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101 - 150 of 2026 citations for 3 4 Dihydro 1H isoquinolin 2 yl piperidin 4 yl methanone since 2020

• A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model

  Swayam Prakash, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CTLA-4 (APC, clone BNI3 – BioLegend), anti-CD137 (APC-Cy-7 ...
• Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

  E. Nicholas Petersen, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4 ug/mL apolipoprotein E3 (BioLegend, USA) was mixed with fresh 10% FBS and applied to the cells for 1hr prior to shear and or fixing.
• Cellular iron governs the host response to malaria

  Sarah K. Wideman, et al., bioRxiv - Immunology 2023

  Quote: ... 10 ng/mL IL-4 (574302, BioLegend), 10 ng/mL IL-5 (581502 ...
• Dendritic cell-mediated responses to secreted Cryptosporidium effectors are required for parasite-specific CD8⁺ T cell responses

  Breanne E. Haskins, et al., bioRxiv - Immunology 2023

  Quote: ... CD11a PE (clone M17/4) from Biolegend; CD90.1 APC-ef780 (clone HIS51) ...
• A PD-1-ST2 axis controls Th2 effector function in tissue via a metabolic checkpoint

  Graham A. Heieis, et al., bioRxiv - Immunology 2023

  Quote: ... 1ug/ml αIL-4 (UBC Ablab/BioLegend); or Th2 ...
• CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β

  Ian E. Prise, et al., bioRxiv - Immunology 2023

  Quote: ... rat anti-Tim-4 (RMT4-54, BioLegend) or rabbit anti-CD163 (ab182422 ...
• CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β

  Ian E. Prise, et al., bioRxiv - Immunology 2023

  Quote: ... and Tim-4 (RMT4-54) from BioLegend as well as CD163 (TNKUPJ ...
• A PD-1-ST2 axis controls Th2 effector function in tissue via a metabolic checkpoint

  Graham A. Heieis, et al., bioRxiv - Immunology 2023

  Quote: ... IL-4 (11B11) conjugated to BV421 (BioLegend); IL-5 (TRFK5 ...
• BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine

  Dilhan J. Perera, et al., bioRxiv - Immunology 2023

  Quote: ... IL-4-BV421 (11B11, RRID: AB_2562594, BioLegend), GrB-PE (QA1602 ...
• A viral-specific CD4⁺ T cell response protects female mice from Coxsackievirus B3 infection

  Aryamav Pattnaik, et al., bioRxiv - Immunology 2023

  Quote: ... CD11a (clone M17/4, BioLegend, catalog # 101106), CD62L (clone MEL-14 ...
• eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk

  Jennifer P. Nguyen, et al., bioRxiv - Genomics 2023

  Quote: ... and SSEA-4 (PE anti-human, Biolegend) 35 ...
• Analysis of regulatory network modules in hundreds of human stem cell lines reveals complex epigenetic and genetic factors contribute to pluripotency state differences between subpopulations

  Timothy D. Arthur, et al., bioRxiv - Genomics 2023

  Quote: ... and SSEA-4 (PE anti-human, Biolegend). Pluripotency was also examined using PluriTest-RNAseq 70 ...
• Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugated butyrate prodrug with enhanced oral bioavailability

  Shijie Cao, et al., bioRxiv - Bioengineering 2023

  Quote: ... CTLA-4 (PE-Cy7, Cat#106314, Biolegend), CD25 (APC ...
• Bone marrow by day, lymph nodes by night: Undernutrition imparts a distinct circadian rhythm to T cells in mice

  Takesha R. Foster, et al., bioRxiv - Immunology 2024

  Quote: ... naïve (CD62L (MEL-4, Biolegend, California, USA) and/or CD44 (IM7 ...
• Increasing Signal Intensity of Fluorescent Oligo-Labeled Antibodies to Enable Combination Multiplexing

  Madeline E. McCarthy, et al., bioRxiv - Molecular Biology 2024

  Quote: ... (4) CD3 (clone UCHT1; Biolegend Cat: 300402) labeled with Atto647 int ...
• Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed Melanoma

  Rotem Leshem, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and CTLA-4 (Cat. 106338) from Biolegend. Tox (Cat ...
• SUMO Inhibition Plus CD40 Agonism Increases Anti-Tumor Immunogenicity Through Interferon Mediated Macrophage Activation

  Kevin Li, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Anti-CTLA-4 (Biolegend, Clone: UC10-4B9), Anti-CD3 (Biolegend ...
• Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

  Archie A. Khan, et al., bioRxiv - Microbiology 2021

  Quote: ... Sections were blocked with 10% sheep serum and 1% BSA in TBS for 30 min then incubated at 4°C overnight with 1 μg ml−1 rabbit polyclonal anti-tubulin β-3 IgG (Biolegend) and 1% BSA in TBS ...
• Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B

  Jun Liu, et al., bioRxiv - Immunology 2021

  Quote: ... and stained with fluorochrome-labeled anti-mouse IFN-γ/TNF-α/IL-2/IL-4/IL-5 mAbs (Biolegend). LSRFortessa was used to acquire the flow cytometry data ...
• Functional single-cell profiling identifies that exosomes are associated with increased immune cell infiltration in non-metastatic breast cancer

  Mohsen Fathi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... we collected the beads and labeled them with 4 µg/ml PE anti-CD63 antibody (BioLegend, clone NVG-2) for 45 minutes at 37°C ...
• Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

  Håvard T. Lindholm, et al., bioRxiv - Immunology 2020

  Quote: ... stained for 20 min at 4 °C in PBS/2% FCS in presence of Fc receptor blocking reagent (Biolegend) with anti-murine CD326-BV605 ...
• Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

  Jean-Christophe Beltra, et al., bioRxiv - Immunology 2022

  Quote: ... enriched CD8 T cells were incubated for 10’ at 4°C in Staining buffer (2%BSA/0.01% Tween in PBS) containing FcBlock (1/10 dilution ;TruStainTM FcX, Biolegend) followed by a 30’ incubation in Staining Buffer containing TotalSeqB antibodies against Ly108 ...
• An IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma

  Madelon M.E. de Jong, et al., bioRxiv - Immunology 2023

  Quote: ... cells were stained for sorting in PBS containing 2% FCS at 4 °C with the following antibodies: CD271-PE (1:200; ME20.4, BioLegend), CD235a-PECy7 (1:20 ...
• Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology

  Thomas Goralski, et al., bioRxiv - Neuroscience 2023

  Quote: ... Slides were incubated in primary antibody in 0.1 M Tris/2% FBS in a humidified chamber overnight at 4°C (SMI-32, Biolegend 801702 ...
• Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation

  Chika Mochizuki, et al., bioRxiv - Immunology 2024

  Quote: ... or 96-well plates precoated overnight at 4°C with 2 µg/ml anti-CD3ε antibody (145-2C11, BioLegend). For Th0 and Th17 differentiation ...
• Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis

  Shang Ma, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 0.3% PBST for 3 days at 4°C on rotating incubator (NFH, 1:500, Abcam, ab4680; Tubulin β-III, 1:200, Biolegend, 801201). Whole muscles were washed in 0.3% PBST for 5 hours then incubated in secondary antibodies for 48h at 4°C on rotating incubator (AlexaFluor 568 ...
• Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

  Lucas H. Armitage, et al., bioRxiv - Immunology 2021

  Quote: ... Undifferentiated donor 2395 iPSC were stained with anti-SSEA-4-APC and anti-Oct-4-PE (BioLegend, San Diego, CA) using the Fixation/Permeabilization Solution kit from BD Biosciences (San Jose ...
• Adaptation to host cell environment during experimental evolution of Zika virus

  Vincent Grass, et al., bioRxiv - Microbiology 2021

  Quote: ... cell surface markers were detected by a 30 minute-incubation at 4°C with 4 µg/mL Pacific Blue-conjugated mouse anti-CD14 (clone 63D3, Biolegend), a 1:20 dilution of APC-conjugated mouse anti-CD163 (clone REA812 ...
• Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in modelled TNF-driven arthritis

  Marietta Armaka, et al., bioRxiv - Cell Biology 2021

  Quote: ... for 10 min at 4°C and stained with fluorophore conjugated antibodies for 20 min at 4°C (anti-Pdpn PE-Cy7, Biolegend 127411 ...
• Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma

  Antonia Kolb, et al., bioRxiv - Cancer Biology 2024

  Quote: ... for 10 minutes at 4°C and then surfaced-stained for 30 minutes at 4°C with the following antibodies obtained from BioLegend: anti-CD3-APC (Cat ...
• Directing an mRNA-LNP vaccine toward lymph nodes improves humoral and cellular immunity against SARS-CoV-2

  David M. Francis, et al., bioRxiv - Immunology 2021

  Quote: ... BV421 anti-mouse IL-4 (Cat: 504127 Biolegend), APC-Cy7 anti-mouse CD3 (Cat ...
• SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

  Lei Shi, et al., bioRxiv - Immunology 2021

  Quote: IL-4 or IL-13 (Biolegend or PeproTech) was added into macrophage cultures at various concentrations to induce the M2/M2a phenotype in the presence or absence of a soluble CD47 extracellular domain (mCD47.ex or hCD47.ex) ...
• Oxaliplatin Resistance in Colorectal Cancer Enhances TRAIL Sensitivity Via Death Receptor 4 Upregulation and Lipid Raft Localization

  Joshua D. Greenlee, et al., bioRxiv - Cancer Biology 2021

  Quote: ... PE antihuman CD262 (DR5) (Biolegend, Clone DJR2-4), PE anti-human TRAILR3 (DcR1 ...
• STING suppresses cancer pain via immune and neuronal modulation

  Kaiyuan Wang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CD-4 APC (1:200, rat, Biolegend, 100411), FoxP3-PE (1:20 ...
• Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

  Takuya Sekine, et al., bioRxiv - Immunology 2020

  Quote: ... and anti-4-1BB–BV421 (clone 4B41; BioLegend).
• Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammation

  Shakti Sagar, et al., bioRxiv - Cell Biology 2021

  Quote: ELISA assay of different cytokines IL-4 (BioLegend), IL-5 (BioLegend ...
• Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

  Jason C. Andrechak, et al., bioRxiv - Bioengineering 2022

  Quote: ... or 20 ng/mL IL-4 (BioLegend 574302) for 48 h prior to use in tumouroid assays or prior to analysis of protein expression by immunofluorescence microscopy or flow cytometry ...
• Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19

  Anna E. Oja, et al., bioRxiv - Immunology 2020

  Quote: ... anti-IL-4 BV421 (Biolegend, clone MP4-25D2), and anti-IL-21 eFluor660 (Thermofisher ...
• A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

  Michael C. Kiritsy, et al., bioRxiv - Immunology 2020

  Quote: ... and 10 μg/ml anti–IL-4 (Biolegend) One week after initial activation resting NR1 cells were co-incubated with untreated or IFNγ-treated macrophages of different genotypes ...
• Metabolic and functional impairment of CD8⁺ T cells from the lungs of influenza-infected obese mice

  William D. Green, et al., bioRxiv - Immunology 2020

  Quote: ... APC Rat anti-mouse CD11a (M17/4, BioLegend), PE Armenian Hamster anti-mouse CD103 (2E7 ...
• A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice

  Naoki Kodama, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-IL-4-PE (clone 11B11, BioLegend), respectively ...
• Programmed death-ligand 1 expression in human cancer three-dimensional cell culture models

  K Hudson, NA Cross, N Jordan-Mahy, R Leyland, bioRxiv - Cancer Biology 2022

  Quote: ... PE anti-human DR5 (clone DJR2-4; Biolegend), PE anti-human Fas (clone DX2 ...
• Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation

  Alok K. Singh, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-RT1D (BioLegend, #110211, 14-4-4S). Cells were subsequently fixed using IC fixation buffer (eBiosciences™ ...
• Eos promotes T_H2 differentiation by propagating the IL-2/STAT5 signaling pathway

  Jasmine A. Tuazon, et al., bioRxiv - Immunology 2022

  Quote: ... IL-4 (APC; 1:50; clone 11B11; BioLegend); IL-13 (PE ...
• Macrophages foster adaptive anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction

  Kathrin Fuchs, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or 20 ng/ ml IL-4 (BioLegend, 574304) for 24 h ...
• DR5 disulfide bonding as a sensor and effector of protein folding stress

  Mary E. Law, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and DR5 (DJR2-4-PE, Cat:307406, Biolegend) markers for 30 min at 4 °C ...
• Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

  Minjing Wang, et al., bioRxiv - Bioengineering 2024

  Quote: ... FITC-conjugated anti-CD155 (clone SKII.4, BioLegend), FITC-conjugated anti- DNAM-1 (clone 11A8 ...
• Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart

  Ivan Milenkovic, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 4 µL of anti-HA antibody (BioLegend, 901513) was added to the remaining cleared lysate and incubated for 4 hours at 4 °C on an end-over-end rotator ...
• IL-15 promotes inflammatory T_h17 cells in the intestine

  Jonathan G. Golob, et al., bioRxiv - Immunology 2023

  Quote: ... anti-mouse IL-4 (10 ug/mL, BioLegend), and anti- mouse IFN-γ (10 µg/mL ...
• CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

  Xiaoyu Zhou, et al., bioRxiv - Immunology 2023

  Quote: ... or anti- CTLA-4-APC (Mouse IgG2a, Biolegend) at 37°C for 1hour ...