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151 - 200 of 10000+ citations for R + SCH 23390 hydrochloride since 2020

• Antibody-directed extracellular proximity biotinylation reveals Contactin-1 regulates axo-axonic innervation of axon initial segments

  Yuki Ogawa, et al., bioRxiv - Neuroscience 2023

  Quote: ... mouse monoclonal anti-Tenascin-R (1:250; R&D Systems Cat# MAB1624, RRID:AB_2207001), rabbit polyclonal anti-NrCAM (1:250 ...
• Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

  Linnea Z. Drexhage, et al., bioRxiv - Cell Biology 2023

  Quote: Broad spectrum metalloprotease-specific inhibitors (GM6001, R&D Systems; Marimastat, R&D Systems) or ADAM10 inhibitor GI254023X ...
• Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

  Linnea Z. Drexhage, et al., bioRxiv - Cell Biology 2023

  Quote: Broad spectrum metalloprotease-specific inhibitors (GM6001, R&D Systems; Marimastat, R&D Systems) or ADAM10 inhibitor GI254023X ...
• The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size

  Shicong Xie, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 500ng ng/mL recombinant mouse R-Spondin1 (R&D Systems #7150-RS).
• Chromatin Remodelling in Damaged Intestinal Crypts Orchestrates Redundant TGFβ and Hippo Signalling to Drive Regeneration

  Mardi Fink, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and either 200 ng/mL human R-spondin1(R&D Systems, #4645-RS) or in conditioned media prepared within the lab and used at 2% after titration ...
• Chromosomal Instability in Human Trophoblast Stem Cells and Placentas

  Danyang Wang, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 80 ng/mL recombinant human R-spondin-1 (R&D Systems, 4645-RS), 100 ng/mL recombinant human FGF-2 ...
• Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture

  Vinod Kumar Reddy Lekkala, et al., bioRxiv - Bioengineering 2024

  Quote: ... and 10% R-spo1 conditioned medium prepared by culturing Cultrex HA-R-Spondin1-Fc 293T cells (R&D Systems; 3710-001-01) to generate premature ...
• The oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling

  Giulia Pizzolato, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Recombinant human WNT3A and R-spondin 3 were from R&D Systems (Minneapolis, USA).
• HIP1 mediates oncogenic transformation and cancer progression through STAT3 signalling

  Roheet Bantval Rao, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Phospho-FGF R (Y653/Y654) (Affinity Purified Polyclonal Rabbit IgG, R&D systems #AF3285), phospho-JAK2 (Y1007 + Y1008 ...
• Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model

  Yu-Han Hung, et al., bioRxiv - Genomics 2022

  Quote: ... 250 ng/μL murine R-spondin (R&D Systems, Minneapolis, MN; 3474-RS-050), and 10 μM Y27632 (Enzo Life Sciences ...
• EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

  Mark W. Urban, et al., bioRxiv - Neuroscience 2023

  Quote: ... Antigen retrieval was performed using R&D Systems Protocol (R&D Systems, Minneapolis, Minnesota). Immediately after antigen retrieval ...
• Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids

  Cole R. McCutcheon, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 80 ng/mL recombinant human R-spondin 1 (R&D systems, 4645-RS-100), 100 ng/mL recombinant human FGF2 (Peprotech ...
• Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

  Cheng Tian, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-HNF4a (R&D System, Minneapolis ...
• A non-invasive method to generate induced pluripotent stem cells from primate urine

  Johanna Geuder, et al., bioRxiv - Cell Biology 2020

  Quote: ... Nanog (R&D Systems, D73G4), Neuron-specific beta -III Tubulin (R&D Systems ...
• SARS-CoV-2 receptor Angiotensin I-Converting Enzyme type 2 (ACE2) is expressed in human pancreatic β-cells and in the human pancreas microvasculature

  Daniela Fignani, et al., bioRxiv - Cell Biology 2020

  Quote: ... and #MAB933 (R&D system) were respectively diluted 1:1000 ...
• Proteomic phenotyping of stimulated Müller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity

  Adrian Schmalen, et al., bioRxiv - Immunology 2021

  Quote: ... from R&D Systems/Bio-Techne (R&D Systems/Bio-Techne ...
• SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs

  Lieve E.H. van der Donk, et al., bioRxiv - Immunology 2021

  Quote: ... ACE2 (AF933, R&D systems), goat-IgG (AB-2535864 ...
• Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4⁺ T cells

  Melanie Lancien, et al., bioRxiv - Immunology 2020

  Quote: ... IL-1β (R&D Systems) at 50 ng/mL (except IL-2 at 50 IU/mL) ...
• Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4⁺ T cells

  Melanie Lancien, et al., bioRxiv - Immunology 2020

  Quote: ... IL-22 (R&D Systems) and IFNγ (BD Biosciences ...
• Base-resolution models of transcription factor binding reveal soft motif syntax

  Žiga Avsec, et al., bioRxiv - Genomics 2020

  Quote: ... ɑ-Klf4 (R&D Systems, AF3158), ɑ-Klf4 (Abcam ...
• Gain-of-function mutation in Gli3 causes ventricular septal defects

  Antonia Wiegering, et al., bioRxiv - Developmental Biology 2020

  Quote: ... GLI2 (#AF3635; R&D Systems), KI67 (#sc-7846 ...
• DOT1L methyltransferase regulates the calcium influx in erythroid progenitor cells in response to erythropoietin

  Yi Feng, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Mouse EPO (R&D systems) was added to a final concentration of 10 units/ml ...
• The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development

  Xin Sun, et al., bioRxiv - Developmental Biology 2020

  Quote: ... while WNT3A (R&D Systems) was used at a concentration of 50ng/ml ...
• Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects

  Szilvia Galgoczi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... or BMP4 (R&D Systems) for 1 hour the following day ...
• Ehrlichia SLiM ligand mimetic activates Notch signaling in human monocytes

  LaNisha L. Patterson, et al., bioRxiv - Pathology 2022

  Quote: ... CF (R&D Systems, MN) were dialyzed in running buffer (100 mM sodium phosphate [pH 7.4] ...
• Prime Editing Efficiency and Fidelity are Enhanced in the Absence of Mismatch Repair

  J Ferreira da Silva, et al., bioRxiv - Molecular Biology 2022

  Quote: ... dTAG-7 (R&D Systems), at the final concentration of 500 nM ...
• A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy

  Darshika Tomer, et al., bioRxiv - Cell Biology 2022

  Quote: ... and laminin (R&D systems, catalog # 3400-010-02 ...
• Glycine targets NINJ1-mediated plasma membrane rupture to provide cytoprotection

  Jazlyn P. Borges, et al., bioRxiv - Cell Biology 2022

  Quote: ... by ELISA (R&D Systems) according to the protocol of the manufacturer.
• CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease

  Dahyun Yu, et al., bioRxiv - Neuroscience 2022

  Quote: ... C3d (R&D Systems AF2655), GFAP (Invitrogen PA1-10019) ...
• A ROLE FOR CORTICAL DOPAMINE IN THE PARADOXICAL CALMING EFFECTS OF PSYCHOSTIMULANTS

  Sharonda S. Harris, et al., bioRxiv - Neuroscience 2021

  Quote: ... and GBR12909 (R&D systems) were dissolved in saline (behavior ...
• Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2

  Garam Kim, et al., bioRxiv - Neuroscience 2021

  Quote: ... BDNF/GDNF (R&D Systems) on Matrigel-coated assay plates ...
• Nascent Polypeptide Associated Complex–alpha and Signal Recognition Particle are required for cardiac development and remodeling

  Analyne M. Schroeder, et al., bioRxiv - Developmental Biology 2022

  Quote: ... CDH5 (R&D Systems, AF938). Wells were washed with PBS for 15 mins and repeated three times ...
• Human NLRP1 is activated by ZAKɑ-driven ribotoxic stress response

  Kim S. Robinson, et al., bioRxiv - Immunology 2022

  Quote: ... NLRP1 (R&D systems, #AF6788), NLRP1 (Biolegend #9F9B12), ...
• SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF

  Marianna Ioannou, et al., bioRxiv - Immunology 2021

  Quote: ... anti-MPO (R&D Systems), anti-SIGNR1 (eBioscience) ...
• High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism

  Andra C. Dumitru, et al., bioRxiv - Biochemistry 2020

  Quote: ... and C5a (R&D Systems). After additional 15 min incubation at 25 °C ...
• Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

  Mitchell L. Leibowitz, et al., bioRxiv - Genetics 2020

  Quote: ... and TPO (R&D Systems). CD34+ cells were maintained in complete SFEM post-electroporation for 1-5 days or subject to erythroid differentiation ...
• Cardioids reveal self-organizing principles of human cardiogenesis

  Pablo Hofbauer, et al., bioRxiv - Developmental Biology 2020

  Quote: ... HAND1 (R&D Systems, AF3168), Cleaved Caspase-3 (Cell Signaling Technology ...
• Endosomal trafficking is required for glycosylation and normal maturation of the Alzheimer’s-associated protein sorLA

  Sofie K. Christensen, et al., bioRxiv - Cell Biology 2020

  Quote: ... SORCS1 (AF3457; R&D Systems), or calnexin (ab22595 ...
• The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex

  Simon MG Braun, et al., bioRxiv - Developmental Biology 2020

  Quote: ... SOX9 (R&D Systems, AF3075), BLBP (Abcam ...
• Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication

  Nawar Naseer, et al., bioRxiv - Microbiology 2021

  Quote: ... IL-18 (R&D Systems), IL-1β (BD Biosciences) ...
• The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

  James L. J. Coleman, et al., bioRxiv - Biochemistry 2020

  Quote: ... and TIMP4 (R&D Systems), were added at the time of GPR37L1 induction (or 5 hours after transfection in the case of U87 MG cells ...
• Combinatorial approach of binary colloidal crystals (BCCs) and CRISPR activation to improve induced pluripotent stem cell differentiation into neurons

  Daniel Urrutia-Cabrera, et al., bioRxiv - Bioengineering 2021

  Quote: ... SMA (R&D systems, MAB1420) or AFP (Millipore ...
• DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

  Maria M. Mikedis, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-FOXC2 (R&D Systems AF6989 ...
• SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection

  Rayan Khaddaj-Mallat, et al., bioRxiv - Neuroscience 2021

  Quote: ... TBARS assay (R&D Systems) was used to assess oxidative stress in pericytes under different experimental conditions ...
• Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

  Abigail K. Grosskopf, et al., bioRxiv - Bioengineering 2021

  Quote: ... IL-15 (R&D Systems) was incorporated with the nanoparticles during hydrogel formulation.
• In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

  Michela Carlet, et al., bioRxiv - Cancer Biology 2020

  Quote: ... DUX4 (MAB9535, R&D system) and β-actin (NB600-501SS ...
• Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

  Lee Shaashua, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and 7AAD (R&D systems). Using flow cytometry ...
• 4β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor

  Ofer Moldavski, et al., bioRxiv - Biochemistry 2020

  Quote: ... LXRβ (K8917, R&D systems), phospho-T308 AKT (C31E5E) ...
• The self-regulated response of the Wnt pathway to an oncogenic mutation in β-catenin

  Ana R Moshkovsky, Wenzhe Ma, Marc W Kirschner, bioRxiv - Systems Biology 2021

  Quote: ... CK1α (AF4569, R&D Systems) and α-tubulin (NeoMarkers ...
• Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

  Ruofan Wang, et al., bioRxiv - Microbiology 2020

  Quote: ... ACE2 (R&D Systems, AF933) at 1:1000 ...