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Citations for Tocris :
251 - 289 of 289 citations for BD 3 Human since 2019
Citations are collected from bioRxiv only, the total number of publications could be much larger.
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bioRxiv - Neuroscience 2019Quote: ... N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide (ANA12, 10 µM) (Tocris), (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester (K252a ...
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bioRxiv - Neuroscience 2020Quote: ... placed in an aCSF-filled borosilicate glass pipette (3-5 MΩ) in the presence of 6,7-Dinitroquinoxaline-2,3-dione (DNQX; 10 μM; Tocris #14A/166549).
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bioRxiv - Neuroscience 2020Quote: ... 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide) and antagonist WRW4 (Trp-Arg-Trp-Trp-Trp-Trp-NH2) were purchased from Tocris Ltd ...
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bioRxiv - Neuroscience 2020Quote: ... The GAT1 blocker NO-711 [(1,2,5,6-tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride] and GAT3 blocker SNAP-5114 [1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid] were purchased from Tocris Bioscience (Minneapolis ...
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bioRxiv - Neuroscience 2022Quote: ... animals were treated with the selective positive allosteric modulator (PAM) of mGluR5 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB; Tocris, UK) that was diluted in saline solution containing 5-10% final concentration of DMSO and polyethylene glycol 400 (DMSO ...
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bioRxiv - Neuroscience 2021Quote: ... The mGluR5 specific negative allosteric modulator MTEP (3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride) was purchased from Tocris (2921) and administered to brain slices at 1 μM by bath perfusion ...
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bioRxiv - Neuroscience 2021Quote: ... Hox propagation was initiated by activation of Wnt signaling using NMP media comprised of E6 medium supplemented with 200 ng/mL FGF8b and 3 μM CHIR99021 (Tocris). This constitutes the “Hox timepoint” of 0hrs ...
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bioRxiv - Neuroscience 2019Quote: ... 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide (DIPPA) HCl (10 mg/kg Tocris) dissolved in 10% DMSO.
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bioRxiv - Neuroscience 2019Quote: ... (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80) (20mg/kg; Tocris) dissolved in 1mM HCl in saline.
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bioRxiv - Neuroscience 2019Quote: ... Specific blockade of GABA-B receptors was performed by wash in of 10 µM CGP 55845 hydrochlorid [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride] (Tocris Bioscience) for 20 minutes.
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bioRxiv - Pharmacology and Toxicology 2021Quote: ... 0.3 or 1 mg/kg of the mGlu2/3 receptor agonist LY379268 (Cat No.: 2453, Batch No.: 9B/232416, CAS No.: 191471-52-0, Tocris Bioscience ...
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bioRxiv - Neuroscience 2022Quote: ... 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolol[1,5-a]pyrimidin-3-yl]phenol (PHTPP, 10 μM dissolved in 10% DMSO, TOCRIS, Minneapolis, MN), microinjected bilaterally into the CeA (0.5 μL over one minute with a one-minute wait post-infusion ...
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bioRxiv - Cell Biology 2023Quote: iPSCs were first differentiated into iAT2s and passaged as above in 3D cultures in iAT2 medium (CK+DCI) supplemented for the first 3 days after passaging with 10 uM Y-27632 (Tocris). To generate iAT1s ...
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bioRxiv - Neuroscience 2023Quote: ... and 10 μM 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide (SR95531; GABAA receptor antagonist, all from Tocris). The resting membrane potential was measured after whole-cell configuration was achieved ...
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bioRxiv - Neuroscience 2023Quote: ... Extracellular action potentials were recorded in 3 independent cultures for either genotype in the presence of 50nM nifedipine (Tocris Bioscience) or vehicle using the MaestroPro (Axion Biosystems ...
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bioRxiv - Bioengineering 2023Quote: ... The media were changed at day 3 to remove the ROCK inhibitor and to add 10 µM DAPT (Tocris Bioscience), which remained until day 7 ...
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bioRxiv - Cell Biology 2020Quote: ... and diabetic NOD mice (14-26 weeks; n=3) were intra-peritoneally injected with 50mg/kg of Chloroquine diphosphate (Tocris #4109). Two hours post injection ...
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bioRxiv - Pharmacology and Toxicology 2022Quote: ... supplemented with 100 ng/mL Activin A (R&D, Minneapolis, MN, USA) and 3–5 µM CHIR99021 (Tocris Bioscience, Bristol, UK) (differentiation day 0 ...
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bioRxiv - Neuroscience 2022Quote: ... 12-well plates at 3-4 × 105 cells/well in mTeSR1 with 10 µM rho-kinase inhibitor (Y-27632; Tocris, 1254). Medium without the inhibitor was replaced daily until the cells reach 80-100% confluency ...
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bioRxiv - Systems Biology 2020Quote: ... On Day 3 we changed the medium to RPMI + 2% B-27 (minus insulin) + 1uM Xav 939 (Tocris Bioscience, cat. 3748) and incubated the cells for 48 hours ...
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bioRxiv - Cell Biology 2020Quote: ... into fibronectin-coated wells of two 96 well plates per biological replicate to assess proliferation on day 0 (D0) and day 3 (D3) in the presence or absence of 10 μM RARβ antagonist LE135 (Tocris Bioscience) using the cell viability MTS assay ...
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bioRxiv - Neuroscience 2023Quote: ... 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl) hydrazino]carbonyl]benzyl]benzene-sulfonamide (TCN 201, 3 μM dissolved in DMSO; Tocris Bioscience), (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate (Ro25-6981 ...
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bioRxiv - Neuroscience 2023Quote: ... 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid (DQP 1105, 10 μM dissolved in DMSO; Tocris Bioscience), or 6-Cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX ...
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bioRxiv - Biochemistry 2022Quote: ... Positive clones were analyzed by Sanger sequencing with primers #3 and #4 (Integrated DNA Technologies, Supplementary Table S5) and degradation upon dTAG-13 (Tocris, 6605) treatment was confirmed by Western Blot by a-Chaf1a antibody (65) ...
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bioRxiv - Neuroscience 2023Quote: ... and 10 µM 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide (SR95531;GABAA receptor antagonist; all from Tocris Bioscience).
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bioRxiv - Physiology 2023Quote: ... PAH was induced by a single subcutaneous injection of SU5416 (SU:3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one) (Tocris, Bristol, United Kingdom) in 0.5% carboxymethyl cellulose followed by 3-weeks chronic hypoxia (9-10% O2) ...
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bioRxiv - Neuroscience 2021Quote: ... n=20) group were randomized to receive either saline or GLP-1R antagonist Exendin-3(9-39)amide (Ex-9) (Tocris Bioscience, UK) (85 μg/kg dissolved in saline ...
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bioRxiv - Genomics 2022Quote: ... iPS cells were grown to 80– 90% confluence and changed into CM Media supplemented with 3 μM CHIR99021 (Tocris Biosciences, Bristol, UK) for 2 days ...
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bioRxiv - Neuroscience 2020Quote: ... co-applied with the competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid AMPA/kainate receptor antagonist CNQX (Tocris; 20 μM) (n=13) ...
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bioRxiv - Genomics 2020Quote: ... supplemented with SMAD inhibitors (DMH-1 2 μM Tocris, Cat.: #4423; SB431542-10 μM Tocris, Cat.: #1614 and CHIR99021 3 μM, CHIR Tocris, Cat.: #4423).
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bioRxiv - Cancer Biology 2022Quote: ... Proteins were then transferred onto PVDF membranes (Cytiva, Catalog #: 10600023) using a wet transfer approach and membranes were then blocked with 3% bovine serum albumin (Tocris, Catalog #: 5217) and probed for CDC42 (Cell Signaling Technology ...
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bioRxiv - Neuroscience 2022Quote: ... food was removed for 3 hours (3 pm – 6 pm) and mice received either vehicle or CCK-8s (20 μg/kg BW; i.p.; Tocris, St. Louis, USA) injection at dark onset (6 pm ...
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bioRxiv - Neuroscience 2021Quote: ... 3 or 6 μg/hemisphere of LY379268 (Cat No.: 2453, Batch No.: 9B/232416, CAS No.: 191471-52-0, Tocris Bioscience, Oakville, Ontario), in a counterbalanced ...
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bioRxiv - Cancer Biology 2022Quote: ... the small molecule 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one (iMDK; TOCRIS Bio-techne, 9mg/kg), rapamycin (Sirolimus A8167 ...
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bioRxiv - Neuroscience 2020Quote: ... The bath solution for recordings contained elevated concentrations of divalent cations [4 mM Ca2+ and 4 mM Mg2+] and NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) [5 mM] (Tocris biosciences, 126453-07-4). Slices were used 1.5–4.5 hours after preparation ...
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bioRxiv - Developmental Biology 2022Quote: ... and 1% Pen/Strep) +2iLIF (10 ng/ml leukemia inhibitory factor + 3 μM CHIR99021 + 1 μM PD0325901 from Tocris, Cat. # 4423 and 4192, respectively). The cells were grown on 0.1% gelatin-coated dishes and usually seeded at a density of 0.5–1.5 × 104/cm2 ...
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bioRxiv - Neuroscience 2020Quote: ... They were left drug-free for 3 weeks before chronic daily treatment with vehicle (NaCl 0.9%) or VU0155041 (Tocris, Bristol, UK; 2.5 or 5 mg/kg, i.p.) started ...
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bioRxiv - Developmental Biology 2021Quote: ... (15) ESC were grown in N2B27 media supplemented with 2i/LIF (1 mM PD0325901, 3 mM CHIR99021, both from Tocris and 1:500 LIF, made in house). N2B27 media consisted of a 1:1 mix of DMEM/F12 and Neurobasal Medium ...
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bioRxiv - Biochemistry 2024Quote: ... The filtrate was diluted two times the volume with buffer UA (8 M urea [Acros Organics, CAS No. 57-13-6], 50 mM sodium acetate [Tocris CAS No. 127-09-3], pH 4). This was loaded onto a HiPrep SP HP 16/10 (Cytiva ...