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251 - 300 of 1645 citations for 2 Amino 6 8 dimethyl 3 phenylquinoline hydrochloride since 2020

• Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

  Liliane Khoryati, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 immune complex (IL-2ic; mouse recombinant IL-2 + anti-IL-2 (JES6-1A12, BioLegend); molar ratio 2:1 ...
• Conditional deletion of HIF-1α provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium

  Laura Robrahn, et al., bioRxiv - Microbiology 2021

  Quote: ... Cells were then filtered using a 40 μm cell strainer and stained with the Live/Dead dye 7 Amino-actinomycin D (7AAD, Biolegend) and antibodies against CD45.2 (Biolegend ...
• Pro-apoptotic caspase deficiency reveals a cell-extrinsic mechanism of NK cell regulation

  Tayla M. Olsen, et al., bioRxiv - Immunology 2021

  Quote: ... All staining were performed in FACS buffer and dead cells were counterstained with 7-amino-actinomycin D (7-AAD, Biolegend). Before analysis ...
• Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

  Jeong Hyun Lee, et al., bioRxiv - Immunology 2021

  Quote: ... TotalSeq-C anti-human Hashtag antibody 1-8 (LNH-94 and 2M2, Biolegend), TotalSeq-C0953 PE Streptavidin (Biolegend).
• Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection

  Lauren Adams, et al., bioRxiv - Microbiology 2024

  Quote: ... 1L-8 and IL-15 were quantified using individual ELISA kits from (Biolegend), following the manufacturer’s protocol ...
• Mapping the epitopes of the Human Leukocyte Antigen E antibodies 3D12 and 4D12

  Simon Brackenridge, et al., bioRxiv - Immunology 2023

  Quote: ... and 8 clones that were negative by surface staining with W6/32 (BioLegend) grown out ...
• Human placental organoids as a model to probe early gestation maternal immune dynamics

  Emily M. Slaby, et al., bioRxiv - Bioengineering 2024

  Quote: ... Chemokine Panel 1 (13-plex) w/VbP (Biolegend catalog #740985; CXCL8 (IL-8), CXCL10 (IP-10) ...
• LRRK2-dependent Rab GTPase phosphorylation in response to endolysosomal damage depends on macrophage differentiation

  Susanne Herbst, Maximiliano G. Gutierrez, bioRxiv - Cell Biology 2020

  Quote: ... anti-Galectin-3-AF647 (125408) from BioLegend and anti-CHMP4B (13683-1-AP ...
• The RAG1 Ubiquitin Ligase Domain Enhances the Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

  Thomas N. Burn, et al., bioRxiv - Immunology 2022

  Quote: ... and 3 μg/ml anti-CD28 (Biolegend) in RPMI with 10% FBS ...
• The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

  Katie J Smith, et al., bioRxiv - Immunology 2022

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5μM mCRAMP ...
• The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

  Danielle Minns, et al., bioRxiv - Immunology 2020

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5 μM mCRAMP for 1 to 3 days ...
• Disruption of augmin-mediated microtubule nucleation in neural stem cells causes p53-dependent apoptosis and aborts brain development

  Ricardo Viais, et al., bioRxiv - Cell Biology 2020

  Quote: ... β3-tubulin (Biolegend #801201, dilution 1:1000), cleaved caspase-3 (Novus Biologicals #MAB835 ...
• Opposing roles of Granzymes A and B in the immune response to intestinal infection

  Maud Vandereyken, et al., bioRxiv - Immunology 2021

  Quote: ... [clone 1D4B (BioLegend)] and CD107b (Mac-3) [clone M384 (BioLegend)].
• Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

  D Lara-Astiaso, et al., bioRxiv - Genomics 2022

  Quote: ... CD55 (PE-conjugated; clone RIKO-3; Biolegend), CD41 (APC-conjugated ...
• Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

  Sharon Yunger, et al., bioRxiv - Immunology 2022

  Quote: ... FITC-TIM-3 (clone F38-2E2, BioLegend), FITC-LAG-3 (clone 11C3C65 ...
• The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection

  Linh Thuy Mai, et al., bioRxiv - Immunology 2024

  Quote: ... anti TIM-3-BV605 (RMT3-23, Biolegend), anti CD44-PE-Cy7 (IM7 ...
• Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection

  Caitlin A Abbott, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-mouse LAG-3 (C9B7W, Biolegend), which were stained for 60 min at 37°C as previously described (Gagliani et al. ...
• Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

  Aisha Souquette, et al., bioRxiv - Immunology 2023

  Quote: ... Panel 3) CD3-AF700 (Biolegend Cat. 300323), CD4-APC Fire750 (Biolegend Cat ...
• Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

  Isaac Dean, et al., bioRxiv - Immunology 2023

  Quote: ... IgG2b BV605 or R718 (R12-3, BioLegend), IL-7Rα BV605 or BV421 (AFR34 ...
• Proteostasis and lysosomal quality control deficits in Alzheimer’s disease neurons

  Ching-Chieh Chou, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Galectin-3 (1:1000; Biolegend, 125401), anti-γ-H2AX (1:200 ...
• Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition

  Xiaotian Zhang, et al., bioRxiv - Neuroscience 2024

  Quote: ... β3 tubulin (mouse, BioLegend, TUJ1, #MMS-435P), myc (rabbit ...
• Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

  Yijuan Zhang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... PE anti-mouse CD366 (Tim-3) (Biolegend), PE/Cy7 anti-mouse CD279 (PD-1 ...
• SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation

  Hülya F. Taner, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Tim-3 (clone RMT3-23, BioLegend), anti-TCRγ/δ (clone GL3 ...
• Enhanced anti-tumor activity by Zinc Finger Repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs

  Marion David, et al., bioRxiv - Cancer Biology 2024

  Quote: ... LAG-3 and TGFBR2 (Biolegend, Amsterdam, Netherlands). For TILs characterization ...
• Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses

  Sonia Ndeupen, et al., bioRxiv - Immunology 2021

  Quote: ... PD-1 (29F.1A12) and Bcl-6 (K112-91) from BioLegend and BD Biosciences ...
• Autoimmunity increases susceptibility to and mortality from sepsis

  Isaac J. Jensen, et al., bioRxiv - Immunology 2021

  Quote: IL-6 and IL-10 ELISAs (ELISA MAX Deluxe Set, Biolegend) were performed according to the manufacturer’s instructions.
• Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells

  Kamala P. Sundararaj, et al., bioRxiv - Cell Biology 2020

  Quote: ... ELISAs were used to measure IL-6 (Biolegend, San Diego, CA), GM-CSF (R&D systems ...
• Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

  Nicholas J Maurice, et al., bioRxiv - Immunology 2021

  Quote: ... we used human RP10 media with combinations of rIL-6 (BioLegend), rIL-12 ...
• Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

  Hyon-Xhi Tan, et al., bioRxiv - Immunology 2020

  Quote: ... and stained intracellularly with anti-BCL-6 Alexa647 (IG191E/A8; Biolegend). Non-human primate LN suspensions and PBMC were stained with the same protocol ...
• High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients

  Xiang Song, et al., bioRxiv - Immunology 2020

  Quote: ... interleukin (IL)-6 (10 ng/mL, Biolegend, San Diego, CA, USA), IL-1β (10 ng/mL ...
• A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology

  Aditi Chandra, et al., bioRxiv - Genomics 2022

  Quote: ... and 20 ng/mL of recombinant IL-6 (BioLegend, Cat# 575702) and 1 μg/mL of soluble anti-CD28 for 6 days at 37°C ...
• Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

  Emanuele Lettera, et al., bioRxiv - Cell Biology 2023

  Quote: Mouse anti-human CD41/CD61-PC7 (Clone: A2A9/6; Biolegend, 359812), Verified Reactivity ...
• In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

  Saijuan Xu, et al., bioRxiv - Bioengineering 2024

  Quote: ... was assessed utilizing the Mouse IL-6 ELISA Kit (BioLegend, 431307). IL1-β ...
• Subset-specific and temporal control of effector and memory CD4+ T cell survival

  Sharmila Shanmuganad, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 (Biolegend), CD127 ...
• Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment

  Jacob Gadwa, et al., bioRxiv - Immunology 2024

  Quote: ... Bcl-2 (BioLegend) or Ki67 (BD Bioscience ...
• Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

  Or-Yam Revach, et al., bioRxiv - Cancer Biology 2024

  Quote: ... T cells were activated for 3 days using 3 μg anti-human CD3 and CD28 antibodies (Biolegend, 300438, 377604) and 50 ng/mL of IL-2 (Peprotech ...
• Stiffness regulates dendritic cell and macrophage subtype development and increased stiffness induces a tumor-associated macrophage phenotype in cancer co-cultures

  Carla Guenther, bioRxiv - Immunology 2024

  Quote: Murine DCs were differentiated from isolated bone marrow via culture in RPMI + 10% FCS 1% Pen/Strep and 1% Amino Acids containing 20 ng/ml GMCSF (Biolegend, #576306) on silicone hydrogels with different stiffnesses ...
• Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro

  Xuanxuan Pu, et al., bioRxiv - Zoology 2020

  Quote: ... IL-8 and IL-12 were gotten from Biolegend (Camino Santa Fe, CA, USA). BCA protein quantitative kit and SYBR Green PCR kit were purchased from Smer Fell Science and Technology Co. ...
• CiDRE⁺ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

  Yuichi Mitsui, et al., bioRxiv - Immunology 2022

  Quote: ... and MRP-8/14 in human blood serum were measured by ELISA kits (BioLegend, R&D Systems ...
• Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

  Maria N Barrachina, et al., bioRxiv - Cell Biology 2023

  Quote: μ-side 8-well Ibidi chambers were coated with an anti-CD31 antibody (102502, BioLegend) for 30 min ...
• Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

  Hsuan-An Chen, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and cultured in presence of IL-2 (2 ng/ml; Biolegend), IL-7 (2.5 ng/ml ...
• Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8⁺ T cells to suppress anti-tumor immunity

  Joanne D. Tejero, et al., bioRxiv - Immunology 2024

  Quote: ... and 10 ng/mL recombinant mouse interleukin-2 (IL-2) (BioLegend); additionally ...
• Notch Signaling Commits Mesoderm to the Cardiac Lineage

  Evan S. Bardot, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-human CD309 (KDR/VEG-FR2) (Biolegend, clone 7D4-6; 1:200); anti-human CD184 (CXCR4 ...
• Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

  Lochana M. Seenappa, et al., bioRxiv - Immunology 2022

  Quote: ... and further stained with anti-human Bcl-6 (PE, clone: 7D1, BioLegend) and anti-human Ki-67 (BV421 ...
• Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo

  Nicholas McCaul, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Il-6 and IL-1β levels were quantified by ELISA (Biolegend kits).
• Tumor-educated Gr1⁺CD11b⁺ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

  Sanam Peyvandi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... recombinant mouse Oncostatin M and IL-6 (Biolegend, Cat #: 762802 & 575702 respectively).
• PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

  Catherine M. Kerr, et al., bioRxiv - Microbiology 2023

  Quote: ... MHC I (H-2Kb/Db) (FITC, Biolegend, 1:200, clone 28.8-6), Ly6C (BV785 ...
• Co-engagement of TIGIT⁺ immune cells to PD-L1⁺ tumours by a bispecific antibody potentiates T-cell response and tumour control

  Xiaopei Cui, et al., bioRxiv - Immunology 2023

  Quote: ... then washed 6 times followed by incubating with TMB substrate (Biolegend/421101) and stop solution ...
• Androgen exposure impairs neutrophil maturation and function within the infected kidney

  Teri N. Hreha, et al., bioRxiv - Immunology 2023

  Quote: ... NK1.1-PE/Dazzle 594 (1:400, for C57BL/6 mice, Biolegend #108748), Ly6C-PE/Cy5.5 (1:200 ...
• Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit

  Nobuyuki Oguri, et al., bioRxiv - Pathology 2023

  Quote: ... and CD66b (mouse monoclonal, clone 6/40c; BioLegend, San Diego, CA, USA). Next ...