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3551 - 3600 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

  Mark W. Urban, et al., bioRxiv - Neuroscience 2023

  Quote: ... Antigen retrieval was performed using R&D Systems Protocol (R&D Systems, Minneapolis, Minnesota). Immediately after antigen retrieval ...
• Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

  Cheng Tian, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-HNF4a (R&D System, Minneapolis ...
• A non-invasive method to generate induced pluripotent stem cells from primate urine

  Johanna Geuder, et al., bioRxiv - Cell Biology 2020

  Quote: ... Nanog (R&D Systems, D73G4), Neuron-specific beta -III Tubulin (R&D Systems ...
• SARS-CoV-2 receptor Angiotensin I-Converting Enzyme type 2 (ACE2) is expressed in human pancreatic β-cells and in the human pancreas microvasculature

  Daniela Fignani, et al., bioRxiv - Cell Biology 2020

  Quote: ... and #MAB933 (R&D system) were respectively diluted 1:1000 ...
• Proteomic phenotyping of stimulated Müller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity

  Adrian Schmalen, et al., bioRxiv - Immunology 2021

  Quote: ... from R&D Systems/Bio-Techne (R&D Systems/Bio-Techne ...
• SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs

  Lieve E.H. van der Donk, et al., bioRxiv - Immunology 2021

  Quote: ... ACE2 (AF933, R&D systems), goat-IgG (AB-2535864 ...
• Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4⁺ T cells

  Melanie Lancien, et al., bioRxiv - Immunology 2020

  Quote: ... IL-1β (R&D Systems) at 50 ng/mL (except IL-2 at 50 IU/mL) ...
• Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4⁺ T cells

  Melanie Lancien, et al., bioRxiv - Immunology 2020

  Quote: ... IL-22 (R&D Systems) and IFNγ (BD Biosciences ...
• Base-resolution models of transcription factor binding reveal soft motif syntax

  Žiga Avsec, et al., bioRxiv - Genomics 2020

  Quote: ... ɑ-Klf4 (R&D Systems, AF3158), ɑ-Klf4 (Abcam ...
• Gain-of-function mutation in Gli3 causes ventricular septal defects

  Antonia Wiegering, et al., bioRxiv - Developmental Biology 2020

  Quote: ... GLI2 (#AF3635; R&D Systems), KI67 (#sc-7846 ...
• DOT1L methyltransferase regulates the calcium influx in erythroid progenitor cells in response to erythropoietin

  Yi Feng, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Mouse EPO (R&D systems) was added to a final concentration of 10 units/ml ...
• The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development

  Xin Sun, et al., bioRxiv - Developmental Biology 2020

  Quote: ... while WNT3A (R&D Systems) was used at a concentration of 50ng/ml ...
• Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects

  Szilvia Galgoczi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... or BMP4 (R&D Systems) for 1 hour the following day ...
• Ehrlichia SLiM ligand mimetic activates Notch signaling in human monocytes

  LaNisha L. Patterson, et al., bioRxiv - Pathology 2022

  Quote: ... CF (R&D Systems, MN) were dialyzed in running buffer (100 mM sodium phosphate [pH 7.4] ...
• A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy

  Darshika Tomer, et al., bioRxiv - Cell Biology 2022

  Quote: ... and laminin (R&D systems, catalog # 3400-010-02 ...
• Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection

  Jazlyn P. Borges, et al., bioRxiv - Cell Biology 2022

  Quote: ... by ELISA (R&D Systems) according to the protocol of the manufacturer.
• CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease

  Dahyun Yu, et al., bioRxiv - Neuroscience 2022

  Quote: ... C3d (R&D Systems AF2655), GFAP (Invitrogen PA1-10019) ...
• A ROLE FOR CORTICAL DOPAMINE IN THE PARADOXICAL CALMING EFFECTS OF PSYCHOSTIMULANTS

  Sharonda S. Harris, et al., bioRxiv - Neuroscience 2021

  Quote: ... and GBR12909 (R&D systems) were dissolved in saline (behavior ...
• Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2

  Garam Kim, et al., bioRxiv - Neuroscience 2021

  Quote: ... BDNF/GDNF (R&D Systems) on Matrigel-coated assay plates ...
• Nascent Polypeptide Associated Complex–alpha and Signal Recognition Particle are required for cardiac development and remodeling

  Analyne M. Schroeder, et al., bioRxiv - Developmental Biology 2022

  Quote: ... CDH5 (R&D Systems, AF938). Wells were washed with PBS for 15 mins and repeated three times ...
• Human NLRP1 is activated by ZAKɑ-driven ribotoxic stress response

  Kim S. Robinson, et al., bioRxiv - Immunology 2022

  Quote: ... NLRP1 (R&D systems, #AF6788), NLRP1 (Biolegend #9F9B12), ...
• SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF

  Marianna Ioannou, et al., bioRxiv - Immunology 2021

  Quote: ... anti-MPO (R&D Systems), anti-SIGNR1 (eBioscience) ...
• High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism

  Andra C. Dumitru, et al., bioRxiv - Biochemistry 2020

  Quote: ... and C5a (R&D Systems). After additional 15 min incubation at 25 °C ...
• Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

  Mitchell L. Leibowitz, et al., bioRxiv - Genetics 2020

  Quote: ... and TPO (R&D Systems). CD34+ cells were maintained in complete SFEM post-electroporation for 1-5 days or subject to erythroid differentiation ...
• Cardioids reveal self-organizing principles of human cardiogenesis

  Pablo Hofbauer, et al., bioRxiv - Developmental Biology 2020

  Quote: ... HAND1 (R&D Systems, AF3168), Cleaved Caspase-3 (Cell Signaling Technology ...
• Endosomal trafficking is required for glycosylation and normal maturation of the Alzheimer’s-associated protein sorLA

  Sofie K. Christensen, et al., bioRxiv - Cell Biology 2020

  Quote: ... SORCS1 (AF3457; R&D Systems), or calnexin (ab22595 ...
• The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex

  Simon MG Braun, et al., bioRxiv - Developmental Biology 2020

  Quote: ... SOX9 (R&D Systems, AF3075), BLBP (Abcam ...
• Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication

  Nawar Naseer, et al., bioRxiv - Microbiology 2021

  Quote: ... IL-18 (R&D Systems), IL-1β (BD Biosciences) ...
• The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

  James L. J. Coleman, et al., bioRxiv - Biochemistry 2020

  Quote: ... and TIMP4 (R&D Systems), were added at the time of GPR37L1 induction (or 5 hours after transfection in the case of U87 MG cells ...
• Combinatorial approach of binary colloidal crystals (BCCs) and CRISPR activation to improve induced pluripotent stem cell differentiation into neurons

  Daniel Urrutia-Cabrera, et al., bioRxiv - Bioengineering 2021

  Quote: ... SMA (R&D systems, MAB1420) or AFP (Millipore ...
• DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

  Maria M. Mikedis, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-FOXC2 (R&D Systems AF6989 ...
• SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection

  Rayan Khaddaj-Mallat, et al., bioRxiv - Neuroscience 2021

  Quote: ... TBARS assay (R&D Systems) was used to assess oxidative stress in pericytes under different experimental conditions ...
• Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

  Abigail K. Grosskopf, et al., bioRxiv - Bioengineering 2021

  Quote: ... IL-15 (R&D Systems) was incorporated with the nanoparticles during hydrogel formulation.
• In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

  Michela Carlet, et al., bioRxiv - Cancer Biology 2020

  Quote: ... DUX4 (MAB9535, R&D system) and β-actin (NB600-501SS ...
• Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

  Lee Shaashua, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and 7AAD (R&D systems). Using flow cytometry ...
• 4β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor

  Ofer Moldavski, et al., bioRxiv - Biochemistry 2020

  Quote: ... LXRβ (K8917, R&D systems), phospho-T308 AKT (C31E5E) ...
• The self-regulated response of the Wnt pathway to an oncogenic mutation in β-catenin

  Ana R Moshkovsky, Wenzhe Ma, Marc W Kirschner, bioRxiv - Systems Biology 2021

  Quote: ... CK1α (AF4569, R&D Systems) and α-tubulin (NeoMarkers ...
• Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

  Ruofan Wang, et al., bioRxiv - Microbiology 2020

  Quote: ... ACE2 (R&D Systems, AF933) at 1:1000 ...
• Intestinal-derived FGF15 preserves muscle and bone mass following sleeve gastrectomy

  Nadejda Bozadjieva Kramer, et al., bioRxiv - Physiology 2020

  Quote: ... Activin-A (R&D Systems), Myostatin (GDF8 ...
• Intestinal-derived FGF15 preserves muscle and bone mass following sleeve gastrectomy

  Nadejda Bozadjieva Kramer, et al., bioRxiv - Physiology 2020

  Quote: ... Myostatin (GDF8) (R&D Systems), FGF21 (R&D Systems) ...
• Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination

  Darpan Saraswat, et al., bioRxiv - Neuroscience 2020

  Quote: ... human WNT3a (R&D Systems) and/or PI-88 (gift of Medigen Biotechnology Corp ...
• Multi-tier mechanics control stromal adaptations in swelling lymph nodes

  Frank P. Assen, et al., bioRxiv - Immunology 2021

  Quote: ... α-CCL21-Biotin (R&D Systems), α-PDPN-Biotin (8.1.1 ...
• Csmd2 interacts with Dab1 and is Required in Reelin-Mediated Neuronal Maturation

  Mark A Gutierrez, Brett E Dwyer, Santos J Franco, bioRxiv - Neuroscience 2020

  Quote: ... Recombinant Reelin was purchased from R&D Systems (R&D Systems, 3820-MR), reconstituted in EMEM and used at the indicated concentration in EMEM-based hippocampal neuron media.
• Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19

  Suchitra Kamle, et al., bioRxiv - Immunology 2021

  Quote: ... α-CTSL (R&D Systems, AF1515). β-actin (Santa Cruz Biotechnology ...
• MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells

  Dan Sun, et al., bioRxiv - Cancer Biology 2021

  Quote: ... (R&D systems, 302-B2) experiments on CAM ...
• Deubiquitinase UCHL1 Maintains Protein Homeostasis through PSMA7-APEH-Proteasome Axis in High-Grade Serous Ovarian Carcinoma

  Apoorva Tangri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... UCHL1 (MAB6007, R&D Systems), PSMA7 (cat# PA5-22289 ...
• Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine

  Jinrui Dong, et al., bioRxiv - Cell Biology 2021

  Quote: ... IL6 (AF506, R&D systems), p-JNK (4668 ...
• Allosteric communications between domains modulate the activity of matrix metalloprotease-1

  Lokender Kumar, et al., bioRxiv - Biophysics 2020

  Quote: ... (R&D Systems, Cat# ES010) (27) ...
• Epigenomic profiling of stem cells within the pilosebaceous unit identifies PRDM16 as a regulator of sebaceous gland homeostasis

  Rizwan Rehimi, et al., bioRxiv - Cell Biology 2021

  Quote: ... LRIG1 (AF3688, R&D systems) and Adipophilin (20R-AP002 ...
• Extracellular Vesicle Antibody Microarray for Multiplexed Inner and Outer Protein Analysis

  Rosalie Martel, et al., bioRxiv - Bioengineering 2022

  Quote: ... EpCAM (MAB9601, R&D Systems) and CD81 (349501 ...