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101 - 150 of 10000+ citations for R 4 5 Isopropylidene 2 pentanoic acid since 2020

• Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

  Phil Pickford, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... 10 mU recombinant DPP-4 (R&D Systems), or no enzyme as a control for non-enzymatic degradation over the same time period ...
• FMRP phosphorylation modulates neuronal translation through YTHDF1

  Zhongyu Zou, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 4 ng/ml WNT-3A (R&D Systems), 1 μM CHIR99021 M SB-431542 (Tocris) ...
• Metabolic sensor AMPK licenses CD103⁺ dendritic cells to induce Treg responses

  Thiago A Patente, et al., bioRxiv - Immunology 2023

  Quote: ... rIL-4 (0.86 ng/mL, R&D system) and rGM-CSF (10 ng/mL ...
• The extracellular matrix differentially directs myoblast motility in distinct forms of muscular dystrophy

  Ashlee M. Long, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-Thrombospondin-4 (cat# AF2390; R&D Systems), and anti-TIMP-1 (cat# AF980 ...
• Red cabbage juice-mediated gut microbiota modulation improves intestinal epithelial homeostasis and ameliorates colitis

  Emily Jean Wilson, et al., bioRxiv - Pathology 2023

  Quote: ... Anti-4-Hydroxynonenal (R&D Systems; Biotechne, MAB3249); Anti-MUC2 (Abcam ...
• The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix

  Joseph G. O’Brien, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Thrombospondin-4 (cat# AF2390; R&D Systems), anti-TGF-β3 (cat# ab15537 ...
• Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

  Hiroyuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... IL-4 (50 ng/ml, R&D Systems) and anti-IFN-γ (10 μg/ml ...
• The effect of UVA light/8-methoxypsoralen exposure used in Extracorporeal Photopheresis treatment on platelets and extracellular vesicles

  Hayley Macleod, et al., bioRxiv - Cell Biology 2023

  Quote: ... and platelet factor 4 (PF4, R&D Systems) were performed according to the manufacturer’s instructions ...
• Functional imaging of conduction dynamics in cortical and spinal axons

  Milos Radivojevic, Anna Rostedt Punga, bioRxiv - Neuroscience 2023

  Quote: ... 1.4 nM neurotrophin 4 (NT4, R&D systems) and 1.3 nM human insulin-like growth factor 1 (hIGF-1 ...
• Physiological role and mechanisms of action for a long noncoding haplotype region

  Hong Xue, et al., bioRxiv - Genetics 2024

  Quote: ... OCT-4 (1:200, AF1759, R&D Systems), NANOG (1:200,ab80892 ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Siglec-4 Fc chimera protein (R&D Systems), Siglec-5 Fc chimera protein (R&D Systems) ...
• T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome

  Cansu Cimen Bozkus, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 (R&D Systems, 500 IU/mL) and Flt3L (R&D Systems ...
• Monitoring macrophage polarization with gene expression reporters and bioluminescence phasor analysis

  Giulia Tedeschi, et al., bioRxiv - Bioengineering 2024

  Quote: ... IL-4 (20 ng/mL, R&D Systems) and IL-13 (20 ng/mL ...
• IL-21 Shapes the B Cell Response in a Context-Dependent Manner

  Youngjun Kim, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 (R&D Systems, 12.5 ng/mL), IL-21 (R&D Systems ...
• NECTIN-4 PET FOR OPTIMIZING ENFORTUMAB VEDOTIN DOSE-RESPONSE IN UROTHELIAL CARCINOMA

  Akhilesh Mishra, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and mouse Nectin-4 proteins (R&D systems, catalog # 3116-N4-050 ...
• The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes

  Jiayi E. Wang, et al., bioRxiv - Immunology 2024

  Quote: ... 10 ng/mL IL-4 (R&D Systems) for M2 polarization ...
• Exercise-stimulated Resolvin Biosynthesis in Adipose Tissue is Abrogated by High Fat Diet-induced Adrenergic Deficiency

  Ernesto Pena Calderin, et al., bioRxiv - Immunology 2024

  Quote: ... and incubated with 5 ng/mL IL-4 (cat. no. 404-ML-010, R&D Systems, Minneapolis, MN, USA) (or vehicle control ...
• Integrating central and peripheral neurons in elongating multi-lineage-organized gastruloids

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2020

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming

  Adriaan Merlevede, et al., bioRxiv - Systems Biology 2020

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/µL ...
• Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

  Endika Prieto-Fernández, et al., bioRxiv - Cell Biology 2021

  Quote: ... syndecan-2 (R&D Systems Cat#: FAB2965P), syndecan-3 (R&D Systems Cat# ...
• A Combined Human Gastruloid Model of Cardiogenesis and Neurogenesis

  Zachary T. Olmsted, Janet L. Paluh, bioRxiv - Developmental Biology 2022

  Quote: ... 2 ng/ml HGF (R&D Systems) and 50 μM Y-27632 (Tocris Bioscience) ...
• Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

  Anne Marchalot, et al., bioRxiv - Immunology 2020

  Quote: ... 5ng/mL hIL-2 (R&D Systems) and 100ng/mL Mega-CD40 ligand (Enzo Life Sciences ...
• Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s disease

  Janelle Drouin-Ouellet, et al., bioRxiv - Neuroscience 2021

  Quote: ... GDNF (2 ng/mL, R&D Systems), NT3 (10 ng/μL ...
• Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens

  Vijayashree Mysore, et al., bioRxiv - Immunology 2021

  Quote: ... anti-IL15(2) (R&D systems, #MAB247) at 5µg/ml ...
• A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa

  Ying Yang, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 ng/ml TGFB1 (R&D Systems) and 0.4 μM IWP2 (Selleck Chemicals) ...
• DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

  Mukesh Kumar, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2% N-21 (R&D Systems, AR008), and 4 μM cytosine β-D-arabinofuranoside (Millipore Sigma ...
• HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A

  Larissa Butler, et al., bioRxiv - Cell Biology 2022

  Quote: ... 20ng/ml FGF-2 (R&D systems), 5μM Y-27632 (Geron) ...
• Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth

  Fiona E. Freeman, et al., bioRxiv - Bioengineering 2022

  Quote: ... A BMP-2 ELISA (R&D systems) was used to quantify the levels of BMP-2 released by the hydrogels ...
• Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities

  Makrina Daniilidou, et al., bioRxiv - Neuroscience 2022

  Quote: ... ENPP-2 (DENP20, R&D Systems, Europe), TRX-1 (RAB1756 ...
• Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

  Kate Huang, et al., bioRxiv - Cell Biology 2023

  Quote: ... followed by IWP-2 (R&D Systems) for 48 hrs (day 1-3) ...
• Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis

  Gabriella Darmasaputra, et al., bioRxiv - Cell Biology 2023

  Quote: ... type 2 (R&D Systems, #3533-001) and cultured and passaged as previously described for Chol-Orgs75 and Hep-Orgs44 ...
• A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM

  Markella Zannikou, et al., bioRxiv - Immunology 2024

  Quote: ... supplemented with 2% FBS (R&D Systems) and TruStain FcX™ anti-mouse CD16/32 (1:200 ...
• An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m⁶A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction

  Lu Lu, et al., bioRxiv - Neuroscience 2024

  Quote: ... Sigma)/Laminin (2 µg/mL; R&D Systems)/Fibronectin (1 µg/mL ...
• Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine

  Avani Yeola, et al., bioRxiv - Cell Biology 2020

  Quote: Mature adipocytes were cultured in complete medium supplemented with AZA (R&D Systems; 5, 10, 20µM; 2 days) and rhPDGF-AB (Miltenyi Biotec ...
• Identification of Aryl Hydrocarbon Receptor as a Barrier to HIV-1 Infection and Outgrowth in CD4⁺ T-Cells

  Debashree Chatterjee, et al., bioRxiv - Immunology 2022

  Quote: ... cells were cultured in the presence of IL-2 (5 ng/ml; R&D Systems, Minneapolis, MN, USA), and in the presence or the absence of CH-223191 or FICZ ...
• Eomes directs the formation of spatially and functionally diverse extra-embryonic hematovascular tissues

  Bart Theeuwes, et al., bioRxiv - Developmental Biology 2024

  Quote: ... EBs were split 1:2 in SF-D media containing rhVEGF (5 ng ml-1; R&D Systems), rhBMP4 (10 ng ml-1 ...
• Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice

  Marie-Sophie Nguyen-Tu, et al., bioRxiv - Physiology 2020

  Quote: ... non-esterified fatty acid (NEFA) serum levels were measured by colorimetric assay (Randox, UK) and dipeptidyl peptidase 4 (DPP4; R&D Systems, UK) levels were measured by ELISA.
• USP47 regulates a 53BP1-based complex function in DNA DSB repair

  Doraid T. Sadideen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... CH12F3-2 cells were incubated in culture medium supplemented with10ng/mL IL-4 (R&D Systems #404-ML-050), 1ng/mL TGFβ (R&D Systems #7666-MB-005 ...
• Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome

  Xiaojing Mao, et al., bioRxiv - Developmental Biology 2022

  Quote: ... containing 25 ng/ml bone morphogenetic protein-4 (BMP-4, R&D Systems) and 1 μM all-trans Retinoid Acid (RA ...
• Cryopreserved cGMP-compliant human pluripotent stem cells-derived immature hepatic progenitors rescue mice from acute liver failure

  Malika Gantier, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 10 ng/mL bone morphogenetic protein 4 (BMP-4) (R&D System) for five days ...
• Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions

  Zachary J. Rogers, et al., bioRxiv - Bioengineering 2023

  Quote: ... and recombinant human interleukin-4 (IL-4) (50 ng/mL) (R&D systems).
• Attenuation of homeostatic signaling from apoptotic thymocytes triggers a global regenerative response in the thymus

  Sinéad Kinsella, et al., bioRxiv - Immunology 2020

  Quote: ... 5 µM SB431542 (1614/10, R&D Systems), 20 ng/ml FGF (100-18B ...
• IFN-λ4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

  Olusegun O. Onabajo, et al., bioRxiv - Cancer Biology 2020

  Quote: ... IFN-λ1 (5 ng/ml, R&D Systems), IFN-λ2 (60 ng/ml ...
• Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

  Franziska Blaeschke, et al., bioRxiv - Immunology 2022

  Quote: ... 5 ng/ml IL-7 (R&D Systems), 5 ng/ml IL-15 (R&D Systems) ...
• Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

  Lijuan Sun, et al., bioRxiv - Cancer Biology 2020

  Quote: ... TNFα (5 μg/ml, #MAB4101, R&D Systems), or CXCL9 (6 μg/ml ...
• Interleukin 31 receptor alpha induces airway hyperresponsiveness in asthma

  Santoshi Akkenepally, et al., bioRxiv - Pathology 2022

  Quote: ... or rIL-13 (5 µg, R&D Systems) and intratracheally instilled in 50 µL of saline on days 0 and 6 ...
• Distinct Functional States of Neutrophils by Actin Disassembly and NF-kB/STAT3 Signaling

  Niko Heineken, et al., bioRxiv - Immunology 2023

  Quote: ... G-CSF (5 ng/ml, R&D systems), GM-CSF (100 U/µl ...
• Selective Inhibition of Interleukin-2 Inducible T Cell Kinase (ITK) Enhances Anti-Tumor Immunity in Association with Th1-skewing, Cytotoxic T cell Activation, and Reduced T Cell Exhaustion

  Lih-Yun Hsu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... IL-5 (10 ng/ml, R&D Systems), anti-human IFNγ (B27 ...
• Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

  Franziska Blaeschke, et al., bioRxiv - Immunology 2022

  Quote: ... 5 ng/ml IL-15 (R&D Systems), and CTS (Cell Therapy Systems ...
• Tethering NDC80-NUF2 to microparticles is sufficient to enable their biorientation in the spindle

  Kohei Asai, Yuanzhuo Zhou, Tomoya S. Kitajima, bioRxiv - Cell Biology 2024

  Quote: ... 5 µM ProTAME (Bio-Techne R&D Systems) and 500 nM AZD1152 (Cosmo-bio ...