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151 - 200 of 950 citations for 6 4 MORPHOLINYL PYRAZINAMINE since 2019

• CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

  Xiaoyu Zhou, et al., bioRxiv - Immunology 2023

  Quote: ... or anti-CTLA-4 antibody (Biolegend) at 37°C for 1 hour ...
• Selective Inhibition of Interleukin-2 Inducible T Cell Kinase (ITK) Enhances Anti-Tumor Immunity in Association with Th1-skewing, Cytotoxic T cell Activation, and Reduced T Cell Exhaustion

  Lih-Yun Hsu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-human IL-4 (OA19A66, Biolegend) and anti-human IL-5 (TRFK5 ...
• Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

  Robert M Johnson, et al., bioRxiv - Microbiology 2023

  Quote: ... IL-4 BV605 (BioLegend, clone: 11B11), and IL-17a BV711 (BioLegend ...
• Soquelitinib, A Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase (ITK), is Active in Several Murine Models of T Cell-Mediated Inflammatory Disease

  Lih-Yun Hsu, et al., bioRxiv - Immunology 2023

  Quote: ... anti-mouse IL-4 (11B11, Biolegend) and anti-mouse IFNγ (XMG1.2 ...
• Membrane positioning across antigen-induced synaptic contacts tunes CAR-T cell signaling and effector responses

  Fenglei Li, Kaushik Choudhuri, bioRxiv - Immunology 2023

  Quote: ... with 100ng/ml hIL-4 (Biolegend) 2days post transduction ...
• Limiting mitochondrial-derived ATP transfer to the cytosol enhances T-cell activation

  Omri Yosef, et al., bioRxiv - Immunology 2024

  Quote: ... and IL-4 (Biolegend, BLG-431104) cytokines using enzyme-linked immunosorbent assay (ELISA).
• Notch Signaling Commits Mesoderm to the Cardiac Lineage

  Evan S. Bardot, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-human CD309 (KDR/VEG-FR2) (Biolegend, clone 7D4-6; 1:200); anti-human CD184 (CXCR4 ...
• Megakaryocyte derived immune-stimulating cells regulate host-defense immunity against bacterial pathogens

  Jin Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... or 2 μg ml−1 IL-6 neutralizing antibody (MP5-20F3, Biolegend) at 37 °C ...
• Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

  Lochana M. Seenappa, et al., bioRxiv - Immunology 2022

  Quote: ... and further stained with anti-human Bcl-6 (PE, clone: 7D1, BioLegend) and anti-human Ki-67 (BV421 ...
• Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo

  Nicholas McCaul, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Il-6 and IL-1β levels were quantified by ELISA (Biolegend kits).
• IL-27R signaling serves as immunological checkpoint for NK cells to promote hepatocellular carcinoma

  Turan Aghayev, et al., bioRxiv - Immunology 2020

  Quote: ... H-2Kb/H-2Db-APC/Fire 750 (28-8-6; BioLegend, 114617), Streptavidin-APC/Cy7 (BioLegend ...
• Tumor-educated Gr1⁺CD11b⁺ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

  Sanam Peyvandi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... recombinant mouse Oncostatin M and IL-6 (Biolegend, Cat #: 762802 & 575702 respectively).
• Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

  Jessica Brown, et al., bioRxiv - Neuroscience 2023

  Quote: ... Four μg of Tau12 (N-terminal [epitope = amino acids 6-18], BioLegend), HT7 (mid-region [epitope = amino acids 159-163] ...
• Setdb1-loss induces type-I interferons and immune clearance of melanoma

  Meaghan K. McGeary, et al., bioRxiv - Cancer Biology 2023

  Quote: ... stained with antibodies to MHC-I (H2dB/H2kB; 28-8-6; Biolegend) and/or ab573(Evans et al. ...
• PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

  Catherine M. Kerr, et al., bioRxiv - Microbiology 2023

  Quote: ... MHC I (H-2Kb/Db) (FITC, Biolegend, 1:200, clone 28.8-6), Ly6C (BV785 ...
• Co-engagement of TIGIT⁺ immune cells to PD-L1⁺ tumours by a bispecific antibody potentiates T-cell response and tumour control

  Xiaopei Cui, et al., bioRxiv - Immunology 2023

  Quote: ... then washed 6 times followed by incubating with TMB substrate (Biolegend/421101) and stop solution ...
• Androgen exposure impairs neutrophil maturation and function within the infected kidney

  Teri N. Hreha, et al., bioRxiv - Immunology 2023

  Quote: ... NK1.1-PE/Dazzle 594 (1:400, for C57BL/6 mice, Biolegend #108748), Ly6C-PE/Cy5.5 (1:200 ...
• Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit

  Nobuyuki Oguri, et al., bioRxiv - Pathology 2023

  Quote: ... and CD66b (mouse monoclonal, clone 6/40c; BioLegend, San Diego, CA, USA). Next ...
• Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1

  Emilie Doz-Deblauwe, et al., bioRxiv - Immunology 2023

  Quote: ... C57BL/6 mice received 200 μg anti-Ly6G antibody (clone 1A8, Biolegend) via the i.p ...
• Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

  Jiaqing Hao, et al., bioRxiv - Cancer Biology 2024

  Quote: ... The intracellular cytokines staining with anti-mouse IL-6 (Cat. #504508, Biolegend) and anti-mouse TNFα (Cat ...
• Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

  Mark S. Lee, et al., bioRxiv - Immunology 2021

  Quote: ... were coated overnight at 4°C with 8µg of biotinylated anti-CD4 antibody (clone RM4-4, BioLegend). Prior to immunoprecipitation (IP) ...
• Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4⁺ regulatory T cells

  Mark Mensink, et al., bioRxiv - Immunology 2022

  Quote: ... Cell surface expression of CTLA-4 was measured by adding anti-CTLA-4-PE-Dazzle594 mAb (BioLegend) in culture during restimulation for 24 h ...
• The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

  Mark S. Lee, et al., bioRxiv - Immunology 2023

  Quote: ... were coated overnight at 4°C with 8μg of biotinylated anti-CD4 antibody (clone RM4-4, BioLegend). Prior to immunoprecipitation (IP) ...
• Macrophage-Based iNos Reporter Reveals Polarization and Reprogramming in the Context of Breast Cancer

  Javier A. Mas-Rosario, et al., bioRxiv - Immunology 2022

  Quote: ... culture media was removed and replaced with media containing either 50 ng/mL interleukin 4 (IL-4) (BioLegend) for 48 hr to generate M2 macrophages or 50 ng/mL interferon-gamma (IFN-γ ...
• Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity

  Paul T. Kennedy, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and supplemented with sCTLA-4 conditioned media or murine CTLA-4-Fc fusion protein (10 µg/mL, BioLegend). After 4 days ...
• Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

  Ameen A. Salahudeen, et al., bioRxiv - Cell Biology 2020

  Quote: ... Mouse anti-TNFRSF12A (clone ITEM-4, Biolegend) was utilized for (Fig ...
• Synergistic activity of Nanog, Pou5f3, and Sox19b establishes chromatin accessibility and developmental competence in a context-dependent manner

  Liyun Miao, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 4 µg of anti-RNA polymerase II CTD repeat YSPTSPS antibody [8WG16] from Abcam (ab817) and 4 µg from BioLegend (664912) were used for each sample ...
• Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

  Ofer Guttman, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 10 ng/ml IL-4 (Biolegend) for 9 days ...
• Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection

  Matheswaran Kandasamy, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-CD4 (2µg/ml, RM4-4; Biolegend), anti-CD3 (2µg/ml ...
• High Frequencies of PD-1⁺TIM3⁺TIGIT⁺CTLA4⁺ Functionally Exhausted SARS-CoV-2-Specific CD4⁺ and CD8⁺ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

  Pierre-Gregoire Coulon, et al., bioRxiv - Immunology 2022

  Quote: ... anti-CTLA-4 (APC, clone BNI3 – BioLegend), anti-CD138 (APC-Cy-7 ...
• Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection

  Ellyse M. Cipolla, et al., bioRxiv - Immunology 2022

  Quote: ... Cd11a (M17/4,BioLegend, San Diego, CA), Cd127 (SB/199,Invitrogen-ThermoFisher Scientific ...
• Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

  Deli Huang, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 at 50ng/ml(Biolegend, #574306), anti-CD40 at 5 μg/ml (Thermo ...
• Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

  Lochana M. Seenappa, et al., bioRxiv - Immunology 2022

  Quote: ... IL-4 (PE, clone: 8D4-8, BioLegend), TNFα (BV605 ...
• Effect of Thrombospondin-4 on Pro-inflammatory Phenotype Differentiation and Apoptosis in Macrophages

  Mohammed Tanjimur Rahman, et al., bioRxiv - Cell Biology 2019

  Quote: ... 40 ng/mL IL-4 (#574306, BioLegend), 1000 IU/mL IFNγ (#NBP2-35071 ...
• Transcriptional analysis defines TCR and cytokine-stimulated MAIT cells as rapid polyfunctional effector T cells that can coordinate the immune response

  Rajesh Lamichhane, et al., bioRxiv - Immunology 2019

  Quote: ... anti-4-1BB PE (4B4-1, BioLegend), anti-RORγt PE (Q21-559 ...
• Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

  Emma Jennings, et al., bioRxiv - Immunology 2020

  Quote: ... TCRVβ5.1/5.2 APC (Clone MR9-4, BioLegend), B220 PerCPcy5.5 (Clone RA3-6B2 ...
• Coordinated changes in glycosylation regulate the germinal centre through CD22

  Jhon R. Enterina, et al., bioRxiv - Immunology 2021

  Quote: ... Mouse IL-4 (1 ng/mL; BioLegend) was added to primary co-culture for 4 days ...
• Acute lymph node slices are a functional model system to study immunity ex vivo

  Maura C. Belanger, et al., bioRxiv - Immunology 2020

  Quote: ... ELISA MAX detection anti-IL-4 (Biolegend), or detection TNFα (R&D Systems ...
• Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal Strength

  Thomas A.E. Elliot, et al., bioRxiv - Immunology 2021

  Quote: ... CTLA-4 PE (clone UC10-4B9, BioLegend), OX40 APC (clone OX-86 ...
• The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin

  Martina Damo, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (clone GK1.5 or RM4-4, BioLegend), CD44 (clone IM7 ...
• The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

  Naomi M Fettig, et al., bioRxiv - Immunology 2022

  Quote: ... and 4 ng/mL TGF-β (Biolegend) for mixed Th1/Th17 skewing conditions ...
• MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

  Em P Harrington, et al., bioRxiv - Neuroscience 2022

  Quote: ... 20 ug/mL anti-IL-4 (BioLegend), 20 ug/mL anti-IFN-γ (BioLegend) ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... CTLA-4 BV605 (clone UC10-4B9, BioLegend). Dead cells were excluded using efluor-780 fixable-viability dye (eBioscience) ...
• STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

  Yulin Wang, et al., bioRxiv - Immunology 2022

  Quote: ... and 4 μg/ml CD49b PeCy7 (BioLegend) in 30 μl PBS for 30 minutes at 37°C ...
• Multi-omic QTL mapping in early developmental tissues reveals phenotypic and temporal complexity of regulatory variants underlying GWAS loci

  Timothy D. Arthur, et al., bioRxiv - Genomics 2024

  Quote: ... and SSEA-4 (PE anti-human, Biolegend). Pluripotency was also examined using PluriTest-RNAseq47.
• Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma

  Khloe S. Gordon, et al., bioRxiv - Immunology 2024

  Quote: ... Anti-4-1BB (clone 4B4-1, Biolegend), anti-CD107a (clone H4A3 ...
• A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model

  Swayam Prakash, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CTLA-4 (APC, clone BNI3 – BioLegend), anti-CD137 (APC-Cy-7 ...
• Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

  E. Nicholas Petersen, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4 ug/mL apolipoprotein E3 (BioLegend, USA) was mixed with fresh 10% FBS and applied to the cells for 1hr prior to shear and or fixing.
• Cellular iron governs the host response to malaria

  Sarah K. Wideman, et al., bioRxiv - Immunology 2023

  Quote: ... 10 ng/mL IL-4 (574302, BioLegend), 10 ng/mL IL-5 (581502 ...
• Dendritic cell-mediated responses to secreted Cryptosporidium effectors are required for parasite-specific CD8⁺ T cell responses

  Breanne E. Haskins, et al., bioRxiv - Immunology 2023

  Quote: ... CD11a PE (clone M17/4) from Biolegend; CD90.1 APC-ef780 (clone HIS51) ...