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2101 - 2150 of 3554 citations for 7 8 DIHYDRO 1 3 DIOXOLO 4 5 G ISOQUINOLIN 5 6H ONE since 2019

• Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis

  Keiramarie Robertson, et al., bioRxiv - Neuroscience 2024

  Quote: ... goat anti-Sox10 (1:1000; R&D Systems, AF2864), rabbit anti-cFos (1:1000 ...
• Cytosolic S100A8/A9 promotes Ca²⁺ supply at LFA-1 adhesion clusters during neutrophil recruitment

  Matteo Napoli, et al., bioRxiv - Physiology 2024

  Quote: ... CXCR2-APC (5μg mL-1; 242216; R&D Systems), CD44-BV570 (0.3μg mL-1 ...
• Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

  Toshiyuki Oda, et al., bioRxiv - Immunology 2022

  Quote: ... and tubulin were detected by immunoblotting using HIV-1 gag p24 antibody (1:1000 dilution, MAB7360, mouse monoclonal, R&D systems, Minneapolis, MN), human CD207 antibody (1:1000 dilution ...
• Genetic control of pluripotency epigenome determines differentiation bias in mouse embryonic stem cells

  Candice Byers, et al., bioRxiv - Genomics 2021

  Quote: ... or PermWash (SOX1) prior to incubation with primary antibody (anti-EpCAM at 1/10k, abcam ab71916; anti-SOX1 at 1/300, R&D Systems AF3369) for 45 minutes at room temperature ...
• The Imprinted Igf2-Igf2r Axis is Critical for Matching Placental Microvasculature Expansion to Fetal Growth

  Ionel Sandovici, et al., bioRxiv - Developmental Biology 2021

  Quote: ... The membranes were then incubated overnight at 4°C with the primary antibody dissolved in 0.5% milk in TBS-T (goat anti-human IGF2, 1:1,000, R&D Systems – AF292-NA or goat anti-mouse SOD1, 1:50,000, R&D Systems – AF3787). After 2x10 minutes washes with milliQ water and 2x10 minutes washes with TBS-T ...
• Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

  Bjoern Meyer, et al., bioRxiv - Microbiology 2021

  Quote: ... Primary antibodies consisted in the human anti-spike mAb 48 (1:1,000; a gift from H. Mouquet) or the mouse anti-p24 Gag MAB7360 (R&D Systems; 1:1000). Anti-human or mouse IgG secondary antibodies ...
• A mouse model for spinal muscular atrophy provides insights into non-alcoholic fatty liver disease pathogenesis

  Marc-Olivier Deguise, et al., bioRxiv - Pathology 2020

  Quote: ... IGF-1 was measured in the samples using a R&D Systems Mouse 1-Plex Luminex Assay (R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s protocol ...
• Epha1 is a cell surface marker for neuromesodermal progenitors and their early mesoderm derivatives

  Luisa de Lemos, et al., bioRxiv - Developmental Biology 2020

  Quote: ... on ice for 30 minutes and then stained on ice for 1 hour with a 1:100 dilution of goat anti-Epha1 antibody (R&D systems #AF3034). After two washes with PBS/10% DS ...
• Adaptive response to BET inhibition induces therapeutic vulnerability to MCL1 inhibitors in breast cancer

  Gonghong Yan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Cells were then blocked with odyssey PBS for 1 hour at room temperature and incubated with the anti-hERBB2/Her2 AF488 antibody (1:200, R&D systems biotechne) overnight at 4 °C ...
• C1q binding to surface-bound IgG is stabilized by C1r₂s₂ proteases

  Seline A. Zwarthoff, et al., bioRxiv - Immunology 2021

  Quote: ... the membrane was incubated in PBS-T with 1% ELK for 45 minutes with either goat anti-human C1r (1:300, R&D Systems, AF1807), sheep anti-human C1s (1:300 ...
• A secreted proteomic footprint for stem cell pluripotency

  Philip Lewis, et al., bioRxiv - Cell Biology 2021

  Quote: ... Some sections were stained with antibodies to early endoderm (GATA6-CST 5851 1:1600) neurectoderm (Beta3 tubulin R&D Systems MAB1195 1:200) or smooth muscle actin in mesoderm (alpha SMA R&D Systems MAB1420 1:200 ...
• Transgenerational effects of exercise on mouse brain and cognition

  Elisa Cintado, et al., bioRxiv - Neuroscience 2023

  Quote: ... Primary antibodies (DCX, Goat anti-doublecortin, 1:500, Santa Cruz; SOX2, Goat anti-sex determining region Y-box 2, 1:200, R&D Systems; CLR ...
• Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling

  Juna-Lisa Knop, et al., bioRxiv - Physiology 2022

  Quote: ... or immunofluorescent (IF) staining as indicated below: Antibody against VE-cadherin extracellular domain (WB 1:1000, IF 1:50, R&D Systems, MAB9381), antibody against VE-cadherin intracellular domain (WB 1:1000 ...
• Median eminence myelin continuously turns over in adult mice

  Sophie Buller, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1:500, rabbit anti-PDGFRα (3164 Cell Signalling Technologies, Danvers, Massachusetts) 1:500 and goat anti-Sox10 (AF2864 R&D Systems, Minneapolis, Minnesota) 1:50 ...
• Microglial IL-1β plays a protective role in epilepsy

  Li Wei, Zhang Wei, Chen Ming, Liu Yang, Li Si-Yan, bioRxiv - Molecular Biology 2023

  Quote: ... Sections were then blocked with 10% normal goat serum and incubated with primary antibodies against Iba1 (1:500, Wako Chemicals, USA) and IL-1β (1:1000, R&D Systems, USA) overnight at 4°C ...
• Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals

  Sarah M. Hammoudeh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Lymphatics were visualized by injecting 0.4ug of Mouse LYVE-1 Alexa Fluor® 594-conjugated Antibody (20ul of concentration 20ug/ml, diluted 1:10 in normal saline; cat# FAB2125T; R&D systems) into the tongue in a region near the tumor 20 minutes before imaging ...
• Morphotype-specific calcium signaling in human microglia

  Sofia Nevelchuk, et al., bioRxiv - Immunology 2024

  Quote: ... followed by incubation with primary antibodies (rabbit-anti RFP, Rockland, diluted 1:1500 and goat anti-PDGFRα, R&D Systems, diluted 1:500) in 1% BSA ...
• Gadolinium-based nanoparticles AGuIX and their combination with ionizing radiation trigger AMPK-dependent proinflammatory reprogramming of tumor-associated macrophages

  Zeinaf Muradova, et al., bioRxiv - Immunology 2024

  Quote: ... anti-AMPKα2 (#AF2850, diluted at 1:1000) and anti-IL6 (#AB-206-NA, diluted at 1:500) antibodies from R&D Systems (Minneapolis, MN, USA). Secondary antibodies used for immunofluorescence labelling of fixed cells were goat anti-rabbit antibodies conjugated to Alexa Fluor 488 (#11034 ...
• Time to run: Late rather than early exercise training in mice remodels the gut microbiome and reduces atherosclerosis development

  Milena Schönke, et al., bioRxiv - Physiology 2022

  Quote: ... Plasma ICAM-1 and VCAM-1 were measured using the Mouse ICAM-1/CD54 and VCAM-1/CD106 Quantikine ELISA kits according to the handbooks (R&D Systems, Minneapolis, USA).
• Imaging angiogenesis in an intracerebrally induced model of brain macrometastasis using α_vβ₃-targeted iron oxide microparticles

  Jessica Buck, et al., bioRxiv - Cancer Biology 2023

  Quote: ... female BALB/c mice were anaesthetized and injected as described above with 1 μg CINC-1 protein (453-KC-050/CF, R&D systems, Abingdon, UK) in 1 μL saline in the left striatum ...
• Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states

  Junjun Yao, et al., bioRxiv - Neuroscience 2024

  Quote: ... sections were incubated overnight at 4℃ with the following primary antibodies: anti-Nestin (rabbit, 1:500, Millpore, PN-MAB5326) and anti-ki67 (mouse, 1:500, R&D system, PN-AF7649); anti-CHI3L1 (rabbit ...
• Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing

  Brian R. Shy, et al., bioRxiv - Synthetic Biology 2021

  Quote: ... and 10 ng mL-1 IL-15 (R&D Systems). Isolated NK cells were activated at 1 x 106 cells mL-1 for 5 days in XVivo15 medium (Lonza ...
• γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

  Natasja L. de Vries, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 1 µg/mL anti-ULBP1 (clone 170818, R&D Systems), 3 µg/mL anti-ULBP2/5/6 (clone 165903 ...
• Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling

  Samuel Ogden, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-HNF4A (R&D Systems, PP-H1415-00, 1:1,000), anti-PPARGC1A (Novus Biologicals ...
• Early growth response 2 (EGR2) is a novel regulator of the senescence program

  Eleanor J. Tyler, et al., bioRxiv - Cell Biology 2020

  Quote: ... goatαIL-6 (1:100, AB-206-NA R&D Systems), followed by donkeyαmouse AlexaFluor-488 or goatαrabbit AlexaFluor-546 (1:500 ...
• A dendritic-like microtubule network is organized from swellings of the basal fiber in neural progenitors

  L. Coquand, et al., bioRxiv - Cell Biology 2020

  Quote: ... and rat anti-Vimentin (R&D systems MAB2105, 1/500).
• Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell

  Mayank Verma, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 10 µM of SU5402 (R&D Systems, 3300/1) and an inhibitor of NRP1 ...
• Cryo-electron tomography of ASC signalling sites in pyroptotic cells

  Yangci Liu, et al., bioRxiv - Immunology 2021

  Quote: ... 1:500 dilution (R&D Systems, AF-401-NA, RRID:AB_416684); mouse anti-γ-Tubulin monoclonal ...
• GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation

  Yasaman Aghazadeh, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and resuspended in unconjugated PDX1 (1/100, R&D Systems) and NKX6.1 (1/1500 ...
• Intermediary role of lung alveolar type 1 cells in epithelial repair upon Sendai virus infection

  Belinda J Hernandez, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-podoplanin (PDPN, 1:500, R&D Systems, AF3244), rat anti-protein tyrosine phosphatase ...
• Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts

  Odemaris Narvaez del Pilar, Jichao Chen, bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-notch3 (NOTCH3, 1:500, AF1308, R&D Systems), rabbit anti-mesenchyme homeobox 2 (MEOX2 ...
• Maf is a regulator of differentiation for gut immune epithelial cell Microfold cell (M cell)

  Joel Johnson George, et al., bioRxiv - Developmental Biology 2021

  Quote: ... recombinant mouse R-spondin1 (1 μg/mL; R&D Systems). Media were changed every 2 days ...
• Self-organized stem cell-derived human lung buds with proximo-distal patterning and novel targets of SARS-CoV-2

  E.A. Rosado-Olivieri, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and goat anti-SOX17 (R&D Systems; AF1924; 1:200). To detect infected cells for HCoV-229E ...
• SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington’s disease progression

  Alena Salašová, et al., bioRxiv - Neuroscience 2021

  Quote: ... and anti-murine-SorCS2 (1:250, #AF4237, R&D Systems) at 4°C overnight ...
• Atoh8 is a regulator of intestinal microfold cell (M cell) differentiation

  Joel Johnson George, et al., bioRxiv - Molecular Biology 2021

  Quote: ... recombinant mouse R-spondin1 (1 μg/mL; R&D Systems). Media were changed every 2 days ...
• Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

  Carolyn M. Walsh, et al., bioRxiv - Immunology 2019

  Quote: ... Compounds injected: 1 µg carrier-free CXCL1 (R&D systems) in PBS ...
• Open the LID: LXRα regulates ChREBPα transactivity in a target gene-specific manner through an agonist-modulated LBD-LID interaction

  Qiong Fan, et al., bioRxiv - Molecular Biology 2019

  Quote: ... LXRα LBD (PP-PPZ0412-00, R&D systems; 1:1000), LXRβ (PP-K8917-00 ...
• Smad4 signaling establishes the somatosensory map of basal vomeronasal sensory neurons

  Ankana S. Naik, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Gt α-NPN2 (1:4000, AF 567,R&D Systems), Gt α-OMP (1:4000 ...
• Expression and distribution of Trophoblast Glycoprotein in the mouse retina

  Colin M Wakeham, Gaoying Ren, Catherine W Morgans, bioRxiv - Neuroscience 2019

  Quote: Sheep anti-5T4 (TPBG-NT) (1:500; R&D Systems; Minneapolis ...
• Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling

  Beatriz Garcia-Diaz, et al., bioRxiv - Neuroscience 2019

  Quote: ... anti-EphrinB3 (1:250, 1µg/mL, AF395 R&D systems), anti-MBP (1:1000 ...
• Cell adhesion molecule interaction with Piezo1 channels is a mechanism for sub cellular regulation of mechanical sensitivity

  E Chuntharpursat-Bon, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-VE-Cadherin (0.5 μg.ml−1, R&D Systems; MAB9381), anti-VEGFR2 (0.2 μg.ml−1 ...
• BDNF controls cognitive processes related to neuropsychiatric manifestations via autophagic regulation of p62 and GABA_A receptor trafficking

  Toshifumi Tomoda, et al., bioRxiv - Neuroscience 2019

  Quote: ... anti-α5-GABAA receptor (rabbit, 1:1,000, R&D Systems), anti-NR1 (rabbit monoclonal [1.17.2.6] ...
• A genetic map of the response to DNA damage in human cells

  Michele Olivieri, et al., bioRxiv - Cancer Biology 2019

  Quote: ... TGFβ (1 ng/mL, R&D Systems #7666-MB-005) and anti-CD40 antibody (1 μg/mL ...
• Plexins Promote Hedgehog Signaling Through Their Cytoplasmic GAP Activity

  Justine M. Pinskey, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat IgG anti-PLXNA1 (1:200, R&D Systems, AF4309), and Mouse IgG1 anti-Beta Tubulin (1:10,000 ...
• Plexins Promote Hedgehog Signaling Through Their Cytoplasmic GAP Activity

  Justine M. Pinskey, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat IgG anti-PLXNA1 (1:250, R&D Systems, AF4309), and mouse IgG2b anti-acetylated tubulin (1:2500 ...
• Pkd1 mutation has no apparent effects on peroxisome structure or lipid metabolism

  Takeshi Terabayashi, et al., bioRxiv - Genetics 2021

  Quote: ... a goat anti-catalase (R&D systems, AF3398, 1: 150), a rabbit anti-Tom20 (Santa Cruz Biotechnology ...
• Spinal cord injury reprograms muscle fibro-adipogenic progenitors to form heterotopic bones within muscles

  Hsu-Wen Tseng, et al., bioRxiv - Pathology 2021

  Quote: ... 1% antibiotics and 10 ng/ml bFGF (R&D Systems).
• Cellular and behavioral characterization of Pcdh19 mutant mice: subtle molecular changes, increased exploratory behavior and an impact of social environment

  Natalia Galindo-Riera, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-Neuropilin1 goat polyclonal (1:300, R&D Systems, AF566).
• Low-density lipoprotein receptor-related protein 1 (LRP1) is a negative regulator of oligodendrocyte progenitor cell differentiation in the adult mouse brain

  Loic Auderset, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-PDGFRα (1:100, R&D Systems AF1062; RRID:AB_2236879); rabbit anti-ASPA (1:200 ...
• DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

  Maria M. Mikedis, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-KIT (R&D Systems AF1356; RRID:AB_354750; 1:250 dilution); anti-mCherry (SICGEN AB0040-200 ...