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401 - 450 of 9349 citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

  Jacob W. Freimer, et al., bioRxiv - Genomics 2021

  Quote: ... IL-2 (Biolegend, Cat #500310), or CTLA-4 (Biolegend ...
• Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

  Jacob W. Freimer, et al., bioRxiv - Genomics 2021

  Quote: ... IL-2 (Biolegend, Cat #500310), or CTLA-4 (Biolegend ...
• Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model

  Floriana Cremasco, et al., bioRxiv - Immunology 2020

  Quote: ... 2) huCD45 APC Cy7 (BioLegend), huCD3 PerCp-Cy5.5 (BioLegend) ...
• IL-4-induced hysteresis in naïve T cell activation

  Alexandre P. Meli, et al., bioRxiv - Immunology 2020

  Quote: ... CD138 (clone 281-2, Biolegend), B220 (clone RA3-6B2 ...
• The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

  Kanagaraju Ponnusamy, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CD138 (BioLegend; clone: 281-2) and analyzed for germinal center activated B cells (GCB) ...
• Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates

  Yong Bok Seo, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 PE (Biolegend 503808), CD4 PE-Cy7 (Biolegend 100528) ...
• Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates

  Yong Bok Seo, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 BV605 (Biolegend 500332), and Live/dead Near-IR (Invitrogen L10119) ...
• Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

  Lucas J. D’Souza, et al., bioRxiv - Immunology 2021

  Quote: ... or -BV510 (281-2, Biolegend) and B220-BV421 (RA3-6B2 ...
• The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

  Naomi M Fettig, et al., bioRxiv - Immunology 2022

  Quote: ... CD49d-FITC (R1-2, BioLegend), Tbet-APC (4B10 ...
• Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

  Jack Polmear, et al., bioRxiv - Immunology 2023

  Quote: ... and CD138 (281-2, BioLegend), while human cells were incubated with CD20 (2H7 ...
• Rationally designed modular STAT-activating scaffolds enforce cell-intrinsic transcriptional programs augmenting the anti-tumor potency of CAR T cells

  Christopher P Saxby, et al., bioRxiv - Bioengineering 2023

  Quote: ... IL-2 (BioLegend, Cat. # 500326), and Perforin (BioLegend ...
• Functional impairment of “helpless” CD8⁺ memory T cells is transient and driven by prolonged but finite cognate antigen presentation

  Verena van der Heide, et al., bioRxiv - Immunology 2024

  Quote: ... and monensin (2 µM; Biolegend). Phorbol 12-myristate13-acetate (PMA)/ionomycin-stimulated (Cell Activation cocktail ...
• Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

  Neuza Domingues, et al., bioRxiv - Pathology 2023

  Quote: ... CD206 (Biolegend; clone 15-2) and CD163 (Biolegend ...
• Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis

  Yiwei Ai, et al., bioRxiv - Cell Biology 2023

  Quote: ... mouse CD63 (NVG-2, Biolegend), CD9 (312102 ...
• Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

  Alastair Copland, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 (JES6-5H4; Biolegend), TNFa-BV605 (MP6-XT22 ...
• Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1⁺ macrophages

  Jiangyan Yu, et al., bioRxiv - Immunology 2023

  Quote: ... and CADM1 (2:100, BioLegend) at 37°C for 25 min ...
• Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

  Loretah Chibaya, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk

  Jayashree Srinivasan, et al., bioRxiv - Immunology 2023

  Quote: ... anti-CD63 (NVG-2, Biolegend) and anti-XCR1-AF647 (ZET ...
• The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization

  Andrea Gramatica, et al., bioRxiv - Immunology 2024

  Quote: ... BCL-2 (AF488, 100, Biolegend), anti-ID2 (Pe-Cy7 ...
• MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

  Katherine C. Murphy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

  Katherine C. Murphy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

  Eunkyu Sung, et al., bioRxiv - Cell Biology 2024

  Quote: ... 2 U/ml erythropoietin (BioLegend), 25 ng/ml stem cell factor (BioLegend) ...
• Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha

  Zhen Xu, et al., bioRxiv - Biochemistry 2024

  Quote: Human FAP (2 µM, Biolegend) was mixed with 5-fold molar excess of SUMO-I3 sdAb in the binding buffer (100 mM PBS pH 7.2 ...
• Bumetanide increases microglia-interneuron contact following traumatic brain injury

  Marine Tessier, et al., bioRxiv - Neuroscience 2022

  Quote: ... The homogenates were first blocked in PBS with 10% rat serum with gentle rotation in a cold room and then stained for 1h protected from light at 4°C with CD206-FITC (cat no. 141704, Biolegend®) + MHCII-PE (cat no ...
• TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to circulating, non-infectious immature dengue virus particles

  José A. Aguilar-Briseño, et al., bioRxiv - Immunology 2022

  Quote: ... prM-DENV2-treated PBMCs were treated (1h, 37 °C) in the presence or absence of anti-TNF-α antibody (4 µg/mL, BioLegend). The TNF-α depleted supernatants were used to stimulate HUVEC for 6 hours and the expression of activation markers were analyzed by flow cytometry ...
• BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

  Yunlong Cao, et al., bioRxiv - Immunology 2022

  Quote: ... 3 μL PE/Cyanine7 anti-human IgM antibody (BioLegend, 314532), 0.0052 μg biotinylated Ovalbumin (SinoBiological ...
• CAR-NK Cells Effectively Target the D614 and G614 SARS-CoV-2-infected Cells

  Minh Ma, et al., bioRxiv - Immunology 2021

  Quote: ... FITC anti-human CD223 (LAG-3) antibody (clone 11C3C65, BioLegend), BV510 anti-human CD314 (NKG2D ...
• FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

  Célia Jeronimo, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-Rpb3 (Neoclone W0012, 3 μL; BioLegend 665004, 1.5 μL), anti-Flag (Sigma-Aldrich F3165 ...
• Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

  Tomokazu S. Sumida, et al., bioRxiv - Immunology 2020

  Quote: ... The following antibodies were used: anti-LAG-3 (11C3C65, BioLegend), anti-PD-1 (EH12.1 ...
• Efficacy of Targeting SARS-CoV-2 by CAR-NK Cells

  Minh Ma, Saiaditya Badeti, Ke Geng, Dongfang Liu, bioRxiv - Immunology 2020

  Quote: ... FITC anti-human CD223 (LAG-3) antibody (clone 11C3C65, BioLegend), BV510 anti-human CD314 (NKG2D ...
• Profound Treg perturbations correlate with COVID-19 severity

  Silvia Galván-Peña, et al., bioRxiv - Immunology 2020

  Quote: ... CD127 AF488 (clone A019D5, BioLegend, cat# 351314, dilution 3:100); CD25 PE-Cy7 (clone BC96 ...
• CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

  Congling Qiu, et al., bioRxiv - Immunology 2021

  Quote: ... washed for 3 times with Washing Buffer (BioLegend Cat#421601) and blocked with Dilution Buffer (0.5M Tris pH 8.0 ...
• Cell-Intrinsic and Extrinsic Effects of Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

  Fei Fei, et al., bioRxiv - Cancer Biology 2021

  Quote: ... cells were incubated with PE-Galectin-3 (Biolegend cat# 126706) or matched isotype control for 15 mins and analyzed on BD Accuri C6 cytometer (BD Biosciences ...
• Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

  Julie Stockis, et al., bioRxiv - Immunology 2024

  Quote: ... injection of 3 µg anti-CD45.2-PE (clone 104, Biolegend) antibody 3 min prior to sacrifice ...
• Early infection response of the first trimester human placenta at single-cell scale

  Regina Hoo, et al., bioRxiv - Genomics 2023

  Quote: ... TotalSeq™-B0253 anti-human Hashtag 3 Antibody (394635, Biolegend), TotalSeq™-B0254 anti-human Hashtag 4 Antibody (394637 ...
• Targeting CXCR4 with [²¹²Pb/²⁰³Pb]-Pentixather Significantly Increases Overall Survival in Small Cell Lung Cancer

  Keegan A. Christensen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 3×106 cells were stained with Zombie Aqua (423102, BioLegend) for 20 min at room temperature for live/dead cells discrimination ...
• Characterization of Target Gene Regulation by the Two Epstein-Barr Virus Oncogene LMP1 Domains Essential for B-cell Transformation

  Bidisha Mitra, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 2 X10^5 cells were then resuspended to be stained with 5ul of Annexin V-FITC (#640945, Biolegend) in 100ul of Annexin V binding buffer (10mM HEPES ...
• Co-engagement of TIGIT⁺ immune cells to PD-L1⁺ tumours by a bispecific antibody potentiates T-cell response and tumour control

  Xiaopei Cui, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 secretion was evaluated with the IL-2 assay ELISA kit (Cat#431801, Biolegend). The absorbance value at 450 nm/570 nm was detected by the microplate reader ...
• Evolutionary fingerprint in rodent PD1 confers weakened activity and enhanced tumor immunity compared to human PD1

  Takeya Masubuchi, et al., bioRxiv - Immunology 2024

  Quote: ... the amount of secreted IL-2 was quantified using Human IL-2 ELISA kit (Biolegend).
• Functional single-cell profiling identifies that exosomes are associated with increased immune cell infiltration in non-metastatic breast cancer

  Mohsen Fathi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... we collected the beads and labeled them with 4 µg/ml PE anti-CD63 antibody (BioLegend, clone NVG-2) for 45 minutes at 37°C ...
• Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

  Håvard T. Lindholm, et al., bioRxiv - Immunology 2020

  Quote: ... stained for 20 min at 4 °C in PBS/2% FCS in presence of Fc receptor blocking reagent (Biolegend) with anti-murine CD326-BV605 ...
• Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology

  Thomas Goralski, et al., bioRxiv - Neuroscience 2023

  Quote: ... Slides were incubated in primary antibody in 0.1 M Tris/2% FBS in a humidified chamber overnight at 4°C (SMI-32, Biolegend 801702 ...
• Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation

  Chika Mochizuki, et al., bioRxiv - Immunology 2024

  Quote: ... or 96-well plates precoated overnight at 4°C with 2 µg/ml anti-CD3ε antibody (145-2C11, BioLegend). For Th0 and Th17 differentiation ...
• The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines

  Kaito Nagashima, et al., bioRxiv - Immunology 2021

  Quote: ... anti-IgD-FITC (1:20 dilution, clone IA6-2, cat. no. 348206, BioLegend), anti-IgM-FITC (1:20 dilution ...
• A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice

  Claudio Counoupas, et al., bioRxiv - Microbiology 2021

  Quote: ... rat anti-mouse CD138-BV605 (clone 281-2, 1:200, Biolegend, cat#142516), rat anti-mouse CD19-BV785 (clone 1D3 ...
• Distinct sets of molecular characteristics define tumor-rejecting neoantigens

  Anngela C. Adams, et al., bioRxiv - Immunology 2024

  Quote: ... H2-Dd-FITC (1:200; clone 34-2-12; BioLegend Cat. No. 110606), H2-Kd-APC (1:160 ...
• Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates

  Martin P. Steinbuck, et al., bioRxiv - Immunology 2024

  Quote: ... anti-human IL-2 (BV421, clone: MQ1-17H12, BioLegend, cat# 500328, 1:20), and anti-human TNFα (BV605 ...
• A brain-body feedback loop driving HPA-axis dysfunction in breast cancer

  Adrian Gomez, et al., bioRxiv - Neuroscience 2024

  Quote: ... For Panel 2: CD45.2 BV711 (clone 104, BioLegend, 109847, B348415, 1:100 dilution), CD3 AF488 (clone 17A2 ...
• MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

  Em P Harrington, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 3 washes were performed prior to secondary antibody staining with anti-rabbit bv421 1:500 (BioLegend 406410) with 3 additional washes after secondary antibody ...
• IL-4 downregulates BCL6 to promote memory B cell selection in germinal centers

  Laila Shehata, et al., bioRxiv - Immunology 2023

  Quote: ... 5 ug of recombinant mouse IL-4 (BioLegend) was diluted to 150 uL with sterile PBS and administered i.v ...