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151 - 200 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

  Andrea B. Alber, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 3 ng/ml rhBMP4 (R&D Systems, #314-BP), and 3 ng/ml rmWNT3a (R&D Systems ...
• Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic culture

  Anika Schumacher, et al., bioRxiv - Bioengineering 2023

  Quote: ... 8 μM GSK-3 inhibitor CHIR99021 (R&D Systems), 200 ng/ml fibroblast growth factor 9 (FGF9 ...
• An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial function

  Erica Bello, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 25 ng/ml rhIL-3 (R&D Systems). Macrophage precursor cells could be routinely harvested from dishes containing EBs every 6/7 days for up to 3/4 months ...
• Differential miRNA Expression Contributes to Emergence of Multiple Cancer Stem Cell Subpopulations in Human Colorectal Cancer

  Victoria A. Stark, et al., bioRxiv - Cancer Biology 2023

  Quote: ... purified sheep IgG (2 mg/mL for LRIG1 R&D Systems #5-001-A), and mouse IgG1-PE conjugate (10 uL for LGR5 ...
• TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

  Rachel L. Rutishauser, et al., bioRxiv - Immunology 2020

  Quote: ... and then brought to 1-2 million PBMCs/mL in R10 buffer plus 500pg/mL rhIL-7 (R&D Systems, Minneapolis, MN, USA) and rested again for four days ...
• Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype

  T.M. O’Shea, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat anti-Lipocalin-2 (Lcn2) (1:200, R&D systems, AF1857), goat anti-Clusterin (Clu ...
• A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

  Savannah M. Rocha, et al., bioRxiv - Immunology 2021

  Quote: ... goat angiotensin converting enzyme 2 (ACE2;R&D Systems; 1:500), rabbit transmembrane serine protease 2 (TMPRSS2 ...
• Social transmission of inflammation in mice

  Silvia Castany Quintana, et al., bioRxiv - Neuroscience 2024

  Quote: ... or goat anti-Lipocalin-2 (MAB1757; 1:1000; R&D systems) overnight at room temperature ...
• Robotics-driven manufacturing of cartilaginous microtissues for the bio-assembly of skeletal implants

  Isaak Decoene, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 0.2 ng mL−1 basic FGF-2 (R&D systems). Half of the medium was changed on day 3 ...
• Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion

  Nikaya Polsani, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Goat anti-Runx 2 (1:100; R&D Systems AF2006-SP) and mouse anti-GM130 (1:100 ...
• Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers

  Zvi Yaari, et al., bioRxiv - Bioengineering 2021

  Quote: ... and Human chitinase 3-like 1 (YKL-40) were purchased from R&D Systems. Bovine serum albumin was purchased from Sigma Aldrich ...
• A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition

  Alexis R. Gibson, et al., bioRxiv - Microbiology 2021

  Quote: ... and Human IL29/IL28B (IFN-lambda 1/3) DuoSet ELISA (DY1598B, R&D Systems). Protein levels of IFNλ from intestinal biopsies were measured by Mouse IL28B/ IFN-lambda 3 DuoSet ELISA (DY1789B ...
• Use of a human small airway epithelial cell line to study the interactions of Aspergillus fumigatus with pulmonary epithelial cells

  Hong Liu, et al., bioRxiv - Microbiology 2023

  Quote: ... or 3 ug/ml of an anti-Dectin-1 antibody (MAB1859; R&D Systems). Mouse IgG was used as a control ...
• Neuronal aging is associated with declined autophagy caused by reduced functionality of cGAS-STING signaling

  Sergio Passarella, et al., bioRxiv - Neuroscience 2023

  Quote: cleaved caspase 3 (Cat. No. MAB835, 1:200 in blocking solution, R&D Systems), dsDNA (Cat No ...
• The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

  Christof Gaunt, et al., bioRxiv - Immunology 2021

  Quote: ... and 2 ng/ml IL-2 (carrier-free; Tocris R&D Systems). Cells treated with only these functioned as the mock control ...
• Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

  Nobuyuki Nosaka, et al., bioRxiv - Immunology 2024

  Quote: ... CXCL-2 (Mouse CXCL2/MIP-2 DuoSet ELISA, DY452, R&D Systems), myeloperoxidase (MPO ...
• Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation

  Magdalena A. Sutcliffe, et al., bioRxiv - Developmental Biology 2024

  Quote: ... TCF-2/HNF-1 beta ((R&D Systems, AF3330 1:200 for IF), OCT4 (Abcam ...
• Endothelial β-arrestins Regulate Mechanotransduction by the Type II Bone Morphogenetic Protein Receptor in Primary Cilia

  Saejeong Park, et al., bioRxiv - Molecular Biology 2022

  Quote: Human recombinant BMP-2 and BMP-4 were purchase from R&D Systems (Minneapolis, MN). Anti-Myc and anti-HA antibodies were purchased from Cell Signaling Technology (Danvers ...
• Single-hit genome edition for expression of single-chain immunoglobulins by edited B cells

  Natsuko Ueda, et al., bioRxiv - Immunology 2022

  Quote: ... 5 ng/ml IL-4 (R&D Systems) and 12 ng/ml IL-10 (R&D Systems ...
• Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

  Roberto R. Ricardo-Gonzalez, et al., bioRxiv - Immunology 2021

  Quote: ... mice were injected subcutaneously with IL-4 complex (IL-4c) comprised of rmIL-4 (2 μg, R&D systems) combined with anti-IL-4 antibody 10 μg ...
• Heterozygous Eif4nif1 Stop Gain Mice Replicate the Primary Ovarian Insufficiency Phenotype in Women

  Mika Moriwaki, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and incubated with rabbit active Caspase-3 (5 μg/ml, AF835-SP, R&D systems, Inc., Minneapolis, MN), rabbit cleaved Caspase-9 (1:50 ...
• The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes

  Alex Moore, et al., bioRxiv - Neuroscience 2021

  Quote: ... supplemented with 3 nM Shh (1845-SH; R&D Systems), as used in Ohyama et al (2005 ...
• Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency

  Benjamin A. Krishna, et al., bioRxiv - Microbiology 2020

  Quote: ... GM-CSF and IL-3 [all from R&D Systems]) ...
• DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

  Yale S. Michaels, et al., bioRxiv - Bioengineering 2021

  Quote: ... and 3 U/mL EPO (R&D Systems 287-TC). Cells were cultured for 7 days followed EHT and assessed using by flow cytometry.
• Mechanisms Underlying WNT-mediated Priming of Human Embryonic Stem Cells

  Anna Yoney, et al., bioRxiv - Developmental Biology 2022

  Quote: ... we used a SMAD2/3 antibody (R&D systems, AF3797) in 2X10^6 hESCs that were treated with Activin for 2 h or 24 h with or without Wnt priming ...
• Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived from human iPSCs

  Zhefu Que, et al., bioRxiv - Physiology 2021

  Quote: ... phrixotoxin-3 (PTx3) (R&D Systems, Cat # 4914. 15 μM); phenytoin (Sigma-Aldrich ...
• Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities

  Esther Redder, et al., bioRxiv - Cell Biology 2021

  Quote: ... goat polyclonal anti-mouse VEGFR-3 (R&D Systems, AF743) and rabbit polyclonal anti-RFP (Rockland ...
• CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis

  Panayiota Stylianou, et al., bioRxiv - Cell Biology 2022

  Quote: ... Mouse Galectin-3 DuoSet (all from R&D Systems,UK).
• Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes

  Rahul Atmaramani, et al., bioRxiv - Neuroscience 2024

  Quote: ... Neurotrophin-3 (1ug/ml, 267-N3-025, R&D Systems), and Doxycycline Hydrochloride (1ug/ml ...
• Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes

  Rahul Atmaramani, et al., bioRxiv - Neuroscience 2024

  Quote: ... Neurotrophin-3 (1ug/ml, 267-N3-025, R&D Systems), EdU (5-ethynyl-2’-deoxyuridine ...
• The GPI sidechain of Toxoplasma gondii prevents parasite pathogenesis

  Julia A Alvarez, et al., bioRxiv - Microbiology 2024

  Quote: Recombinant Gal-3 (R&D Systems, Cat# 1197-GA-050) was pre-diluted in phosphate-buffered saline (PBS ...
• Accelerated Hematopoietic Stem Cell Aging in Space

  Jessica Pham, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Thrombopoietin (Tpo) and FLT-3 (all from R&D Systems)36 ...
• GATA1 knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

  Thomas C. Harper, et al., bioRxiv - Immunology 2023

  Quote: ... 30 ng/ml IL-3 (R&D Systems, 203-IL), 30 ng/ml TPO (PeproTech ...
• COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors

  Lucas G. A. Ferreira, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 3 days with 200 ng/mL FGF9 (R&D Systems), 1 μg/mL heparin (Sigma-Aldrich) ...
• A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

  Inseon Kim, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 3 µM CHIR99021 (C) (R&D Systems, 4423/50).
• Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

  Jakushin Nakahara, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10 ng/ml rhIL-3 (#203-IL, R&D Systems) and 10 ng/ml rhIL-6 (#206-IL ...
• Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

  Yale S. Michaels, et al., bioRxiv - Immunology 2023

  Quote: ... IL-3 (5.3 ng/ml; R&D Systems, 203-IL), CXCL12 (9.7 ng/ml ...
• Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

  Yale S. Michaels, et al., bioRxiv - Immunology 2023

  Quote: ... IL-3 (0.97 ng/ml; R&D Systems, 203-IL), CXCL12 (97.39 ng/ml) ...
• Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function

  Nora Bramey, et al., bioRxiv - Cell Biology 2023

  Quote: ... and human total MMP-3 (R&D Systems, cat.# DY513) according to manufacturer’s instructions ...
• Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils

  Adriana Rosa Gambardella, et al., bioRxiv - Cell Biology 2024

  Quote: Recombinant mouse (rm)IL-3 (#403-ML, R&D System)
• Activity-dependent extracellular proteolytic cascade remodels ECM to promote structural plasticity

  Jeet Bahadur Singh, et al., bioRxiv - Neuroscience 2024

  Quote: ... rhTIMP-3 (R&D Systems, Minneapolis / USA, Cat# 973-TM), was dissolved in distilled water at a concentration of 5 µM and stored at −20°C in small amounts ...
• Stepwise transmigration cascade of T and B cells through the perivascular channel in lymph node high endothelial venules

  Kibaek Choe, et al., bioRxiv - Immunology 2020

  Quote: T or B cells (2-4 × 107) obtained from 2 spleens of actin-GFP mice by negative MACS kits (Thermo Fisher Scientific, 114.13D; R&D Systems, MAGM204) were intravenously injected to an actin-DsRed mouse ...
• Integrating central and peripheral neurons in elongating multi-lineage-organized gastruloids

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2020

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming

  Adriaan Merlevede, et al., bioRxiv - Systems Biology 2020

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/µL ...
• Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

  Endika Prieto-Fernández, et al., bioRxiv - Cell Biology 2021

  Quote: ... syndecan-2 (R&D Systems Cat#: FAB2965P), syndecan-3 (R&D Systems Cat# ...
• A Combined Human Gastruloid Model of Cardiogenesis and Neurogenesis

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2022

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

  Anne Marchalot, et al., bioRxiv - Immunology 2020

  Quote: ... 5ng/mL hIL-2 (R&D Systems) and 100ng/mL Mega-CD40 ligand (Enzo Life Sciences ...
• Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s disease

  Janelle Drouin-Ouellet, et al., bioRxiv - Neuroscience 2021

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/μL ...
• Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens

  Vijayashree Mysore, et al., bioRxiv - Immunology 2021

  Quote: ... anti-IL15(2) (R&D systems, #MAB247) at 5µg/ml ...
• HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A

  Larissa Butler, et al., bioRxiv - Cell Biology 2022

  Quote: ... 20ng/ml FGF-2 (R&D systems), 5μM Y-27632 (Geron) ...