Labshake search

1 - 50 of 2121 citations for 5R 3 4 5 6 Tetrahydro 5 phenyl N benzyloxycarbonyl 4 H 1 4 oxazin 2 one since 2020

• Serotonin, Etonogestrel and breathing activity in murine Congenital Central Hypoventilation Syndrome

  Alexis Casciato, et al., bioRxiv - Physiology 2022

  Quote: ... LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride) was purchased from Tocris Bioscience (Bristol ...
• The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons

  José Miguel Arcas, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide (WS-12) was purchased from Tocris Bioscience and prepared in a DMSO stock (20 mM) ...
• TRPV1 in arteries enables a rapid myogenic tone

  Thieu X. Phan, et al., bioRxiv - Physiology 2021

  Quote: ... resiniferatoxin and 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide (BCTC) were purchased from Tocris Bioscience or Adooq Bioscience and stock solutions were prepared in EtOH at 1 M and 100 mM ...
• PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

  Pojeong Park, et al., bioRxiv - Neuroscience 2020

  Quote: ... 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester (KN-62; Tocris and HelloBio); D-AP5 (HelloBio) ...
• Long-lasting reduction of intrinsic excitability in O-LM interneurons is mediated by endocannabinoid-dependent up-regulation of Kv7 channels

  Salvatore Incontro, et al., bioRxiv - Neuroscience 2021

  Quote: ... AM 251 (N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) from Tocris and ...
• Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner

  Jessica L Hoffman, et al., bioRxiv - Neuroscience 2022

  Quote: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one (JNJ-5; Tocris, Minneapolis, MN) is a high affinity ...
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... 4-(3-chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide (BCTC, Tocris #3875) 10 mM in DMSO ...
• Short chain fatty acids enhance expression and activity of the umami taste receptor in enteroendocrine cells via a Gα_i/o pathway

  Matilda Shackley, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4-CMTB; Tocris) was used as a FFAR2-specific agonist and AR420626 (Cayman ...
• Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique

  Huamei Forsman, et al., bioRxiv - Immunology 2024

  Quote: ... The FFA2R antagonist CATPB ((S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl) phenyl) butanoic acid) was from Tocris Bioscience (Bristol ...
• Calcium-independent astrocytic lipid release modulates neuronal excitability

  Fushun Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251, 5 µM, Tocris); Tetrodotoxin (TTX ...
• Behavioral pharmacology of mescaline - the role of serotonin 5-HT2A, 5-HT2B, 5-HT2C and 5-HT1A receptors

  Lucie Olejníková-Ladislavová, et al., bioRxiv - Animal Behavior and Cognition 2024

  Quote: The 5-HT1A antagonist N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate (WAY100635; Tocris Bioscience) at a dose of 1.0 mg/kg.
• Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

  Luisa Saecker, Hanns Häberlein, Sebastian Franken, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy) phenyl]-2-pyridinyl]thio]-acetamide (BAY 60-6583; Tocris, 910487-58-0), 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide (2-Chloro-IB-MECA ...
• Gallein and isoniazid act synergistically to attenuate Mycobacterium tuberculosis growth in human macrophages

  Ramesh Rijal, Richard H. Gomer, bioRxiv - Microbiology 2024

  Quote: To investigate the impact of gallein (3’,4’,5’,6’-Tetrahydroxyspiro[isobenzofuran-1(3H),9’- (9H)xanthen]-3-one) (Cat#3090, Tocris, Minneapolis, MN) and/or INH on Mtb growth ...
• SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca²⁺ dependent manner by cAMP AND ATP in intestinal epithelial cells

  Rafiquel Sarker, et al., bioRxiv - Physiology 2022

  Quote: ... BPTU (1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy) phenyl) urea was from Tocris Bioscience.
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... Drugs were added from the following stock solutions: (2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (WS-12, Tocris #3040, Bio-Techne Ltd, Abingdon, UK) 5 mM in ethanol ...
• Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

  Luisa Saecker, Hanns Häberlein, Sebastian Franken, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl] phenylmethanone (VCP 171; Tocris, 1018830-99-3), 5-[2-(5-nitro-2-furanyl)ethenyl]-2-furancarboxylic acid ...
• The ketone body acetoacetate activates human neutrophils through FFA2R

  Jonas Mårtensson, et al., bioRxiv - Cell Biology 2022

  Quote: ... The FFA2R antagonist CATPB ((S)-3-(2-(3-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)-phenyl) butanoic acid) was from Tocris (Britsol, UK).
• Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

  Gregory G. Grecco, et al., bioRxiv - Neuroscience 2020

  Quote: ... The bath solution for recordings contained elevated concentrations of divalent cations [4 mM Ca2+ and 4 mM Mg2+] and NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) [5 mM] (Tocris biosciences, 126453-07-4). Slices were used 1.5–4.5 hours after preparation ...
• Independent regulation of early trafficking of NMDA receptors by ligand-binding domains of the GluN1 and GluN2A subunits

  Jakub Netolicky, et al., bioRxiv - Neuroscience 2024

  Quote: ... 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone (L-701-324; Tocris); (R)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid ((R)-CPP ...
• The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection

  Fumiya Kozawa, et al., bioRxiv - Cell Biology 2024

  Quote: ... and P2Y1 antagonist 1-(2- (2- tert-butylphenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea (BPTU; BMS- 646786, #870544-59-5) were obtained from Tocris Bioscience (Bristol ...
• Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription

  Janne Purhonen, Jukka Kallijärvi, bioRxiv - Molecular Biology 2023

  Quote: ... BI stands for Broccoli aptamer ligand (5Z)-3-(1H-Benzimidazol-7-ylmethyl)-5-[(3,5-di-fluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2-methyl-4H-imidazol-4-one dihydrochloride) (Cat. No. 7466, Tocris) (14) ...
• A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance

  Gianna Giacoletti, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ST034307 (6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one) was purchased from Tocris Bioscience and morphine sulphate from Spectrum Laboratory Products ...
• Loss of synaptopodin impairs mGluR5 and protein synthesis dependent mGluR-LTD at CA3-CA1 synapses

  Pei You Wu, et al., bioRxiv - Neuroscience 2023

  Quote: ... anisomycin and N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM-251) were purchased from Tocris Bioscience ...
• Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

  Jharna Datta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazoledihydro-chloride (MPP; cat# 1991) were purchased from Tocris Bioscience ...
• Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and rewires the microenvironment toward an immune-suppressive state

  Yan Tang, et al., bioRxiv - Cancer Biology 2022

  Quote: ... the small molecule 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one (iMDK; TOCRIS Bio-techne, 9mg/kg), rapamycin (Sirolimus A8167 ...
• Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

  Crozat Elysa, et al., bioRxiv - Neuroscience 2024

  Quote: ... α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA, Tocris Bioscience), Kainate and N-methyl-D-aspartate acid (NMDA ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride (SKF-96365; 1147, Tocris) in ddH20 ...
• Allosteric receptor modulation uncovers an FFAR2 antagonist as a positive orthosteric modulator/agonist in disguise

  Simon Lind, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... as well as the P2Y2R antagonist AR-C118925XX (5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide) were obtained from Tocris (Abingdon, UK). Subsequent dilutions of receptor ligand and other reagents were made in Krebs-Ringer Glucose phosphate buffer (KRG ...
• A consensus definition for deep layer 6 excitatory neurons in mouse neocortex

  Su-Jeong Kim, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 5 μM (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP, NMDA receptor antagonist, Tocris, 0173) were added to the aCSF and perfused for 3 min after which the synaptic responses of the neurons to photostimulation were measured again ...
• Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain processing neurons across sex in rats and humans

  Annemarie Dedek, et al., bioRxiv - Neuroscience 2023

  Quote: ... and (3-chloro-4-fluoro-N-[(4-([2-(phenylcarbonyl)hydrazino]carbonyl) phenyl)methyl]benzene-sulfonamide) (TCN-201) (Hansen et al., 2012)were obtained from Tocris Bioscience ...
• Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I

  Graham. M. Pitcher, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl) hydrazino]carbonyl]benzyl]benzene-sulfonamide (TCN 201, 3 μM dissolved in DMSO; Tocris Bioscience), (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate (Ro25-6981 ...
• Inhibition of SARS-CoV-2 infection in human cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoskeleton architecture and contractility

  José Alexandre Salerno, et al., bioRxiv - Cell Biology 2021

  Quote: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride (NE-100 hydrochloride) was purchased from Tocris (3133). Stock and work solutions were prepared using 100% dimethyl sulfoxide sterile-filtered (DMSO ...
• Superoxide enters neurons via LRRC8A – containing volume-regulated anion channels

  Kate Harris, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB; Tocris), superoxide dismutase (SOD ...
• mir124-dependent tagging of glutamatergic synapses by synaptopodin controls non-uniform and input-specific homeostatic synaptic plasticity

  Sandra Dubes, et al., bioRxiv - Neuroscience 2021

  Quote: ... mEPSCs were recorded in aCSF supplemented with 10 μM N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-naphthalen-1-ylacetamide trihydrochloride (NASPM, Tocris) to selectively block CP-AMPARs ...
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... 1-(2-hydroxyphenyl)-4-(V3-nitrophenyl)-l,2,3,6-tetrahydropyrimidine-2-one (icilin, Tocris #1531) 10 mM in DMSO ...
• A role for the V0 sector of the V-ATPase in neuroexocytosis: exogenous V0d blocks complexin and SNARE interactions with V0c

  Christian Leveque, et al., bioRxiv - Cell Biology 2023

  Quote: ... Neurosensor 510 (7-(Diethylamino)-4-(4-methoxyphenyl)-2-oxo-2H-1-benzopyran-3-carboxaldehyde) was purchased from (Tocris).
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4-AP (10 μM, Tocris, #504-24-5), Phenytoin (25 μM ...
• Dopamine depletion can be predicted by the aperiodic component of subthalamic local field potentials

  Jinmo Kim, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4 or 8 μl of 6-OHDA (5 μg in 1 μl saline containing 0.1% ascorbic acid; Tocris, Bristol ...
• ATP activation of peritubular cells drives testicular sperm transport

  David Fleck, et al., bioRxiv - Cell Biology 2020

  Quote: ... Cyclopiazonic-acid (CPA) and 2’(3’)-O-(4-Benzoylbenzoyl)adenosine-5’-triphosphate (BzATP) triethylammonium salt was purchased from Tocris Bioscience (Bristol ...
• Nucleolin acute degradation reveals novel functions in cell cycle progression and division in TNBC

  Joseph Mills, et al., bioRxiv - Cancer Biology 2024

  Quote: To induce the degradation of AID-NCL, cells were treated with 5-phenyl-indole-3-acetic acid (phenyl-auxin, 5-Ph-IAA) (Tocris, #7392). To block the interaction between APC/C and cdc20 ...
• Global mapping of the Chlamydia trachomatis conventional secreted effector – host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation

  Brianna Steiert, et al., bioRxiv - Microbiology 2024

  Quote: ... along with 10 µM GSK-3 α and β inhibitor 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea (Tocris) as previously described20 ...
• Light-up split Broccoli aptamer as a versatile tool for RNA assembly monitoring in cell-free TX-TL system, hybrid RNA/DNA origami tagging and DNA biosensing

  Emanuela Torelli, et al., bioRxiv - Synthetic Biology 2022

  Quote: (5Z)-5[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2-methyl-3-(2,2,2-trifluoroethyl)-4H-imidazol-4-one (DFHBI-1T) was purchased from Tocris Bio-techne ...
• Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

  Akiko Ueno, et al., bioRxiv - Neuroscience 2024

  Quote: ... L-(+)-2-amino-4-phosphonobutyric acid (10 µM; L-AP4, 23052-81-5, Tocris, UK) dissolved in Ames’ medium was bath-applied to the retina.
• A distinct hypothalamus-habenula circuit governs risk preference

  Dominik Groos, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4-AP (100 µM, Tocris, 0940, CAS: 504-24-5), CNQX (20 µM ...
• Effect of channel assembly (KCNQ1 or KCNQ1 + KCNE1) on the response of zebrafish I_Ks to I_Ks inhibitors and activators

  Jaakko Haverinen, Minna Hassinen, Matti Vornanen, bioRxiv - Physiology 2021

  Quote: ... L-364,373 (R-L3 or 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one) (Tocris Cookson; Bristol, UK) and mefenamic (dimethylphenylaminobenzoic ...
• Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

  T Fuchsberger, et al., bioRxiv - Neuroscience 2024

  Quote: ... 10 µM N,N,H,-trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1- pentanaminiumbromide hydrobromide (IEM1460; Tocris Bioscience).
• CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability

  Marina P. Hommersom, et al., bioRxiv - Neuroscience 2024

  Quote: ... CACNA1A+/− networks on MEA at DIV51 were treated with 20 µM 4-aminopyridine (4-AP; Tocris, #504-24-5) and recorded for 30 minutes after the compound was added ...
• High Mobility Group Box 1 enhances ADP-mediated platelet activation by increasing platelet surface P2Y₁₂ localization

  Deirdre Nolfi-Donegan, et al., bioRxiv - Cell Biology 2021

  Quote: ... interleukin-1 receptor-associated kinase 1 and 4 (IRAK 1/4; IRAK 1/4 inhibitor, 0.1 μM; Tocris); TANK-binding kinase 1 (TBK1 ...
• Axonal transport of Hrs is activity-dependent and rate limiting for synaptic vesicle protein degradation

  Veronica Birdsall, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4- aminopyridine (Tocris Bioscience, 50 µM, 5 min-2hrs or 20hrs), AP5 (Tocris Bioscience ...
• Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

  Gaël Moquin-Beaudry, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris) ...