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101 - 150 of 503 citations for 3 22 Dihydroxyolean 12 En 29 Oic Acid since 2020

• BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

  Taylor L. Hickman, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and TIM-3 (F38-2E2) (Biolegend) were used to evaluate T cell phenotype ...
• Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

  Scott A. Scarneo, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... 3:20,000 anti-CD28 (BioLegend 302913), and 1:10,000 (30 IU/mL ...
• Probiotic-guided CAR-T cells for universal solid tumor targeting

  Rosa L. Vincent, et al., bioRxiv - Bioengineering 2021

  Quote: ... LAG-3 BV421 (Biolegend clone 11C3C65), PD-1 PE-Cy7 (Biolegend clone EH12.2H7).
• A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

  Huan Du, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Galectin-3 (BioLegend, 126702), goat anti-Galectin-3 (R&D Systems ...
• Role of T cells in intrauterine administration of activated peripheral blood mononuclear cells in recurrent implantation failure

  Guillaume Ricaud, et al., bioRxiv - Immunology 2021

  Quote: ... anti-GATA-3/BV421 (Biolegend, USA), anti-IL-4/BV510 (Biolegend ...
• Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

  Tomokazu S. Sumida, et al., bioRxiv - Immunology 2020

  Quote: ... anti-Tim-3 (F38-2E2, Biolegend), anti-IFN-γ (4S.B3 ...
• Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation

  Scott McComb, et al., bioRxiv - Immunology 2021

  Quote: ... OKT-3 stock (BioLegend Inc, USA) was diluted to 50mg/ul ...
• Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

  Robert Parker, et al., bioRxiv - Immunology 2020

  Quote: ... and CD11c (S-HCL-3, Biolegend) for 20 minutes at room temperature ...
• Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche

  Aidan E. Gilchrist, Brendan A.C. Harley, bioRxiv - Bioengineering 2020

  Quote: ... recombinant murine MMP-3 (#552704, BioLegend), recombinant murine c-RP (#50409-M08H ...
• Cell-Intrinsic and Extrinsic Effects of Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

  Fei Fei, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Galectin-3 (Biolegend, San Diego, USA), phospho-ERK1/2 ...
• Machine learning analysis of the T cell receptor repertoire identifies sequence features that predict self-reactivity

  Johannes Textor, et al., bioRxiv - Immunology 2023

  Quote: ... 20 ng/mL IL-3 (Biolegend), 50 ng/mL IL-6 (Biolegend) ...
• The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6

  Brandon M. Murphy, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Lag-3 (Biolegend #C9B7W; 1:250), CD3 (BD Biosciences #145-2C11 ...
• Emergence and suppressive function of Tr1 cells in glomerulonephritis

  Shiwa Soukou-Wargalla, et al., bioRxiv - Immunology 2023

  Quote: ... CD366 (TIM-3) (BV 421, BioLegend, clone RMT3-23 ...
• Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice

  Tuancheng Feng, Huan Du, Fenghua Hu, bioRxiv - Neuroscience 2023

  Quote: ... mouse anti-Galectin-3 (BioLegend, 126702), rabbit anti-TFE3 (Sigma ...
• The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate lysosomal stress responses

  Tomoya Eguchi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-galectin-3 [M3/38] (BioLegend), anti-α-tubulin [DM1A] (Sigma) ...
• Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses

  Yang Li, et al., bioRxiv - Immunology 2022

  Quote: ... Tim-3 (BioLegend, 119721, RMT3-23), LAG-3 (BioLegend ...
• Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

  Yaeko Nakajima-Takagi, et al., bioRxiv - Immunology 2022

  Quote: ... recombinant mouse IL-3 (575506; Biolegend), and recombinant murine GM-CSF (315-03 ...
• Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

  Maria E. Mercau, et al., bioRxiv - Immunology 2022

  Quote: ... Galectin-3 (BioLegend clone M3/38), CD11c (BioLegend clone N418) ...
• Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

  Sharon Yunger, et al., bioRxiv - Immunology 2022

  Quote: ... FITC-LAG-3 (clone 11C3C65, BioLegend) APC-CD25 (clone BC96 ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... LAG-3-PE (clone C9B7W, Biolegend), RORgT-BV421 (clone Q31-378 ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... GATA-3-AF647 (clone 16E10A23, BioLegend), RORgT-PE (clone AFKJS-9 ...
• Tregs constrain CD8⁺ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

  Joseph R. Palmeri, et al., bioRxiv - Immunology 2023

  Quote: ... αTIM-3-BV785 (RMT3-23, Biolegend), αTCF1/TCF7-AF488 (C63D9 ...
• Dendritic cell targeting in lymph nodes with engineered modular adapters improves HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21

  Fabian Weiss, et al., bioRxiv - Biochemistry 2024

  Quote: ... anti-muCD40 (BioLegend clone 3/23), anti-muDEC205 (BioLegend clone NLDC-145) ...
• Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

  Eunkyu Sung, et al., bioRxiv - Cell Biology 2024

  Quote: ... 25 ng/ml IL-3 (BioLegend), 25 ng/ml IL-6 (BioLegend) ...
• Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy

  Megan M. Wyatt, et al., bioRxiv - Immunology 2022

  Quote: ... and antibodies at a 1:200 dilution (anti-IFNγ, clone B27, Biolegend; anti-IL-17A, clone N49-653, BD Bioscience; anti-IL-22, clone 2G12A41, Biolegend; anti-IL-2, clone MQ1-17H12). Cells were washed and resuspended in FACS buffer and then analyzed on either an Accuri C6 flow cytometer (BD Biosciences ...
• Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease

  Kyle T. Reid, et al., bioRxiv - Immunology 2023

  Quote: ... Analytes were measured using the 12-plex LegendPlex Human Th Cytokine Panel(BioLegend) or the 13-plex LegendPlex Human Proinflammatory Chemokine Panel 1(BioLegend ...
• Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes

  Jisu Oh, et al., bioRxiv - Physiology 2022

  Quote: ... with utilization of PE rat IgG2a K isotype Control (BioLegend#12-4321-80) to determine the percentage of ATM cells ...
• Distinct sets of molecular characteristics define tumor-rejecting neoantigens

  Anngela C. Adams, et al., bioRxiv - Immunology 2024

  Quote: ... H2-Dd-FITC (1:200; clone 34-2-12; BioLegend Cat. No. 110606), H2-Kd-APC (1:160 ...
• NR4A3 deficiency ameliorates contact hypersensitivity and exacerbates psoriasis by regulating gene expression in dendritic cells

  Mayuka Katagiri, et al., bioRxiv - Immunology 2024

  Quote: ... and 10 μg/mL anti-mouse IL-12/23p40 antibody (clone C17.8, BioLegend)).
• Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells

  Ellen J.K. Xu, et al., bioRxiv - Immunology 2024

  Quote: ... and ELISA MAX™ Standard Set Mouse IL-12/IL-23 (p40) (Biolegend) were used to quantify IFNγ production and untethered IL-12 respectively ...
• TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation

  Karoliina Tuomela, et al., bioRxiv - Immunology 2024

  Quote: ... Cytokines were quantified using the LEGENDplex 12-plex Human Th Cytokine Panel (BioLegend) according to the manufacturer’s protocol and samples were analysed using a BD FACS Symphony A1 (BD Life Sciences ...
• A three-dimensional ex vivo model recapitulates in vivo features and unravels increased drug resistance in childhood acute lymphoblastic leukemia

  Magdalini Kanari, et al., bioRxiv - Cancer Biology 2024

  Quote: ... CD19 PE or CD7 PE(304018 Biolegend, 302208 Biolegend, 12-0079-42 Thermofisher) and anti-mouse CD45 eFluor450 (48- 0451-82 ...
• LRRK2-dependent Rab GTPase phosphorylation in response to endolysosomal damage depends on macrophage differentiation

  Susanne Herbst, Maximiliano G. Gutierrez, bioRxiv - Cell Biology 2020

  Quote: ... anti-Galectin-3-AF647 (125408) from BioLegend and anti-CHMP4B (13683-1-AP ...
• The RAG1 Ubiquitin Ligase Domain Enhances the Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

  Thomas N. Burn, et al., bioRxiv - Immunology 2022

  Quote: ... and 3 μg/ml anti-CD28 (Biolegend) in RPMI with 10% FBS ...
• The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

  Katie J Smith, et al., bioRxiv - Immunology 2022

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5μM mCRAMP ...
• The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

  Danielle Minns, et al., bioRxiv - Immunology 2020

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5 μM mCRAMP for 1 to 3 days ...
• Disruption of augmin-mediated microtubule nucleation in neural stem cells causes p53-dependent apoptosis and aborts brain development

  Ricardo Viais, et al., bioRxiv - Cell Biology 2020

  Quote: ... β3-tubulin (Biolegend #801201, dilution 1:1000), cleaved caspase-3 (Novus Biologicals #MAB835 ...
• Opposing roles of Granzymes A and B in the immune response to intestinal infection

  Maud Vandereyken, et al., bioRxiv - Immunology 2021

  Quote: ... [clone 1D4B (BioLegend)] and CD107b (Mac-3) [clone M384 (BioLegend)].
• Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection

  Caitlin A Abbott, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-mouse LAG-3 (C9B7W, Biolegend), which were stained for 60 min at 37°C as previously described (Gagliani et al. ...
• Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

  Isaac Dean, et al., bioRxiv - Immunology 2023

  Quote: ... IgG2b BV605 or R718 (R12-3, BioLegend), IL-7Rα BV605 or BV421 (AFR34 ...
• Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

  Aisha Souquette, et al., bioRxiv - Immunology 2023

  Quote: ... Panel 3) CD3-AF700 (Biolegend Cat. 300323), CD4-APC Fire750 (Biolegend Cat ...
• Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

  Sharon Yunger, et al., bioRxiv - Immunology 2022

  Quote: ... FITC-TIM-3 (clone F38-2E2, BioLegend), FITC-LAG-3 (clone 11C3C65 ...
• The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection

  Linh Thuy Mai, et al., bioRxiv - Immunology 2024

  Quote: ... anti TIM-3-BV605 (RMT3-23, Biolegend), anti CD44-PE-Cy7 (IM7 ...
• Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

  D Lara-Astiaso, et al., bioRxiv - Genomics 2022

  Quote: ... CD55 (PE-conjugated; clone RIKO-3; Biolegend), CD41 (APC-conjugated ...
• Proteostasis and lysosomal quality control deficits in Alzheimer’s disease neurons

  Ching-Chieh Chou, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Galectin-3 (1:1000; Biolegend, 125401), anti-γ-H2AX (1:200 ...
• Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition

  Xiaotian Zhang, et al., bioRxiv - Neuroscience 2024

  Quote: ... β3 tubulin (mouse, BioLegend, TUJ1, #MMS-435P), myc (rabbit ...
• Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

  Yijuan Zhang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... PE anti-mouse CD366 (Tim-3) (Biolegend), PE/Cy7 anti-mouse CD279 (PD-1 ...
• SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation

  Hülya F. Taner, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Tim-3 (clone RMT3-23, BioLegend), anti-TCRγ/δ (clone GL3 ...
• Enhanced anti-tumor activity by Zinc Finger Repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs

  Marion David, et al., bioRxiv - Cancer Biology 2024

  Quote: ... LAG-3 and TGFBR2 (Biolegend, Amsterdam, Netherlands). For TILs characterization ...
• Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

  Or-Yam Revach, et al., bioRxiv - Cancer Biology 2024

  Quote: ... T cells were activated for 3 days using 3 μg anti-human CD3 and CD28 antibodies (Biolegend, 300438, 377604) and 50 ng/mL of IL-2 (Peprotech ...