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1501 - 1550 of 3554 citations for 7 8 DIHYDRO 1 3 DIOXOLO 4 5 G ISOQUINOLIN 5 6H ONE since 2019

• PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

  Thomas E. Forman, et al., bioRxiv - Molecular Biology 2024

  Quote: ... PDGFRα (1:20, AF1062, R&D Systems). For assessment of Rab5 puncta size and colocalization experiments ...
• Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

  Li Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... SPARCL1 (R&D systems, AF2728, 1:50), SOX10 (Santa Cruz ...
• Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

  Li Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... SPARCL1 (R&D systems, AF2728, 1:50), and DLX5 (Sigma ...
• Lesion-remote astrocytes govern microglia-mediated white matter repair

  Sarah McCallum, et al., bioRxiv - Neuroscience 2024

  Quote: ... Goat-SOX9 (1:200, R&D system), Mouse-SMI32 (1:3000 ...
• SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

  Haowen Qiao, et al., bioRxiv - Neuroscience 2024

  Quote: ... CD13 (1:200; R&D System: AF2335); IBA1 (1:800 ...
• Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo

  Dejin Zheng, et al., bioRxiv - Cancer Biology 2024

  Quote: ... SOX2 (1:1000, R&D Systems, AF2018), TP63 (1:1000 ...
• The scramblases VMP1 and TMEM41b are required for primitive endoderm specification by targeting WNT signaling

  Markus Holzner, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Sox2 (1:50, R&D Systems #AF2018), Lc3 (1:200 ...
• Defining the structure, signals, and cellular elements of the gastric mesenchymal niche

  Elisa Manieri, et al., bioRxiv - Cell Biology 2023

  Quote: ... PDGFRA (R&D Systems, AF1062, 1:100); MUC5AC (Cell Signaling Technology ...
• Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

  Nishant Ranjan Chauhan, et al., bioRxiv - Immunology 2022

  Quote: ... ACE2 (R&D systems #AF933; 1:1000). HRP conjugated secondary antibodies were purchased from Promega (1:5000 ...
• Accurate quantification of lysyl oxidase concentration in human tissue

  Yimin Yao, et al., bioRxiv - Molecular Biology 2023

  Quote: ... LOXL2 (R&D Systems, AF2639, 1:500), rabbit anti-human LOXL4 (provided by Fernando Rodriguez-Pascual ...
• Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

  Benjamin L.L. Clayton, et al., bioRxiv - Neuroscience 2023

  Quote: SOX10 (1:200, R&D Systems, AF2864)
• Morphodynamics of human early brain organoid development

  Akanksha Jain, et al., bioRxiv - Developmental Biology 2023

  Quote: ... CDH2 (1:100, R&D Systems, AF6426), COL4A1 (1:25 ...
• Personalized models of breast cancer desmoplasia reveal biomechanical determinants of drug penetration

  Giovanni S. Offeddu, et al., bioRxiv - Bioengineering 2023

  Quote: ... COL-1 (#AF6220-SP, R&D Systems), ZO-1 (#33-9100 ...
• WFIKKN2 is a bifunctional axon guidance cue that signals through divergent DCC family receptors

  Kelsey R. Nickerson, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and TrkC (R&D Systems, 1:200), rabbit polyclonal antibodies against TuJ1 (Biolegend ...
• Non-canonical function of folate/folate receptor 1 during neural tube formation

  Olga A. Balashova, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1:200 (R&D Systems, cat. # AF2018), anti-α-tubulin ...
• Non-canonical function of folate/folate receptor 1 during neural tube formation

  Olga A. Balashova, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1:300 (Cat # AF2018, R&D Systems), anti-α-tubulin ...
• Non-canonical function of folate/folate receptor 1 during neural tube formation

  Olga A. Balashova, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1:200 (R&D Systems, cat. # AF2018); pan-cadherin ...
• Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution

  Nicolò Caporale, et al., bioRxiv - Neuroscience 2023

  Quote: ... SOX2 (Goat, 1:1000, R&D System). The day after ...
• A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

  Aleksandra Boikova, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and IWR1 (1 µM, R&D Systems) for 48 hours and was refreshed for a further 48 hours ...
• The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

  Yanqiu Li, et al., bioRxiv - Cell Biology 2023

  Quote: ... cisplatin (R&D systems, #15663-27-1), propidium iodide (PI ...
• The salt-and-pepper pattern in mouse blastocysts is compatible with signalling beyond the nearest neighbours

  Sabine C. Fischer, et al., bioRxiv - Developmental Biology 2023

  Quote: ... anti-GATA6 (R&D Systems, 1:200) They were rinsed three time in blocking buffer for 15 minutes each and incubated in secondary antibody solution for 1 hour in the dark ...
• Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

  Laura M. Pikkupeura, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Sox17 (R&D systems #AF1924, 1:300) and Gata4 (Santa Cruz #sc-25310 ...
• NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

  Abrar Choudhury, et al., bioRxiv - Cancer Biology 2023

  Quote: ... CD34 (AF7227, R&D Systems, 1:200), or NOTCH3/N3ECD as described above were used with overnight incubation at room temperature at 1:200 dilutions in TBS++++ ...
• Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

  Davide Capauto, et al., bioRxiv - Genomics 2023

  Quote: ... SOX1 (goat, 1:100, R&D Systems), CTIP2 (rat ...
• Liver-specification of human iPSC-derived endothelial cells transplanted into mouse liver

  Kiryu K. Yap, et al., bioRxiv - Cell Biology 2023

  Quote: ... PDGFRβ (1:100, AF385, R&D Systems), glutamine synthetase (1:200 ...
• NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

  Diones Bueno, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1:2000 (R&D Systems, Minneapolis, USA), ...
• ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

  Alexandre Jourdon, et al., bioRxiv - Neuroscience 2023

  Quote: ... OTX2 (goat, 1:200, R&D Systems), PAX6 (mouse ...
• Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

  Fei Li, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 53BP1 (1:300, AF1877; R&D Systems), BLM (1:250 ...
• An EOMES induced epigenetic deflection initiates lineage commitment at mammalian gastrulation

  Chiara M. Schröder, et al., bioRxiv - Developmental Biology 2023

  Quote: ... α-Brachyury (AF2085, R&D Systems, 1:1,000), α-Brg1 (SMARCA4 ...
• Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendroglia

  Raquel Garza, et al., bioRxiv - Neuroscience 2023

  Quote: ... OLIG2 (R&D Systems, AF2418, 1:500), OLIG2 (Sigma-Aldrich ...
• PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves

  Yen-Chun Ho, et al., bioRxiv - Developmental Biology 2023

  Quote: ... PROX1 (R&D systems; AF2727; 1:200), and DPEAAE (cleaved-versican ...
• PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves

  Yen-Chun Ho, et al., bioRxiv - Developmental Biology 2023

  Quote: ... PROX1 (R&D systems; AF2727; 1:200), PROX1 (AngioBio ...
• Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies

  Simon L. April-Monn, et al., bioRxiv - Cancer Biology 2022

  Quote: ... PDX1 (1:100, R&D Systems, MAB2419); in a Tris-EDTA buffer for 30min at 100°C for synaptophysin (1:100 ...
• Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies

  Simon L. April-Monn, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ARX (1:1500, R&D Systems, AF7068), PDX1 (1:100 ...
• ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

  Alexandre Jourdon, et al., bioRxiv - Neuroscience 2023

  Quote: ... SOX1 (goat, 1:100, R&D Systems), TBR1 (rabbit ...
• Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells

  Kevin W. Southerland, et al., bioRxiv - Genomics 2023

  Quote: ... IGF-1 (R&D systems, 791-MG), FGF2 (Thermo Fisher ...
• A transient dermal niche and dual epidermal programs underlie sweat gland development

  Heather L. Dingwall, et al., bioRxiv - Developmental Biology 2023

  Quote: ... EDAR (1:100, R&D Systems AF745), PDGFRA (1:100 ...
• A transient dermal niche and dual epidermal programs underlie sweat gland development

  Heather L. Dingwall, et al., bioRxiv - Developmental Biology 2023

  Quote: ... PDGFRA (1:100, R&D Systems AF1062), and GFP (1:1000 ...
• The scramblases VMP1 and TMEM41b are required for primitive endoderm specification by targeting WNT signaling

  Markus Holzner, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Sox1 (1:50, R&D Systems, # AF3369), Sox17 (1:200 R&D Systems ...
• NEUROG2 regulates a human-specific neurodevelopmental gene regulatory program

  Vorapin Chinchalongporn, et al., bioRxiv - Developmental Biology 2024

  Quote: ... NESTIN (1:500, R&D Systems #MAB1259), DCX (1:500 ...
• Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

  Na Zhao, et al., bioRxiv - Cancer Biology 2023

  Quote: ... S100A8 (1:5000, R&D Systems #MAB3059), BrdU (1:1000 ...
• Deep Visual Proteomics advances human colon organoid models by revealing a switch to an in vivo-like phenotype upon xenotransplantation

  Frederik Post, et al., bioRxiv - Cell Biology 2024

  Quote: ... Lrig1 (R&D Systems AF3688, 1:50), PDGFR (EPR22059-270 ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... PAX2 (R&D Systems, AF3364, 1:50), SIX1 (Cell Signaling Technology ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... HAVCR1 (R&D Systems, AF1750, 1:200), γH2AX (Cell Signaling Technology ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... JAG1 (R&D Systems, AF599, 1:300), HNF1B (Thermo Fisher Scientific ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... HNF4A (R&D Systems, MAB4605, 1:200), CDH1 (BD Biosciences ...
• A foundational atlas of autism protein interactions reveals molecular convergence

  Belinda Wang, et al., bioRxiv - Systems Biology 2024

  Quote: ... FOXP2 (R&D Systems #AF5647 1:500), FOXG1 (Abcam #ab18259 1:1000) ...
• The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

  Will Campodonico, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1% L-glutamine (R&D Systems, Inc.), and 10% FBS (Millipore Sigma) ...
• A central role for Numb/Nbl in multiple Shh-mediated axon repulsion processes

  Tiphaine Dolique, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Tag-1 (R&D Systems, AF4439) and anti-L1 (Chemicon MAB5272) ...
• DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects

  A Colomer-Boronat, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Sox17 (1:200, AF1924, R&D Systems) and Pax6 (1:200 ...