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551 - 600 of 3717 citations for 2 Aminomethyl 1 3 thiazole 4 carboxylic Acid Hydrochloride since 2020

• IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

  Erik Van Dis, et al., bioRxiv - Immunology 2021

  Quote: ... 10 ng/mL IL-4 from R&D Systems (404-ML), and 3 μg/mL anti-IFN-γ was added ...
• Cell-type specific innate immune responses shape rabies virus tropism

  Lena Feige, et al., bioRxiv - Microbiology 2021

  Quote: ... 5 ng/mL BMP-4 (314-BP-050, R&D Systems), 50 ng/mL VEGF (293-VE-500 ...
• CD13 is a Critical Regulator of Cell-cell Fusion in Osteoclastogenesis

  Mallika Ghosh, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 and IL-13 were purchased from R&D Systems. Acid Phosphatase ...
• A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

  Lindsay B Alcaraz, et al., bioRxiv - Cancer Biology 2021

  Quote: Recombinant 52-kDa pro-cath-D (4 µM; R&D Systems) was auto-activated to 51-kDa pseudo-cath-D in 0.1 M Na-acetate buffer (pH 3.5) ...
• Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

  Whee-Soo Kim, et al., bioRxiv - Biochemistry 2022

  Quote: ... 20 ng/mL bone morphogenetic protein 4 (BMP4, R&D Systems), and 10 ng/mL fibroblast growth factor-basic (bFGF ...
• Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

  Richard J Mills, et al., bioRxiv - Cell Biology 2021

  Quote: ... 30 ng/ml Bone morphogenic protein-4 (BMP4) (R&D systems), 1.5 μM CHIR99021 (Stemgent) ...
• Potent programmable antiviral against dengue virus in primary human cells by Cas13b RNP with short spacer and delivery by virus-like particle

  Ekapot Singsuksawat, et al., bioRxiv - Microbiology 2020

  Quote: ... and 4,000 U/ml of rh IL-4 (R&D Systems) and cultured for 5 days ...
• Neuronal wiring receptors Dprs and DIPs are GPI anchored and this modification contributes to their cell surface organization

  Meike Lobb-Rabe, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4 µl of anti-V5-AF647 antibody (R&D Systems, FAB8926R) was used for staining cells for 20 minutes on a shaker at 500 rpm (Thermo Microplate Shaker) ...
• A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

  Aleksandra Boikova, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and growth factors: 5 ng/ml BMP-4 (R&D Systems), 9 ng/ml Activin A (R&D Systems) ...
• Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA Triplex Element

  Tamer Ali, et al., bioRxiv - Developmental Biology 2022

  Quote: ... BMP-4 (40 ng/ml, R&D Systems #5020-BP-010) or CHIR99021 (3 μM ...
• CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

  Victoria Roulstone, et al., bioRxiv - Cancer Biology 2022

  Quote: ... The caspase 4 inhibitor (Z-YVAD-FMK, FMK005, R&D systems) was used in further experiments at the dose of 50 µM ...
• Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

  Kathryn M. Moore, et al., bioRxiv - Microbiology 2024

  Quote: ... and IL-4 (R&D Systems, Cat# 6507-IL-025/CF) in complete RPMI ...
• NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni

  Madhusoodhanan Suresh Kumar Meena Kumari, et al., bioRxiv - Immunology 2024

  Quote: ... TNFα and IL-4 using ELISA kits from R&D Systems in accordance with the manufacturer’s instructions ...
• Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

  Michael J. D. Daniels, et al., bioRxiv - Neuroscience 2022

  Quote: ... or IL-4 (20 ng/mL, 24 h, R&D Systems). Following stimulation ...
• Intercellular epigenomic signaling during B cell maturation

  Kevin Ho Wai Yim, Alaa Al Hrout, Richard Chahwan, bioRxiv - Immunology 2024

  Quote: ... 10 ng/mL of recombinant mouse IL-4 (R&D Systems) and 2 μg/mL of functional-grade purified anti-mouse CD40 (eBiosciences ...
• Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

  Elizabeth Elder, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 21 ng/mL BMP-4 (R&D Systems, 5020-BP) for 3 days.
• Vitamin D receptor protects against dysbiosis and tumorigenesis via the JAK/STAT pathway in intestine

  Yong-Guo Zhang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Lcn-2 levels were estimated in the supernatants using Duoset murine Lcn-2 ELISA kit (R&D Systems, Minneapolis, MN), as described in our previous study [53].
• Increased receptor affinity and reduced recognition by specific antibodies contribute to immune escape of SARS-CoV-2 variant Omicron

  Anne-Cathrine Vogt, et al., bioRxiv - Immunology 2022

  Quote: ... recombinant SARS-CoV-2 Spike RBD and recombinant SARS-CoV-2 Spike RBD B.1.617.2 L452R T478K were purchased from R&D systems. Proteins were reconstituted as per the manufacturer’s instructions.
• Tritrichomonas muris sensitizes the intestinal epithelium to doxorubicin-induced apoptosis

  Nicolas V. Janto, et al., bioRxiv - Cell Biology 2024

  Quote: ... Lipocalin-2 titration was performed using the DuoSet© ELISA Mouse Lipocalin-2/NGAL kit (R&D Systems, DY1857-05) according to manufacturer’s instructions.
• Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

  LE. Carter, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 2 μg/mL EGF (R&D Systems)] ...
• DSS-induced inflammation in the colon drives a pro-inflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod

  Sarah Talley, et al., bioRxiv - Immunology 2021

  Quote: ... anti-Lipocalin-2 (AF1857-SP, R&D Systems) and anti-β-Actin (sc-8432 ...
• Modeling Cell-Specific Dynamics and Regulation of the Common Gamma Chain Cytokines

  Ali M. Farhat, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 (R&D Systems, 202-IL-010) or IL-15 (R&D Systems ...
• Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

  Nikita P. Patil, et al., bioRxiv - Physiology 2022

  Quote: ... with EGM-2 growth factors (R&D Systems), 10% fetal bovine serum (FBS) ...
• Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes

  Geoffrey L. Rogers, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 10 ng/mL IL-2 (R&D Systems), 50 ng/mL IL-10 ...
• Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes

  Geoffrey L. Rogers, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 10 ng/mL IL-2 (R&D Systems), 50 ng/mL IL-6 (Peprotech) ...
• Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

  Jonah Lin, et al., bioRxiv - Immunology 2022

  Quote: ... 50 U/mL IL-2 (R&D Systems), 10 ng/mL IL-15 (R&D Systems) ...
• NOTCH1 drives immune-escape mechanisms in B cell malignancies

  Maurizio Mangolini, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 1000 unit/mL IL-2 (R&D systems), anti-CD3 (2ug/mL) ...
• Membrane-proximal external region is a superior target for mediating effector activity of HIV-1 specific chimeric antigen receptor modified T cells

  Emiko Kranz, et al., bioRxiv - Microbiology 2020

  Quote: ... 30 IU/ml IL-2 (R&D Systems), Glutamax ...
• Selective modulation of cell surface proteins during vaccinia infection: implications for immune evasion strategies

  Delphine M Depierreux, et al., bioRxiv - Microbiology 2021

  Quote: ... ULBP-2/5/6 (65903, R&D systems), Plexin-B1 (rea728 ...
• Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

  Roberto R. Ricardo-Gonzalez, et al., bioRxiv - Immunology 2021

  Quote: ... or rmIL-13 (2 μg, R&D systems) in calcium- and magnesium-free phosphate buffered saline (PBS) ...
• Novel roles of small extracellular vesicles in regulating the quiescence and proliferation of neural stem cells

  Jingtian Zhang, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and N-2 Plus supplement (R&D Systems) in DMEM/F-12 (Gibco ...
• Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers

  Keito Okazaki, et al., bioRxiv - Cancer Biology 2020

  Quote: ... N-2 Plus Media Supplement (R&D Systems), Gibco B-27 Supplement (Thermo Fisher Scientific) ...
• Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy

  MI Oliveira da Silva, et al., bioRxiv - Neuroscience 2021

  Quote: ... supplemented with 2% N21 (R&D Systems, AR008), 1% penicillin/streptomycin (ThermoFisher Scientific ...
• Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

  LE. Carter, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 2 μg/mL EGF (R&D Systems)] at 5×10^4 cells/mL in non-adherent 24-well culture plates (Corning ...
• OXPHOS Promotes Apoptotic Resistance and Persistence in T_H17 cells

  Hanna S. Hong, et al., bioRxiv - Immunology 2021

  Quote: ... and mIL-2 (10ng/ml; R&D Systems) for Treg polarization ...
• Cell-matrix adhesion contributes to permeability control in human colon organoids

  James Varani, et al., bioRxiv - Cell Biology 2021

  Quote: ... This antibody (clone #P3H9-2; R&D Systems) has been demonstrated to detect antigen in a variety of epithelia and has been shown to inhibit cell proliferation of both rat and human epithelial cells (32) ...
• Quantitative analysis and genome-scale modeling of human CD4⁺ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

  Partho Sen, et al., bioRxiv - Immunology 2021

  Quote: ... 17 ng/ml IL-2 (R&D Systems) was added to the cultures ...
• A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

  Aleksandra Boikova, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 5 ng/ml FGF-2 (R&D Systems) and 1 μM CHIR99021 (STEMCELL Technologies) ...
• Patient-derived functional immuno-oncology platform identifies responders to ATR inhibitor and immunotherapy combinations in ovarian cancer

  Ashwini S Nagaraj, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Type 2 (# 3533-010-02 R&D systems), or 2.5 mg/mL OmGel at a concentration of 1000 cells / µL and plated as a droplet in 48-well or 96 well plates ...
• Safety switch optimization enhances antibody-mediated elimination of CAR T cells

  Tamer B Shabaneh, et al., bioRxiv - Bioengineering 2022

  Quote: ... 200 IU/ml IL-2 (R&D systems), 120 IU/mL IL-7 (R&D systems) ...
• CRISPRi-Driven Osteogenesis in Adipose-Derived Stem Cells for Bone Healing and Tissue Engineering

  Jacob D. Weston, et al., bioRxiv - Bioengineering 2022

  Quote: ... recombinant BMP-2 (R&D Systems, Minneapolis, MN) at varying doses (0 ...
• Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

  Sara G Romeo, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 2 μM Forskolin (R&D system, 1099) for vascular lineage promotion ...
• Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

  Sara G Romeo, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 2 μM Forskolin (R&D system, 1099). On day 6 ...
• Methionine uptake via SLC43A2 transporter is essential for regulatory T lymphocyte survival

  Afsana Naaz, et al., bioRxiv - Immunology 2022

  Quote: ... Recombinant IL-2 (R&D Systems MN, Canada), Magnetic beads coated with anti-CD3 and anti-CD28 antibodies (Invitrogen ...
• Multivalent, asymmetric IL-2-Fc fusions provide optimally enhanced regulatory T cell selectivity

  Brian Orcutt-Jahns, et al., bioRxiv - Systems Biology 2022

  Quote: ... IL-2 (R&D Systems, 202-IL-010) or IL-15 (R&D Systems ...
• HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function

  Syed Bilal Ahmad Andrabi, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 (12 ng/ml; R&D Systems); all-trans retinoic acid (ATRA ...
• Reprogramming human B cells with custom heavy chain antibodies

  Geoffrey L. Rogers, et al., bioRxiv - Immunology 2023

  Quote: ... 10 ng/mL IL-2 (R&D Systems), 50 ng/mL IL-10 ...
• Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

  Jin Young Lee, et al., bioRxiv - Cancer Biology 2024

  Quote: ... LY6A (R&D systems, 2 μg/ml, AF1226), APOE (1:200 ...
• T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome

  Cansu Cimen Bozkus, et al., bioRxiv - Immunology 2024

  Quote: ... IL-2 (R&D Systems, 10 IU/mL), IL-7 (R&D Systems ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Siglec-2 Fc chimera protein (R&D Systems), Siglec-3 Fc chimera protein (R&D Systems) ...