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401 - 450 of 746 citations for 3 3 17 17 Bis ethylenedioxy 19 hydroxyandrost 5 ene 19 d2 since 2020

• An unconventional GABAergic circuit differently controls pyramidal neuron activity in two visual cortical areas via endocannabinoids

  Martin Montmerle, et al., bioRxiv - Neuroscience 2021

  Quote: ... with Rimonabant (5 mg/kg, TOCRIS) or vehicle (1.25% (vol/vol ...
• Peptidergic modulation of fear responses by the Edinger-Westphal nucleus

  Michael F. Priest, et al., bioRxiv - Neuroscience 2021

  Quote: ... 20 µM PKI (5-24) (Tocris) was added to the internal solution ...
• Cholinergic control of striatal GABAergic microcircuits

  S. Kocaturk, et al., bioRxiv - Neuroscience 2021

  Quote: ... mecamylamine hydrochloride (MEC; 5 μm, Tocris), Atropine (Sigma ...
• Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis

  Amer Jamalpoor, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... 5 μM A83-01 (Tocris Bioscience) and 10 μM Y-27632 was added as “expansion medium” ...
• Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension

  Luke Grundy, et al., bioRxiv - Neuroscience 2020

  Quote: ... and NPFF (5 μM; Tocris, #3137) with changes in intracellular calcium (Ca2+i ...
• Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

  Juli Liu, et al., bioRxiv - Cell Biology 2020

  Quote: ... 5 μM XAV-939 (Tocris Bioscience) from day 2 to day 4 ...
• Adhesion-mediated mechanosignaling forces mitohormesis

  Kevin M. Tharp, et al., bioRxiv - Cell Biology 2020

  Quote: ... or 5 μM MitoPy1 (Tocris, 4428) was added to media 1 h prior to imaging ...
• A single cell transcriptional roadmap for human pacemaker cell differentiation

  Alexandra Wiesinger, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 5 μmol/L SB431542 (Tocris, #1614), 250 nmol/L RA (Sigma ...
• A Self-Limiting Circuit Regulates Mammary Cap Cell Plasticity Through TGF-beta Signaling

  Armelle Le Guelte, Ian G. Macara, bioRxiv - Developmental Biology 2021

  Quote: ... Hedgehog inhibitor (Cyclopamine, 5 μM, Tocris), Wnt inhibitor (LGK974 ...
• Liver Organoid and T Cell Coculture Models Cytotoxic T Cell Responses against Hepatitis C Virus

  Vaishaali Natarajan, et al., bioRxiv - Immunology 2021

  Quote: ... 5 μM A83-01 (Tocris Bioscience) and 1:1000 diluted R-spondin-1 conditioned media ...
• Altered GABAergic inhibition in CA1 pyramidal neurons modifies despair-like behavior in mice

  Sang Ho Yoon, et al., bioRxiv - Neuroscience 2021

  Quote: ... AP-5 from Tocris (Bristol, UK).
• NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

  Hayden T. Pacl, et al., bioRxiv - Microbiology 2022

  Quote: ... GSK 2837808A (5 μM; Tocris, 5189) or the NAMPT inhibitor FK866 (200 μM ...
• Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

  Michael J. Seibert, et al., bioRxiv - Neuroscience 2022

  Quote: ... 5 mM QX 314 chloride (Tocris) was included in the pipette solutions for all recordings ...
• Linking medicinal cannabis to autotaxin-lysophosphatic acid signaling

  Mathias C. Eymery, et al., bioRxiv - Biochemistry 2022

  Quote: ... 5-DMH-CBD (#1481) from Tocris; CBD (#HB2785 ...
• Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction, progression, and prion-like spread of Alzheimer’s disease pathogenesis

  Yuriy Pomeshchik, et al., bioRxiv - Neuroscience 2023

  Quote: ... and XAV-939 (Tocris, 5 μM). On the tenth day ...
• Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth

  Rachel Hills, et al., bioRxiv - Neuroscience 2022

  Quote: ... SB431542 (days 1-5, 2μM, Tocris), CHIR99021 (days 3-13 ...
• Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice

  Matthew B. Pomrenze, et al., bioRxiv - Neuroscience 2024

  Quote: ... Naltrexone (5 mg/kg, Tocris, 0677), beta-funaltrexamine (β-FNA ...
• Early inflammatory response mediated by Angiotensin II in cardiac arteries of normotensive mice

  Thais Cristina de Souza Oliveira, et al., bioRxiv - Physiology 2023

  Quote: ... 5-PD123.319 (AT2R blocker, ToCris®) and 6-PD+Ang II.
• A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish

  Ugo Coppola, Jennifer Kenney, Joshua S. Waxman, bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM BIO (Tocris, Cat # 3194), 10 μM XAV939 (Tocris ...
• Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans

  Danielle Sadowski, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 µM A83-01 (Tocris Bioscience), and 2 µM CHIR99021 (Tocris Bioscience) ...
• Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

  Renhe Luo, et al., bioRxiv - Genetics 2023

  Quote: ... and 5 µM CHIR99021 (TOCRIS; 4423) for the first day.
• Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C^+/- During Development

  Sanam Shafaatalab, et al., bioRxiv - Cell Biology 2023

  Quote: ... followed by 5 mM IWP4 (Tocris) for 2 days without medium change ...
• Re-engineering of TNF_α-NF-_κB signalling dynamics in cancer cells using pathogenic E. coli effectors

  Qiyun Zhong, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 5 μM necrosulfonamide (NSA) (Tocris) were added to the cells 30 min before infection.
• An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC

  Maroussia M.P. Ganpat, et al., bioRxiv - Cancer Biology 2023

  Quote: ... A83-01 (5 µM, Tocris Bioscience) and Next Generation Surrogate (NGS ...
• Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

  Yasuhiro Nakano, et al., bioRxiv - Cell Biology 2023

  Quote: ... supplemented with SB431542 (5 μM) (Tocris), Dorsomorphin dihydrochloride (0.5 μM ...
• The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells

  Shashi P. Singh, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µM SB431542 (Tocris Bioscience, UK) was added ...
• Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity

  Shuhan Huang, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 mM QX314-Cl (Tocris, #2313), 0.4% biocytin (Sigma ...
• Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism

  Ozan Baytas, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 mM QX-314 (Tocris, 2313) (pH 7.23-7.28 ...
• CircPVT1 sponges miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer

  Alina Catalina Palcau, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 5 μM A83-01 (Tocris Bioscience), and 500 nM SB202190 (PeproTech ...
• Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner

  Jessica L Hoffman, et al., bioRxiv - Neuroscience 2022

  Quote: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one (JNJ-5; Tocris, Minneapolis, MN) is a high affinity ...
• Amyloid-beta mediates homeostatic synaptic plasticity

  Christos Galanis, et al., bioRxiv - Neuroscience 2020

  Quote: ... KN-92 (5 μM; Tocris, Cat# 4130), KN-93 (5 μM ...
• Amyloid-beta mediates homeostatic synaptic plasticity

  Christos Galanis, et al., bioRxiv - Neuroscience 2020

  Quote: ... KN-93 (5 μM; Tocris, Cat# 1278), BNT77 (1.3 μg/ml ...
• Inhibitory control of synaptic signals preceding motor action in mouse frontal cortex

  Chun-Lei Zhang, et al., bioRxiv - Neuroscience 2021

  Quote: ... CNO (Tocris Biosciences; 5 mg/kg i.p.) was administered to activate the hM4D receptor 30 min prior to recordings (Jackson et al. ...
• STK25 inhibits PKA signaling by phosphorylating PRKAR1A

  Xiaokan Zhang, et al., bioRxiv - Physiology 2022

  Quote: ... 5 μM Y-27632 dihydrochloride (Tocris, 1254) was supplemented to culture medium.
• A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

  Jinsoo Seo, et al., bioRxiv - Neuroscience 2020

  Quote: ... 5 μM TGFβ-inhibitor (SB431532, Tocris Biosciences), 3 μM Wnt-inhibitor (IWRe1 ...
• SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2020

  Quote: ... and 5 μM Y-2763 (Tocris: #12543). The cells were maintained in RPMI 1640 medium supplemented with insulin-containing B-27 until day 30-50 ...
• Distinct molecular pathways govern presynaptic homeostatic plasticity

  Anu G. Nair, Paola Muttathukunnel, Martin Müller, bioRxiv - Neuroscience 2021

  Quote: ... and γDGG (5 mM; Cat # 0112, Tocris). Except for experiments in Fig ...
• Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway

  Shan Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... H89 (5 mM in MQ, Tocris 2910); KT5720 (1 mM in DMSO ...
• NASP maintains histone H3–H4 homeostasis through two distinct H3 binding modes

  Hongyu Bao, et al., bioRxiv - Biochemistry 2021

  Quote: ... or 5 μM dTAG-13 (6605, Tocris) for the indicated times ...
• Disparate temperature-dependent virus – host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

  Philip V’kovski, et al., bioRxiv - Microbiology 2020

  Quote: ... and 5 μmol/L Y27832 (Tocris, USA) 53 ...
• Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT_1A and 5-HT_1B receptors in monkeys

  Yukiko Hori, et al., bioRxiv - Neuroscience 2023

  Quote: ... GR55562 (cat# 1054, Tocris; for 5-HT1BR), MDL100907 (M3324 ...
• Renal mechanotransduction is an essential regulator of renin

  Rose Z. Hill, et al., bioRxiv - Physiology 2023

  Quote: ... with 5 mg/kg indomethacin (Tocris, 1708) dissolved in 0.01 M sodium carbonate with 1% DMSO in water.
• Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

  Shana M. Owens, et al., bioRxiv - Microbiology 2023

  Quote: ... and KU-55933 (5 μM, Tocris Bioscience) were reconstituted in DMSO ...
• BLOC1S1 control of vacuolar organelle fidelity modulates T_H2 cell immunity and allergy susceptibility

  Rahul Sharma, et al., bioRxiv - Immunology 2024

  Quote: ... STING inhibitor H151 (5 µM, Tocris Bioscience), or Rapamycin (2 µM ...
• A Consequence of Immature Breathing induces Persistent Changes in Hippocampal Synaptic Plasticity and Behavior: A Role of Pro-Oxidant State and NMDA Receptor Imbalance

  Alejandra Arias-Cavieres, Alfredo J. Garcia III, bioRxiv - Neuroscience 2023

  Quote: ... TCN-213 (5 µM, Tocris, Cat#4163) was used to block GluN2A and ifenprodil (5 µM ...
• Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

  Stijn De Munter, et al., bioRxiv - Immunology 2023

  Quote: ... and 5 μM A83-01 (Tocris Bioscience)) ...
• Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

  Sierra N. Cullati, et al., bioRxiv - Cell Biology 2023

  Quote: ... and aphidicolin (5 μg/mL; Tocris Bioscience) block-and-release protocol ...
• Network-level encoding of local neurotransmitters in cortical astrocytes

  Michelle K. Cahill, et al., bioRxiv - Neuroscience 2023

  Quote: ... (1S,3R)-ACPD (t-ACPD, 5–100 μM, Tocris); LY 379268 disodium salt (100 μM ...
• NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration

  Juliano V Alves, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... NOX1 inhibitor (NOXA1ds, Tocris, 10−5 M); NOX5 inhibitor (Melittin ...
• Human Trophoblast Stem Cells Restrict Human Cytomegalovirus Replication

  Tyler B. Rollman, et al., bioRxiv - Microbiology 2023

  Quote: ... 5 µM A83-01 (Tocris Bioscience 2939), 0.8 mM valproic acid (Millipore Sigma 676380) ...