunology 2021

  Quote: ... we used human RP10 media with combinations of rIL-6 (BioLegend), rIL-12 ...
• Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

  Hyon-Xhi Tan, et al., bioRxiv - Immunology 2020

  Quote: ... and stained intracellularly with anti-BCL-6 Alexa647 (IG191E/A8; Biolegend). Non-human primate LN suspensions and PBMC were stained with the same protocol ...
• High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients

  Xiang Song, et al., bioRxiv - Immunology 2020

  Quote: ... interleukin (IL)-6 (10 ng/mL, Biolegend, San Diego, CA, USA), IL-1β (10 ng/mL ...
• A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology

  Aditi Chandra, et al., bioRxiv - Genomics 2022

  Quote: ... and 20 ng/mL of recombinant IL-6 (BioLegend, Cat# 575702) and 1 μg/mL of soluble anti-CD28 for 6 days at 37°C ...
• Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

  Emanuele Lettera, et al., bioRxiv - Cell Biology 2023

  Quote: Mouse anti-human CD41/CD61-PC7 (Clone: A2A9/6; Biolegend, 359812), Verified Reactivity ...
• Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia

  J.R. Rivas, et al., bioRxiv - Immunology 2021

  Quote: ... Cell sorts were performed with MojoSort Mouse Pan B Isolation Kit II (BioLegend, San Diego, CA) for CD19+ cells and with Miltenyi’s magnetic-activated cell sorting (MACS ...
• The IgE production is initially induced in subcutaneous fat and depends on extrafollicular B cells

  Dmitrii Borisovich Chudakov, et al., bioRxiv - Immunology 2021

  Quote: ... To discriminate B-cell subpopulations antibodies were used as follows: CD5- BV510 (clone 53-7.3, BioLegend), CD1d-FITC (clone 1B1 ...
• B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation

  Iana Gadjalova, et al., bioRxiv - Immunology 2022

  Quote: ... in B cell medium in the presence or absence of 10 μg/ml anti-CD86 (BioLegend) or 1 μg/ml CD40L (Peprotech ...
• Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

  Francisco M. Barriga, et al., bioRxiv - Cancer Biology 2022

  Quote: ... B cell depletion was done by a monthly intravenous injection of anti-CD20 (Clone SA271G2, BioLegend), starting one week prior to orthotopic transplantation of cells.
• Single shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad and durable systemic and mucosal immune responses

  Nicholas You Zhi Cheang, et al., bioRxiv - Immunology 2023

  Quote: Antigen-specific B cell subsets were detected using biotinylated SARS-CoV-2 RBD protein (793906; Biolegend) in combination with streptavidin (SAv)-fluorophore conjugates as described [7] ...
• Dendritic Cells Overcome Cre/Lox Induced Gene Deficiency by Siphoning Material From Neighboring Cells Using Intracellular Monitoring—a Novel Mechanism of Antigen Acquisition

  Christopher H. Herbst, et al., bioRxiv - Immunology 2023

  Quote: BALB/c T and B cell purified by negative selection following the instruction provided by BioLegend and Stem Cells ...
• Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction

  Kyle Vaccaro, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Alexa Fluor 647-conjugated anti-HLA-A,B,C (MHC class I) clone W6/32 (BioLegend), APC-conjugated anti-PD-L1 clone 29E.2A3 (BioLegend) ...
• Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

  Suhas Sureshchandra, et al., bioRxiv - Immunology 2022

  Quote: ... 5×105-1×106 cells were stained with antibodies to CD45 (D058-1283, Biolegend, San Diego, CSA, USA), CD3 (clone SP34 ...
• Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification

  Verónica Delgado-Benito, et al., bioRxiv - Immunology 2020

  Quote: CH12 cells were stimulated to undergo CSR to IgA by treatment with 1-5 μg/mL αCD40 (BioLegend), 5 ng/ml TGFβ (R&D Systems ...
• Endothelial Caveolin-1 and CXCL10 promote transcellular migration of autoreactive T cells across the blood-brain barrier

  Troy N. Trevino, et al., bioRxiv - Immunology 2022

  Quote: ... were injected into the microfluidic circulation in HBSS with 1% FBS supplemented with 5 nM CXCL10 (Biolegend 573604) or vehicle (PBS) ...
• Reciprocal inflammatory signals establish profibrotic cross-feeding metabolism

  Preeti Yadav, et al., bioRxiv - Immunology 2023

  Quote: ... Single-cell suspensions were pre-stained with Fc blocker for 10 min in ice followed by staining at 1:300 with anti-CD64 (139304, PE anti-mouse CD64, clone:X54-5/7.1, BioLegend) and anti-Pdgfra (25-1401-82 ...
• Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

  Lochana M. Seenappa, et al., bioRxiv - Immunology 2022

  Quote: ... and further stained with anti-human Bcl-6 (PE, clone: 7D1, BioLegend) and anti-human Ki-67 (BV421 ...
• Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo

  Nicholas McCaul, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Il-6 and IL-1β levels were quantified by ELISA (Biolegend kits).
• IL-27R signaling serves as immunological checkpoint for NK cells to promote hepatocellular carcinoma

  Turan Aghayev, et al., bioRxiv - Immunology 2020

  Quote: ... H-2Kb/H-2Db-APC/Fire 750 (28-8-6; BioLegend, 114617), Streptavidin-APC/Cy7 (BioLegend ...
• Tumor-educated Gr1⁺CD11b⁺ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

  Sanam Peyvandi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... recombinant mouse Oncostatin M and IL-6 (Biolegend, Cat #: 762802 & 575702 respectively).
• Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

  Jessica Brown, et al., bioRxiv - Neuroscience 2023

  Quote: ... Four μg of Tau12 (N-terminal [epitope = amino acids 6-18], BioLegend), HT7 (mid-region [epitope = amino acids 159-163] ...
• Setdb1-loss induces type-I interferons and immune clearance of melanoma

  Meaghan K. McGeary, et al., bioRxiv - Cancer Biology 2023

  Quote: ... stained with antibodies to MHC-I (H2dB/H2kB; 28-8-6; Biolegend) and/or ab573(Evans et al. ...
• Co-engagement of TIGIT⁺ immune cells to PD-L1⁺ tumours by a bispecific antibody potentiates T-cell response and tumour control

  Xiaopei Cui, et al., bioRxiv - Immunology 2023

  Quote: ... then washed 6 times followed by incubating with TMB substrate (Biolegend/421101) and stop solution ...
• Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit

  Nobuyuki Oguri, et al., bioRxiv - Pathology 2023

  Quote: ... and CD66b (mouse monoclonal, clone 6/40c; BioLegend, San Diego, CA, USA). Next ...
• Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1

  Emilie Doz-Deblauwe, et al., bioRxiv - Immunology 2023

  Quote: ... C57BL/6 mice received 200 μg anti-Ly6G antibody (clone 1A8, Biolegend) via the i.p ...
• Tissue environment, not ontogeny, defines intestinal intraepithelial T lymphocytes

  Alejandro Brenes, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 [clone RM4-5 (BioLegend)] ...
• A third vaccination with a single T cell epitope protects against SARS-CoV-2 infection in the absence of neutralizing antibodies

  Iris N. Pardieck, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (clone RM4-5, BioLegend), CD8 (clone 53-6.7 ...
• IL-27 receptor signaling regulated stress myelopoiesis drives Abdominal Aortic Aneurysm development

  Iulia Peshkova, et al., bioRxiv - Immunology 2019

  Quote: ... CD4-Cy5PE (RM4-5; Biolegend), CD8a-Cy5PE (53-6.7 ...
• Comprehensive proteomics analyses identify PIM kinases as key regulators of IL-15 driven activation of intestinal intraepithelial lymphocytes

  Olivia J. James, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 [clone RM4-5 (BioLegend)] ...
• Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery

  Manuel O. Jakob, et al., bioRxiv - Immunology 2019

  Quote: ... CD4-BV785 (RM4-5, Biolegend), CD62L BV510 (MEL-14) ...
• NLRP1B and NLRP3 control the host response following colonization with the commensal protist Tritrichomonas musculis

  Pailin Chiaranunt, et al., bioRxiv - Immunology 2021

  Quote: ... CD64 (X54-5/7.1; BioLegend), and MHCII (I-A/I-E ...