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251 - 300 of 1079 citations for 6 Hydroxymethyl 4 methoxy 5 methyl nicotinic acid methyl ester since 2020

• MLL1 directs gut-associated antibody responses to helminth and bacterial infections

  Yan Zhang, et al., bioRxiv - Immunology 2024

  Quote: ... 5ng/ml IL-5 (R&D Systems), 10ng/ml TGFβ (R&D Systems ...
• Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells

  Milad Rezvani, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 ng/ml FGF2 (R&D Systems), and 6 ng/ml Activin A (Peprotech) ...
• DNA Hanger: Surface Free Single-Molecule Blotting Platform

  Jincheol Seol, et al., bioRxiv - Biophysics 2024

  Quote: ... TNF-α (5 µg, R&D Systems) was reconstituted in PBS to 5 µM and stored at -80°C.
• Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate

  David M. Gonzalez, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 ng/ml bFGF (R&D Systems) and 1 μmol Thiazovivin (Milipore) ...
• Species-specific satellite DNA composition dictates de novo formation of PRC1-mediated pericentric heterochromatin

  Piero Lamelza, et al., bioRxiv - Cell Biology 2024

  Quote: ... or 5 μM proTAME (R&D Systems) (to arrest zygotes in metaphase ...
• Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

  Kaja Nicole Wächtershäuser, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 5 µM Y-27632 (R&D systems), 10 mM nicotinamide (Sigma) ...
• Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2

  Pooja Hoovina Venkatesh, et al., bioRxiv - Cell Biology 2021

  Quote: ... IL-6 and TNF-α were measured using DuoSet® ELISA kits (R&D Systems).
• Cadherin-6 mediates thrombosis in vivo

  Emma G. Bouck, et al., bioRxiv - Pathology 2020

  Quote: ... probed with mouse monoclonal anti-cadherin-6 antibody (1:500, R&D Systems, catalog # MAB2715), then IRDYE 800CW donkey anti-mouse IgG (LI-COR Biosciences ...
• Cadherin-6 mediates thrombosis in vivo

  Emma G. Bouck, et al., bioRxiv - Pathology 2020

  Quote: ... Platelets were incubated with APC-conjugated anti-cadherin-6 antibody (R&D systems, catalog # FAB2175A) and analyzed using a BD LSRFortessa™ ...
• Resistance of endothelial cells to SARS-CoV-2 infection in vitro

  Blerina Ahmetaj-Shala, et al., bioRxiv - Immunology 2020

  Quote: IL-6 and IL-8 was measured using duo set ELISAs from R&D Systems according to manufactures instructions.
• Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function

  Nora Bramey, et al., bioRxiv - Cell Biology 2023

  Quote: ELISA was performed using the human IL-6 Duo-Set (R&D Systems, cat.# DY206), human GDF-15 Duo Set (R&D Systems ...
• LPS-Induced Inflammation Reduces GABAergic Interneuron markers and Brain-derived Neurotrophic Factor in Mouse Prefrontal Cortex and Hippocampus

  Sara Rezaei, et al., bioRxiv - Neuroscience 2023

  Quote: ... DuoSet® ELISA kits for IL-6 (catalog no.DY406-05, R&D System, Minneapolis, Minnesota), TNF-alpha (catalog no.DY410-05 ...
• 3D Bioprinting of Stem Cell-Derived Central Nervous System Cells Enables Astrocyte Growth, Vasculogenesis and Enhances Neural Differentiation/Function

  Michael A. Sullivan, et al., bioRxiv - Neuroscience 2022

  Quote: ... IL-6 ELISA was performed according to manufacturer’s protocols (R&D Systems product number DY206), with slight amendments including ...
• An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial function

  Erica Bello, et al., bioRxiv - Neuroscience 2024

  Quote: hiPSC-derived microglia at day 6 of differentiation were stimulated with IFNγ (R&D Systems) 200 ng/ml or Lipopolysaccharide (LPS ...
• Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

  Ole Bæk, et al., bioRxiv - Immunology 2024

  Quote: ... IL-10 (DY693B) and IL-6 (DY686, all porcine DuoSet, R&D systems, Abingdon, UK). Plasma samples at planned euthanasia or human endpoints were used for biochemical analysis ...
• The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

  Angela Armento, et al., bioRxiv - Cell Biology 2024

  Quote: ... DKK-1 10 ng/ml (day 0-6, 5439-DK-010/CF, R&D Systems), IGF-1 10ng/ml (day 0-6 ...
• Osteoblast-Induced Collagen Alignment in a 3D in vitro Bone Model

  Judith M. Schaart, et al., bioRxiv - Cell Biology 2024

  Quote: ... 0.2mM ascorbic acid and 1 ng/mL recombinant human FGF (R&D system, 233-GMP-025). The adherent cells were split by trypsinization at 80% confluency and frozen at passage 2 (50% αMEM ...
• Blocking IL-10 signaling with soluble IL-10 receptor restores specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

  Catiule de Oliveira Santos, et al., bioRxiv - Immunology 2020

  Quote: ... 1.25% of supernatant from Con-A-stimulated rat splenocytes (assay positive control), c) recombinant canine IL-4 (rcaIL-4, 360 ng/mL) (R&D Systems), d ...
• Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

  Philip E. Brandish, et al., bioRxiv - Cancer Biology 2021

  Quote: ... supplemented with GM-CSF (1000 U/mL) and IL-4 (1000 U/mL) or GM-CSF & IL-4 (20 and 40 ng/mL, R&D Systems) and seeded into 24-well low binding plates at 1 × 106 cells/well ...
• Conserved epigenetic programming and enhanced heme metabolism drive memory B cell reactivation

  Madeline J. Price, et al., bioRxiv - Immunology 2021

  Quote: ... 10ng/ml IL-4 (R&D Systems, 404-ML), and 10 ng/ml IL-5 in complete RPMI ...
• High throughput functional screening for next generation cancer immunotherapy using droplet-based microfluidics

  Yuan Wang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and 10 ng/mL IL-4 (R&D Systems). Suspended cells were harvested and confirmed to be dendritic cells by CD11c expression ...
• CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation

  Daniel Hwang, et al., bioRxiv - Immunology 2021

  Quote: Recombinant CSF-1 (4 µg/dose; R&D Systems) was given to EAE mice on days 4 ...
• CRTC2 regulates plasma cell metabolism and survival

  Jason S Hong, et al., bioRxiv - Immunology 2021

  Quote: ... and 25 ng/ml IL-4 (R&D Systems) or with 0.1 ug/ml CD40L ...
• Street RABV induces the cholinergic anti-inflammatory pathway in human monocyte-derived macrophages by binding to nAChr ɑ7, and upregulates the M2-c marker CD163

  C.W.E. Embregts, et al., bioRxiv - Immunology 2021

  Quote: ... with IL-4 (20 ng/mL, R&D Systems), or with IL-1 (20 ng/mL R&D Systems) ...
• Blocking IL-10 signaling with soluble IL-10 receptor restores specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

  Catiule de Oliveira Santos, et al., bioRxiv - Immunology 2020

  Quote: ... b) canine IL-4 (R&D Systems, Minneapolis, USA) at 125 ...
• Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer

  Santoshi Muppala, et al., bioRxiv - Cancer Biology 2020

  Quote: ... goat anti-human TSP-4 (AF2390, R&D Systems), monoclonal mouse anti-human alpha smooth muscle actin (M0851 ...
• The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

  Leila Revollo, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti Platelet Factor 4 (PF4) (R&D Systems, #AF595), anti GPIbɑ (Emfret Analytics ...
• Quantitative analysis and genome-scale modeling of human CD4⁺ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

  Partho Sen, et al., bioRxiv - Immunology 2021

  Quote: ... or 10 ng/ml IL-4 (R&D Systems) (for Th2) ...
• An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for DNA repair activity

  Chérine Sifri, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and 10 ng/mL mIL-4 (R&D Systems). After 48 h ...
• Epithelial heme oxygenase-1 enhances colonic tumorigenesis by inhibiting ferroptosis

  Rosemary C. Callahan, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 4-HNE antibody was purchased from R&D Systems. Representative photomicrographs were obtained using an EVOS m5000 microscope.
• A Serum- and Feeder-Free System to Generate CD4 and Regulatory T Cells from Human iPSCs

  Helen Fong, et al., bioRxiv - Cell Biology 2024

  Quote: ... SSEA-4 (#MAB1435) were obtained from R&D Systems. TRA-1–81 (#MAB8495 ...
• The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins

  Mallika Ghosh, et al., bioRxiv - Cell Biology 2023

  Quote: ... Fusion inducing cytokines IL-4 (R&D Systems; 404ML010) and IL-13 (R&D Systems ...
• A “ tug-of-war” between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancer

  Roberto Stabile, et al., bioRxiv - Cancer Biology 2024

  Quote: ... with IL-4 (20 ng/mL, R&D Systems), or with IL-10 (20 ng/mL R&D Systems) ...
• ATM and MSH2 control blunt DNA end joining in immunoglobulin class switch recombination

  Emily Sible, et al., bioRxiv - Immunology 2022

  Quote: ... and 12.5 ng/ml IL-4 (R&D Systems). B cells were split 1:2 v/v 48 and 72 hours after isolation ...
• Autofluorescence lifetime imaging classifies human lymphocyte activation and subtype

  Rebecca L. Schmitz, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 20 ng/mL IL-4 (R&D Systems) (6 ...
• MYC directly transactivates CR2/CD21, the receptor of the Epstein-Barr virus, and enhances the viral infection of Burkitt lymphoma cells

  Ester Molina, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and IL-4 (20 ng/mL; R&D Systems) for 48 hours ...
• Neuro-Regenerative Behavior of Adipose-Derived Stem Cells in Aligned Collagen I Hydrogels

  Mackenzie Lewis, et al., bioRxiv - Bioengineering 2023

  Quote: ... Custom-designed 4-Plex Luminex kits (R&D Systems) were used to quantify beta-nerve growth factor (βNGF) ...
• GPR43 in eosinophils prevents the emergence of pathogenic Siglec-F^hi neutrophils in allergic airway inflammation

  Jihyun Yu, et al., bioRxiv - Immunology 2024

  Quote: ... and 10 ng/ml IL-4 (R&D Systems), respectively ...
• Identification of a Neuroimmune Circuit that Regulates Allergic Inflammation in the Esophagus

  Kendall Kellerman, et al., bioRxiv - Immunology 2024

  Quote: Murine recombinant IL-4,(Peprotech and R&D Systems), capsaicin ...
• BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function

  Nathaniel E. Wright, et al., bioRxiv - Immunology 2024

  Quote: ... and 10 ng/ml IL-4 (R&D Systems) were added to the media.
• IL-27 neutralization to modulate the tumor microenvironment and increase immune checkpoint immunotherapy efficacy

  Loukas Papargyris, et al., bioRxiv - Immunology 2024

  Quote: ... IL-27-neutralizing antibody (5 µg/mL) or isotype control antibody (5 µg/mL) (both R&D Systems, Abingdon, UK) were added in the monocyte cultures (Day 0 and Day 3 ...
• Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

  John D. Mason, et al., bioRxiv - Cancer Biology 2023

  Quote: AREG-neutralising experiments were performed by pre-incubating freshly prepared EVs (at 4 x 103 EVs per recipient cell) with either 4 µg/ml of goat anti-AREG (R&D Systems #AF262) or goat anti-IgG (R&D Systems #AB-1080-C ...
• Attenuation of homeostatic signaling from apoptotic thymocytes triggers a global regenerative response in the thymus

  Sinéad Kinsella, et al., bioRxiv - Immunology 2020

  Quote: ... 5 µM SB431542 (1614/10, R&D Systems), 20 ng/ml FGF (100-18B ...
• IFN-λ4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

  Olusegun O. Onabajo, et al., bioRxiv - Cancer Biology 2020

  Quote: ... IFN-λ1 (5 ng/ml, R&D Systems), IFN-λ2 (60 ng/ml ...
• Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

  Franziska Blaeschke, et al., bioRxiv - Immunology 2022

  Quote: ... 5 ng/ml IL-7 (R&D Systems), 5 ng/ml IL-15 (R&D Systems) ...
• Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

  Lijuan Sun, et al., bioRxiv - Cancer Biology 2020

  Quote: ... TNFα (5 μg/ml, #MAB4101, R&D Systems), or CXCL9 (6 μg/ml ...
• Interleukin 31 receptor alpha induces airway hyperresponsiveness in asthma

  Santoshi Akkenepally, et al., bioRxiv - Pathology 2022

  Quote: ... or rIL-13 (5 µg, R&D Systems) and intratracheally instilled in 50 µL of saline on days 0 and 6 ...
• Distinct Functional States of Neutrophils by Actin Disassembly and NF-kB/STAT3 Signaling

  Niko Heineken, et al., bioRxiv - Immunology 2023

  Quote: ... G-CSF (5 ng/ml, R&D systems), GM-CSF (100 U/µl ...
• Selective Inhibition of Interleukin-2 Inducible T Cell Kinase (ITK) Enhances Anti-Tumor Immunity in Association with Th1-skewing, Cytotoxic T cell Activation, and Reduced T Cell Exhaustion

  Lih-Yun Hsu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... IL-5 (10 ng/ml, R&D Systems), anti-human IFNγ (B27 ...
• A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

  Aleksandra Boikova, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 5 ng/ml FGF-2 (R&D Systems) and 1 μM CHIR99021 (STEMCELL Technologies) ...