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151 - 200 of 1690 citations for 4 Tert Butyldimethylsilyl Oxy Methyl 2 Iodothiazole since 2020

• Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed Melanoma

  Rotem Leshem, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and CTLA-4 (Cat. 106338) from Biolegend. Tox (Cat ...
• SUMO Inhibition Plus CD40 Agonism Increases Anti-Tumor Immunogenicity Through Interferon Mediated Macrophage Activation

  Kevin Li, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Anti-CTLA-4 (Biolegend, Clone: UC10-4B9), Anti-CD3 (Biolegend ...
• Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

  Yunlong Cao, et al., bioRxiv - Immunology 2022

  Quote: ... 2 μl PE/Cyanine7 anti-human IgD antibody (BioLegend, 348210, clone: IA6-2), 0.13 μg biotinylated SARS-CoV-2 BA.2 RBD protein (customized from Sino Biological ...
• Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

  Xiao Niu, et al., bioRxiv - Immunology 2024

  Quote: ... 2 μL PE/Cyanine7 anti-human IgD antibody (BioLegend, 348210, clone: IA6-2), 0.013 μg biotinylated SARS-CoV-2 BA.5/BF.7 NTD protein (Sino Biological ...
• Long-term efficacy of adoptive cell therapy is determined by host CD8⁺ T cells and undermined by lymphodepleting preconditioning

  Diego Figueroa, et al., bioRxiv - Immunology 2024

  Quote: ... 100 UI/mL of recombinant human IL-2 (rhIL-2; Biolegend, ref 589108) and 50 μM of 2-mercaptoethanol (Merck ...
• Macrophages in the uterus are functionally specialised and continually replenished from the circulation

  Nicholas A. Scott, et al., bioRxiv - Immunology 2021

  Quote: ... in PBS with 2% FCS and 2% EDTA (FACS buffer) with Fc block (Biolegend) for 25 minutes ...
• Cytotoxic CD4⁺ T cells eliminate senescent cells by targeting cytomegalovirus antigen

  Tatsuya Hasegawa, et al., bioRxiv - Immunology 2023

  Quote: ... and 2 ng/ml human interleukin (IL)-2 recombinant (BioLegend, San Diego, CA, 589104).
• Innate receptors with high specificity for HLA class I–peptide complexes

  Malcolm J. W. Sim, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 concentration in thawed supernatant was measured by ELISA (Biolegend, IL-2 human). For experiments with KIR2DS1 reporter cells ...
• Integrated, high-dimensional analysis of CD4 T cell epitope specificities and phenotypes reveals unexpected diversity in the response to Mycobacterium tuberculosis

  Heather L Mead, et al., bioRxiv - Immunology 2024

  Quote: ... Media included recombinant human interleukin-2 (IL-2) at 230IU/mL – 1,025IU/mL (Biolegend), with the lower concentrations used on days 1-2 ...
• Endothelial mTOR maintains hematopoiesis during aging

  Pradeep Ramalingam, et al., bioRxiv - Cell Biology 2020

  Quote: ... Diamidino-2-Phenylindole (DAPI) (Biolegend) for live/dead exclusion and cell sorting ...
• Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

  Suhas Sureshchandra, et al., bioRxiv - Immunology 2021

  Quote: ... IL-2 (MQ1-17H12, Biolegend), and IFNγ (4S.B3 ...
• CXCR4⁺ Treg cells control serum IgM levels and natural IgM autoantibody production by B1 cells in the bone marrow

  Shlomo Elias, et al., bioRxiv - Immunology 2021

  Quote: ... and 2 μM monensin (BioLegend). For intracellular staining of IgM ...
• EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

  Loretah Chibaya, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary cells

  Mitchell G. Kluesner, et al., bioRxiv - Bioengineering 2020

  Quote: ... beta-2-microglobulin (BioLegend #316306) and Fixable Viability Dye eFluor780 or LIVE/DEAD Fixable Aqua Dead Cell Stain (ThermoFisher #65-0865-14 1:500 dilution ...
• Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

  H. Theobald, et al., bioRxiv - Immunology 2022

  Quote: ... and 2 nM Monensin (BioLegend) were added to each well and incubated for further 2 h ...
• Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity

  Xian Zhou, et al., bioRxiv - Immunology 2020

  Quote: ... anti-CD138 (281-2, Biolegend), anti-IgD (11-26c.2a ...
• Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

  Jacob W. Freimer, et al., bioRxiv - Genomics 2021

  Quote: ... IL-2 (Biolegend, Cat #500310), or CTLA-4 (Biolegend ...
• Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

  Jacob W. Freimer, et al., bioRxiv - Genomics 2021

  Quote: ... IL-2 (Biolegend, Cat #500310), or CTLA-4 (Biolegend ...
• Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model

  Floriana Cremasco, et al., bioRxiv - Immunology 2020

  Quote: ... 2) huCD45 APC Cy7 (BioLegend), huCD3 PerCp-Cy5.5 (BioLegend) ...
• IL-4-induced hysteresis in naïve T cell activation

  Alexandre P. Meli, et al., bioRxiv - Immunology 2020

  Quote: ... CD138 (clone 281-2, Biolegend), B220 (clone RA3-6B2 ...
• The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

  Kanagaraju Ponnusamy, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CD138 (BioLegend; clone: 281-2) and analyzed for germinal center activated B cells (GCB) ...
• Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates

  Yong Bok Seo, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 PE (Biolegend 503808), CD4 PE-Cy7 (Biolegend 100528) ...
• Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates

  Yong Bok Seo, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 BV605 (Biolegend 500332), and Live/dead Near-IR (Invitrogen L10119) ...
• Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

  Lucas J. D’Souza, et al., bioRxiv - Immunology 2021

  Quote: ... or -BV510 (281-2, Biolegend) and B220-BV421 (RA3-6B2 ...
• Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

  Neuza Domingues, et al., bioRxiv - Pathology 2023

  Quote: ... CD206 (Biolegend; clone 15-2) and CD163 (Biolegend ...
• Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis

  Yiwei Ai, et al., bioRxiv - Cell Biology 2023

  Quote: ... mouse CD63 (NVG-2, Biolegend), CD9 (312102 ...
• Functional impairment of “helpless” CD8⁺ memory T cells is transient and driven by prolonged but finite cognate antigen presentation

  Verena van der Heide, et al., bioRxiv - Immunology 2024

  Quote: ... and monensin (2 µM; Biolegend). Phorbol 12-myristate13-acetate (PMA)/ionomycin-stimulated (Cell Activation cocktail ...
• Rationally designed modular STAT-activating scaffolds enforce cell-intrinsic transcriptional programs augmenting the anti-tumor potency of CAR T cells

  Christopher P Saxby, et al., bioRxiv - Bioengineering 2023

  Quote: ... IL-2 (BioLegend, Cat. # 500326), and Perforin (BioLegend ...
• Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

  Loretah Chibaya, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1⁺ macrophages

  Jiangyan Yu, et al., bioRxiv - Immunology 2023

  Quote: ... and CADM1 (2:100, BioLegend) at 37°C for 25 min ...
• Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk

  Jayashree Srinivasan, et al., bioRxiv - Immunology 2023

  Quote: ... anti-CD63 (NVG-2, Biolegend) and anti-XCR1-AF647 (ZET ...
• Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

  Jack Polmear, et al., bioRxiv - Immunology 2023

  Quote: ... and CD138 (281-2, BioLegend), while human cells were incubated with CD20 (2H7 ...
• The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

  Naomi M Fettig, et al., bioRxiv - Immunology 2022

  Quote: ... CD49d-FITC (R1-2, BioLegend), Tbet-APC (4B10 ...
• Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

  Alastair Copland, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 (JES6-5H4; Biolegend), TNFa-BV605 (MP6-XT22 ...
• The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization

  Andrea Gramatica, et al., bioRxiv - Immunology 2024

  Quote: ... BCL-2 (AF488, 100, Biolegend), anti-ID2 (Pe-Cy7 ...
• Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha

  Zhen Xu, et al., bioRxiv - Biochemistry 2024

  Quote: Human FAP (2 µM, Biolegend) was mixed with 5-fold molar excess of SUMO-I3 sdAb in the binding buffer (100 mM PBS pH 7.2 ...
• Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

  Eunkyu Sung, et al., bioRxiv - Cell Biology 2024

  Quote: ... 2 U/ml erythropoietin (BioLegend), 25 ng/ml stem cell factor (BioLegend) ...
• MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

  Katherine C. Murphy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

  Katherine C. Murphy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and monensin (2 μM, Biolegend) in a humidified incubator at 37°C with 5% CO2 ...
• Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

  Lucas H. Armitage, et al., bioRxiv - Immunology 2021

  Quote: ... Undifferentiated donor 2395 iPSC were stained with anti-SSEA-4-APC and anti-Oct-4-PE (BioLegend, San Diego, CA) using the Fixation/Permeabilization Solution kit from BD Biosciences (San Jose ...
• Adaptation to host cell environment during experimental evolution of Zika virus

  Vincent Grass, et al., bioRxiv - Microbiology 2021

  Quote: ... cell surface markers were detected by a 30 minute-incubation at 4°C with 4 µg/mL Pacific Blue-conjugated mouse anti-CD14 (clone 63D3, Biolegend), a 1:20 dilution of APC-conjugated mouse anti-CD163 (clone REA812 ...
• Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in modelled TNF-driven arthritis

  Marietta Armaka, et al., bioRxiv - Cell Biology 2021

  Quote: ... for 10 min at 4°C and stained with fluorophore conjugated antibodies for 20 min at 4°C (anti-Pdpn PE-Cy7, Biolegend 127411 ...
• Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma

  Antonia Kolb, et al., bioRxiv - Cancer Biology 2024

  Quote: ... for 10 minutes at 4°C and then surfaced-stained for 30 minutes at 4°C with the following antibodies obtained from BioLegend: anti-CD3-APC (Cat ...
• Directing an mRNA-LNP vaccine toward lymph nodes improves humoral and cellular immunity against SARS-CoV-2

  David M. Francis, et al., bioRxiv - Immunology 2021

  Quote: ... BV421 anti-mouse IL-4 (Cat: 504127 Biolegend), APC-Cy7 anti-mouse CD3 (Cat ...
• SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

  Lei Shi, et al., bioRxiv - Immunology 2021

  Quote: IL-4 or IL-13 (Biolegend or PeproTech) was added into macrophage cultures at various concentrations to induce the M2/M2a phenotype in the presence or absence of a soluble CD47 extracellular domain (mCD47.ex or hCD47.ex) ...
• Oxaliplatin Resistance in Colorectal Cancer Enhances TRAIL Sensitivity Via Death Receptor 4 Upregulation and Lipid Raft Localization

  Joshua D. Greenlee, et al., bioRxiv - Cancer Biology 2021

  Quote: ... PE antihuman CD262 (DR5) (Biolegend, Clone DJR2-4), PE anti-human TRAILR3 (DcR1 ...
• STING suppresses cancer pain via immune and neuronal modulation

  Kaiyuan Wang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CD-4 APC (1:200, rat, Biolegend, 100411), FoxP3-PE (1:20 ...
• Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

  Takuya Sekine, et al., bioRxiv - Immunology 2020

  Quote: ... and anti-4-1BB–BV421 (clone 4B41; BioLegend).
• Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammation

  Shakti Sagar, et al., bioRxiv - Cell Biology 2021

  Quote: ELISA assay of different cytokines IL-4 (BioLegend), IL-5 (BioLegend ...
• Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

  Jason C. Andrechak, et al., bioRxiv - Bioengineering 2022

  Quote: ... or 20 ng/mL IL-4 (BioLegend 574302) for 48 h prior to use in tumouroid assays or prior to analysis of protein expression by immunofluorescence microscopy or flow cytometry ...