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401 - 450 of 1684 citations for 3 2 5 Dioxoimidazolidin 4 yl propanoic acid since 2020

• A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

  Estela González-Gualda, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and the Human TGF-beta 3 DuoSet ELISA Kit (R&D Systems).
• Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

  Suel-Kee Kim, et al., bioRxiv - Neuroscience 2022

  Quote: ... and human NT-3 (10 ng/ml, 267-N3, R&D Systems) for another 20 days.
• Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson’s disease

  Amalie Holm Nygaard, et al., bioRxiv - Developmental Biology 2024

  Quote: ... or NT-3 10-20ng/ml (R&D Systems, #267-N3-005) on top of FGF8b 100ng/ml from day 9 to 16 ...
• Skull bone marrow-derived immune cells infiltrate the damaged cortex and exhibit anti-inflammatory properties

  Eman Soliman, et al., bioRxiv - Neuroscience 2024

  Quote: ... and rabbit anti-active caspase 3 (R&D systems, Minneapolis, MN, USA). The secondary antibodies used include donkey anti-rabbit 647 ...
• Sde Proteins Coordinate Ubiquitin Utilization and Phosphoribosylation to Promote Establishment and Maintenance of the Legionella Replication Vacuole

  Kristin M. Kotewicz, et al., bioRxiv - Microbiology 2024

  Quote: ... 3) 50 nM recombinant PolyHistidine-CYLD (R&D systems, Cat# E-556), or 50nM recombinant SdeC DUB (1-192 ...
• Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation

  Selma Dahmane, et al., bioRxiv - Microbiology 2024

  Quote: ... 1 µg recombinant human PC1/3 (R&D Systems, Minneapolis, MN, USA) was mixed with 100 µM of substrate in a total volume of 100 µl reaction buffer (25 mM MES pH 6.0 + 5 mM CaCl2 + 1% (w/v ...
• Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer’s disease

  Yuanyuan Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... + 3 ng/mL IL-1α (R&D systems; 400-ML-025/CF) + 30 ng/mL IFNγ (R&D systems ...
• Bovine Formative Embryonic Stem Cell Plasticity in Embryonic and Extraembryonic Differentiation

  Yue Su, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 3 μM CHIR99021 and 20 ng/ml Activin (R&D Systems, 338AC010). Half of the medium was changed to DMEM with 10% FBS every other day ...
• Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

  Hourinaz Behesti, et al., bioRxiv - Developmental Biology 2021

  Quote: ... BMP4 (range tested: 4-160 ng/ml, R&D Systems), 100 ng/ml GDF7 (R&D Systems) ...
• A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

  Joep Beumer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... goat anti-DPP-4 (1:200; R&D systems, AF1180) and rabbit anti-MERS S1 (1:200 ...
• Nuclear stiffness decreases with disruption of the extracellular matrix in living tissues

  Kaitlin P. McCreery, et al., bioRxiv - Biophysics 2020

  Quote: Recombinant human ADAMTS-4 (R&D Systems, Minneapolis, MN, USA) and MMP-13 (R&D Systems ...
• Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay

  Yvonne Sundström, et al., bioRxiv - Immunology 2020

  Quote: ... rhIL-4 (final concentration 200 ng/ml, R&D Systems) and CpG ODN2006 (final concentration 1 μg/ml ...
• Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer

  Santoshi Muppala, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and goat anti-human TSP-4 (AF2390, R&D Systems) using Vecta Stain ABC Kit (PK-6104 ...
• Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer

  Santoshi Muppala, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and goat anti-human TSP-4 (AF2390, R&D Systems). Sections of human tumors were stained with mouse anti-human CD68 (Dako ...
• Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

  Johanna Theruvath, et al., bioRxiv - Immunology 2021

  Quote: ... 4 μg/mL of each Siglec-Fc (R&D Systems) was pre-complexed with either 8 μg/mL AffiniPure Donkey anti-human IgG Alexa Fluor 647 (Jackson ImmunoResearch ...
• Generation of CD34⁺CD43⁺ hematopoietic progenitors to induce thymocytes from human pluripotent stem cells

  Léa Flippe, et al., bioRxiv - Developmental Biology 2021

  Quote: ... All recombinant factors were purchased from PeproTech with the exception of hBMP-4 from R&D Systems.
• Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

  Michael J. D. Daniels, et al., bioRxiv - Neuroscience 2022

  Quote: ... IL-4 (20 ng/mL, 24 h, R&D Systems) or apoptotic SH-SY5Y neuroblastoma cells (2:1 ratio neurons:microglia ...
• Human pluripotent stem cells-derived inner ear organoids recapitulate otic development in vitro

  Daniela Doda, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and BMP-4 (314-BP-010 Biotechne/R&D Systems) from 0.5-10ng/ml ...
• PD-1 negatively regulates helper T cell differentiation into Th2

  Masaki Tajima, et al., bioRxiv - Immunology 2024

  Quote: ... Mouse IL-4 DuoSet ELISA (R&D Systems, catalog# DY404) and Mouse IL-13 DuoSet ELISA (R&D Systems ...
• Integrating central and peripheral neurons in elongating multi-lineage-organized gastruloids

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2020

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming

  Adriaan Merlevede, et al., bioRxiv - Systems Biology 2020

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/µL ...
• Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

  Endika Prieto-Fernández, et al., bioRxiv - Cell Biology 2021

  Quote: ... syndecan-2 (R&D Systems Cat#: FAB2965P), syndecan-3 (R&D Systems Cat# ...
• A Combined Human Gastruloid Model of Cardiogenesis and Neurogenesis

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2022

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

  Anne Marchalot, et al., bioRxiv - Immunology 2020

  Quote: ... 5ng/mL hIL-2 (R&D Systems) and 100ng/mL Mega-CD40 ligand (Enzo Life Sciences ...
• Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s disease

  Janelle Drouin-Ouellet, et al., bioRxiv - Neuroscience 2021

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/μL ...
• Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens

  Vijayashree Mysore, et al., bioRxiv - Immunology 2021

  Quote: ... anti-IL15(2) (R&D systems, #MAB247) at 5µg/ml ...
• A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa

  Ying Yang, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 ng/ml TGFB1 (R&D Systems) and 0.4 μM IWP2 (Selleck Chemicals) ...
• DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

  Mukesh Kumar, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2% N-21 (R&D Systems, AR008), and 4 μM cytosine β-D-arabinofuranoside (Millipore Sigma ...
• HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A

  Larissa Butler, et al., bioRxiv - Cell Biology 2022

  Quote: ... 20ng/ml FGF-2 (R&D systems), 5μM Y-27632 (Geron) ...
• Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth

  Fiona E. Freeman, et al., bioRxiv - Bioengineering 2022

  Quote: ... A BMP-2 ELISA (R&D systems) was used to quantify the levels of BMP-2 released by the hydrogels ...
• Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities

  Makrina Daniilidou, et al., bioRxiv - Neuroscience 2022

  Quote: ... ENPP-2 (DENP20, R&D Systems, Europe), TRX-1 (RAB1756 ...
• Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

  Kate Huang, et al., bioRxiv - Cell Biology 2023

  Quote: ... followed by IWP-2 (R&D Systems) for 48 hrs (day 1-3) ...
• Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis

  Gabriella Darmasaputra, et al., bioRxiv - Cell Biology 2023

  Quote: ... type 2 (R&D Systems, #3533-001) and cultured and passaged as previously described for Chol-Orgs75 and Hep-Orgs44 ...
• A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM

  Markella Zannikou, et al., bioRxiv - Immunology 2024

  Quote: ... supplemented with 2% FBS (R&D Systems) and TruStain FcX™ anti-mouse CD16/32 (1:200 ...
• An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m⁶A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction

  Lu Lu, et al., bioRxiv - Neuroscience 2024

  Quote: ... Sigma)/Laminin (2 µg/mL; R&D Systems)/Fibronectin (1 µg/mL ...
• Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

  Farhat Parween, et al., bioRxiv - Immunology 2023

  Quote: ... CXCL9 (5 μg, MAB392), mouse IgG1 isotype control (5 μg, MAB002) and mouse IgG2B isotype control (MAB004) all from R&D Systems, at RT for 2 h ...
• Reprogramming human B cells with custom heavy chain antibodies

  Geoffrey L. Rogers, et al., bioRxiv - Immunology 2023

  Quote: ... cells were initially activated at 5 x 105 cells/mL in B cell activation media: 5 µg/mL soluble CD40L (R&D Systems), 10 µg/mL anti-His tag antibody (clone AD1.1.10 ...
• Penile cavernous sinusoids are Prox1-positive hybrid vessels

  Sarah Schnabellehner, et al., bioRxiv - Cell Biology 2023

  Quote: ... Mouse VEGFR3 domains 1-4 and 4-7 were detected by probing with the polyclonal goat anti-mouse VEGFR3 antibody (R&D Systems, AF743, 1:1000) against the extracellular domain of VEGFR3 ...
• Association of a Common Genetic Variant with Parkinson’s Disease is Propagated through Microglia

  R. G. Langston, et al., bioRxiv - Neuroscience 2021

  Quote: ... coated plates in N4 media (N3 with 0.05uM Retinoic acid, 2ng/ml BDNF (R&D Systems #248-BDB) and 2 ng/ul GDNF (R&D Systems #212-GD)) ...
• Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors

  Chenyan Wu, et al., bioRxiv - Cell Biology 2021

  Quote: ... IL-5 (Peprotech and R&D Systems, Minneapolis, MN), erythropoietin (Janssen-Cilag Ab ...
• Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

  Melanie Werner-Klein, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 5 ng/ml GRO-α (R&D Systems, Germany), 20 ng/ml hyper interleukin-6 (kindly provided by S ...
• Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes

  Helene R. McMurray, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and 5 U/ml interferon γ (R&D Systems). All experiments testing the effects of genetic perturbations were carried out at the non-permissive temperature for large T function (39°C ...
• The Modular µSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro

  Molly C. McCloskey, et al., bioRxiv - Bioengineering 2022

  Quote: ... and human fibronectin (5 µg/cm2, R&D Systems) for 1 hour at 37°C ...
• Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity

  Erica R. Vander Mause, et al., bioRxiv - Bioengineering 2022

  Quote: ... 5 μg/ml recombinant human CD229 (R&D Systems) was immobilized on a black 96-well plate (Greiner Bio-One ...
• Breast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands

  Katrin Raute, et al., bioRxiv - Immunology 2022

  Quote: ... α-ULPB2/5/6 (clone 165903) from R&D Systems. α-CD103 (clone 2G5 ...
• A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

  Inseon Kim, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 µM Forskolin (F) (R&D Systems, 1099/50), 5 µM RepSox (R ...
• Bioengineering of a human innervated cardiac muscle model

  Lennart Valentin Schneider, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 ng/mL BMP4 (R&D systems, #314-BP), 1 μM CHIR99021 (Stemgent ...
• Monomeric amyloid-β inhibits microglial inflammatory activity in the brain via an APP/heterotrimeric G protein-mediated pathway

  Hyo Jun Kwon, Devi Santhosh, Zhen Huang, bioRxiv - Neuroscience 2023

  Quote: ... goat anti-MMP2 (R&D Systems; 5 μg/ml), rabbit anti-Calretinin (Chemicon ...
• Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway

  Liu Liu, et al., bioRxiv - Cell Biology 2024

  Quote: ... recombinant human VEGF165 (5 ng/ml, R&D Systems), recombinant human FGF10 (25 ng/ml ...
• Generation of human-pig chimeric renal organoids using iPSC technology

  Koki Fujimori, et al., bioRxiv - Bioengineering 2024

  Quote: ... 5 ng/mL human Bmp4 (R&D Systems, Inc.), 3 μM CHIR99021 ...