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6451 - 6500 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Epigenetic regulation of Leukocyte associated immunoglobulin-like receptors 1 and 2 by interferon signaling in macrophages and T cells

  Hannah K. Dorando, et al., bioRxiv - Immunology 2023

  Quote: ... 20ng/mL mouse TNF-α (410MT010, R&D Systems), 100ng/mL LPS (L3012 ...
• Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guérin vaccination in rhesus macaques

  Edward B. Irvine, et al., bioRxiv - Immunology 2023

  Quote: ... and Zaire ebolavirus glycoprotein (R&D Systems, 9016-EB).
• GATA1 knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

  Thomas C. Harper, et al., bioRxiv - Immunology 2023

  Quote: ... 100 ng/ml SCF (R&D Systems, 255-SC), 20 ng/ml SHH (PeproTech ...
• Non-genetic differences underlie variability in proliferation among esophageal epithelial clones

  Raúl A. Reyes Hueros, et al., bioRxiv - Systems Biology 2023

  Quote: ... Human recombinant DKK1 (rhDkk, R&D Systems, 5439-DK) was reconstituted at 100µg/mL in 0.1% bovine serum albumin (BSA ...
• CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan

  Linda Heilig, et al., bioRxiv - Microbiology 2023

  Quote: ... CCL4 (MIP-1β, R&D Systems, Minneapolis, MN, USA), CCL5 (RANTES ...
• Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

  Blake A. Caldwell, Yajun Wu, Jing Wang, Liwu Li, bioRxiv - Immunology 2023

  Quote: ... and TREM2 (Alexa Fluor 700; R&D Systems #FAB17291N). For panel 3 ...
• Engagement of sialylated glycans with Siglec receptors on myeloid suppressor cells inhibit anti-cancer immunity via CCL2

  Ronja Wieboldt, et al., bioRxiv - Immunology 2023

  Quote: ... Siglec-9 blocking antibody (Clone 191240, R&D Systems) was added at a final concentration of 10 µg/mL ...
• SCF^FBXW11 complex targets interleukin-17 receptor A for ubiquitin-proteasome-mediated degradation

  Ben Jin, et al., bioRxiv - Biochemistry 2023

  Quote: ... rhIL-17B (R&D Systems, #8129-IL-025/CF), rhIL-17C (R&D Systems ...
• SCF^FBXW11 complex targets interleukin-17 receptor A for ubiquitin-proteasome-mediated degradation

  Ben Jin, et al., bioRxiv - Biochemistry 2023

  Quote: ... rhIL-17C (R&D Systems, #9640-IL-025/CF), rhIL-17E (R&D Systems ...
• Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

  Rahaf Issa, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... All growth factors were purchased from R&D systems, unless otherwise stated ...
• The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase

  Yue Zhou, et al., bioRxiv - Microbiology 2023

  Quote: ... 0.4 ng CD73 nucleotidase (R&D systems, cat# EA002), 1 mM MnCl2 ...
• Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

  Yale S. Michaels, et al., bioRxiv - Immunology 2023

  Quote: ... IL-11 (5ng/mL, R&D Systems, 218-IL), TPO (30ng/mL ...
• Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion

  Angélica Díaz-Basabe, et al., bioRxiv - Immunology 2023

  Quote: ... and the Human CHI3L1 DuoSet ELISA (R&D systems) according to manufacturers’ instructions.
• Structural factors of RGS14 regulating hormone-dependent phosphate transport mediated by NPT2A

  W. Bruce Sneddon, et al., bioRxiv - Cell Biology 2024

  Quote: ... was obtained from R&D Systems (2604-FG-025).
• Apicosome: newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells

  Xiaofen Li, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat polyclonal anti-human FLRT3 (AF2795; R&D Systems), mouse monoclonal anti-centrin (04-1624 ...
• Pathogenic TDP-43 Disrupts Axon Initial Segment Structure and Neuronal Excitability in a Human iPSC Model of ALS

  Peter Harley, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-mouse IgM 405 (Alexa Fluor R&D systems), anti-mouse IgG1 647 (Alexa Fluor R&D systems ...
• Biocompatible polymers for scalable production of human neural organoids

  Genta Narazaki, et al., bioRxiv - Neuroscience 2022

  Quote: ... and SB-431542 (10 μM, R&D Systems, 1614). On day 6 in suspension the organoids were transferred to neural medium containing Neurobasal™-A Medium (Thermo Fisher Scientific ...
• Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks

  Matthew W. Kenaston, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and IFN-β (50 U/mL, R&D Systems) at the given concentrations ...
• Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment

  Julia Kolb, et al., bioRxiv - Neuroscience 2022

  Quote: ... sheep polyclonal anti-PRELP (R&D Systems Cat#AF6447), rabbit polyclonal anti-CHAD (Invitrogen Cat#PA-553761) ...
• LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

  Shengyun Ma, et al., bioRxiv - Immunology 2022

  Quote: ... All the cytokines were obtained from R&D Systems.
• USP47 regulates a 53BP1-based complex function in DNA DSB repair

  Doraid T. Sadideen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 1ng/mL TGFβ (R&D Systems #7666-MB-005) and 1μg/mLanti-CD40 antibody (Thermo Fisher#16-0401-86 ...
• Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c

  TCL Oates, et al., bioRxiv - Immunology 2022

  Quote: ... and ACE2 (R&D Systems, Cat: AF-933-SP). Secondary antibodies used ...
• RNA m⁶A and 5hmC regulate monocyte and macrophage gene expression programs

  Natalia Pinello, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and 20 ng/ml IL-13 (R&D system) for 24 hours.
• Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

  Andreza U. Quadros, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... Mice received C5a recombinant (R&D Systems; Cat. 2150), diluted in BSA 0.1% and stocked at -70 °C until the moment of use.
• Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

  Andreza U. Quadros, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... using DuoSet enzyme immunoassay kits from R&D Systems.
• Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

  Andrea B. Alber, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 3ng/ml rmWNT3a (R&D Systems, #1324-WN-010) and/or 3 ng/ml rhBMP4 (R&D Systems ...
• Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

  Andrea B. Alber, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 100 ng/ml rhFGF10 (R&D Systems, # 345-FG), 100 ng/ml Heparin Salt (Millipore Sigma ...
• Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

  Andrea B. Alber, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 100 ng/ml rhFGF10 (R&D Systems, # 345-FG), and 10 μM Y-27632 (Tocris ...
• Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

  Andrea B. Alber, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 100 ng/ml rhFGF2 (R&D Systems, #233-FB), 100 ng/ml rhFGF10 (R&D Systems ...
• CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

  Victoria Roulstone, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 13 and a pan-caspase inhibitor (R&D systems), was used on cells treated with combination therapy to observe rescue from cells treated without inhibitors ...
• Role of histone variants H2BC1 and H2AZ.2 in H2AK119ub nucleosome organization and Polycomb gene silencing

  Xiangyu Shen, et al., bioRxiv - Molecular Biology 2024

  Quote: ... supplemented with 10% FBS (FCS, R&D Systems, S11550) and 1% Ampicillin-Streptomycin (Gibco ...
• Human receptive endometrial organoid for deciphering the implantation window

  Yu Zhang, et al., bioRxiv - Cell Biology 2024

  Quote: ... Human Placental Lactogen (HPL) (R&D Systems 5757-PL), and prolactin (Peprotech 100-07 ...
• Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

  KC Farrell, Jennifer T. Wang, Tim Stearns, bioRxiv - Cell Biology 2024

  Quote: ... proTAME (R&D Systems, stock concentration: 20mM in DMSO), S-Trityl-L-cysteine (STLC ...
• Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting

  Sunil Shrestha, et al., bioRxiv - Bioengineering 2024

  Quote: ... 0.5 µM A 83-01 (R&D Systems; 2939), 50 µg/mL L-ascorbic acid (Sigma ...
• Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting

  Sunil Shrestha, et al., bioRxiv - Bioengineering 2024

  Quote: ... and 0.7 µM trans-ISRIB (R&D systems; 5284). The medium volume used in the 24-well plate was 1 mL per well ...
• Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

  Tengteng Huang, et al., bioRxiv - Molecular Biology 2024

  Quote: ... anti-IL-15 (R&D system, cat. no. AF447), anti-PGC-1α (Proteintech ...
• Endogenous CD28 drives CAR T cell responses in multiple myeloma

  Mackenzie M. Lieberman, et al., bioRxiv - Cancer Biology 2024

  Quote: ... supplemented with 10% heat-inactivated FBS (R&D Systems), 1% nonessential amino acids (Gibco) ...
• Connexin 43 Regulates Intercellular Mitochondrial Transfer from Human Mesenchymal Stromal Cells to Chondrocytes

  Rebecca M. Irwin, et al., bioRxiv - Bioengineering 2024

  Quote: ... with 10% fetal bovine serum (R&D Systems, S11550), 1% Penicillin/Streptomycin (VWR ...
• Role of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 in Maintaining Redox Homeostasis and DNA Repair in Non-Small Cell Lung Cancers Under EGFR-Targeting Therapy

  Nadiia Lypova, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10% dialyzed fetal bovine serum (R&D Systems, #S12810H), and the appropriate treatments were maintained ...
• The Cyclin-Like Protein Spy1 Mediates Tumourigenic Potential of Triple Negative Breast Cancer

  Bre-Anne Fifield, et al., bioRxiv - Cancer Biology 2024

  Quote: ... precoated with Cultrex (R&D Systems 3433-005-01), or collagen type I (5µg/mL ...
• GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

  J.K. Bruce, et al., bioRxiv - Cell Biology 2024

  Quote: ... peroxidase conjugated anti-goat secondary (HAF109; R&D Systems).
• Regionalized cell and gene signatures govern oesophageal epithelial homeostasis

  David Grommisch, et al., bioRxiv - Cell Biology 2024

  Quote: ... 100ng/ml BMP4 (R&D systems, #5020-BP-010), 5ng/ml IL-17A (R&D systems ...
• Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway

  Liu Liu, et al., bioRxiv - Cell Biology 2024

  Quote: ... recombinant human FGF10 (25 ng/ml, R&D Systems), and recombinant human FGF basic146 aa (10 ng/ml ...
• Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

  Morgan Holcomb, et al., bioRxiv - Neuroscience 2024

  Quote: ... and anti-rat F4/80 (R&D Systems, #MAB5580) at a dilution of 1:200 ...
• Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

  Dymonn Johnson, et al., bioRxiv - Cell Biology 2024

  Quote: ... and SDF1a (#350-NS-010/CF, R&D systems) were supplied in the collagen gel (42 ...
• Cancer-Associated Hypercalcemia Signals Through the Hindbrain to cause Anorexia

  Diego Y. Grinman, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 75ug/mouse of anti-LCN2 (MAB1857, R&D systems) & 10 mg/kg of anti-PTHR1 antibody (XOMA ...
• Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN Haploinsufficiency

  Jon Ondaro, et al., bioRxiv - Neuroscience 2024

  Quote: ... Primary Antibodies: PGRN (1μg/mL, AF2420, R&D systems), LAMP-1(1:10 000 ...
• iSCORE-PD: an isogenic stem cell collection to research Parkinson’s Disease

  Oriol Busquets, et al., bioRxiv - Neuroscience 2024

  Quote: ... + SHH C25II (R&D Systems; 100-200 ng/ml) + CHIR99021 (ToCris ...
• Impact of IL-21 on Natural Killer cell proliferation and function – a mathematical and functional assessment

  Rosalba Biondo, et al., bioRxiv - Immunology 2024

  Quote: ... IL-21 (25 ng/ml) (R&D System, UK), for 10 days.
• Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

  Seda Yasa, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 10 ng/ml GM-CSF (R&D System)] and plated onto 12 mm glass coverslips ...