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1551 - 1600 of 3795 citations for 6 Bromo 2 4 fluoro phenyl imidazo 1 2 a pyrimidine since 2019

• Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells

  Inês Caldeira Brás, et al., bioRxiv - Neuroscience 2021

  Quote: ... Tau (1:5000, A0024, Dako), USP19 (1:1000 ...
• TERT-mediated induction of MIR500A contributes to tumor invasiveness by targeting Hedgehog pathway

  Manuel Bernabé-García, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 1 color array (Agilent, #G4470C). These arrays contained probes for 2689 microRNAs ...
• Red-light (670 nm) therapy reduces mechanical sensitivity and neuronal cell death, and alters glial responses following spinal cord injury in rats

  Di Hu, Gila Moalem-Taylor, Jason R Potas, bioRxiv - Neuroscience 2020

  Quote: ... GFAP (1:1000, Dako Z0334); IL1β (1:200 ...
• IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic SNCA mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release

  Peter A. Barbuti, et al., bioRxiv - Neuroscience 2020

  Quote: ... -GFAP (1:1000; Dako, Z0334), -NF68 (1:200 ...
• Alzheimer’s disease-related dysregulation of protein synthesis causes key pathological features with ageing

  Anshua Ghosh, et al., bioRxiv - Neuroscience 2019

  Quote: ... GFAP (Dako Z0334, 1:1000), pGSK3β (Tyr216 ...
• Alzheimer’s disease-related dysregulation of protein synthesis causes key pathological features with ageing

  Anshua Ghosh, et al., bioRxiv - Neuroscience 2019

  Quote: ... tau (Dako A0024, 1:1000), Iba1 (Wako Chemicals 019-19741 ...
• Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma

  Pilar Delgado, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and antimouse (1/10000, DAKO) antibodies ...
• Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

  Lara R. Heij, et al., bioRxiv - Cancer Biology 2020

  Quote: ... FOXP3 (DAKO, PCH101, 1:300) with subsequent visualization using fluorescein FITC (1:100) ...
• Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

  Lara R. Heij, et al., bioRxiv - Cancer Biology 2020

  Quote: ... FOXP3 (DAKO, PCH101, 1:50). All sections were counterstained with haematoxylin ...
• Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

  Lara R. Heij, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CD4 (DAKO, 4B12 1:50), CD8 (DAKO ...
• BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

  Martijn AJ Koppens, et al., bioRxiv - Cell Biology 2021

  Quote: ... Lysozyme (DAKO, EC3.2.1.17, 1/500), LY6G (BD biosciences ...
• SARS-CoV-2 infects lung epithelial cells and induces senescence and an inflammatory response in patients with severe COVID-19

  Konstantinos Evangelou, et al., bioRxiv - Cell Biology 2021

  Quote: ... iii) anti-TTF-1 (Dako), iv ...
• Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice

  Suzanne Lam, et al., bioRxiv - Neuroscience 2022

  Quote: ... GFAP (Dako Z0334, 1/5000) or actin (Sigma A2066 ...
• High fat diet initiates rapid adaptation of the intestine

  Jacob R. Enriquez, et al., bioRxiv - Cell Biology 2022

  Quote: ... Lysozyme (Dako, rab, 1:200), Chga (ImmunoStar ...
• Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic Development

  de la O Sean, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Insulin (1:200, DAKO, A0564), Somatostatin (1:200 ...
• Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic Development

  de la O Sean, et al., bioRxiv - Developmental Biology 2022

  Quote: ... PECAM (1:100, Dako, M0823). The next day ...
• Nucleolin is expressed in human fetal brain development and reactivated in human glial brain tumors regulating angiogenesis and vascular metabolism

  Marc Schwab, et al., bioRxiv - Neuroscience 2020

  Quote: ... or rabbit (1:2,000, Dako) was applied for 1 hour ...
• Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

  Júlia Canet-Pons, et al., bioRxiv - Neuroscience 2019

  Quote: ... GFAP (Dako ZO334, 1:2000), GPNMB (Biotechne AF 2330 ...
• Insights into calcium signaling and gene expression in astrocytes uncovered with 129S4 Slc1a3-2A-CreERT2 knock-in mice

  Lech Kaczmarczyk, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1:500 (Dako, RRID: AB_10013382), Iba1 ...
• Prions induce minor genome-wide translational changes in neurons compared to glia

  Claudia Scheckel, et al., bioRxiv - Neuroscience 2020

  Quote: ... GFAP (1:250, Dako, Z0334); GFP (1:250 ...
• Acute expression of human APOBEC3B in mice causes lethality associated with RNA editing

  Alicia Alonso de la Vega, et al., bioRxiv - Molecular Biology 2022

  Quote: ... CD3 (1:200, Dako A045229). Sections were visualized under a TissueFAXS slide scanning platform (TissueGnostics ...
• Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

  Paul C. Moore, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Insulin (DAKO A0564, 1:200), IRE1α (CST #3294 ...
• In Vivo Study of Key Transcription Factors in Muscle Satellite Cells by CRISPR/Cas9/AAV9-sgRNA Mediated Genome Editing

  Liangqiang He, et al., bioRxiv - Genetics 2020

  Quote: ... MyoD (Dako, M3512, 1:200). All fluorescent images were captured with a fluorescence microscope (Leica).
• Interdependence of CTL and NK cell cytotoxicity against melanoma cells

  Kim S. Friedmann, et al., bioRxiv - Immunology 2020

  Quote: ... anti-MART-1 (Agilent/Dako, 1:1000 ...
• Computer Designed PRC2 Inhibitor, EBdCas9, Reveals Functional TATA boxes in Distal Promoter Regions

  Shiri Levy, et al., bioRxiv - Molecular Biology 2020

  Quote: ... CGB (DAKO GA508; 1:200). Slides were rinsed with PBS-T and incubated with secondary antibodies ...
• Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum

  María A. Duque-Correa, et al., bioRxiv - Immunology 2020

  Quote: ... α-Lysosyme (1:40, Dako, A0099), α-Ki-67 (1:250 ...
• Defined neuronal populations drive fatal phenotype in Leigh Syndrome

  Irene Bolea, et al., bioRxiv - Neuroscience 2019

  Quote: ... NSE (Dako, mouse, 1:1,000), GFAP (Sigma ...
• An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

  Molly M. Wilson, et al., bioRxiv - Cell Biology 2020

  Quote: ... Vimentin (Dako M0725, 1:1000), Fibronectin (BD Biosciences 610077 ...
• An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

  Molly M. Wilson, et al., bioRxiv - Cell Biology 2020

  Quote: ... VIM (Dako M0725, 1:200), TSPAN8 (Personal gift from Jane Visvader ...
• Evaluation of lamin A/C mechanotransduction under different surface topography in LMNA related muscular dystrophy

  Subarna Dutta, T. Muraganadan, Madavan Vasudevan, bioRxiv - Cell Biology 2022

  Quote: ... Integrin β 1 by Agilent 2100 Bioanalyzer ...
• Acquired RAD51C promoter methylation loss causes PARP inhibitor resistance in high grade serous ovarian carcinoma

  Ksenija Nesic, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Ki67 (M7240 1:50; Dako), Cytokeratin (Pan-CK ...
• Adiponectin Preserves Metabolic Fitness During Aging

  Na Li, et al., bioRxiv - Cell Biology 2021

  Quote: ... insulin (1:500, Dako #A0564) and glucagon (1:500 ...
• IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic SNCA mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release

  Peter A. Barbuti, et al., bioRxiv - Neuroscience 2020

  Quote: ... GFAP (1:300; Dako, Z0334), S100β (1:100 ...
• LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

  Rosalie T. Zwiggelaar, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Lysozyme (1:750, Dako A0099), Sox9 (1:200 ...
• HIV-specific CD8⁺ T-cells in tonsils express exhaustive T_RM-like signatures

  Rabiah Fardoos, et al., bioRxiv - Immunology 2021

  Quote: ... p24 (clone: Kal-1, Dako), CXCR5 (clone ...
• Role of the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway in Human β Cell Proliferation

  Caterina Iorio, et al., bioRxiv - Cell Biology 2021

  Quote: ... Immunofluorescence: insulin (Dako 1:1,000), PDX1 (Abcam AB47383 1:2000) ...
• Succinate mediates inflammation-induced adrenocortical dysfunction

  Ivona Mateska, et al., bioRxiv - Immunology 2022

  Quote: ... FCCP (1 μM; Agilent Technologies), OM (500 nM ...
• CRISPR-mediated correction of skeletal muscle Ca²⁺ handling in a novel DMD patient-derived pluripotent stem cell model

  Cristina Morera, et al., bioRxiv - Cell Biology 2022

  Quote: ... MYOD1 (Dako, M3512; 1:100), MYOG (DSHB ...
• Distinctive chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4

  Michio Inoue, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-desmin (Dako, 1:500), anti-DNAJB4 (Abgent ...
• Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation

  Shijie Jin, et al., bioRxiv - Neuroscience 2023

  Quote: ... GFAP (1:2000, Dako, #Z0334), mouse CD63 (1:200 ...
• Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

  Devin Wahl, et al., bioRxiv - Physiology 2024

  Quote: ... and GFAP (1:100; Dako). Slides were washed with TBS and incubated for 1 h in the dark with AlexaFluor 555 or 647 (Invitrogen ...
• Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism

  Gabriela C. De Paula, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 pyruvate (Agilent #103578-100), 2 glutamine (Agilent #103579-100 ...
• ROSALIND protects the mitochondrial translational machinery from oxidative damage

  Vicky Katopodi, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1 mM sodium pyruvate (Agilent) and 2 mM L-glutamine (Agilent ...
• Lesion-remote astrocytes govern microglia-mediated white matter repair

  Sarah McCallum, et al., bioRxiv - Neuroscience 2024

  Quote: ... Rabbit-GFAP (1:1000, Dako), Goat-IBA1 (1:1000 ...
• The role of cortistatin in neuroimmune dysregulation underlying ischemic stroke

  J Castillo-González, et al., bioRxiv - Immunology 2024

  Quote: ... anti-GFAP (1:5000, Dako), anti-CD31/PECAM-1 (1:300 ...
• Novel Mechanism for Tubular Injury in Nephropathic Cystinosis

  Swastika Sur, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 mM pyruvate (Agilent Technologies), and 2 mM glutamine (Agilent Technologies ...
• CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect

  Zachary R. Crook, et al., bioRxiv - Bioengineering 2024

  Quote: ... clone 22C3 (Agilent M365329-1). Primary antibodies for Western blotting are as follows ...
• Matrimeres are systemic nanoscale mediators of tissue integrity and function

  Koushik Debnath, et al., bioRxiv - Bioengineering 2024

  Quote: 1 mg of streptavidin (Agilent) was dissolved in 370 µL of deionized (DI ...
• Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease

  S. L. Fowler, et al., bioRxiv - Neuroscience 2023

  Quote: ... TauC (DAKO A0024, 1/5000), PHF1 (mouse monoclonal ...
• Unbalancing cAMP and Ras/MAPK pathways as a therapeutic strategy for cutaneous neurofibromas

  Helena Mazuelas, et al., bioRxiv - Cancer Biology 2022

  Quote: ... S100B (1:1000, Z0311, Dako) and vimentin (1:200 ...