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401 - 450 of 1003 citations for 1 4 Nitrophenyl cyclobutanecarbonitrile since 2020

• Calsyntenin-3, an atypical cadherin, suppresses inhibitory basket- and stellate-cell synapses but boosts excitatory parallel-fiber synapses in cerebellum

  Zhihui Liu, et al., bioRxiv - Neuroscience 2021

  Quote: ... (1) 10 μM CNQX (1045, Tocris) and 10 μM APV were included in ACSF ...
• Nogo-A Beyond the RhoA/ROCK Pathway – Novel Components of Intracellular Nogo-A Signaling Cascades

  Martina A. Maibach, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 nM JTE-013 (Tocris, 2392), 0.5 U Heparinase III (Sigma ...
• Dopaminergic neuromodulation of spike timing dependent plasticity in mature adult rodent and human cortical neurons

  Emma Louise Louth, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 μM gabazine (SR 95531, Tocris) was applied at the end of an STDP recordings ...
• Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons

  Rahel Kastli, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 µM TTX (Tetrodotoxin citrate, Tocris) was added to the circulating aCSF and 12 min after ...
• Delta Oscillations Are a Robust Biomarker of Dopamine Depletion Severity and Motor Dysfunction in Awake Mice

  Timothy C. Whalen, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 mg/kg SKF81297 (Tocris Biosciences), or 3 mg/kg quinpirole ...
• Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

  Caroline E. Strong, et al., bioRxiv - Bioengineering 2022

  Quote: ... 1 mM cAMP (Tocris, cat# 1141), and 20 nM ascorbic acid (Tocris ...
• Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain

  Yu-Ling Lin, et al., bioRxiv - Neuroscience 2022

  Quote: ... and tetrodotoxin (TTX; 1 µM, Tocris) to block GABAA-receptor- ...
• Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells

  Thulaj Meharwade, et al., bioRxiv - Developmental Biology 2022

  Quote: ... TAK1 inhibitor (1 μM, Tocris 3604), SB431542 (2 μM ...
• Augmentation of extracellular ATP synergizes with chemotherapy in triple negative breast cancer

  Jasmine M Manouchehri, et al., bioRxiv - Cancer Biology 2022

  Quote: ... sodium polyoxotungstate or POM-1 (Tocris), PSB 069 (Tocris) ...
• Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia

  Silvia De Cicco, et al., bioRxiv - Neuroscience 2020

  Quote: ... LRRK2-IN-1 and GSK2578215A (Tocris).
• Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid-beta degrading enzyme in brain

  Per Nilsson, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 μM cyclo-SST (Tocris #3493), 100 nM CH275 (Tocris #2454) ...
• Purinergic signaling controls spontaneous activity in the auditory system throughout early development

  Travis A. Babola, et al., bioRxiv - Neuroscience 2020

  Quote: ... or MRS2500 (1 µM; Tocris, 2154) were added directly to the bath and allowed to equilibrate for 5 minutes before capturing an additional 5-minutes used for analysis of pharmacological block.
• Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

  Gaël Moquin-Beaudry, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and 1 μM A83-01 (Tocris). From day 10 to day 15 ...
• Intracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules

  Tao Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 2 μM DMH-1 (Tocris) for 6 d ...
• Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

  Calvin J. Kersbergen, et al., bioRxiv - Neuroscience 2022

  Quote: ... Application of MRS2500 (Tocris, 1 μM) was performed by superfusion by gravity of MRS2500-containing aCSF without interruption of continuous aCSF flow ...
• High Mobility Group Box 1 enhances ADP-mediated platelet activation by increasing platelet surface P2Y₁₂ localization

  Deirdre Nolfi-Donegan, et al., bioRxiv - Cell Biology 2021

  Quote: ... P2Y1 (MRS 2500, 1 nM; Tocris); P2Y12 (AR-C 66096 ...
• New and improved GRAB fluorescent sensors for monitoring dopaminergic activity in vivo

  Fangmiao Sun, et al., bioRxiv - Neuroscience 2020

  Quote: ... and/or 1 μM Halo (Tocris), SCH-23390 (Tocris) ...
• Reconstructing human early embryogenesis in vitro with pluripotent stem cells

  Berna Sozen, et al., bioRxiv - Developmental Biology 2021

  Quote: ... (S)-(+)-Dimethindenemaleate (D, 1 mM; Tocris, 1425) and Minocycline hydrochloride (M ...
• Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle in vitro

  Ziad Al Tanoury, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM Chiron (Tocris, Cat. # 4423), 0.2% Pen/Strep (Life Technologies ...
• The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling Golgi-to-ER retrograde transport

  HA Bustamante, et al., bioRxiv - Cell Biology 2020

  Quote: ... Torin-1 was purchased from Tocris Bioscience (Bristol ...
• Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle in vitro

  Ziad Al Tanoury, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM Chiron (Tocris, Cat. # 4423), 0.2% Pen/Strep (Life Technologies ...
• High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

  A.L. Gard, et al., bioRxiv - Microbiology 2020

  Quote: ... 1 μM A-83-01 (Tocris), 0.2 μM DMH-1 (Tocris) ...
• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and 1 μM A83-01 (Tocris) for 5 days ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CHIR99021 (1 μM, Cat# 4423, Tocris), BMP4 (15ng/ml ...
• Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

  Paul Batty, et al., bioRxiv - Cell Biology 2023

  Quote: ... 1 µM dTAG-7 (Tocris, 6912) was added 14 h after the release from the final aphidicolin block ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... BAY-293 (Tocris, 6857, 1 μM), LY294002 (Sigma‒Aldrich ...
• Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4

  Simone Franziska Glaser, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and HOECHST (1:500; #5117, Tocris) in blocking buffer at 4 °C ...
• PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

  Payam Gharibani, et al., bioRxiv - Neuroscience 2023

  Quote: Bryo-1 was purchased from Tocris Bioscience (catalog no ...
• Neuronal FOS reports synchronized activity of presynaptic neurons

  Margarita Anisimova, et al., bioRxiv - Neuroscience 2023

  Quote: ... or L-CCG-1 (Tocris, 0333) at 10 or 500 µM ...
• LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

  Narayana Yadavalli, Shawn M. Ferguson, bioRxiv - Cell Biology 2023

  Quote: ... LRRK2-IN-1 (Tocris Bioscience # 4273), EDTA (Invitrogen#15575-038).
• A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

  Landys Lopez Quezada, et al., bioRxiv - Bioengineering 2023

  Quote: ... 1 μM A-83-01 (Tocris), 0.2 μM DMH-1 (Tocris) ...
• Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth

  Rachel Hills, et al., bioRxiv - Neuroscience 2022

  Quote: ... SB431542 (days 1-5, 2μM, Tocris), CHIR99021 (days 3-13 ...
• Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

  Samuel L Palframan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 1 nM gastrin (Tocris, Cat# G9145), 2 µM A-83-01 (Tocris ...
• Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression

  Ruhul Amin, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 1 μM dTAG-13 (Tocris Bioscience) was used for 24 h.
• Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicity

  Prabha Acharya, et al., bioRxiv - Bioengineering 2024

  Quote: ... 50 nM Chroman 1 (7163, Tocris), 0.7 µM Trans-ISRIB (5284 ...
• Synthesis and application of a photocaged L-lactate

  Ikumi Miyazaki, et al., bioRxiv - Biochemistry 2024

  Quote: ... and 1 μM AR-C155858 (Tocris) with 5 mM MNI-l-lac (1% DMSO ...
• Diverse GABA signaling in the inner retina enables spatiotemporal coding

  Akihiro Matsumoto, et al., bioRxiv - Neuroscience 2024

  Quote: ... we used tetrodotoxin (1 μM, Tocris) to block Na+ channels by bath application (Extended Data Figure 3).
• Chemogenetic attenuation of PFC pyramidal neurons restores deficits in recognition memory following adolescent NMDA receptor blockade

  Hagar Bauminger, et al., bioRxiv - Neuroscience 2024

  Quote: ... and CAS40709–69-1 (Tocris Bioscience); and applied through the bath to the slice to isolate postsynaptic effects ...
• Chemogenetic attenuation of PFC pyramidal neurons restores deficits in recognition memory following adolescent NMDA receptor blockade

  Hagar Bauminger, et al., bioRxiv - Neuroscience 2024

  Quote: ... and tetrodotoxin (TTX) 1 μM (Tocris) were added to the external ACSF solution ...
• Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

  Shana M. Owens, et al., bioRxiv - Microbiology 2023

  Quote: ... VE-821 (1 μM, Tocris Bioscience), and KU-55933 (5 μM ...
• Higher-order thalamocortical projections selectively control excitability via NMDAR and mGluRI-mediated mechanisms

  Federico Brandalise, et al., bioRxiv - Neuroscience 2023

  Quote: ... QX-314 (1 mM, Tocris Bioscience), Barium (1 mM ...
• Uniform cerebral organoid culture on a pillar plate by simple and reproducible spheroid transfer from an ultralow attachment well plate

  Prabha Acharya, et al., bioRxiv - Bioengineering 2023

  Quote: ... 50 nM Chroman 1 (7163, Tocris), 0.7 µM Trans-ISRIB (5284 ...
• Axo-vascular coupling mediated by oligodendrocytes

  Alejandro Restrepo, et al., bioRxiv - Neuroscience 2022

  Quote: ... L-161,982 (1 µM – Tocris, 2514), Indomethacin (25 µM – Tocris ...
• The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

  Tuba Barut, et al., bioRxiv - Microbiology 2022

  Quote: ... 1 μM A-83-01 (Tocris), 3 μM isoproterenol (abcam) ...
• A dedicated hypothalamic oxytocin circuit controls aversive social learning

  Takuya Osakada, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 mg/kg Agonist2127 (Tocris, #5548) in saline was administered intraperitoneally ...
• Ketamine’s rapid antidepressant effects are mediated by Ca²⁺-permeable AMPA receptors in the hippocampus

  Anastasiya Zaytseva, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM (-)-Bicuculline methochloride (Tocris, 0131) and incubated in glycine buffer (Mg2+ free buffer with 0.2 mM glycine ...
• Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis

  Victor M. Bii, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 1 μM prostaglandin E2 (Tocris, 2296), 10 mM Nicotinamide ...
• A Resource of Gene Expression Data from a Multiethnic Population Cohort of Induced Pluripotent Cell–Derived Cardiomyocytes

  Wenjian Lv, et al., bioRxiv - Genomics 2023

  Quote: ... and CHIR 99021 (1 nM, Tocris) for 2 days ...
• A human in vitro neuronal model for studying homeostatic plasticity at the network level

  Xiuming Yuan, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM tetrodotoxin (TTX, Tocris, 1069) was added to certain wells ...
• Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits

  Olivia Pedroncini, et al., bioRxiv - Neuroscience 2024

  Quote: ... When tetrodotoxin (TTX, 1 μM, Tocris) and 4-aminopyridine (4-AP ...