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2301 - 2350 of 3903 citations for 7 Oxabicyclo 4.1.0 hept 3 ene 2 5 dione 3 hydroxymethyl 4 1E 1 penten 1 yl 1S 6R since 2019

• Hedgehog-dependent and Hedgehog-independent roles for Growth Arrest Specific 1 in mammalian kidney morphogenesis

  Nicole E. Franks, Benjamin L. Allen, bioRxiv - Developmental Biology 2024

  Quote: ... Membranes were incubated in goat anti-GAS1 (1:4000, R&D Systems, AF2644) primary antibody overnight at 4°C ...
• Intercellular adhesion molecule-1 reprograms microglia to improve cognitive functions by inhibiting ERK/STAT3 signalling pathway in a model of Alzheimer’s disease

  Soumita Goswami, Subhas Chandra Biswas, bioRxiv - Neuroscience 2024

  Quote: ... ICAM-1 ELISA kit and cytokine array kit were from R&D systems. Cell culture dishes ...
• Sinking the way: a dual role for CCR7 in collective leukocyte migration

  Jonna Alanko, et al., bioRxiv - Cell Biology 2022

  Quote: ... for 2 days in R10 medium supplemented with IL-2 (10ng/ml, 402-ML-020, R&D Systems) for 2 days ...
• Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice

  Xin Yang, et al., bioRxiv - Microbiology 2022

  Quote: Fecal lipocalin-2 content was quantified with a Lipocalin-2/NGAL Quantikine ELISA kit (DLCN20, R&D Systems).
• Ym1 protein crystals promote type 2 immunity

  Ines Heyndrickx, et al., bioRxiv - Immunology 2023

  Quote: ... CCL24 concentrations were evaluated using the Mouse CCL24/Eotaxin-2/MPIF-2 DuoSet ELISA kit (R&D Systems). Serum Ym1-specific immunoglobulin M (IgM ...
• The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner

  Guillermo O. Rangel Rivera, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 complex was made with 1.5μg of recombinant human IL-2 (NIH) and 7.5μg of anti-human IL-2 (R&D Systems) per injection in 100μL of sterile PBS ...
• Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer

  Travis J Gates, et al., bioRxiv - Microbiology 2022

  Quote: ... Lcn-2 levels were approximated using a Duoset murine Lcn-2 ELISA kit (R&D Systems, Minneapolis, MN) following the manufacturer’s protocol ...
• Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

  Changsheng Chen, et al., bioRxiv - Cell Biology 2023

  Quote: ... EBs were formed in an ESC medium depleted of recombinant human FGF-2 (rhFGF-2) (R&D Systems) on day 0 ...
• mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity

  Philip Samaan, et al., bioRxiv - Immunology 2024

  Quote: ... or CEFTA were supplemented with 10IU/mL of recombinant human IL-2 (rh IL-2; R&D Systems) and 10ng/mL of recombinant human IL-7 (rh IL-7 ...
• Clostridioides difficile binary toxin CDT induces biofilm-like persisting microcolonies

  Jazmin Meza Torres, et al., bioRxiv - Microbiology 2024

  Quote: ... Lcn-2 levels were estimated in the supernatants using Duoset murine Lcn-2 ELISA kit (R&D Systems). Samples from day 0 (before infection ...
• Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

  Hourinaz Behesti, et al., bioRxiv - Developmental Biology 2021

  Quote: ... BMP4 (range tested: 4-160 ng/ml, R&D Systems), 100 ng/ml GDF7 (R&D Systems) ...
• Single-cell transcriptome analysis reveals TOX as a promoting factor for T-cell exhaustion and a predictor for anti-PD1 responses in human cancer

  Kyungsoo Kim, et al., bioRxiv - Cancer Biology 2019

  Quote: ... CTLA-4-Alexa Fluor 700 (63828) antibody (R&D Systems); TCF1-Alexa Fluor 488 (C63D9 ...
• Nuclear stiffness decreases with disruption of the extracellular matrix in living tissues

  Kaitlin P. McCreery, et al., bioRxiv - Biophysics 2020

  Quote: Recombinant human ADAMTS-4 (R&D Systems, Minneapolis, MN, USA) and MMP-13 (R&D Systems ...
• Syndecan-4 is required for VE-Cadherin trafficking during pathological angiogenesis

  Giulia De Rossi, et al., bioRxiv - Cell Biology 2019

  Quote: ... recombinant syndecan-4 (R&D Systems Cat# 6267-SD-050) and recombinant syndecan-2 (R&D Systems Cat#6585-SD-050) ...
• Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay

  Yvonne Sundström, et al., bioRxiv - Immunology 2020

  Quote: ... rhIL-4 (final concentration 200 ng/ml, R&D Systems) and CpG ODN2006 (final concentration 1 μg/ml ...
• Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer

  Santoshi Muppala, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and goat anti-human TSP-4 (AF2390, R&D Systems) using Vecta Stain ABC Kit (PK-6104 ...
• Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer

  Santoshi Muppala, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and goat anti-human TSP-4 (AF2390, R&D Systems). Sections of human tumors were stained with mouse anti-human CD68 (Dako ...
• Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

  Johanna Theruvath, et al., bioRxiv - Immunology 2021

  Quote: ... 4 μg/mL of each Siglec-Fc (R&D Systems) was pre-complexed with either 8 μg/mL AffiniPure Donkey anti-human IgG Alexa Fluor 647 (Jackson ImmunoResearch ...
• Generation of CD34⁺CD43⁺ hematopoietic progenitors to induce thymocytes from human pluripotent stem cells

  Léa Flippe, et al., bioRxiv - Developmental Biology 2021

  Quote: ... All recombinant factors were purchased from PeproTech with the exception of hBMP-4 from R&D Systems.
• Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

  Michael J. D. Daniels, et al., bioRxiv - Neuroscience 2022

  Quote: ... IL-4 (20 ng/mL, 24 h, R&D Systems) or apoptotic SH-SY5Y neuroblastoma cells (2:1 ratio neurons:microglia ...
• Human pluripotent stem cells-derived inner ear organoids recapitulate otic development in vitro

  Daniela Doda, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and BMP-4 (314-BP-010 Biotechne/R&D Systems) from 0.5-10ng/ml ...
• Integrating central and peripheral neurons in elongating multi-lineage-organized gastruloids

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2020

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

  Rani K. Powers, et al., bioRxiv - Physiology 2019

  Quote: ... IFN-α (R&D Systems, 11101-2) was added at 10 ng/mL in RPMI (Corning ...
• A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming

  Adriaan Merlevede, et al., bioRxiv - Systems Biology 2020

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/µL ...
• Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

  Endika Prieto-Fernández, et al., bioRxiv - Cell Biology 2021

  Quote: ... syndecan-2 (R&D Systems Cat#: FAB2965P), syndecan-3 (R&D Systems Cat# ...
• A Combined Human Gastruloid Model of Cardiogenesis and Neurogenesis

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2022

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

  Anne Marchalot, et al., bioRxiv - Immunology 2020

  Quote: ... 5ng/mL hIL-2 (R&D Systems) and 100ng/mL Mega-CD40 ligand (Enzo Life Sciences ...
• Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s disease

  Janelle Drouin-Ouellet, et al., bioRxiv - Neuroscience 2021

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/μL ...
• Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens

  Vijayashree Mysore, et al., bioRxiv - Immunology 2021

  Quote: ... anti-IL15(2) (R&D systems, #MAB247) at 5µg/ml ...
• HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A

  Larissa Butler, et al., bioRxiv - Cell Biology 2022

  Quote: ... 20ng/ml FGF-2 (R&D systems), 5μM Y-27632 (Geron) ...
• Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth

  Fiona E. Freeman, et al., bioRxiv - Bioengineering 2022

  Quote: ... A BMP-2 ELISA (R&D systems) was used to quantify the levels of BMP-2 released by the hydrogels ...
• Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities

  Makrina Daniilidou, et al., bioRxiv - Neuroscience 2022

  Quote: ... ENPP-2 (DENP20, R&D Systems, Europe), TRX-1 (RAB1756 ...
• Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

  Kate Huang, et al., bioRxiv - Cell Biology 2023

  Quote: ... followed by IWP-2 (R&D Systems) for 48 hrs (day 1-3) ...
• Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis

  Gabriella Darmasaputra, et al., bioRxiv - Cell Biology 2023

  Quote: ... type 2 (R&D Systems, #3533-001) and cultured and passaged as previously described for Chol-Orgs75 and Hep-Orgs44 ...
• A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa

  Ying Yang, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 ng/ml TGFB1 (R&D Systems) and 0.4 μM IWP2 (Selleck Chemicals) ...
• DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

  Mukesh Kumar, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2% N-21 (R&D Systems, AR008), and 4 μM cytosine β-D-arabinofuranoside (Millipore Sigma ...
• Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia

  Abolfazl Doostparast Torshizi, et al., bioRxiv - Neuroscience 2019

  Quote: ... and cells were passaged as clumps every 5 days using ReLeSR (StemCell) in the presence of 5 μm ROCK inhibitor (R&D Systems). hiPSCs were characterized by positive IF staining of pluripotent stem cell markers OCT4 ...
• Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

  Farhat Parween, et al., bioRxiv - Immunology 2023

  Quote: ... CXCL9 (5 μg, MAB392), mouse IgG1 isotype control (5 μg, MAB002) and mouse IgG2B isotype control (MAB004) all from R&D Systems, at RT for 2 h ...
• Reprogramming human B cells with custom heavy chain antibodies

  Geoffrey L. Rogers, et al., bioRxiv - Immunology 2023

  Quote: ... cells were initially activated at 5 x 105 cells/mL in B cell activation media: 5 µg/mL soluble CD40L (R&D Systems), 10 µg/mL anti-His tag antibody (clone AD1.1.10 ...
• Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors

  Chenyan Wu, et al., bioRxiv - Cell Biology 2021

  Quote: ... IL-5 (Peprotech and R&D Systems, Minneapolis, MN), erythropoietin (Janssen-Cilag Ab ...
• Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

  Melanie Werner-Klein, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 5 ng/ml GRO-α (R&D Systems, Germany), 20 ng/ml hyper interleukin-6 (kindly provided by S ...
• Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes

  Helene R. McMurray, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and 5 U/ml interferon γ (R&D Systems). All experiments testing the effects of genetic perturbations were carried out at the non-permissive temperature for large T function (39°C ...
• The Modular µSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro

  Molly C. McCloskey, et al., bioRxiv - Bioengineering 2022

  Quote: ... and human fibronectin (5 µg/cm2, R&D Systems) for 1 hour at 37°C ...
• Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity

  Erica R. Vander Mause, et al., bioRxiv - Bioengineering 2022

  Quote: ... 5 μg/ml recombinant human CD229 (R&D Systems) was immobilized on a black 96-well plate (Greiner Bio-One ...
• Breast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands

  Katrin Raute, et al., bioRxiv - Immunology 2022

  Quote: ... α-ULPB2/5/6 (clone 165903) from R&D Systems. α-CD103 (clone 2G5 ...
• Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy

  Alessandro Bertero, et al., bioRxiv - Genomics 2019

  Quote: ... goat polyclonal anti-NKX2-5 (R&D Systems AF2444), dilution 1:500 ...
• Enhancing Cardiac Reprogramming by Suppressing Specific C-C Chemokine Signaling Pathways

  Yijing Guo, et al., bioRxiv - Cell Biology 2019

  Quote: ... recombinant human VEGF165 (5 ng/ml, R&D Systems), recombinant human FGF basic146 aa (10 ng/ml ...
• Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway

  Liu Liu, et al., bioRxiv - Cell Biology 2024

  Quote: ... recombinant human VEGF165 (5 ng/ml, R&D Systems), recombinant human FGF10 (25 ng/ml ...
• Generation of human-pig chimeric renal organoids using iPSC technology

  Koki Fujimori, et al., bioRxiv - Bioengineering 2024

  Quote: ... 5 ng/mL human Bmp4 (R&D Systems, Inc.), 3 μM CHIR99021 ...
• A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

  Inseon Kim, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 µM Forskolin (F) (R&D Systems, 1099/50), 5 µM RepSox (R ...