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351 - 400 of 1379 citations for 3 5 Diacetoxy 2 acetoxymethyl 6 phenethyl tetrahydro pyran 4 yl ester since 2020

• Single-cell profiling of transcriptome and histone modifications with EpiDamID

  Franka J. Rang, et al., bioRxiv - Genomics 2021

  Quote: ... 3 μM CHIR99021 (Tocris, SML1046-5MG), 1000 U/mL ESGRO mLIF ...
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

  Kizito-Tshitoko Tshilenge, et al., bioRxiv - Neuroscience 2022

  Quote: ... GABA (3 mM, Tocris Bioscience, 0344), CaCl2 (1.8 mM ...
• Identification of the main barriers to Ku accumulation in chromatin

  Madeleine Bossaert, et al., bioRxiv - Molecular Biology 2024

  Quote: ... or NU-7441 (3 µM, Tocris) were added when specified 1 h prior to irradiation ...
• Defective Schwann cell lipid metabolism alters plasma membrane dynamics in Charcot-Marie-Tooth disease 1A

  Robert Prior, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 mM CHIR-99021 (Tocris Biosciences), and 20 µM SB 431542 (Tocris Biosciences) ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 3 μM CHIR 99021 (Tocris, 4423), and 50 nM PI 103 (Tocris ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

  Giovanni Pietrogrande, et al., bioRxiv - Neuroscience 2023

  Quote: ... and CHIR99021 3 μM (4423, Tocris). After 3 days ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection

  Weixing Cai, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Ang II (4474-91-3, Tocris) was injected subcutaneously at a total dose of 1 ...
• Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway

  Artemis Koumoundourou, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 μM DCG-IV (Tocris Bioscience) was applied after each experiment ...
• Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts

  Hsiu-Chuan Lin, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 3 µM CHIR99021 (Tocris Bioscience).
• Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

  Alwyn Dady, et al., bioRxiv - Developmental Biology 2024

  Quote: ... supplemented with 3 µM Chiron99021 (Tocris) and 20 ng/ml bFGF (PeproTech ...
• GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory

  Hyun Jin Kim, et al., bioRxiv - Neuroscience 2024

  Quote: ... Ifenprodil hemitartrate (3 μM, #0545, Tocris) and PPDA (0.1 μM ...
• Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

  Madison R. Glass, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 μM CHIR99021 (Tocris Bioscience # 4423) and the MEK inhibitor ...
• Modelling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype

  Stephen Qi Rong Wong, et al., bioRxiv - Cancer Biology 2024

  Quote: Oxaliplatin (CAS#: 61825-94-3, Tocris) was dissolved in DMSO ...
• The transcription factor GABPA is a master regulator of naïve pluripotency

  Chengjie Zhou, Meng Wang, Chunxia Zhang, Yi Zhang, bioRxiv - Developmental Biology 2024

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Experience Shapes Chandelier Cell Function and Structure in the Visual Cortex

  Koen Seignette, et al., bioRxiv - Neuroscience 2023

  Quote: ... in combination with potassium channel blocker 4-aminopyridine (4-AP, 1 mM, Tocris) to facilitate transmitter release at monosynaptic connections from RSC to ChC and recorded the PSP amplitudes (Figure 1H) ...
• B cell receptor induced IL-10 production from neonatal CD19+CD43- cells depends on STAT5 mediated IL-6 secretion

  Jiro Sakai, et al., bioRxiv - Immunology 2022

  Quote: ... cells were treated with Pyridone 6 (Tocris Bioscience, Minneapolis, MN), Pimozide (Tocris Bioscience) ...
• Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs

  Tanja Fuchsberger, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 µM PKA inhibitor fragment (6-22) amide (Tocris Bioscience), 0.5 mM anisomycin (stock solution in EtOH ...
• Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function

  Leonardo A. Parra-Rivas, et al., bioRxiv - Neuroscience 2022

  Quote: ... 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, TOCRIS bioscience #0190), D,L-2-amino-5-phosphonovaleric acid (AP5 ...
• Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

  T Fuchsberger, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 µM PKA inhibitor fragment (6-22) amide (Tocris Bioscience), 100 μM 1-naphthyl acetyl spermine trihydrochloride (NASPM trihydrochloride ...
• Cholinergic modulation of distinct inhibitory domains in granule cells of the olfactory bulb

  Pablo S. Villar, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4-DAMP (Catalog #0482, Tocris), AFDX-384 (Catalog #1345 ...
• Endophilin A1 promotes Actin Polymerization in response to Ca²⁺/calmodulin to Initiate Structural Plasticity of Dendritic Spines

  Yanrui Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... KN-62 (4 μM, TOCRIS), BAPTA-AM (10 μM ...
• Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca²⁺ channel activity in continuously active midbrain dopamine neurons

  Anita Siller, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4 µM SR 95531 (Tocris) and 10 µM DL-AP5 (Tocris) ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... Topiramate (Tocris, #97240-79-4), and Carbamazepine (Tocris ...
• Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

  Quyen B. Do, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 4 μM XAV (Tocris). On DIV 04 ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 4-DAMP (10μM, Tocris) was added and incubated for a further 24h ...
• Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis

  Célia Alecki, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 4 μM CHIR99021 (Tocris, #4423) and 10 μM Y-27632 hydrochloride (ROCK inhibitor ...
• SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model

  Christine R. Fisher, et al., bioRxiv - Bioengineering 2021

  Quote: ... + 5 μM ROCKi (Tocris)) and transported on ice to Draper (Cambridge ...
• Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

  Joshua M. Tworig, Chandler Coate, Marla B. Feller, bioRxiv - Neuroscience 2021

  Quote: ... 5 μM pirenzepine (Tocris), 5 μM gabazine (Tocris) ...
• Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

  Joshua M. Tworig, Chandler Coate, Marla B. Feller, bioRxiv - Neuroscience 2021

  Quote: ... 5 μM gabazine (Tocris), 25 μM DL-TBOA (Tocris) ...
• High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

  A.L. Gard, et al., bioRxiv - Microbiology 2020

  Quote: ... 5 μM ROCKi (Tocris), 1 μM A-83-01 (Tocris) ...
• DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

  Daniel J. Wilcock, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 5 μM Ebselen (Tocris), 1 mM Tempol ...
• Cortical spheroids display oscillatory network dynamics

  Jessica L. Sevetson, et al., bioRxiv - Neuroscience 2021

  Quote: ... AP-5 (Tocris 0105) was used at a concentration of 50 μM or 5 μM and incubated with the spheroid for 10 minutes prior to imaging ...
• Osteoarthritis: articular chondrocyte inflammatory signaling leads to enhanced gene expression and function of mechanotransduction channel Piezo1 as a pathogenic feed-forward mechanism

  Whasil Lee, et al., bioRxiv - Molecular Biology 2020

  Quote: ... dynasore (5 μM, Tocris), verapamil (0.5 μM ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µM GSK2033 (Tocris), 10 or 100 µM Zileuton (Sigma) ...
• A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

  Landys Lopez Quezada, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 μM ROCKi (Tocris), 1 μM A-83-01 (Tocris) ...
• Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

  Thomas A. Kluiver, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 µM A83.01 (Tocris), 10 µM forskolin (Tocris ...
• miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity

  Theresa M. Welle, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5 µM FK506 (Tocris), or 20 µM BAPTA-AM (Tocris ...
• Glutamate receptor-dependent cytosolic acidification in hippocampal neurons involves passive flux of protons from the extracellular space

  Sofie E. Pedersen, et al., bioRxiv - Neuroscience 2024

  Quote: ... CCCP (5 µM, Tocris), GABA (50 or 200 µM ...
• The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

  Andrew C. Fleming, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 μM DAPT (Tocris), and 4 μM SU5402 (DNSK International ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... TRO19622 (5 μM; Tocris) and β-mercaptoethanol (Gibco) ...
• Chrna5 is essential for a rapid and protected response to optogenetic release of endogenous acetylcholine in prefrontal cortex

  Sridevi Venkatesan, Evelyn K. Lambe, bioRxiv - Neuroscience 2020

  Quote: ... Dihydro-β-erythroidine (DhβE, 3 μM, Tocris) was used to block β2 containing nicotinic receptors ...
• The mammalian rod synaptic ribbon is essential for Ca_v channel facilitation and ultrafast fusion of the readily releasable pool of vesicles

  Chad Paul Grabner, Tobias Moser, bioRxiv - Biophysics 2020

  Quote: ... at a concentration of 3 μM (TOCRIS). It showed better stability over time ...
• Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis

  Haoyuan Jing, et al., bioRxiv - Cell Biology 2022

  Quote: ... 300 mOsm) containing NBQX (3 µM, Tocris) and bicuculine (30 µM ...
• A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

  Jinsoo Seo, et al., bioRxiv - Neuroscience 2020

  Quote: ... 3 μM Wnt-inhibitor (IWRe1, Tocris Biosciences) for 20 days ...
• Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

  Yasuhiro Umemura, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 µM CHIRON99021 (Wako or Tocris Biosciences), and 1 µM PD0325901 (Wako ...
• Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

  Delfina Larrea, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 3 µM CHIR 99021 (Tocris 4423/10) and 10 µM ascorbic acid (AA ...
• α₁ adrenergic receptor - PKC - Pyk2 - Src signaling boosts L-type Ca²⁺ channel Ca_v1.2 activity and long-term potentiation in rodents

  Kwun Nok Mimi Man, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 µM PF-431396 (Tocris Cat#4278), 10 µM PP2 (Sigma-Aldrich Cat#P0042) ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... GABAB receptor antagonist CGP55845 (3 μM, Tocris), Na+ channel blocker tetrodotoxin (TTX ...