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1 - 50 of 743 citations for CU 115 CAS 2471982 20 2 98% since 2020

• Predicting the activation of the androgen receptor by mixtures of ligands using Generalized Concentration Addition

  Jennifer J Schlezinger, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... Cat. # 5274, purity ≥ 98%) and TFM-4AS-1 (CAS # 188589-61-9, Cat. # 3813, purity ≥ 98%) were purchased from Tocris Bioscience (Bristol ...
• Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina

  Isabella Palazzo, et al., bioRxiv - Neuroscience 2022

  Quote: ... CU-T12-9 (TLR1/2 agonist; 2.5ug/dose; Tocris; 5414), CU-CPT22 (TLR antagonist ...
• Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina

  Isabella Palazzo, et al., bioRxiv - Neuroscience 2022

  Quote: ... CU-CPT22 (TLR antagonist; 2.5ug/dose; Tocris; 4884), and a cocktail of three different GSK3β inhibitors (referred to as ABC ...
• Comprehensive genomic analysis reveals virulence factors and antibiotic resistance genes in Pantoea agglomerans KM1, a potential opportunistic pathogen

  Robin B. Guevarra, et al., bioRxiv - Genomics 2020

  Quote: ... The involvement of the TLR1/2 in signal transduction was tested using CU-CPT22 at 10 µM (Tocris Bioscience, UK). The used concentrations of inhibitors were selected based on recommendations provided by the manufacturers ...
• GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release

  Carlos G. Ardanaz, et al., bioRxiv - Neuroscience 2022

  Quote: ... or 20 μM 2-methylthyo-adenosine-5’-triphosphate (2-MeSATP, Tocris, 1062) over a 5-min period ...
• A distinct hypothalamus-habenula circuit governs risk preference

  Dominik Groos, et al., bioRxiv - Neuroscience 2024

  Quote: ... CNQX (20 µM, Tocris, 1045, CAS: 479347-85-8), D-APV (100 µM ...
• Optical Control of Neuronal Activities with Photoswitchable Nanovesicles

  Hejian Xiong, et al., bioRxiv - Bioengineering 2022

  Quote: ... SKF-81297 hydrobromide (370.67 g/mol, ≥ 98%) was purchased from Tocris Bioscience ...
• Molecular identification of wide-field amacrine cells in mouse retina that encode stimulus orientation

  Silvia J. Park, et al., bioRxiv - Neuroscience 2023

  Quote: ... 20 L-AP4 (Alomone Labs) and 2-5 ACET (Tocris) (Park et al. ...
• The astrocyte α1-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

  Jérôme Wahis, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2 μl 20% Pluronic F-127 in DMSO (Tocris Biosciences), and 1 μl 0.5% Kolliphor EL (Sigma-Aldrich ...
• A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina

  Gaia Ziraldo, et al., bioRxiv - Neuroscience 2024

  Quote: ... 20 µM L-(+)-2-amino-4-phosphonobutyric acid (L-AP4, Tocris) or 10 µM strychnine hydrochloride (Sigma-Aldrich ...
• The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo

  Bressan Cedric, et al., bioRxiv - Neuroscience 2020

  Quote: ... GABA (10 μM, Tocris, #A5835-25G, CAS: 56-12-2), bafilomycin (4 μM ...
• HB-EGF Promotes Horizontal Basal Cell Proliferation and Olfactory Sensory Neuron Regeneration in the Zebrafish Olfactory Epithelium

  Siran Sireci, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and GM6001 (Illomastat; CAS: 142880-36-2; Tocris, Bristol, UK) were used ...
• Axonal CB1 receptors mediate inhibitory bouton formation via cAMP increase

  Jian Liang, et al., bioRxiv - Neuroscience 2021

  Quote: The following drugs were used: 20 µM WIN 55212-2 (WIN; Tocris Bioscience), 100 µM 2-AG (Tocris Bioscience) ...
• The protease interpain A of Prevotella intermedia promotes human OSCC cells proliferation and migration

  Szu-Min Chang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 20 µM PAR-2 antagonist FSLLRY-NH2 (#4751, TOCRIS/Bio-Techne, Minneapolis, MN, USA) or 0.5 µM cysteine protease inhibitor E64 (#324890 ...
• Recurrent impairments in visual perception and place avoidance across autism models are causally linked in the haploinsufficiency model of intellectual disability Setd5

  Laura E. Burnett, et al., bioRxiv - Neuroscience 2024

  Quote: ... USA) and superfused with ACSF containing 2 mM CaCl2 and 20 µM bicuculline methiodide (Tocris) at a rate of 3 – 4 ml/min at RT ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... Readings were taken before and 3–4 min after application of 20 μM 2-AG (Tocris) to activate CB1R or the eCB sensor.
• Suppression of PIK3CA-driven epileptiform activity by acute pathway control

  Achira Roy, et al., bioRxiv - Neuroscience 2021

  Quote: ... 3-((±)2-carboxypiperazin-4yl) propyl-1-phosphate (CPP, NMDA receptor antagonist, 20 μM; Tocris Bioscience, UK) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX ...
• Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

  Amanda R. Dicks, et al., bioRxiv - Developmental Biology 2021

  Quote: ... paraxial mesoderm (1 day; 20 ng/ml FGF2, 3 µM CHIR99021, 2 µM SB505124 [cat. num. 3263; Tocris Bioscience ...
• Activation of group II metabotropic receptors attenuates cortical E-I imbalance in a 15q13.3 microdeletion mouse model

  Marzieh Funk, et al., bioRxiv - Neuroscience 2020

  Quote: ... 20 μM 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 20 μM D-(-)-2-amino-5-phosphopentanoic acid (D-AP5) (Tocris Bioscience) to block glycine- ...
• Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCF ^βTrCP

  Ana Paula Zen Petisco Fiore, et al., bioRxiv - Cell Biology 2021

  Quote: ... AKT (20 μM MK2206, Cayman Biochemicals #1032350-13-2) and myosin ATPase activity inhibitor (5 μM Blebbistatin, Tocris #1852).
• Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells

  Kristine Henriksen, et al., bioRxiv - Cell Biology 2024

  Quote: ... supplemented with 5.5 mM glucose prior to sequential 30 min incubations of KRBH containing low (2 mM) and high (20 mM) glucose with or without 2.5 nM GIP (Tocris Bioscience ...
• Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish model

  P Whyte-Fagundes, et al., bioRxiv - Neuroscience 2023

  Quote: ... Candidate ASM order information was as follows: 1-Ethyl-2-benzimidazolinone (Alternative name 1-EBIO, Tocris, CAS: 1041), AA43279 (Focus biomolecules ...
• A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

  Huan Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 20 Taltirelin (Tocris), 1 VIP ...
• Reciprocal changes in voltage-gated potassium and subthreshold inward currents help maintain firing dynamics of AVPV kisspeptin neurons during the estrous cycle

  J. Rudolph Starrett, et al., bioRxiv - Physiology 2021

  Quote: ... Picrotoxin (100 µM) was used to block GABAA-receptor-mediated currents and D-2-amino-5-phosphonovalerate (APV; 20 µMm, Tocris Bioscience), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX ...
• Derivation of elephant induced pluripotent stem cells

  Evan Appleton, et al., bioRxiv - Cell Biology 2024

  Quote: ... + 10 μM Tranylcypromine (2-PCPA) HCl (DMSO; Selleckchem S4246) + 20 μM Forskolin (DMSO; Selleckchem S2449) + 1 μM Ch 55 (DMSO; Tocris 2020) + 5 μM EPZ004777 (DMSO ...
• Peripheral kappa opioid receptor activation drives noxious cold hypersensitivity in mice

  Manish K. Madasu, et al., bioRxiv - Neuroscience 2021

  Quote: ... and nor-Binaltorphimine dihydrochloride (norBNI, KOR antagonist, 10 mg/kg, i.p.) (CAS# 113158-34-2) were obtained from Tocris and dissolved in 0.9% sterile saline ...
• PRMT5 epigenetically regulates the E3 ubiquitin ligase ITCH to influence lipid accumulation during mycobacterial infection

  Salik Miskat Borbora, et al., bioRxiv - Microbiology 2021

  Quote: ... EPZ015666 (Tocris, 20 μM); Gefitinib (Cayman Chemicals ...
• Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

  Joshua M. Tworig, Chandler Coate, Marla B. Feller, bioRxiv - Neuroscience 2021

  Quote: ... 20 μM DNQX (Tocris), 50 μM AP5 (Tocris) ...
• Generation of Vascularized Brain Organoids to Study Neurovascular Interactions

  Xin-Yao Sun, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 20 μM DNQX (TOCRIS), and 50 μM DL-AP5 (TOCRIS) ...
• Dopamine D1 receptor activation drives plasticity in the songbird auditory pallium

  Matheus Macedo-Lima, et al., bioRxiv - Neuroscience 2020

  Quote: ... DNQX (20 µM; Tocris) was added to the standard recording solution ...
• Dopaminergic neuromodulation of spike timing dependent plasticity in mature adult rodent and human cortical neurons

  Emma Louise Louth, et al., bioRxiv - Neuroscience 2020

  Quote: ... Dopamine (20 μM, Tocris) was bath applied for ten minutes starting during the last minute of baseline recordings and lasting throughout the induction protocol.
• A retinal circuit that vetoes optokinetic responses to fast visual motion

  Adam Mani, et al., bioRxiv - Neuroscience 2022

  Quote: ... CNQX (20 µM, Tocris), D-AP5 (50 µM ...
• Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

  Nicolas Pelaez-Llaneza, et al., bioRxiv - Cell Biology 2022

  Quote: ... CPA (20 µM, Tocris), 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAMP ...
• AMPK-p38 axis converts human pluripotent stem cells to naïve state

  Zhennan Yang, et al., bioRxiv - Cell Biology 2022

  Quote: ... SB431542 (Tocris, 20 mM), and Noggin (R&D ...
• LTD at amygdalocortical synapses as a novel mechanism for hedonic learning

  Melissa S. Haley, et al., bioRxiv - Neuroscience 2020

  Quote: ... 20 picrotoxin (Tocris Bioscience).
• Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

  Simon A. Sharples, Gareth B. Miles, bioRxiv - Neuroscience 2021

  Quote: ... Nifedipine (20 µM; Tocris) was used to assess the contribution of L-type calcium channels ...
• Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA_A receptors

  Meredith Lodge, et al., bioRxiv - Neuroscience 2020

  Quote: ... NBQX (20 mM; Tocris), and the α5-NAM RO4938581 (10 mM ...
• Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca²⁺ channel activity in continuously active midbrain dopamine neurons

  Anita Siller, et al., bioRxiv - Neuroscience 2021

  Quote: ... 20 µM CNQX (Tocris), 4 µM SR 95531 (Tocris ...
• Inhibitory input directs astrocyte morphogenesis through glial GABA_BR

  Yi-Ting Cheng, et al., bioRxiv - Neuroscience 2023

  Quote: ... bicuculline (20 μM, Tocris). IPSCs were measured in the presence of ionotropic glutamate receptor antagonists ...
• Chrysin, but not flavone backbone, decreases anxiety-like behavior in animal screens

  León Jesús German-Ponciano, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... and a fourth group (DZP) received 2 mg/kg diazepam (CAS #439-14-5; Tocris, 2805; German-Ponciano et al., 2020) as a pharmacological control of anxiolytic activity ...
• NLRP3 inflammasome priming and activation are regulated by a novel phosphatidylinositol-dependent mechanism

  Claire Hamilton, et al., bioRxiv - Immunology 2021

  Quote: ... or Nigericin (20 nM, Tocris) for approximately 45 minutes ...
• Multiscale activity imaging in mammary gland reveals how oxytocin enables lactation

  Alexander J. Stevenson, et al., bioRxiv - Cell Biology 2020

  Quote: ... KN93 (Tocris, 12791, 20 μM), calphostin C (Tocris ...
• Mast cell regranulation involves a metabolic switch promoted by the interaction between mTORC1 and a glucose-6-phosphate transporter

  Jason A Iskarpatyoti, et al., bioRxiv - Cell Biology 2021

  Quote: ... or 20 nM torin (Tocris), BMMCs were treated 1 hr post degranulation with each respective inhibitor in BMMC medium ...
• Lack of sex differences in gonadotropin-releasing hormone (GnRH) neuron potassium currents and excitability

  R. Anthony DeFazio, Suzanne M. Moenter, bioRxiv - Neuroscience 2021

  Quote: ... 20 µM D-APV (Tocris), 10 µM CNQX ...
• Presynaptic NMDA receptors cooperate with local action potentials to implement activity-dependent GABA release from the reciprocal olfactory bulb granule cell spine

  Vanessa Lage-Rupprecht, et al., bioRxiv - Neuroscience 2020

  Quote: ... gabazine (GBZ, 20 μM, Tocris). In pharmacological experiments we waited for 10 minutes after wash-in of the drugs TTX ...
• Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses

  Lisa A.E. Catsburg, et al., bioRxiv - Cell Biology 2021

  Quote: ... or Jasplakinolide (20 µM, Tocris) in E4 for 30 minutes at 37°C and fixed immediately after ...
• A retinal circuit that vetoes optokinetic responses to fast visual motion

  Adam Mani, et al., bioRxiv - Neuroscience 2022

  Quote: ... L-AP4 (20 µM, Tocris), ACET (10 µM ...
• An epigenetic barrier sets the timing of human neuronal maturation

  Gabriele Ciceri, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 20 μM (−)-Bicuculline methochloride (Tocris), 1 μM strychnine HCl (Sigma) ...
• Membrane Ca²⁺ permeability and IP3R2 dependent Ca²⁺-induced Ca²⁺ release are essential for astrocytic intracellular Ca²⁺ elevation upon neuronal stimulation at the mouse hippocampal CA3 - CA1 excitatory synapses

  Jarand B. Hjukse, et al., bioRxiv - Neuroscience 2020

  Quote: ... KB-R7943 (20 μM, Tocris), and PPADS (100 μM ...
• Endophilin A1 promotes Actin Polymerization in response to Ca²⁺/calmodulin to Initiate Structural Plasticity of Dendritic Spines

  Yanrui Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... W-7 (20 μM, TOCRIS), KN-62 (4 μM ...